Mayo Clinic Kullo Laboratory
@MayoClinic_KLab
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Atherosclerosis & Lipid Genomics Laboratory @MayoClinic | Focused on Improving Patient Outcomes | Heritable Cardiovascular Diseases | Led by Dr. Iftikhar Kullo
Rochester, Minnesota
Joined June 2017
Congratulations to our PI and mentor, Dr. Kullo for being invited to serve on the National Advisory Council for Human Genome Research! @iftikhar_kullo
Honored to serve on National Advisory Council for Human Genome Research along with distinguished colleagues @howardychang @OlgaTroyanskaya @kylebrothers @genegj @ssr4n Hal Dietz, Laura Beirut, Lynne Jorde, Len Pennachio, Mark Craven, Lisa Parker, Peter Robinson, @NHGRI_Director
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Disclosure of high genetic risk is often associated with no significant measures to mitigate risk @Naderian_mr & I comment on a syst review on behavior outcomes after disclosing CV genetic risk Genetic risk disclosure and behavioural change: not so fast
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Read about how including genetic, social, lifestyle, and psychological factors in clinical risk calculators for #heartdisease could improve their ability to predict coronary heart disease:
acpjournals.org
Background: Clinical risk calculators for coronary heart disease (CHD) do not include genetic, social, and lifestyle–psychological risk factors. Objective: To improve CHD risk prediction by develop...
1/3 📊 Excited to share our latest publication in @AnnalsofIM from @MayoClinic_KLab, @iftikhar_kullo, as a step toward a more personalized risk prediction for CHD 🫀 https://t.co/OoR5bSMqva
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Trending now at https://t.co/HQyUgwV2bm: Development and Evaluation of a Comprehensive Prediction Model for Incident Coronary Heart Disease Using Genetic, Social, and Lifestyle–Psychological Factors: A Prospective Analysis of the UK Biobank: https://t.co/lLsybgivSq
@MayoClinic
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🗓️TOMORROW! Learn how the NIH's PRIMED Consortium is advancing equitable polygenic risk predictions via its methods and tools w/ speakers @iftikhar_kullo, MD, & Sarah C. Nelson, MPH, PhD. It's not too late to register 👉 https://t.co/jHpkbIIqDX
#ASHG
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About to wrap up Session III w/ my friend & co-director @iftikhar_kullo sharing exciting advances in the familial hyperlipidemias. Love seeing the desire in our 100+ attendees to become more fluent in the language of #Genetic #Cardiology.
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1/3 📊 Excited to share our latest publication in @AnnalsofIM from @MayoClinic_KLab, @iftikhar_kullo, as a step toward a more personalized risk prediction for CHD 🫀 https://t.co/OoR5bSMqva
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@roxanne_coderre at our 8th CV genomics course presenting a Case of very severe hypercholesterolemia due to compound heterozygosity in LDLR
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We are joined by the team of @MJAckermanMDPhD @iftikhar_kullo @T_Kruisselbrink and @nl_pereira for the final panel of the day. These experts and attendees are diving into the latest advancements, challenges revolving around genetic cardiology! @MayoClinicCV @MayoClinic #genetics
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@iftikhar_kullo is now sharing insights on the interpretation and utilization of polygenic risk scores in clinical practice, helping attendees learn how these scores are transforming personalized medicine. @MayoClinic @MayoClinicCV #CardioGenetics #HeartHealth #GHRC #genetics
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Looking forward to a great meeting in a great location! This is our 8th CME course on CV genomics covering general principles, monogenic & polygenic conditions, as well as exciting advances in therapy Privileged to co-direct with the @MJAckermanMDPhD and @nl_pereira
Arrived to a beautiful @Hyatt resort here in Puerto Rico after gr8 flight on my favorite airline @Delta. Now, getting ready to welcome over 100 attendees from all over the world 🌎 for @MayoClinic @MayoClinicCV 8th course on #Genetic #Cardiology.
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Polysocial score (PSS) was higher in non-whites The greater CHD risk in non-whites may be partly due to higher PSS The effect of PSS and PRS on CHD risk was independent and additive At a 7.5% 10-y risk threshold, adding both PSS and PRS led to a 12% reclassification rate
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1/2 A UK Biobank analysis by @Naderian_mr highlights the value of incorporating social & environmental factors as well as #PRS to improve CHD risk prediction Main findings: 1 SD increase in a polysocial score led to a HR of 1.43 & a 1 SD increase in PRS led to a HR of 1.59
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With more layers of data, our ability to predict a person's risk of heart disease is getting better and better https://t.co/BI0ltvTodY
@AnnalsofIM adding in social determinants of health, lifestyle, and other data @iftikhar_kullo @uk_biobank
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Model shows how data on genetic, social, and lifestyle-psychological factors help better predict individual heart disease risk. https://t.co/qwkHJzJOIW
@Naderian_mr @MayoClinicCV @iftikhar_kullo @MayoClinic
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A new Perspective from @PRSDiversity is out in @AJHGNews! PRIMED is bringing together researchers and data from across the globe to develop new polygenic risk score methods and improve risk prediction across diverse populations and genetic ancestries🧵 1/ https://t.co/Y8FIuRxvs8
cell.com
To lessen health and healthcare disparities and extend advances in genomic medicine to all, the PRIMED Consortiumis bringing together investigators and datasets from across the globe to develop PRS...
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See also this report by Satterfield et al. describing MR phenome wide analyses of genetically predicted Lp(a) levels It is unclear, however, whether Lp(a) is equally atherogenic in individuals of African genetic ancestry. https://t.co/JmwkkDiVoP
#LPA
pubmed.ncbi.nlm.nih.gov
Many cardiovascular associations of genetically increased Lp(a) that were significant in EA were not significant in AA. Lp(a) was associated with atherosclerotic cardiovascular disease in four major...
Another strategy for cardiovascular disease prevention that has been partly driven by genetic evidence linking very robustly genetically proxied Lp(a) levels with cardiovascular risk 🧬 e.g. 1⃣ https://t.co/hRUNH8ZmyL 2⃣ https://t.co/RrojfFVnGe
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SDOH and PRS were independently associated with CHD Including both PRS and SDOH in CHD risk models could improve their accuracy Accompanying editorial by Dr. Nilay Shah here https://t.co/xxUOJdnhg1
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1/2 Associations of Race, SDOH & PRS with CHD risk in the All of Us dataset by Kristjan Norland https://t.co/XrN1YorQKP ⬆️ odds of CHD in people who self-report as Black are due to a higher SDOH burden Emphasizing Race as a social not biological construct
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The PRIMED consortium represents an effort to share genetic data and develop polygenic risk scores that work equally well across ancestries. Important step towards addressing the historical oversampling of Europeans in GWAS studies. 🔗 https://t.co/47uo8OOqRA
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📢Online now! 📰The PRIMED Consortium: Reducing disparities in polygenic risk assessment 🧑🤝🧑@iftikhar_kullo @pnatarajanmd @johnwitte & @PRSdiversity colleagues https://t.co/nFmE1Qzcxh
cell.com
To lessen health and healthcare disparities and extend advances in genomic medicine to all, the PRIMED Consortiumis bringing together investigators and datasets from across the globe to develop PRS...
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