Rishi J Desai
@Rishidesai11
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Faculty at Harvard | Operations lead FDA Sentinel Innovation Center https://t.co/imTIzWYcEJ
Boston, MA
Joined September 2014
Time to ask the question- are your observational studies PRINCIPLED? At Sentinel, we are setting the bar high for ourselves and hope the community will follow suit! Check out @bmj_latest describing our process
A five step process guide to help ask and answer a causal question regarding drug treatment effects using healthcare data @Rishidesai11
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Excited to share our latest paper in @AmJEpi led by Janick Weberpals We introduce high-dimensional multiple imputations (hdMI) to handle MNAR through data-driven identification of auxiliary covariates and show that this approach outperforms standard MI
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In a study @npjDigitalMed led by Bowen Gu and @JieHealthAI, we find that LLMs struggle to convey uncertainty and can be overly confident in their answer even when it is wrong. Imp area for research and improvement for detection of hallucinations..
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@haiderwarraich @US_FDA @ARPA_H Congrats Haider on a highly productive stint at the FDA and all the best for your new role!
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RT @BrighamResearch: In 2019, the @US_FDA requested a team of investigators to create a new data infrastructure to improve drug safety surv…
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Thrilled to share that the vision we described 4 years ago is now realized with unveiling of the RWE DE- a fully functional system of 25+ mil individuals with linked EHR and claims data ready to serve the FDA for post marketing surveillance of drugs!
** New paper ** Our vision for integrating large scale EHRs with insurance claims to enhance capabilities of the FDA Sentinel system Working with an exceptional group of investigators who are committed to achieving this goal has been a true privilege
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@noah_greifer Noah I’m curious about your thoughts regarding bag of little bootstraps since you mentioned speed..
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@Michael_Harhay @TheLancet @ecgoligher @UofT @uoftmedicine @UHN @UofT_dlsph Looks fantastic, congrats Michael
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RT @statnews: Researchers suggest FDA could use artificial intelligence to enhance Sentinel, the agency's safety surveillance system for dr…
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RT @MichaelEMatheny: It has been tremendously fun and rewarding to be a part of the FDA's Sentinel Innovation Center, and to work with @Ri…
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LLMs are undoubtedly going to be used increasingly in extracting and synthesizing information from free-text EHRs and other sources of data. Very glad share some considerations published in @JAMANetworkOpen led by @MichaelEMatheny..
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@mvaduganathan @scottdsolomon @PSJhund @ValleAlfonso @AndrewJSauer @MkosiborodMD @P_Rossing @brendonneuen @HanCardiomd @ShelleyZieroth @kidney_boy @NMHheartdoc @gcfmd Fantastic news for the patients! Congratulations Muthu
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@FralickMike @JACCJournals @ankeetbhatt @mvaduganathan Thanks Mike, even the “high use” counties per our definition (quintile 5) had use ranging from 20-55%. So much room for improvement here to get patients on these cheap generic life saving meds..
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@asouth_neph @AmJEpi Thanks, Andrew. The following snapshot from our discussion section explains this in detail..
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Finally, also check out this outstanding commentary by @ProfMattFox @MaartenvSmeden et al., which I have to reluctantly admit is a better read than the actual paper😊
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