Phil Corlett
@PhilCorlett1
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I study how the brain makes up the mind He/Him
Yale University, CT, USA
Joined February 2012
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I’m delighted to share our work on the impact of the pandemic on paranoia and belief updating, out today in
@NatureHumBehav
: spearheaded by
@P_Suthaharan
,
@ErinJFeeney
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I got tenure today. I am immensely grateful to everyone I have been lucky enough to be mentored by, collaborate with and learn from. Thank you to those who wrote letters for me. And a special thank you to lab members, old and new - this is a reflection on all of us, not just me.
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Dennett and Darwin dying on the same day as each other is a little on the nose
Remembering Charles Darwin
#OnThisDay
, as he died today in 1882. "There is grandeur in this view of life...from so simple a beginning endless forms most beautiful and most wonderful have been, and are being, evolved."
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Functions in the brain are BOTH specialized AND distributed - the combinatorial explosion that affords is at the root of our innovative abilities. See here for example:
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If you had to pick 3 books that were foundational texts on human cognition what would you pick?
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Sees: LSD “connects parts of the brain that have not spoken since early childhood” in a Guardian article about a preprint.
Closes computer for the day
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In a first for us both,
@tompollak
and I just had a paper accepted first time round without revisions :-) We try to explain the puzzling observation that there are no congenitally blind people with schizophrenia. Looking forward to sharing soon.
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New paper with
@tompollak
- we think together about why there are vanishingly few (if any) congenitally blind people with schizophrenia - the primacy of vision in organizing our world model and psychosis
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This was a lovely surprise and a true honor - grateful to everyone I have been so fortunate to work with over the years - colleagues and participants
Philip Corlett named the
@SIRSGlobal
SIRS 2022 Outstanding Translational Research Awardee. See the full announcement on our website at Congratulations Dr. Corlett!
#schizophrenia
#schizophreniaresearch
@PhilCorlett1
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Here is our comprehensive meta-analysis of human prediction errors (PE) for incentives, perception, cognition, and actions: a wonderful collaboration with
@jmollick_neuro
@hedykober
and a return to human prediction error signals - my first love
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Excited to share new work from
@jmollick_neuro
,
@hedykober
, and myself:
The largest meta-analysis of human prediction error signals encompassing reward tasks, punishments, perceptual tasks, and cognitive tasks...
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Delighted to share our latest on hallucinations
driven by strong prior beliefs, by
@AlPowers7
,
@chmathys
and myself
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Really cool case: a person with schizophrenia whose hallucinations and delusions largely RESOLVED after a right frontal stroke: Consistent with our observation of hyperengagement of rDLPFC prediction error and delusions
@CogNPsychiatry
FTW
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Some thoughts from
@ManojDoss
@FredBarrettPhD
and I on the recent psilocybin and depression paper. We feel the data don’t warrant the conclusions, and certainly not the bloviating in the media
Skepticism About Recent Evidence that Psilocybin Opens Depressed Minds
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My son just asked:
“what if your mind had a mind of its own?”
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Priors impact perception
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Article on blindness and schizophrenia in Vice feat
@tompollak
Steve Silverstein and me Thanks
@shayla__love
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I'm hiring a post-doc for a 4 year position on an imaging and computational psychiatry project examining the psychosis continuum - psychics, patients, targeted individuals. Hoping to understand hallucinations and delusions, brain and mind Please DM if you are interested and/or RT
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Our Templeton grant on religious experiences and cognition was funded :-)
If you are interested in a multidisciplinary qual/quant post doc with Brian Scholl,
@tanyaluhrmann
, Dean Zimmerman, Ann Taves, me, and many others, please reach out
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When you realize academia is a multi-level marketing scheme
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Weird misperception of a person perched on their laptop. Immediately thought this was some cool zoom background function - instead of an in person talk on a stage. Pandemic has changed my priors
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Four weekly karaoke groups significantly decrease paranoia in patients with schizophrenia (unlike making and listening to playlists)
#preliminary
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Comparing hallucinations in psychosis to those induced by psychedelics - similarities and differences summarized in Table 3. Pre Nature Med incident.
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This is really cool! Implanted electrodes into cortex can decode and reproduce words from a patient unable to speak
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Delighted to share new work from
@ErinJFeeney
- with
@StephanieGroman
@stefanuddenberg
@chmathys
and Jane Taylor
Thread 1/n
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First paper of 2024, and first official foray into philosophy with
@fedebng
- we try to address some critiques of the predictive coding account of delusions - like 'why believe anything at all?' and 'where do these ideas come from?'
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First official day as an Associate Professor. A long and sometimes unpleasant process. Thank you to my local and arms length letter writers, and to all lab members, colleagues and friends!
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Delighted to learn I am recipient of
@BAPsych
2018 Senior Non-Clinical Psychopharmacology Award. Nowhere near 5 BAFTAs but thanks still due to
@PaulPcf22
, Trevor Robbins, John Krystal, Jane Taylor, Ralph Hoffman,
@GarryHoney2
,
@cdfrith
@AlPowers7
,
@itschekkers
and all
@YalePsych
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My h-index may be puny, I am not a member of any Royal Colleges, but cross me and know, you are crossing the guy with the cheekiest smile in North West England in 1985. Therefore, any detraction would be a cheap shot
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Latest paper with
@jamesmgold
, led by
@S0niaBansal
- people with psychosis are impaired at detecting changes in motion direction, weighting initial percept more strongly. This overweighting correlates with positive symptoms, and replicates across sites
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If pseudoscience allegations make you uncomfortable, wait until someone calls your work ‘a vacuous tautology’ 😝
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Serotonin neuron activity correlates with expected and unexpected uncertainty!
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BOTH MDMA and methamphetamine increase feelings of connectedness
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They are turning this long abandoned brutalist masterpiece into a hotel: can’t wait to go inside!
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New from me, a primer on Computational Psychiatry and its application to psychosis, with a focus cross-species translation - from bench to bedside, and back
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Human single neurons in dmPFC encode other’s beliefs!
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The dopamine reward prediction error story further refined by
@DeepMindAI
in
@nature
- its a distributional code, rather than a mean reward value, which they claim allows multiple possible outcomes to be captured in the signal
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‘To be hopeful and optimistic about psychedelic drugs and their potential is one thing; to be messianic is another’
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I find myself increasingly fascinated by academic disagreements, their social and scientific consequences. I wonder about the reviewers at Molecular Psychiatry, having learned a little more about those at Nature Medicine in the course of my disagreement…
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And, it appears to have happened again, same dataset, same author, 4 years later, no interaction tested/reported, and differences in baseline between the two treatments
@shayla__love
🍄 Psilocybin & escitalopram create different reconfigurations in the global functional hierarchy of 🧠 brain dynamics in people with major depressive disorder 👇
@HedoniaResearch
@RCarhartHarris
@ysanz6
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Delighted to have played a small role in this:
ML models applied to clinical trials do not generalize well to new trials (even of similar drugs). Fabulous work spearheaded by
@itschekkers
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The new psychedelics papers read like someone asked ChatGPT to write an article about psychedelic neuroscience in the style of Deepak Chopra
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Super excited to be part of this seminar series on Conspiracy Theories - thank you for the invite
@krysdolega
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Karl Jaspers in General Psychopathology: biological and psychological investigations of the mind are like “the exploration of an unknown continent from opposite directions, where the explorers never meet because of the impenetrable country that intervenes"
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Really love this chart - measles cases by state, pre and post vaccine
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This is pretty harsh
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For the ‘predictive coding types’: Woo Hoo Predictive Coding in the retina :-)
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People will love you. People will hate you. And none of it will have anything to do with you
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A tour de force of interoceptive neuroscience
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Find and replace ‘meditation’ with ‘psychedelics’ - no errors detected
I am often asked why I left meditation/mindfulness research after my PhD. The simple answer is that I wanted to persue basic research in computational neuroscience and perception science. The longer answer...
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I hired him
My son just asked:
“what if your mind had a mind of its own?”
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2009 moved to US. Excited and precocious. Enjoyed it and was lucky to stay. Struggled to get funding. Got angry & unhealthy. Almost left academia. Ran. Got healthier. Became a Dad. Persisted. Started dream work with the team I longed for. 2020: still excited
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Notice of Award for my first R01 arrived. Bless up! Thankful to Jim Gold and his team incl
@hernaus_tweets
and special shout out to to
@AlPowers7
for collaboration and cameraderie. More work on predictive coding, delusions, hallucinations and psychics to come from us :-)
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Suddenly accruing followers from the psychedelics and breath work communities - Hi 🙋🏻♂️- I am not the enemy, I promise. Very interested in psychedelics’ potential. Want to make sure it is realized convincingly.
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New from
@joan_ongchoco
@santiagocdeo
and me: We show that thinking that random events have relevance and importance is associated with aberrant associative learning, rather than reasoning processes
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New preprint from the lab -
@PLeptourgos
replicates and extends our conditioned hallucinations work - people who hallucinate show more conditioned hallucinations, more prior overweighting, related to LOWER glutamate levels in the insula
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“I eat pieces of shit like you for breakfast”
‘You eat shit for breakfast?’
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I really don’t want to become THAT guy, but these are self-reported drinking days following an unblinded intervention (they guessed correctly they got the drug). It’s still promising and interesting.
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Neat paper on infants’ attentional allocation - they look at things that maximize learning
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In a crowd, those who decide sooner can influence the rest and trigger a cascade:
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The rush of dopamine when, after 21 years of trying, I finally successfully merge two documents in word retaining the comments of various contributing authors. It’s the little things
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Some thoughts from
@Kurt_Fraser
and I on the aberrant salience account of psychosis, what we now know about dopamine, its dysfunction in, and its role in behavior. The original paper was beautiful, but the story must now move beyond incentive salience
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New in
@iScience_CP
- spearheaded by the inimitable
@joan_ongchoco
with modeling by
@santiagocdeo
- Kamin blocking reveals excessive teleological thinking is driven by aberrant associations (and prediction errors) NOT failures of reasoning:
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My new favorite paper: Bravo
@hugospiers
and team. Your (n=400,000) real-world developmental experience of the environment colors how you process new online environments 🔥🔥🔥
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I couldn’t be more proud of Erin Reed, the first grad student in my lab, defending her thesis on paranoia and belief updating
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Amsterdam is very very nice. Europe is very very nice. I am glad to be home with family and COVID free, but the differences in lifestyle and apparent quality were stark. More bikes than cars makes a huge difference - imagine a quiet, clean, rush hour
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What’s an album you heard at 15 (16) that changed your brain chemistry?
What’s album that you heard at 15 and changed your brain chemistry ?
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associative learning without a brain:
Cnidaria 😍
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New paper with
@AlPowers7
in World Psychiatry - unpacking some of the roots of conditioned hallucinations: dating back to Carl Seashore in 1895 at Yale and Jerzy Konorsk who wrote of a 'perceptual hunger' which we suggest relates to strong priors:
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Wonderful new review and hypothesis from
@MelissaJSharpe
and co - on dopamine, learning and schizophrenia
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Excited to share that this was just accepted at
@eLife
Delighted to share new work from
@ErinJFeeney
- with
@StephanieGroman
@stefanuddenberg
@chmathys
and Jane Taylor
Thread 1/n
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TIL monkeys do not attribute agency to the Haider & Simmel shapes
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More conditioned hallucinations in people at clinical high risk for psychosis, + effect correlates with detection of speech in sine wave stimuli
@AlPowers7
@GregStrauss8
@EllmanLauren
@jamesmgold
Vijay Mittal and team - a first from our CAPR project 🎉
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New preprint from the lab: Paranoia and belief updating during a crisis. It’s what we’ve been focusing on before, during, and after the lockdown. Led by
@ErinJFeeney
and
@PraveenS_
who’ve worked tirelessly. Thread👇
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New from
@HTMcGovern1
@PLeptourgos
Brendan Hutchinson and myself:
Do Psychedelics Change Beliefs?
They might, but not universally - some things changes, others don't.
More fundamentally, we must consider baseline expectations and collider bias
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