The epigenetic factor Zrf1 regulates intestinal stem cell proliferation during midgut regeneration Joshua Shin Shun Li, Liu, Kim, Qadiri, Xu, Xia, Binari, Asara, Hu, Perrimon bioRxiv 2025.01.16.633419; doi:

Virtual seminar series that the US National Cancer Institute (NCI) is holding on non-mammalian models of cancer.

Cell-death induced immune response and coagulopathy promote cachexia in Drosophila. Ankita Singh, Yanhui Hu, Raphael Fragoso Lopes, Liz Lane, Hilina Woldemichael, Charles Xu, Namrata D. Udeshi, Steven A. Carr, Norbert Perrimon doi:

Colorectal tumor-induced orexigenic imbalance lowers protein appetite and drives early organ wasting symptoms Afroditi Petsakou, Elizabeth Filine, Matthew Li, Alice Zheng, Norbert Perrimon doi:

Phage-displayed synthetic library and screening platform for nanobody discovery Baolong Xia, Ah-Ram Kim, Feimei Liu, Myeonghoon Han, Emily Stoneburner, Stephanie Makdissi, Francesca Di Cara, Stephanie E. Mohr, Aaron M. Ring, Norbert Perrimon doi:

Desaturase-dependent secretory functions of hepatocyte-like cells control systemic lipid metabolism during starvation in Drosophila. Li J, Huang K, Dibra I, Liu Y, Perrimon N, Simons M. 2024 11:rs.3.rs-5566817. doi: 10.21203/rs.3.rs-5566817/v1. PMID: 39711529

CESA: Cross-species Epitope Sequence Analysis for discovery of existing antibodies useful for phospho-specific protein detection in model species. Yanhui Hu, Chenxi Gao, William McKenna, Baolong Xia, Majd Ariss, Stephanie Mohr, Norbert Perrimon doi:

Y Hu, A Comjean, J Rodiger, W Chen, A Kim, M Qadiri, C Gao, J Zirin, S Mohr, N Perrimon, 2025 update—expanded resources for new technologies and species, Nucleic Acids Research, 2024;, gkae917,

New paper: A collection of split-Gal4 drivers targeting conserved signaling ligands in Drosophila Ben Ewen-Campen, Neha Joshi, Ashley Suraj Herman, Tanuj Thakkar, Jonathan Zirin, Norbert Perrimon doi:

This link should work: doi:

New paper: A genome-wide CRISPR screen in Anopheles mosquito cells identifies essential genes and required components of clodronate liposome function Mameli, Samantsidis, Viswanatha, Kwon, Hall, Butnaru, Hu, Mohr, Perrimon, Smith doi:

Higher resolution pooled genome-wide CRISPR knockout screening in Drosophila cells using integration and anti-CRISPR (IntAC) Raghuvir Viswanatha, Samuel Entwisle, Yanhui Hu, Stephanie Elizabeth Mohr, Norbert Perrimon bioRxiv 2024.09.19.613976; doi:

Inhibition of autophagy as a novel treatment for neurofibromatosis type 1 tumors. Stevens M, Wang Y, Bouley SJ, Mandigo TR, Sharma A, Sengupta S, Housden A, Perrimon N, Walker JA, Housden BE. Mol Oncol. doi: 10.1002/1878-0261.13704. PMID: 39129390

New paper: Ewen-Campen B, Perrimon N (2024) Wnt signaling modulates the response to DNA damage in the Drosophila wing imaginal disc by regulating the EGFR pathway. PLoS Biol 22(7): e3002547.

New paper: Gut tumors in flies alter the taste valence of an anti-tumorigenic bitter compound. Leung, Xu, Li, Ganguly, Meyerhof, Regimbald-Dumas, Lane, Breault, He, Perrimon, Montell

New paper: Mitochondrial transfer mediates endothelial cell engraftment through mitophagy. Lin RZ, Im GB, Luo AC, Zhu Y, Hong X, Neumeyer J, Tang HW, Perrimon N, Melero-Martin JM. Nature. 2024 May 1. doi: 10.1038/s41586-024-07340-0. PMID: 38693258

New paper: Moon, Hu, Dzieciatkowska, Kim, Chen, Asara, D'Alssandro, Perrimon Identification of high sugar diet-induced dysregulated metabolic pathways in muscle using tissue-specific metabolic models in Drosophila

Expanding the Drosophila toolkit for dual control of gene expression. Zirin J, Jusiak B, Lopes R, Ewen-Campen B, Bosch JA, Risbeck A, Forman C, Villalta C, Hu Y, Perrimon N. Elife. 2024 Apr 3;12:RP94073. doi: 10.7554/eLife.94073. PMID: 38569007

Updates to the Alliance of Genome Resources Central Infrastructure. Alliance of Genome Resources Consortium. Genetics. 2024 Mar 29:iyae049. doi: 10.1093/genetics/iyae049. Online ahead of print. PMID: 38552170