Luca Franchini
@Memantine10mg
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'everything you see I owe to spaghetti' Neuroscience. Molecular pharmacology. #GPCR #orphanGPCR #molecularpharmacology #drugdiscovery
PhD student in Pharmacology
Joined March 2012
Great work from postdoc Luca Franchini @Memantine10mg in collaboration with the Lueck lab, Joe Porter and @littlelueck
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My main postdoc project is finally available on Biorxiv!! 🎉🎉🎉 i have setup a high sensitive screening platform for Gi/o coupled receptors, which allowed us to detect ligand presence for GPR37 and GPR176 in the brain. https://t.co/3a7lVeBfM9
biorxiv.org
G protein-coupled receptors (GPCRs) are key pharmacological targets, yet many remain underutilized due to unknown activation mechanisms and ligands. Orphan GPCRs, lacking identified natural ligands,...
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Check our last review on @MolPharmJournal !! "Deorphanization of G Protein Coupled Receptors (GPCRs): a historical perspective." Looking to the past to get new perspectives on GPCR deorphanization strategies. https://t.co/hOOB7xciQi
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Check out our paper about ligand-biased signaling, on how different antidepressants and antipsychotics activating 5HT1A preferentially initiate different G-alpha proteins. @ASPET @MolPharmJournal
https://t.co/84IxfWRyWl
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Check out our paper on how cholesterol excretion via CYP46A1 leads to neuroprotection in aged females but not male mice. This sex dimorphism is linked to a shift in neurosteroids metabolism. @ScienceAdvances @karolinskainst
https://t.co/ouiZh0hJDL
science.org
CYP46A1 overexpression is neuroprotective in female mice during chronological and endocrine aging.
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Next week I will be a speaker at #ASPET2023 during the symposium about #orphanGPCR! I am honored and excited to share what I have been working for the last couple of years… Hopefully, we will provide scientists new tools for #drugdiscovery ! https://t.co/eYgjRK3EAH
aspet.org
Although G protein-coupled receptors (GPCRs) are successful therapeutic targets for 35% of FDA-approved medications, roughly 120 remain orphan receptors with poorly understood physiology and pharma...
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📣 EBC is excited to be featured in this week's @Parlimag! Read EBC President Prof Monica Di Luca's #ThoughtLeader piece 📰 Together we can foster an integrated approach to improve #BrainHealth 🧠 https://t.co/z0WPYL7GW1
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Check out our work on brain cholesterol turnover and its sex dimorphic effects on cognitive functions! #neuroscience #cholesterol #CYP46A1
biorxiv.org
Cholesterol turnover and CYP46A1 regulation are reported to be crucial for memory functions. An increasing body of evidence shows that CYP46A1 activation is able to reduce Alzheimer’s Disease (AD)...
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PhD opportunity - I have a funded PhD project starting in Sept 2021, to look at cell division in different multicellular contexts. Mostly using 🪱🔬🧬, details below.
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Maybe, we will be soon out of this.
#LNews Il numero dei tamponi effettuati è 16.987 e 1.929 sono i nuovi positivi (11,3%). I guariti/dimessi sono 8.940. 👉 https://t.co/5esKKdwhCW
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The #BIDays Launch was opened with a welcome by Prof. Monica Di Luca, @EU_Brain President, who pointed out the urgent need to accelerate #innovation to improve the lives of the estimated 1️⃣7️⃣9️⃣ million Europeans living with #brain 🧠 conditions. @MonicadilucaL @diluca_monica
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Prof. Monica Di Luca, EBC President, is featured in the October 2020 edition of @OpenAccessGov where she sheds light on the greater impact of #Brexit in terms of #health & #brain 🧠 #research. @MonicadilucaL Read the publication here ➡️ https://t.co/Rm5Wab1vz6
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🆕🔬 #MalattieRare Un progetto di ricerca per contrastare l'#atassia. Scopri di più sul progetto del ricercatore de @LaStatale e #IstitutoBesta, vincitore di un finanziamento @Telethonitalia e sostenuto da Associazione Italiana Sindromi Atassiche 👉 https://t.co/Fku4SOI5zc
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This Thursday, 17 September, EBC Executive Director @BrusselsDC will take part in an @incisivehealth Morning Club to discuss the future of #brain #health #innovation in #Europe with @fscassellati and @pisanie7. For more details & to RSVP, click here: https://t.co/JQPqRrRzXl
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Our paper on the ppH protocol is finally out at @NatureProtocols🥳 Imaging endocytic vesicle formation at high spatial and temporal resolutions with the pulsed-pH protocol
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Congrats to the CAP2 team @SilviaPelucchi2 @linav9 ! Hard work and passion to put together the pieces of this CAP2 puzzle! Thanks to @FondCariplo for funding @Acacia87123779 project!
Our paper is finally out! CAP2 dimer is a key regulator of cofilin recruitment to the spines during LTP and this mechanism is impaired in Alzheimer disease..new insights into actin cytoskeleton role in #Alzheimer Disease synaptic failure! @Acacia87123779 @FondCariplo @LaStatale
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Neurons in the CA1 region of the #hippocampus encode events as discrete and transferable units of experience https://t.co/9ZaRDi9aqF
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👇🏻 Check out our review on synaptic GluN2A-containing NMDARs, their functions and their intracellular interactors in physiological and pathological mechanisms. #neuroscience @LaStatale #disfeb #NMDAR #glutamate #science
mdpi.com
N-Methyl-d-Aspartate Receptors (NMDARs) are ionotropic glutamate-gated receptors. NMDARs are tetramers composed by several homologous subunits of GluN1-, GluN2-, or GluN3-type, leading to the...
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