Segun Fatumo
@SFatumo
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Professor and Chair of Genomic Diversity @QMUL ; Head, NCD Genomics at MRC/UVRI and LSHTM Uganda. Genomics | GWAS | Africa | Capacity Building | Global Health
UK, Uganda, Nigeria and Global
Joined November 2014
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Pinned Tweet
5 years is a VERY LONG time for a paper to be under review.
That was the case for our recently published paper in Nature.
Submitted in 2018 and published in 2023
What do you do as an early career researcher while waiting for a very important paper to be published ?
1/4
RT
46
205
970
I am deeply honoured and grateful to win the inaugural
@The_MRC
MRC impact Award 2022. So grateful to everyone who made this happen especially all members of my group
@TACG_Group
and the management of
@MRC_Uganda
and
@LSHTM
for nominating me for this award.
@H3ABioNet
@H3Africa
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I have no words to describe the feeling I felt yesterday at my inaugural lecture.
It was my opportunity to share my career journey of 20 years in bioinformatics & genomics with a diverse audience of many colleagues, students, family members, friends, and the public.
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43
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Our paper "Promoting the Genomic Revolution in Africa through the Nigerian 100K Genome Project" is published in
@NatureGenet
today
The wait for the AFRICAN LARGEST RICH WELL-CHARACTERIZED Genomic data is almost over.
@weare54gene
@AbasiEneobong
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The underrepresentation of Africans in genomics is largely due to a lack of capacity, data and analytical expertise in the continent.
Last year, we trained about 25 African scientists in Polygenic Risk Score Analysis.
1/3
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Our paper on "Roadmap to Increase Diversity in Genomic Studies" is published in
@NatureMedicine
We describe factors contributing to genomics imbalance and propose a roadmap to enhance inclusion. 1/5
Team
@tchikowore1
@Ayub1985
@genetisaur
@Kkuchenbaecker
8
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Have you heard about the Nigerian 100K genome project?
Amazing results from the initial 1K whole-genome sequence of 50 tribal groups in Nigeria, presented by
@codushlaine
at
#ASHG21
.
Exciting moment to see great science from the beloved motherland
@weare54gene
@AbasiEneobong
5
43
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Our new GWAS/finemapping paper of lipid traits in 125,000 individuals of African ancestry is published online today
@NatureComms
We reported 18 novel loci associated with lipid traits & 18% mean reduction in the 99% credible set using for multi-trait finemapping.
RT
1/5
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Africa is underrepresented in genomic studies.
This isn’t all due to lack of genomic data but partly due to lack of motivation by African scientists to share their data as a result of previous exploitation, mistrust, and misuse of research participant samples and data.
1/4
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Super excited to see our paper titled “Transferability of genetic risk scores in African populations” published
@NatureMedicine
Excellent collaborative work co-led with my friend
@tchikowore1
and a senior postdoc in our group
@TACG_Group
- Abram Kamiza.
5
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Delighted to see this piece published
@Nature
.
Only about 1% of genomic studies use data from people of African ancestry, and those data are mainly from African Americans.
@MRC_Uganda
@LSHTM
@H3Africa
1/2
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I am hiring a postdoc who is interested in leading projects on genetic epidemiology
@TACG_Group
@MRC_Uganda
and can support postgraduate students' supervision
Please help RT
@H3Africa
@DSI_Africa
@H3ABioNet
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Uganda Genome Resource (UGR) has been highly successful. In this paper published today
@CellGenomics
, We provide an overview of UGR - genetic/phenotype characteristics, genetic discoveries to date, and data access and sharing.
@MRC_Uganda
@LSHTM
1
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Africa's underrepresentation in genomics is largely due to limited capacity for large-scale genomic data analysis.
Over the past 3 years, we are strategically tackling this issue by training approx 25 African scientists yearly in PRS/GWAS.
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167
Excited to have contributed to a new landmark
@Nature
paper published today.
Genomes Analysis of HIV-1-infected individuals shows a novel African-specific genetic variation associated with reduced viral loads
1/4
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I am very excited to invite you to attend my inaugural lecture titled
One World, Many Genomes: Bridging the Gap for Precision Medicine
When: Thurs, June 6, 2024, 3-4pm
Where: Milton Lecture Theatre, Garrod Building, Turner Street, E1 2AD, Whitechapel
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Fees for publishing start from about US$800 and can reach over US$11,000
Salaries of researchers in developing world range from US$350 to about US$3,000
Waiver systems ‘too complex and bureaucratic’
Open access ‘excludes’ developing world scientists
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90
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Super excited to be awarded
@wellcometrust
Intermediate Fellowship to lead an innovative research programme
@MRC_Uganda
and
@LSHTM
. Really grateful to everyone who supported me on this journey
@MUIIPlus
@UVRIug
@H3AbioNet
@H3Africa
@NBG__Network
@sangerinstitute
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The lack of diversity in genomic research could mean Africans are missing out on potential life-changing care for chronic health disorders
It is crucial that we address this lack of diversity in genomic data.
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African genomes hold the key to accurate genetic risk prediction
@minouye271
@H3Africa
@ICHG2023
@MRC_Uganda
@LSHTM
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So beautiful to see a part of the Nigerian 100K genomes project published today
@CellGenomics
47 unique ethnolinguistic groups from 449 Nigerians.
We provide catalog of novel and medically relevant variation
Great work led by
@codushlaine
@_EshaJoshi
@aabiddanda
RT 🙏
1/4
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Super excited for an excellent Postdoc in my group
@TACG_Group
-Dr Allan Kalungi
@kaluallan
who has been awarded the prestigious
@wellcometrust
Early Career fellowship to investigate the Genetic risk for Major Depressive Disorder in Uganda
@MRC_Uganda
. Congratulations Allan !
1/2
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During
#ICHG2023
@Nicky_Mulder
and Francis Collins launched an ambitious plan to establish eight Genomics Centres of Excellence across Africa aims to transform genomics and provide access to cutting-edge technologies.
3
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We are in Abuja this week for the FINAL
@H3Africa
Consortium meeting.
I feel so grateful to have benefitted from
@H3ABioNet
capacity building in 2013 as a Postdoc.
It is now my moral responsibility to help other young scientists achieve their career goal unto genomic leadership
5
15
122
So difficult to say goodbye to another member
@KesterBevin13
of our group
@TACG_Group
who secured and starting a fully funded PhD position on the Wellcome Trust Doctoral Training Programme in Genomic Epi
@uniofleicester
We know Kester will do great science.
Congrat Kester
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I am hiring
Join our dynamic team in London
1️⃣ Senior Research Fellow (Assistant Professor).
Salary: £52,549-£58,595.
2️⃣ Programme Manager
Salary: £42,405-£49,785.
Join us and make a real impact on Genomic medicine! 🌍
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Applications are now open to do a fully-funded 4-year PhD at the Sanger Institute
@sangerinstitute
to be awarded by the uni of Cambridge, working at the cutting edge of genomics.
Please share this info with any students who may be interested.
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Charity begins at home - they say.
Today, I was privileged to give a seminar on "Genomics in Africa - Why" at my University to the
@LSHTM
community.
I argue that by prioritizing genomic research in Africa, we not only tap into this rich diversity but also pave the
1/5
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If you are a Black early-career researcher who is interested in genomic research. Here is your opportunity to work
@sangerinstitute
Deadline: 25th March '24
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1) Papers in very high impact factor journals such as Nature, Science, Cell, Lancet are great for your career.
But your career shouldn’t stop because of such paper is stuck under review.
Work on other high-quality science that can be published quicker in other good journals.
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2) Increase the visibility of your delayed high impact paper by getting a permission to get the paper on a preprint.
Preprint makes the world to see your work more quickly and while you are still very excited about it
Your preprint paper can be on your CV for any applications
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It is always a pleasure to be back at the Genome Campus, Hinxton Cambridge. This week I am attending the
#EquityInGenomics23
where I made a few calls to action.
1. We need to act collectively and with urgency: "Africa’s genetic diversity is both its treasure and its promise.
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I am so thrilled to be recognized as a finalist for making outstanding impacts in medical research under the award category MRC Impact Prize
@The_MRC
.
Special thanks
@Wellcome
for funding me and to my organization
@MRC_Uganda
and
@LSHTM
for providing enabling environment to work
@DrNShenker
@imperialcollege
@heartsmilkbank
@milk_foundation
Dr Segun Fatumo
@SFatumo
, Wellcome Intermediate Fellow
@MRC_Uganda
Virus Research Institute and
@LSHTM
Uganda Research Unit, for pioneering genetic risk prediction of complex diseases in Africa and advancing representation of Africans in genomics.
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Today, we celebrate a victory for science, resilience, and the unwavering spirit of those affected by Sickle Cell.
Imagine a world where diseases like Sickle Cell are not just treated but edited at the genetic level.
1/2
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Navigating a career as an early career can be so confusing and challenging.
In my presentation at the ongoing Polygenic Risk Score Analysis
#PRSUganda23
co-organised by
@eventsWCS
@AceUganda
, I had the opportunity to provide 7 pieces of advice for Early Career.
RT
1/8
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To address the lack of diversity in GWAS and PRS studies, and evaluate the relationship between the genetic diversity and PRS performance, we have established the PRS for Cardiometabolic Disorders in African-Ancestry Populations (CARDINAL) study
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By unravelling the genetic architecture of T2D across diverse ancestral backgrounds, we can pave the way for more effective personalized medicine and a healthier future for all.
1
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After almost 4 years of hard work, I am so delighted to see
@Chriskintu2021
excellently defend his PhD work today
@Makerere
.
I am very proud of Chris’ work & his resilience to keep going when it was very tough.
Congratulations Dr Christopher Kintu!
#ProudSupervisor
1/3
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Fantastic Opportunity today to speak in Copenhagen on the need to unveil the Genomic Richness of Africa!
🌍🧬 It is indeed an exciting time as a surge in African genome resources paints a vivid picture of genetic diversity across the continent. 🚀✨
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Bioinformatics has greatly evolved in Africa in the last 10 years.
Our group members
@TACG_Group
and I were delighted to see the success recorded by The ACE Bioinformatics
@AceUganda
only in a few years.
It was a good opportunity to strengthen our group collaboration with them
1
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First GWAS of eGFR in continental African Population.
Discovery and fine-mapping of kidney function loci in first genome-wide association study in Africans
@biorxiv_genetic
@tchikowore1
@Roxytonin
@rnnsubuga
@rkalyes1
@MUIIPlus
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3) Attend conferences and speak with journal editors. They are mostly nice people and approachable.
Try to understand what their expectations are
Ask them what you could do to get your work publish much quicker.
2
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Delighted to make an invited talk
@eshgsociety
#ESHG2022
highlight the importance of Africa ancestry generic risk score.
Using primarily genomic data from white EUR populatns to infer broad scientific conclusion on genomic medicine could be misleading and unhelpful for anyone.
1
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Funds for a major genomics programme in Africa will run dry this year. A chance to address global inequity in health-related genomics by building on the success of this initiative must not be missed.
Could Africa be the future for genomics research?
3
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Super excited to see our new paper published in
@GenomeMedicine
on “Polygenic risk scores for disease risk prediction in Africa: current challenges and future directions”
The majority of existing PRS are developed from European data with limited transferability to African pops.
2
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70
There's a critical need for strong genomic analysis skills in Africa to tackle health disparities. That's why I'm passionate about dedicating 2 weeks every other year to train MSc Bioinformatics students at the African Centre of Excellence in Bioinformatics, Bamako, Mali
1/6
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During the Career Development Forum at the ongoing
#GenevaG2MC
. I offer 5 advice/tips to Early Career Researchers.
1. Every time you have an opportunity to make a presentation – it is your opportunity to sell yourself. Don’t sell yourself CHEAP. People are taking note of you.
1
22
70
The Final "final"
@H3ABioNet
consortium meeting in South Africa (and virtually). So many achievements to report in the last 10 years. No doubt
@H3ABioNet
is indeed a great success and great value for
@NIH
money.
Thanks
@Nicky_Mulder
for an excellent leadership.
1
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Last week it was Dr. Chris Kintu but today it is Dr. Richard Mayanja
Join me to celebrate the remarkable achievement of Dr.
@mayanjarichard_
,who has successfully defended his PhD
@MakerereCHS
. It was indeed a great experience supervising Richard’s work in the last 4years
1/7
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Here is my challenge to African scientists today at
#AfSHG22
"To improve representation of Africans in genomics - recruit participants across all ethnic groups in continental Africa, set the African genomics agenda and train African scientists who can confidently analyse our data
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Our paper reporting the First ever GWAS of kidney function in Africa has been published in
@hmg_journal
.
Excellent editorial process and reviewers.
Discovery and fine-mapping of kidney function loci in first GWAS in Africans
2
13
67
Nice article from the communication and engagement team at
@lshtm
featuring our genomics work
@MRCUganda
Thanks to everyone who is supporting our little contributions
African genomics research is improving health of Africans | LSHTM
1
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African genomic is so important for global precision medicine initiative and shouldnt be left behind.
Join me as I present today at
#PersGen21
2
11
63
I feel honoured to speak at the “Diversity in Clinical Genomics: Minding the gap” meeting today in Cambridge
Parachute science hindered Africa's genomics. Initiatives like
@H3Africa
empower local researchers, but more strategic efforts are needed to build capacity and leadership
0
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Embracing diversity in genomic research ensures that the benefits of advancements in genomics reach everyone, regardless of their population.
By fostering inclusivity, we unlock the full potential of genomic insights, leading to personalized and effective healthcare solutions
0
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Polygenic Risk Score is important to investigate individuals' risk of developing a disease.
This week, we are building this capacity for young scientists
@MRC_Uganda
and postgraduate students from Makerere University.
Taught by Dr
@tchikowore1
from
@SBIMB1
Dr
@OPS
and myself.
0
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63
I'm thrilled to have had the opportunity to speak to a primarily Spanish-speaking audience today in Madrid on “Unlocking the World’s Genomic Diversity for Precision Medicine.”
In my talk, I highlighted the urgent need to close the knowledge gap in genomics....
#genomicamed
4
12
64
Delighted to announce our new paper
@molpsychiatry
Our research highlights the potential of genetics for mental health burdens in Africa
The prevalence of Lifetime MDD is 23% in our population with significant association with high blood pressure
Great work led by
@kaluallan
1
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62
Apply for
@sangerinstitute
three-year Fellowship aimed at people from Black heritage backgrounds.
Sanger is keen to enable Black early career researchers to develop their portfolio of research experience and thrive in the field of UK genomics science.
2
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I have an exciting position for a Postdoc in genetic epidemiology and 2 PhD fellowships to join our dynamic research group
@TACG_Group
at the
@MRC_Uganda
@H3Africa
@H3Abionet
@NBGN12
@MUIIPlus
.
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The Polygenic Risk Score Analysis
#PRSUganda23
ended over the weekend but the collaboration between the participants/tutors continues
The great hunger for learning manifested by the participants gives assurance of sure increased capacity and hope for more high quality science.
1
13
58
We're thrilled to have successfully completed the PRS workshop in Uganda
After a week of learning, they coined the phrase: "If not us, then who? If not now, then when?"
This powerful call to action highlights the urgency of bridging the gap in genomic research
1
5
60
Let's sequence three million genomes across Africa. Why isnt it possible?
Good piece by Prof Ambroise Wonkam
2
24
57
Today at the ongoing PRS workshop organised by
@eventsWCS
, I gave a seminar on Precision Medicine in Africa
Equally important, I offer 10 pieces of advice to this ECR cohort
1] Collaborate, don’t compete. Find the right people and collaborate with them
1
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59
An exciting opportunity for a fully-funded 4-year PhD studentship in epigenetics at MRCG/LSHTM.
Contact Dr Matt Silver for further details
0
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GSK is calling for research proposals focusing on infectious disease research that has the potential to deliver significant health impact and develop future research leaders, with up to £75,000 available per award.
1
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This week we are in Mauritius for a Polygenic Risk Scores workshop funded by
@H3Abionet
to train the next generation of African genomic scientists
Thanks to
@paul_f_oreilly
and
@conrad_iyegbe
4 coming to deliver dis training in-person
Great host
@ShakunBaichoo
, Yasmina & others
2
5
56
Delighted to see our new paper - the first ever GWAS of cystatin C Kidney function in continental Africa published
@eBioMedicine
We reported two novel loci and validated known loci.
Work led by an excellent PhD student
@Richardmayanja6
@MRC_Uganda
0
15
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Really excited to be organising a Mendelian Randomisation workshop this week in Uganda
@MRCUganda
and
@LSHTM
to address the training needs in analysing large-scale genomic data in Africa
Very lucky to have an excellent team of tutors from
@mrc_ieu
@BristolUni
@explodecomputer
2
13
56
Our paper Polygenic Prediction of T2DM in Continental Africa (CA) is published in Diabetes Care
We show that AA–derived PRS was more transferable and predictive in CA.
Great collaborative work and co-led with my colleagues
@tchikowore1
@H3Africa
0
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LSHTM and St George’s will fund six PhD students a year for at least three years under the themes of global health, health data science, infectious disease and translational and implementation research
0
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Excited to share our new perspective
@ScienceMagazine
We highlight the need for broader representation in genomic research to ensure global health equity
The new MVP cohort shows progress with 29% non-EUR ancestry, but more efforts are needed in LMICs
3
15
54
Our paper describing the fantastic effort to strengthen genomics/Bioinformatics in Nigeria has been published.
"NBGN: a collaborative platform to advance bioinformatics and genomics in Nigeria"
2
11
53
Excited to see our paper published
@eBioMedicine
. Great collaborative work led by
@OpeSoremekun
@karhunen_v
with support of
@dpsg108
@stevesphd
In contrast to findings in EUR individuals, we found that LDL-C were associated with an increased risk of T2DM in AFR individual
1/3
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51
Absolutely delighted to be awarded a Fellow of the Higher Education Academy (FHEA)
@AdvanceHE
.Thanks to everyone
@LSHTM
and
@MRC_Uganda
that has helped me along the way
3
7
52
We
@MRC_Uganda
with
@eventsWCS
@AceUganda
@Makerere
are organising a Polygenic Risk Score (PRS) analysis workshop in Uganda.
The course is subsidised by Wellcome Connecting Science Courses and Conferences and is FREE to attend.
APPLY and Join us in Uganda
@H3Africa
3
35
51
Members of our group
@TACG_Group
had a great opportunity to interact with Prof Mike Inouye's
@minouye271
group
@HLRI_Cambridge
at Cambridge Biomedical Campus.
A fantastic research group in a great location to do excellent science. Thank you Mike for the nice lunch.
2
4
50
Fantastic trans-ancestry gwas paper led by
@InesBarroso4
and others published in
@NatureGenet
today
We are only about 400 authors.
Trans-ancestry and single-ancestry meta-analyses identified 242 loci
3
14
51
Best way to learn Mendelian Randomisation is on the Lake Victoria - Africa's largest lake by area, the world's largest tropical lake.
This is how we do it in Uganda
@MRC_Uganda
with an excellent team of tutor from
@mrc_ieu
@lucygoudswaard
@venexia
@explodecomputer
1
9
51
Dear grant agencies: tell me where I went wrong
0
24
50
There are only a few whole genome sequences done in indigenous African populations.
This week, we gather in the beautiful city of Nairobi discussing the potential of sequencing up to 12K Africans and contributing to the representation of Africans in genomics.
3
8
52
Only about 1 out of 10 existing genomic studies are based on data collected from Africans. One way to improve the representation is to have more people in Africa to be in a position to write the continent's own genomics agenda.
@H3Africa
@MRC_Uganda
Genetics has changed healthcare in the last decade, but white Europeans currently make up 86% of all genomic studies. Data from entire ethnic groups is missing.
Why is this, what are the implications and how can we do better? My story for
@BBC_Future
?
1
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0
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It is always my great delight to teach genome-wide association study (GWAS) almost yearly here at the University of Science Technical and Technologies in Bamako Mali building one of the most needed research capacities in Africa.
0
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51
Join me tomorrow (4th May at 11AM Nigerian/UK time) as I speak on "Unlocking the African Genome and the Potential in African Scientists for Precision Medicine"
Register here:
@SFatumo
@cmesbahf
@LSHTM
@MRC_Uganda
@H3ABioNet
@MUIIPlus
@MentorshipMuii
2
21
49
It gladdens my heart to see two members
@rnkamya
@Brendaudosen
of our group
@TACG_Group
starting 4 years fully funded PhD at the University of Leicester today.
Such a joy when young African women succeed against all odds!
Looking forward to their contribution to science.
3
7
48
Here is a good paper that confirms what we already know.
Non-White scientists appear on fewer editorial boards, spend more time under review, and receive fewer citations | Proceedings of the National Academy of Sciences.
1
30
48
Our group
@TACG_Group
today in Uganda, saying goodbye to an amazing postdoc
@OpeSoremekun
who has won two fellowships and leaving to the UK - to spend 3wks in Cambridge University with
@amymariemason
@CambridgeAfrica
and 9months at Imperial college with
@dpsg108
@AfrResExFund
2
5
48
It feels so great to have the opportunity to champion genomics inclusion & diversity at the renowned QMUL ensuring that underrepresented voices are heard and valued
Super excited about the opportunity to retain a parttime position as the head of NCD Genomics
@MRC_Uganda
2/8
3
5
48
Had an amazing time speaking on Genomics in Africa at the New York University Abu Dhabi yesterday
It was an absolute pleasure sharing insights from my career journey with the talented Postdoc & students & a thought-provoking session.
Thanks for the great host Prof
@YIdaghdour
2
1
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@QMUL
is a member of the Russell Group with a difference, ranked 5th in the UK and 14th in the world for quality of research.
I'm looking forward to contributing to the university's cutting-edge genomic research and academic excellence.
3/8
2
2
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Postgraduate Training Fellowship in Medical Statistics for African Scientists
MRC International Statistics and Epidemiology Group | LSHTM
4
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Feel honored to chair the
#ICHG2023
's session on "Diversity for the Future of Precision Medicine & Health Population Screening"
Amazing Presentations by Dr Janina Jeff from
@illumina
, Dr
@romyboua
@SBIMB1
&
@AhmadTayoun
Al Jalila Children hospital Dubai
@ICHG2023
@MRC_Uganda
0
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