Sam Tsimikas
@OxPL_apoB
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All things OxPL, @Lpa_doc
San Diego, CA
Joined December 2018
For those interested in research studies, OxPL-apoB and OxPL-apo(a) are now be available at Medpace. We will continue doing the tests @UCSanDiego for academic collaborations. For clinical care, OxPL-apoB is available @BostonHeartDX
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We have a new, comprehensive review on oxidized phospholipids since last one in 2011. Covers pathophysiology, methodologies, evolution, clinical data, risk reclassification, therapy and more. I will be reviewing parts of this in the OxPL Sat AM Class
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For those working on OxPL research and want/need antibody E06, there was a hiatus due to Avanti being bought out, but you can now buy E06 IgM through our collaborators at Millipore.
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No, Lp(a) is a risk factor, not a disease, therefore, it has no sxs until the disease starts (CAD, stroke, etc). That is why it is important to identify and treat early.
If a person with high Lp(a) of 219mnol/(88mg/dL) starts taking a PCSK9 inhibitor - will that person "feel" a difference? Given that person in already on a statin with cholesterol panel in range except high non-HDL @PeterAttiaMD @OxPL_apoB
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Dr Constantinides was an MD/PhD pathologist. Being ahead of your time is good in retrospect, but not at that moment when you can't convince more people of the importance of your findings. Its that for many things in life, timing is a big part of succcess and progress....
20/20 Dr Constantinides was a: 1- Pathologist 2- Internist 3- Cardiologist 4- Cancer researcher
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Answers are in: 75% got it right- C. Note in the figure of a ruptured plaque how little apoB is present (noted by antibody MB47 that stains it) vs how many macrophages, OxPL (E06), Lp(a) (LPA4) and OxLDL (MDA2/IK17). Bottom line, inflamed lesions = ⏫ OxPL>OxLDL>Lp(a), ⏬ apoB
19/20 and the quiz: What is the correct statement: A- apoB accumulates as lesions progress B- Lp(a) diminishes as lesions progress C- OxPL accumulates and peaks at plaque rupture stage D- Answer please
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20/20 Dr Constantinides was a: 1- Pathologist 2- Internist 3- Cardiologist 4- Cancer researcher
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