Dr Spiros Makris
@S_Makris
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#Preprint
doi:
It started as a small story...but we are now understanding the role of
#podoplanin
in fibroblastic reticular cell function and lymph node tissue organisation. Thank you to everyone involved in the paper.
#Preprint
Latest work from super postdoc
@S_Makris
is now online
@biorxiv_immuno
We conditionally deleted
#podoplanin
in adult lymphoid tissues and found serious defects in homeostatic tissue organisation and fibroblastic reticular cell function
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Excited to share a publication from my PhD with
@cjohansson_lab
on immune responses in neonatal lungs.
@MucosalImmunol
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@ActonLab
trying her lymph node superhero cape (new design for our team lab coats?) credit to
@hughzford
and
@LMCB_UCL
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Back in London full of ideas after an amazing NIF Winter School in Awaji Island and Osaka, Japan. Amazing science, new friends and great culture.
#NIF2020
#NIFwinterschool
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My first review article in the
@ActonLab
in
@DMM_Journal
on how lymphoid tissue function determines disease progression during infections, chronic inflammatory conditions and cancer.
Team effort from
@lotte_dewinde
@hlhorsnell2
@j_cantoral
@rach_finlay
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#podoplanin
impact on lymph node function. Available as a preprint soon..! Also join us at the
#BSI22
conference where I will present this work (and more!) at the Bright Sparks and Stromal Cell Immunology sessions!
@ActonLab
Shiny new
#preprint
coming soon!
Work led by
@S_Makris
and
@yuktihari
featuring the 2020 lockdown project of fantastic master's student
@j_cantoral
. We examine alternative signalling pathways downstream of
#podoplanin
and how they impact lymph node function.
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It was exciting to be involved in this
@ImmunityCP
preview covering two great papers.
Our preview in
@ImmunityCP
"The Stromal Niche Guarding the Gatekeepers"
2 great papers showing
#stroma
in lymph nodes controls differentiation and replenishment of sub capsular sinus macrophages.
Tissue
#microenvironment
is always key
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Who said you only have early starts during your PhD? Even managed to wake up before my son. 💪🏻
#postdoclife
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Looking forward to answering more questions about
#stromal
cells with our new toy! Makes my lab area more colourful as well..
@ActonLab
@LMCB_UCL
@miltenyibiotec
New toy!
@miltenyibiotec
thanks for the help setting up.
@S_Makris
will be testing this out to enrich our super delicate
#stromal
cells for analysis...
@LMCB_UCL
colleagues come and ask us about it if you want gentle sorting for your cells!
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Great Stromal Immunology session at the ASI 2021. Amazing science and great experience of a post-midnight presentation.
@Stromal_Immunol
@ImmunologyMelb
@SMuellerLab
@hlhorsnell2
@ActonLab
#ASI2021Online
@LMCB_UCL
All the way from London, UK
@S_Makris
with his presentation: “Podoplanin maintains lymph node tissue integrity and is required for immune response in the lymph node” in the
@Stromal_Immunol
stream
#ASI2021Online
@ASImmunology
@ucl
@SMuellerLab
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@ActonLab
enjoying the view to Liverpool for
#BSI22
. Looking forward to the science and seeing old friends. Come and find us if you are interested in Stromal Immunology
@ActonLab
@LachinaNika
@nicolanguyxn
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And another 14 hours with BD Symphony cytometer and my lymph nodes...! Only possible with the coffee
@christabenji
surprised me with!
#teamwork
@ActonLab
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Congratulations
@hlhorsnell2
! Amazing work!
Congratulations to Harry Horsnell for his beautiful work on 'Lymph node homestasis & adaptation to immune challenge resolved by fibroblast network mechanics'. Harry is the winner of the 2021 Gabrielle Murphy Prize for Stromal Immunology!
@hlhorsnell2
@ASImmunology
#ASI2021Online
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A nice mini-review on rhinovirus immunity: Recent advances in understanding rhinovirus immunity. Makris S and Johnston S, published by
@F1000Research
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Another great story from
@ActonLab
and amazing team effort!
@MillwardLindsey
brought her image analysis skills to show the amoeboid blebs of invading podoplanin+ cells in vivo...
@S_Makris
brought his flow cytometry skills to add important controls showing that the blabbing we see is for migration and not apoptosis
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@ActonLab
@lotte_dewinde
@VctorGMartinez2
You need to wear the correct clothes, listen to the correct music and do the experiment at the same time of the day for it to go well...!
#allornothing
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Another great paper by
@lotte_dewinde
in
@ActonLab
! Very happy to be involved in this project.
My first
#postdoc
paper from
@Actonlab
#specialmoment
How can one protein perform different functions on the same cell?
Different partner proteins are necessary to control podoplanin expression on lymph node FRCs, and to switch its function upon interaction with dendritic cells.
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If you are interested in our work and stromal immunology the
@ActonLab
will be at the
@bsicongress
next week were I will be presenting new data at the
#brightsparks
and the
#stromalimmunology
sessions.
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Deletion of podoplanin expression in fibroblastic stoma in vivo caused changes to the phenotype of FRCs.
doi:
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@lotte_dewinde
@ActonLab
Not throwing him in the deep end yet…!Starting him ‘easy’ with assisting me on a couple of my All or nothing days…
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@lotte_dewinde
@ActonLab
Story coming along well and enjoying the new technology in the meeting rooms
@LMCB_UCL
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@ActonLab
@VctorGMartinez2
@JorgeBarbazan
@YannDesfougeres
@tranejoan
I don’t mind! I am awake early to book the microscope!
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Congrats Cecilia, well deserved!
Very happy to have been promoted to Professor of Mucosal Immunology at
@imperialcollege
@ImperialNHLI
Huge thanks to current and past group members, colleagues, collaborators, mentors, supervisors, funders, friends and family.🥂
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