Stephen J. Tucker
@ProfKalium
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Ion Channel Biophysics, K+ Channels, OXION PhD programme, @UniofOxford @OxfordPhysics @KavliOxford etc... Find me now on Bluesky....
Oxford, England
Joined January 2017
RT @RSC_BMCS: Do not forget to submit an oral abstract for 8th RSC-BMCS / SCI Symposium on Ion Channels as Therapeutic Targets! This sympo…
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Want to know when is a hydrophobic gate not a hydrophobic gate? Read more here in this Viewpoint:
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RT @biorxiv_biophys: Structures of TASK-1 and TASK-3 K2P channels provide insight into their gating and dysfunction in disease https://t.c…
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Our latest Preprint: More new CryoEM structures of TASK1 and TASK3 @K2pChannels including the G239R disease-causing mutant structure of TASK3 (KCNK9 Imprinting Syndrome/Birk Barel Syndrome)
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RT @ChandaLab06: One of the unforgettable moments at the 2024 Ion Channels GRC was the closing lecture by Fred Sigworth. If you missed it,…
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RT @SlavBagria: I feel hungry after just a few hours, but hibernating squirrels don't even after several months. This remarkable feat is po…
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Exciting times for @K2pChannels indeed!
Structure of the human K2P13.1(THIK-1) channel reveals a novel hydrophilic pore restriction and lipid cofactor site New work from our lab shows a hydrophilic gate (the flow restrictor) and polyunsaturated fatty acid site. See also work from @ProfKalium
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Our latest Preprint on structure of THIK-1 K2P Channel - lots of new features including a lower 'Y-gate'. Also exciting that Dan Minor's group @ElectrosomeUCSF have almost identical results and some additional structures - also on @biorxiv_biophys
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RT @philbiggin: Are you thinking about starting your own group? Thinking of sponsors for a Fellowship application. Then consider coming…
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Our latest paper on Extracellular modulation of TREK2 K2P channels by nanobodies is now finally online in @NatureComms
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RT @whippletom: 38 years ago a woman in Coventry sent a letter to some scientists. That letter went on to be the most important in Alzheime…
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"A fundamental mistake in receptor theory has led to an enduring misunderstanding of how to estimate the affinity and efficacy of an agonist."
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