Priyamvada Acharya
@PriyamvadaA_Lab
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Professor @DukeSurgery @dukebiochem @DukeMedSchool @DukeU | Director @DHVI_Struc_Bio | Director @DukeHIVStrucBio | Member @PriyamvadaA_Lab @TheDHVI
Duke University
Joined June 2022
New preprint from the lab out on "Structural and antigenic characterization of novel and diverse Henipavirus glycoproteins"
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Graduate student Ellie Zhang's cryo-EM structure, beautifully rendered by @swansolive made the cover of Science Translational Medicine. @dukebiochem @TheDHVI @DukeMedSchool @DukeU @AzoiteiLab
This week's issue of #ScienceTranslationalMedicine has arrived! Personalized electric stimulation shows promise in two patients with spinal cord injuries, a study shows that Staph bacteria rapidly evolve resistance to new antibiotic candidates, and more.
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RT @AzoiteiLab: Our latest paper was just published in @ScienceTM and highlighted on the cover! 🔬🧪🧬 Congrats to first authors Olivia Swans…
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Check out our study on B cell receptor (BCR) structure: The movie below shows the range of motion of the antigen binding fragment (Fab) captured in the cryo-EM dataset. @BhishemThakur @TheDHVI @DukeHIVStrucBio @DukeMedSchool @DukeU
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RT @biorxiv_biochem: Structural and antigenic characterization of novel and diverse Henipavirus glycoproteins #bio…
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@Aaron_J_May @muralik_lella @HanaXiao93 @Kumar___Ujjwal @kijun_song @katayoun_mn and others not on X. @TheDHVI @dukebiochem @DukeMedSchool @DukeU
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We purified and characterized a diverse panel of G protein head domains. In HNVs G protein head domains form the receptor binding component and are also a major antigenic site.
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Cryo-EM structures of diverse F proteins elucidate molecular determinants of differential pre-fusion state metastability & higher order contacts. We determined Angavokely virus (AngV) F protein structure to discover a possible "in-built" mechanism for pre-fusion stabilization.
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We characetrized the thermostability of HNV F proteins using DSF and identified biophysical markers for conformational conversion.
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Here, to explore the limits of structural and antigenic variation in HNVs, we construct an expanded, antigenically diverse panel of HNV fusion (F) and attachment (G) glycoproteins from 56 unique HNV strains that better reflects global HNV diversity.
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Henipaviruses (HNVs), a genus within the Paramyxoviridae family, includes highly virulent Nipah and Hendra viruses that cause yearly outbreaks of deadly disease. Recent discoveries of new Henipavirus species have revealed much higher diversity than currently characterized.
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RT @RoryCHenderson: Our molecular dynamics simulation based vaccine design paper is out in Nature Communications! We show that studying tr…
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Check out special research collection led by @DukeHIVStrucBio affiliated investigators, Maolin Lu, @asharma_lab & @sophie_gobeil Aligned with @DukeHIVStrucBio objectives the collection invites submissions of Original Research, Reviews & Mini-Reviews
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Cryo-EM images of wildtype H5N1 influenza virus. Imaged on our in-lab 100 keV Tundra cryo-TEM . In collaboration with Nick Heaton and Brook Heaton, just out in Journal of Virology:
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It was an honor (and great fun!) to march in the Durham pride parade alongside Duke/DHVI colleagues and the LGBTQ+ community of the larger Durham area. #PrideDurhamNC
@DukeU @TheDHVI @DukeHIVStrucBio
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Check out this paper on broadly reactive IgG3 antibodies led by Matt Vukovich @IG_lab. Backstory here is that our collaboration was accelerated by Matt's visit to our lab @DukeU under the Duke Center for HIV Structural Biology Trainee Exchange program @DukeHIVStrucBio
IgG3 #antibodies with exceptional breadth of virus cross-reactivity, with no signs of autoreactivity. Work led by Dr. Matt Vukovich, in collaboration with the groups of @PriyamvadaA_Lab, Giuseppe Sautto, @DannySheward, and others.
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