Shiv Pillai
@ShivPillai4
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Have a blast in a lab out in Cambridge Mass/ Maybe I had you once in my immunology class/ Love lymphocytes - study disease/ Silly rhymes - so stop me please
Cambridge, MA
Joined January 2020
An old dog is learning new tricks. Will be putting out a couple of rhymes with explanations each month in a series called "There is Poetry in Immunology". A couple of links below:
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RT @sampathpillai: @vikramsampath Seems to me you cannot take the heat from your own cooking. You might consider leaving the kitchen in tha…
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@mksin149 Many nice studies show T cell responses - protective role unclear. T cell epitopes in all proteins but variant mutations largely in Spike. Unlike HIV, no mutations of T cell epitopes, no protective HLA class I alleles shown. No solid human evidence yet for protective CD8+T cells.
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In this study from well-established epidemiologists, the green lines are a surrogate for Omicron. In southern California ICUs (as on the East coast), death is frequently linked to Delta not Omicron
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RT @jkagan1: Grad school is hard when you love it and impossible when you do not. With PhD interview season beginning, applicants should n…
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RT @SohiniPillai: My lecture for @karwaanheritage, “The Multiplicity of the Mahabharata Tradition,” and my discussion with @iameshansharma_…
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RT @SohiniPillai: Today my aunt found this lovely photo of my Patti (grandmother), Dr. Jaya Kothai Pillai. She was a professor of education…
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@KateJeffrey1 @moderna_tx @MGH_RI @harvardmed Kate, sorry to see you leave the Harvard Immunology program - you will be missed- but welcome to Tech square - you will now be next door to us!
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@covid19_alex @mksin149 T cells are activated. Helper cells that aid antibody production? Yes of course. But, vaccine induced PROTECTIVE cytotoxic T cell immunity that can clear virus in humans? Not established
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RT @SohiniPillai: Looking forward to reading excerpts from this beautiful translation of the Therigatha with the students in my @kcollege R…
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@mksin149 While vaccines do activate T cells and hopefully they do protect, the evidence that the T cells are mediating viral clearance after vaccination is not yet well established in human studies
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Others such as our colleagues @BalazsLab have shown that boosting generates better neutralization of Omicron. Special thanks to Cory Perugino, Hang Liu, our many collaborators especially colleagues @ragon institute, @SchmidtLabHMS, @BalazsLab, @NaranbhaiVivek, @GaihaGaurav.
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Vaccination activates and induces these specialized long-lived memory B cells. After a booster it is “ancient” memory cells “molded” by many long-standing previous exposures that are activated most avidly and can bind most tightly to shapes on the Omicron spike protein.
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Repeated previous exposures to viruses and other microbes have shaped our memory B cells likely over years and decades. Memory B cells that recognize some parts of the Spike protein of SARS-CoV-2 exist in most people and were probably induced by common cold coronaviruses.
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Others have been commenting on a previous and accurate tweet (from @EricTopol) about this preprint of ours so maybe I should try and explain it a little.
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@AnkeetKumar1 @ScienceMagazine @profshanecrotty Currently 99.5% of COVID deaths in the US are in unvaccinated people. But yes, you can be vaccinated first and still get infected - uncommon but does happen. Severe disease and death are rare and one would predict a robust immune response.
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RT @SohiniPillai: I would one day love to own a complete set of the critical edition of the Sanskrit Mahabharata. My PhD advisor Robert Gol…
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