Pancreatic Cell News
@PancreaticCell
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An online resource for researchers studying pancreatic cells, pancreatic cancer, and diabetes. Part of the @STEMCELLTech Science News service.
Joined June 2010
Congrats to the @SoleimanpourLab at @UMich on their new @ScienceMagazine study! 👏 It shows that retrograde #MitochondrialSignaling governs the identity and maturity of metabolic tissues. 📖 Read the paper:
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Enhance your in vitro models and drug discovery workflows by co-culturing cancer #organoids with T cells! 🦠 Learn how in @STEMCELLTech's protocol.
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@MaraShermanLab @CD_AACR Thank you for sharing your research with us. Congratulations to all the authors behind this study! 👏
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Collaborators highlight the critical role of anterior gradient 2 secreted by #PDAC cells to activate cancer-associated #fibroblasts via the Wnt signaling pathway. 📖 Read their study in @CellRepMed:
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At @VUmedicine, scientists found that Atf4 expression in β-cells is minimally required for glucose homeostasis in juvenile and adolescent mice but it is needed for β-cell function during aging and under obesity-related metabolic stress. @ADA_Pubs |
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Scientists identified a stroma gene signature that differentiates #PDAC-patient-derived xenografts by their responsiveness to #gemcitabine plus Nab-paclitaxel treatment. This confirms the active role of the tumor microenvironment in the drug response. 💊
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Drs. @CrocketHamish and Lynne Chepulis from @waikato will co-lead a $1.4 million project addressing longstanding inequities experienced by Māori and Pacific people with #T1D. We wish them our best as they work to improve health equity. 😊 🗞️
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RT @SoleimanpourLab: 🚨 Excited to share new results! We find that beta cells activate innate immune signaling to adapt to obesity or metabo…
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Scientists found that advanced glycosylation end product–specific receptor contributed to MRTX1133 resistance in #PDAC through modulation of #macropinocytosis and glutathione synthesis. 💬 More on this in @ScienceTM:
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Researchers reported that DAAM1 functions as an #oncogene and is immunologically implicated in #PancreaticCancer. DAAM1 was upregulated in pancreatic cancer tissues and high expression of DAAM1 was associated with poor prognosis. 👉
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Researchers identified a strong association between S100A13, a calcium-binding protein, and cancer-associated #fibroblasts (CAFs) in #PDAC. 🧬 Gene expression analysis revealed that S100A13 was highly expressed in #CAFs and correlated with poor prognosis.
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Dr. Christos Karampelias and colleagues summarize recent chemical biology breakthroughs advancing our knowledge of #BetaCell regeneration. 💬 Get an in-depth view:
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✨ Don’t miss this fantastic episode of the Lab Coats & Life Podcast, where Dr. @RaekaAiyar, geneticist turned science communicator, discusses the importance of inclusive science and what organizations can do to foster equity. 🖥️ Listen here:
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The @kusterlab's recent research provides a strong rationale for why the combination of gemcitabine and ATR inhibition may be useful for the treatment of #PDAC patients. 🖨️ @MolSystBiol
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A research team at @KovlerDiabetes provides evidence for an independent role for eIF5ALys in regulating developmental and functional responses in pancreas health and disease. 📖 Dig into the full research:
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.@eloise_g_lloyd from the @BiffiGiulia lab led this study showing that SMAD4 and KRAS status shape cancer cell-stromal crosstalk and therapeutic response in #PancreaticCancer. @CR_AACR |
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🩺 Dr. Thomas Stoop (@TFStoop) and colleagues investigated the association of adjuvant #chemotherapy following resection of #PDAC after preoperative (m)FOLFIRINOX with overall survival. 💬 More about FOLFIRINOX and the study:
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Pancreatic Cell News delivers curated pancreatic cancer, pancreatitis, and #diabetes research highlights straight to your inbox. Subscribe to the newsletter and never miss a beat!💡
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In this @jbiolchem study, researchers isolated and identified a new intestine-derived hormone, betagenin, and showed that it stimulates insulin secretion and β-cell proliferation and suppresses β-cell apoptosis. 👉
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Results detailed in this study reveal that BE-43547A2, targeting eEF1A1, disrupts its interaction with FoxO1 in human #PancreaticCancer cells under hypoxia. This compound could serve as a potential hypoxia-selective therapy. 🩺
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