Serena Nik-Zainal
@SerenaNikZainal
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Professor of Genomic Medicine | #NHS | needs regular snacks | delivers an effective roundhouse kick | Though she be but little, she is fierce
Cambridge, England
Joined October 2015
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PAPER OUT!!! 🎉😄💃🏻🕺🏻
Single & double substitution signatures of
#100kGenomesProject
validated with
#ICGC
&
#Hartwig
data🙏
Cannot be achieved without contributions
#NHSpatients
nationwide🇬🇧🥲
#visionary
@GenomicsEngland
@_ADegasperi
tweetorial 2moro!
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Wow!
Thrilled & hugely grateful for this immense honour 😌
Francis Crick Medal & Lecture 🧬!
Thank you
@royalsociety
!
Thank you 🙏 to all that have taught, supported, pushed & mentored me.
So appreciative!
My wonderful TEAM 💖- this is for us!!
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PAPER OUT!!! 😄💃🏻🕺💃🏻
A systematic CRISPR screen defines mutational mechanisms underpinning signatures caused by replication errors & endogenous DNA damage
@NatureCancer
@xueqing_zou
@BillSkarnes
@GenomicsEngland
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Mum 🤍💖
1946-2020
For 27 years, I had afternoon chats with her
Every.Single.Weekend.
Suddenly.. she’s not there... 😔😭
#metastaticBC
makes weekends hard for me
My rock, confidante, grounding force.
Her quote after any major paper:
#AndThisBenefitsMankindHow
😆🥺😭😚
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Two roles available in our team😁! Postdoc & RA.
Looking 4:
decent human
hungry to learn
just
reflective
listener
team-player
able 2 treat others the way they'd expect 2 b treated themselves.
EVERYTHING else can be learned😉
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This is poor
@BBCNews
1) Use her title: Professor. Not Ms.
2) she had the courage to be honest, many bury the truth - your article style (shaming) doesn’t help
3) many a titled, white male in UK academia have done much worse & u look the other way
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My WhatsApp, FB & twitter accounts have exploded!
Please forgive delayed responses!
Altho’ I am going to🇨🇭pick up this
#JosefSteiner
award, it represents collective effort, laughter, tears, enthusiasm, passion, energy, hard work from my wonderful
#TEAM
😭
#WishUWereWithMe
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OMG... Damn you autocorrect!!
I submitted a session proposal for a conference.
Have just spotted autocorrect changed a word in the proposed title for my Invited Guest from:
“Omics” to “Comics” 😳
It says :
Translating COMICS into biological insights.
😱😱😱
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Yay! Our review is paper out!!🤓🥳🕺💃🕺💃
Hope it is useful for the community!
#MutationalSignatures
: Emerging concepts, caveats and clinical applications
Access it here:
🙌
@GeneChChKoh
@_ADegasperi
@xueqing_zou
@SophieMomen
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PAPER OUT!!!🥳
An unfortunate, incidental finding😬
Chemotherapeutic CX-5461 developed 4 patients with BRCA1/2 mutations
in early-phase clinical trials
is a potent mutagen!
@NatureGenet
led by
@GeneChChKoh
Funded by
@CR_UK
@NIHRresearch
@BasserBRCA
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Fantastic (if somewhat disturbing) work from
@michelle_monje
@VirusesImmunity
Mild respiratory COVID causes persistently elevated CSF chemokines, microglial reactivity, impaired hippocampal neurogenesis
#CovidFog
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Diary of a
#UKimmigrant
In an amazing twist, thru the kindness of people I’ve never met, I have been able to get home to my mom in 🇲🇾 on compassionate grounds, in spite of
#covid19
Thank you so very much 🙏😭!
So so so very grateful to be getting this
#precioustime
with her
Diary of a
#UKimmigrant
My mum is dying in Malaysia.
I've been denied entry 2 see her in her last weeks of life.
#BrokenRightNow
When my dad died in an accident, I didn't make it home in time to see him b4 he was buried.
#ThingsYouTake4Granted
#ThingsWeSacrifice
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Thrilled to bits!
Our effort to build a foundation or reference set of mutational signatures of environmental agents is out😁!
#collaboration
@Cambridge_Uni
@KingsCollegeLon
@sangerinstitute
@wellcometrust
#StrategicAward
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Our paper is out! 😊
Showcasing the complexity of
#mutationalsignatures
A practical framework and online tool for mutational signature analyses show intertissue variation and driver dependencies
@NatureCancer
👇
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Our paper on clinical value of whole genome sequencing (WGS) of triple negative breast cancers (TNBC) is out!
@NatureMedicine
#SCANB
@Cambridge_Uni
@lunduniversity
Can our mutational-signature-based algorithm HRDetect predict outcome? Find out👇
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PAPER OUT!! 🥳😁
Let me share a
#tweetorial
about how a nerd moment 🤓when
@foad_rouhani
& I were PhD students >10yrs ago (!)
has (finally) arrived
@NatureGenet
with implications in using
#hiPSCs
in clinical studies & research modelling
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Woo hoo!! 🥳
Hey team, our paper on the cover! 🙌🏼
Thank you
@NatureCancer
!! So honoured!!
@xueqing_zou
@GeneChChKoh
@_ADegasperi
@SophieMomen
@GenomicsEngland
@jc4_jyoti
@DrRebeccaHarris
@ScottNanda
@CherifBadja
@BillSkarnes
💫 In the June issue of
@NatureCancer
:
#MutationalSignatures
of DNA damage, evolution of
#TherapyResistance
in breast cancer, POLQ
#DrugDiscovery
,
#RNAmodifications
in cancer progression + the latest addition in our
#SeriesOnCancerTherapy
Don't miss it!
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Diary of a
#UKimmigrant
My mum is dying in Malaysia.
I've been denied entry 2 see her in her last weeks of life.
#BrokenRightNow
When my dad died in an accident, I didn't make it home in time to see him b4 he was buried.
#ThingsYouTake4Granted
#ThingsWeSacrifice
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It’s OFFICIAL!!!!
CHOCOLATE FOR BREAKFAST IS THE WAY TO GO!!!!
🍫 🤤
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Pregnancy triggers transient olfactory neurogenesis
a.k.a
New mums make new neurons to smell their babies
🐭
How cool is that 😎
@ScienceMagazine
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Pleasure & privilege 2 discuss our research on
@BBCBreakfast
Thank you 2 thousands of people that conceived, planned & executed
#100kGenomes
project, so that we could analyse >12k NHS
#WholeGenomes
#CollectiveEndeavour
And my wonderful TEAM, u r amazing!💖🙏🎉
#WellDoneAll
💪🏼
@SerenaNikZainal
&
@BBCBenThompson
with
@NinaWarhurst
had a fascinating engaging exploration of cancer & its nature on
@BBCBreakfast
!
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Wow. 👇 is a story you have to read! 💪🏼
Casual mentions of what tough moments she must have had to endure.
“titles, promotions, older men, power, it all gets in the way…”
Her impact is on millions!🤩
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Admitted as an Honorary Fellow of my alma mater
@MECCambridge
today.
Feeling super grateful to be part of this community.
Thank you!!😊
PS: Cambridge gowns are a minefield...
It's an IQ test to figure out where to to put your hands😂
(Good deep pockets for hiding stuff tho')
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This will decimate UK academia
We’re increasing the minimum earnings threshold for skilled workers by 48% to £38,700, encouraging businesses to look to British talent first and invest in their workforce.
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Less than 24hrs later…
12-15 year olds will get vaccines! 🥲😭
YAY to Chris Whitty for stepping in!! 👍👏🏼
#leadership
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29th October.
My dad died suddenly on this day 15 years ago.
I didn’t make it home in time to see him before he was buried.
My mum was diagnosed with
#mbc
on this day 8 years later.
There’s them👇 enjoying life! 🥲
Live your best life folks! 💖
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Paper accepted!!!!
WOO HOO!! 🕺💃🏻🕺💃🏻🕺💃🏻
(No matter how old I get, it’s still very exciting to get this sort of news!!
It just makes me wanna BOOOOOGIEEE... )
😆🥳😃😄😎
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Paper out! ☺️💃🏻
Lovely collab with
#NickTurner
team
@ICR_London
using
#HRDetect
algorithm + functional
#HRassay
in
#RIO
#clinicaltrial
on
#TNBC
HR deficiency & PARP inhibition activity in primary triple negative BC
@NatureComms
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Thank you
#reviewer2
!!!! 🕺💃🕺💃
So rare to get a plain positive review.
You've just made two people
@xueqing_zou
and I, very happy little bunnies... 😁😭🤩😁
🙏
🕺💃🕺💃 🕺💃🕺💃 🕺💃🕺💃
💃🕺💃 🕺💃🕺💃 🕺💃🕺💃🕺
🕺💃🕺💃 🕺💃🕺💃 🕺💃🕺💃
😆😆
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That’s us sealing a pact on this day yonks ago 💖
Hope you are ok holding the fort
... with the kids... 🤪.. while I am away.
Just feed them pizza sometimes & take away the XBox controls from time to time...
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Monday morning news!👇😳
Thank you,
#Agong
!
🙏
#AmpunTuanku
How awesome... the week can only gonna go downhill from here!
😆🙈😂
#DJSCRP2019
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PAPER OUT!!🥳
It's on kids with
#XP
A DNA repair defective syndrome where patients are unable to fix UV damage in skin.
Used 2 die as kids from Skin Cancer.
No longer, thx 2 surveillance!
But now some live 2 adulthood & develop early-onset dementia..
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Most large structural variants in cancer genomes can be detected without long reads |
@skimomiks
Important paper!
@NHSgms
take note!
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Luck.
So much of what happens in
#academia
is sheer, damn luck.
Of course hard work and mentoring and all that, yes, but a stroke of good luck sure helps
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PAPER ACCEPTED !! 🥳
This one means a lot😭
(It’s not in
#cancer
)
It is in early-onset
#neurodegeneration
in young adults with DNA repair defects…
So humbling.. that these kids r 2day saved from cancer, but succumb to neurology as young adults… we set out to understand why..
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A new one from our team!!
Dissecting mutational mechanisms underpinning signatures caused by replication errors and endogenous DNA damage
Kudos to
@xueqing_zou
and
@GeneChChKoh
for all their efforts here!
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Signature 18 walks into a bar.
The other Signatures say:
😱 What’s happened to you?
Why have you got so many C>A/G>T mutations?
Sig 18: what can I say… Oxidants happen.
#SignatureDadJokes
🤓
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Oh my word. What an inspiring thread! 👍🏼
THIS is the UK I believe in.
Medics, parents, teachers and media that care enough to make a positive change from the ground up!!
Go Matt! Love it!
If we can't vaccinate our kids, at least fund schools to do this below!
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I was invited to write this
#turningpoints
piece about how/why I became a physician-scientist.
There was no light bulb moment! 😆
I am here because of the people who have inspired me along the way
#grateful
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WOOHOO 🎉!
Cool.....
thank you
@webofscience
!!
V honoured..
Shout out to my
#AweSomeTeam
😍without which none of this would be possible!! 💪🏼💃🏻🕺🤓
Now let’s make it matter for patients 😉☺️
Congratulations to
@SerenaNikZainal
on being included in
@webofscience
#HighlyCited2020
list of influential researchers who have published multiple highly cited papers during the last decade. Full list:
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Bursting with pride!
My
#BigBrother
👇 given an honorific by the King today.
Dead proud, BRUV 🤩!
(And about 3 decades previously👉, my dad was conferred the same title !) 😍😭💓
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Wishing peace and contentment to all this
#EidAlAdha
Feeling hugely
#grateful
for the opportunity to celebrate one more Eid with my mum 🤲🏼
☺️
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Diary of a
#UKimmigrant
Travelling
#longhaul
to Asia in
#CovidTimes
Border entry papers required otherwise ⛔️
Heathrow deserted
Shops closed (except Boots & WHSmith)
On the flight:
1)
#DistancedSeats
2) Flight attendants in full
#PPE
3) Passengers in
#facemasks
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Two young women of mixed ethnicity
in the
#USOpen
final!!
Raducanu vs Fernandez
Romanian/Chinese and Ecuadorian/Filipino-Canadian
Amazing
All the brown girls the world over (including this one🙋🏻♀️) will be squealing & sharing in your delight.
So exciting!!!
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For our next mutational signatures study,
we will endeavour to perform systematic gene-editing of vegetables.
For tempura.
They’ve got to be CRISPR.
#2022resolutions
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In the midst of current life events, we have found some time 4 a bit of respite.
My dad (Tolkien fan) built this place up in the mountains, edge of the rainforest😍
#Bliss
#BackToNature
#Tranquility
#CuzzensPlayTime
#PristineRiver
#ForestTrees
#FruitTrees
#JandaBaik
#Lorien
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Returning to the UK soon...
I feel much safer here in 🇲🇾,
superb
#TTI
process,
airport day-0 testing, quarantine,
day-13 testing,
a working app,
daily updates of all new cases (not just sick cases),
NOT outsourced....😏
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WOW! Spectacular piece!
Differences in somatic alterations in haematopoietic clones between Japanese & UK populations predispose to different types of🩸cancers.
Also large-effect modulating germline variants...
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5-letter & 6-letter seq 🤩
@CEGX_news
published today!
Find more from one assay with no change to sequencing machines, just a tweak to library prep and informatics (processing provided 😅)!
What an exciting time ahead in the omics field!
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Gosh! Humbled to be on this list! 😊
With
@RFitzgerald_lab
@MRC_CU
@meyersonlab
@gaddyg
And many others I don’t have twitter handles for!
Learn about 15 of the incredible "Global Shakers" in the fight to cure
#cancer
--in areas from AI to genomics 🧬
#CancerAwareness
#CancerDay2020
#CancerFighter
#WorldCancerDay2020
#WorldCancerDay
#CancerResearch
#genomics
@SerenaNikZainal
@carlhjune
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Inherited this dying twig-thing in a huge pot 18 years ago from the previous owners of our home.
Didn’t have the heart to throw it out then.
Now it BLOOMS every May in my favourite colour too! 😆🥳
💖
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Well now..... what a privilege.
I get to be part of an enormous non-ethics-approved experiment, conducted by the non-expert government that I didn’t vote for.
The news from abroad: ‘Britain is an outlier. No other country is openly pursuing a policy of ‘herd immunity’. It is deeply controversial’
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Egmond aan zee
Catching a bit of DNA damage ☀️ while at a
#DNARepair
conference 😆
First in-person conference in 2 years!!
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Wow 🤩.... progress!
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Well.. 🙁
Clear signal that if she does become NHS chief, it’s time to leave 🇬🇧.
“Dido Harding vows to end UK reliance on foreign doctors & nurses.”
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Lovely night out with the wonderful team 💗🤩💖💝
#academicMedicine
Celebrating:
People coming & going😘🥲🥰
Distinction graduates😇
Papers/Signal website updates😅
Promotions 🤓
BABIES 👶👶👶
And just being together
🎉🎉🥳🙌🏼
#Grateful
#Happy
#LoveYouAllToBits
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When I was a little girl,
mitochondria were drawn as static peanuts
But look! 👇
A cancer cell videoed through a microscope. It has three nuclei (blue). The mitochondria (yellow) and a cytoskeletal component (VASP;red) are also shown.
#CellBiology
#microscopy
#SciArt
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When I was younger, I used to 🙄 cuz my mom fussed over me when I went home - CONSTANTLY feeding me.
#AsianMom
Today my eldest comes home from Uni for the weekend, and all I can think of is plan food, prep food, what else I am going to feed him… 😂
#AlsoAsianMom
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Paper accepted!!!
🥳🥳
💃🏻🕺🏻💃🏻🕺🏻
(Shocking scientific story. Needs telling. )
🙏 to the amazing
#Team
that pulled this together quickly led by
@GeneChChKoh
(including the editors that pushed us with their advice! )
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So
#MyLovelyTeam
organised a night out but I have covid in my house 🙄, so stayed away…
they’ve brought a photo of me
😳😂🤣
But.. but..
#AmNotDeadYet
💖💖
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😆.. This rings true especially by Tuesday morning...
#AcademicMedicine
#WomenInSTEM
Don't. Say. You. Haven't. Been. Warned.
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Work smart, travel alone, eat out fast: South Korea's prescription for 2 year post-coronavirus recovery
Yes... that’s right folks... That timeline indeed..
This is how we need to think too
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UK's first
#EarlyCancerInstitute
is launched in
@Cambridge_Uni
🥳🎉
That’s where we are!
Looking forward to the launch today!
@EarlyCancerCam
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Deflated
#AcademicMedicine
No matter how hard you try sometimes, it’s just not enough.
Bureaucracy has gotten the better of our efforts to submit an innovative grant.
Just circulated an email around our consortium to give them the bad news.
Sorry team ☹️…
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Leaving soon 2 go 2
#JosefSteiner
ceremony. Wish I had family here!
Sokay, I have
#SemangatRakyat
behind me today💪 !
Completely humbled by the response from 🇲🇾!
😭😊😄😁
#MalaysiaBoleh
Thank you 2 the Josef Steiner foundation 4 giving us the opportunity 2 do more work like👇
Our paper on clinical value of whole genome sequencing (WGS) of triple negative breast cancers (TNBC) is out!
@NatureMedicine
#SCANB
@Cambridge_Uni
@lunduniversity
Can our mutational-signature-based algorithm HRDetect predict outcome? Find out👇
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Our paper on
#ValidatingMutationalSignatures
using isogenic cell models is out!
Fab collaboration with
#JoannaLoizou
#CeMMAustriaAcademySciences
@SPJacksonGroup
Great to be able to
#recapitulate
endogenous
#signatures
experimentally
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Thank you for coverage!! 🥲🙏
It is the greatest privilege of our lives to do research on these samples. Thank you 2 all who donate samples, recruit patients, came up with the visionary project, & the consortia that shared their data 4 validation!
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Opportunity!!
5 year UL Clinical Genetics post with me
#fiftyfifty
clinical/academic 🥳
Come do cancer/general genomics🧑🏻💻
Broad spectrum academic/NHS exposure🧑🏻🔬
Consultant level🧑🏻⚕️
Email/DM me
Attitude valued +++
Everything else can be learned ☺️🤓💪🏼
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Gonna go find that pot of gold at the bottom of my garden... 💪🏼🤩💰
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Pls can someone explain 😇
Why have we moved away from having CVs in grant applications in the UK?
Why is it being replaced by a ‘narrative CV’?
It makes serving on grant panels decidedly difficult…
facts replaced by endless waffle…
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WOW! 💪🏼 🤗
Total courage shown in what must be an intimidating environment
#WomenInSTEM
She socked him one 😆
And I AM CHEERING!! 📣🤩
Here’s a clip of the woman who confronted the panel. I deeply admire her courage.
“It is nothing compared to the systematic and structural discrimination have to face, especially in the stem fields”
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Happy Chinese New Year!!!! 🧧
Missing fam 🥲....
Sharing this amazing 3D thang from my hometown
#pavilion
#kl
Isn’t it spectacular ? 😳🤩
#YearOfTheOx
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Wow! They’re DOUBLING the numbers..... wait for it.........
from 62 to 120 a year.....🙄🙄🙄
FFS.
Priti, hold the exit door open
cuz a whole bunch of us
will fast-track our way out of the UK at a much higher rate than that.
The UK is a world leader in science, that’s why I’m introducing fast track entry to the UK for more scientists so we can attract the brightest global talent.
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If you have met me in person, you will know what a wee dot I am, often dismissed as small & meek on appearance
Today I was told that I can be intimidating👌
Brilliant!
I am taking this as positive feedback😆
💃🏻🕺🏻💃🏻🕺🏻
#WillCallOutMisogyny
#DontAskMeToUnderstand
#NoMorePanels
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Wow 🤩
Amazing case report. The medicine of tomorrow. 5 week old boy admitted to NICU. Within 37 hours he had his whole genome sequenced, gene defect identified, treatment ordered and received by patient. Within 6 hr symptoms resolved.
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Some dude walks into meeting room, takes one look at me and says:
I thought I was meeting with your PI? His name is Nick Zainal.
#FacePalm
#GiveMeStrength
#WomenInSTEM
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Attending
#CRUKGrandChallenge
Annual Summit
@CR_UK
While making supper for the fam
#Roti
#RotiCanai
#WomenInSTEM
#AcademicMedicine
#juggling
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@BallouxFrancois
I'm not part of this debate at all.
As a mum of two, I don't remember many supporting school closures.
I do remember loud voices calling for improved mitigations in school tho.
The problem with your tweet is that it creates a polarising situation out of a non-argument.
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I got new glasses! 🤓
(to improve my eyesight but also)
to look like I had more… umm..
#gravitas
My kids reckon it hasn’t worked
😏😫😂
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🥲
My dad mentioned early in the article below💖.
Pioneering, visionary man.
Sowed the seeds of the National Heart Institute in 🇲🇾.
Recruited, got funding for, fought for (in this article) cardiothoracic surgery & lots more (cath, CHD screening, etc)✊
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@acmedsci
@Cambridge_Uni
@CR_UK
@sangerinstitute
Thank you Foulkes Foundation for this immense honour.
My team and I are thrilled to bits! 🥳
Thanks to all our supporters, mentors, sponsors, funders, collaborators and friends! 🙏
Huge gratitude to all the patients and families that make our research possible!
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UK Clinical Genomics 2021 tomorrow!
Three AMAZING women in my team giving talks💪
@xueqing_zou
- signatures of environmental mutagens
@SophieMomen
- XPC sarcoma responding 2 immunotherapy
Helen
#BRAF
Davies - retinoblastoma genomics
I am Dead Proud! ☺️💖
#allworkingmums
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Bioinformatics postdoc position in my team!
Promise it will be exciting!
☺️
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Muahahaha... 🙋🏻♀️
"It actually doesn't take much to be considered a difficult woman. That's why there are so many of us." Jane Goodall.
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First Eid with neither parent
#MissingLovedOnes
Live your best lives folks
Celebrate when you can 💖
#SelamatHariRaya
#MaafZahirBatin
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Am particularly delighted as a rock solid mentor is also on the list 👇 as a Croonian lecture medalist!! 🤩
#SadafFarooqi
And I am so impressed at the gender balance in the 2021
@royalsociety
awards! 👏🏼
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In my next life,
I want to be a
#MasterchefFoodCritique
What a great job…
I mean….
I would really miss
academic admin,
passive-aggressive egoists,
box-ticking bureaucrats,
online training…
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