Marcus Goncalves
@MarcusDGon
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MD/PhD Endocrinologist and scientist. Cancer metabolism, cachexia, insulin, PI3K, diabetes, obesity. GI Villi lover. Metabolic Consulting. NYJ/NYY/NYCFC fan.
New York
Joined April 2009
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A couple years ago, we showed that dietary fructose enhances intestinal tumor growth. Today, I’m excited to expand these results to the normal intestine and discuss the implications for obesity and cancer.
@Nature
35
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689
Now online
@NatureRevCancer
Our latest thoughts on a rapidly advancing field. Which diet for which tumor? What diet-drug combinations do we have? How can we make our trials more robust?
@SamwiseT
@CantleyLab
@notwitterFalcone
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87
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Another year, another metformin mechanism.
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@pipcosper
but it's worth it...right? because you have all this academic freedom, job security, and... Damn, I wish I had a boat and a free weekend to be on it.
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Thank you
@CancerGrand
and
@theNCI
for the opportunity to tackle
#cachexia
with an amazing team
@EileenWhitePhD
@JanowitzTobias
@DrR_DUNNE
@StephenORahilly
@BiffiGiulia
@MariamJHanjani
@PerrimonLab
@realTonyHui
@theayreslab
@DavidYLewis
#yesweCANCAN
#notimetowaste
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I’m pleased to announce the Weill Cornell Medicine: Emerging Scientists in Metabolism Prize. A national competition for senior graduate students with cash prizes of up to $1000
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End of an era today. We closed up shop at the WCM lab. Onwards to new opportunities! Thank you to this special group who never stopped working hard and innovating. It’s been an honor to work with you.
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"Our study also raises a potential health risk of the Keto diet in human patients with cancer."
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Happy to present our paper, "Blocking ActRIIB and restoring appetite reverses
#cachexia
and improves survival in mice with
#lungcancer
" now online
@NatureComms
Congrats to
@EzequielCDantas
and
@andrelq1
.
#myostatin
#activinA
#cancer
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Fasting induces a highly resilient deep quiescent state in muscle stem cells via ketone body signaling: Cell Metabolism
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Dear Science Twitter, I’m looking for a postdoc with some muscle physiology expertise who wants to come to NYC and study cachexia with me and Lew Cantley. Please RT and DM me any leads.
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Ketogenic diet and chemotherapy combine to disrupt pancreatic cancer metabolism and growth - ScienceDirect. Therapeutic benefit correlates with elevated tumor NADH/NAD ratio
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Nicely designed randomized cross-over trial comparing large breakfast vs large dinner. --> Both diets produced similar weight loss, fat loss, and no differences in energy metabolism.
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How did I get so lucky to have a team like this!? Thank you all for another great year and I look forward to more success in 2024!
#MDGLab
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Ketogenic diet promotes tumor ferroptosis but induces relative corticosterone deficiency that accelerates cachexia. Brilliant work by
@miriamferrer95
and
@JanowitzTobias
. Happy to have contributed with
@EileenWhitePhD
and others.
#CANCAN
#cachexia
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9
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@CharlesMBrenner
@davidasinclair
“he submitted the paper on June 30 & it was accepted on July 4 by a journal of which he is coeditor-in-chief”
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The bar has been raised for the assessment of skeletal muscle metabolic disorders. Very nice paper!
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In 2012, I was told we were starting a center of metabolic health. The kickoff event was today. Better late than never. Congrats to all.
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Congrats to
@RogerLiang9
for publication of my lab's first paper! He led all this work as a technician😮No surprise he's now a
@UTSWmstp
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Really proud of this one. History of PI3K role in cancer. Collaboration with
@Hopkins914
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Six years ago, we committed ourselves to making Precision Nutrition the standard of care in cancer research.
#Faeth
now seeks to bring this dream to a reality.
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10
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The next generation of PI3Ki’s are here: STX-478, a Mutant-Selective, Allosteric PI3Ka Inhibitor Spares Metabolic Dysfunction and Improves Therapeutic Response in PI3Ka-Mutant Xenografts. Fun collaboration with
@ScorpionTx
@CD_AACR
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As we were looking for
#cachexia
biomarkers, we stumbled on TIMP1 as a great marker for lung cancer. Check out this beautiful translational work by
@EzequielCDantas
adding to the support for using TIMP1 as an early biomarker.
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Ketogenic diet and chemotherapy combine to disrupt pancreatic cancer metabolism and growth - ScienceDirect
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"Here, we show on two different [ketogenic diets] that mice accumulate senescent cells in the normal tissue of multiple organs."
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Proud to present this data showing high fructose corn syrup directly enhances tumor growth
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👀🤯Spatially resolved isotope tracing reveals tissue metabolic activity
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Lew Cantley (
@CantleyLab
) and I on the latest fasting and cancer study by Caffa... Longo & Nencioni in Nature: A ‘fast’er way to treat breast cancer
#Fasting
#breastcancer
@Neil_Iyengar
@PeterAttiaMD
@ethanjweiss
@prolonfmd
@DrSidMukherjee
@nature
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Activation of GPR81 by lactate drives tumour-induced cachexia | Nature Metabolism
1
10
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Congrats to Maira for winning a poster award at
@NYASciences
Cancer Metabolism and Signaling in the TME conference! Here she is, soaking in wisdom from the legendary Craig Thompson!
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We found mice w/lung cancer
#cachexia
have low blood ketones. we thought
#keto
or ketone-esters would improve outcomes. Neither did. Congrats
@HenningLanger
@SRamsamooj7
@RogerLiang9
@rgroverMD
@FrontOncology
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So excited to present
@biorxivpreprint
from me and
#JaredJohnson
from
@CantleyLab
: Epinephrine inhibits PI3K alpha via the Hippo kinases. Really fun collaboration to go from an in-vitro kinase screen to cells to mouse liver metabolism. Please check it out:
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Now in press! Epinephrine inhibits PI3Kα via the Hippo kinases: thank you
@TingL25729475
for your patience, hard work, and dedication. Thank you
#JaredJohnson
and
@CantleyLab
for the collabo.
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FDA approves first PI3K inhibitor for breast cancer! Champagne toast to all the Cantley disciples out there
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Fasting Mimicking Diet (FMD) alters systemic metabolism and tumor immunity in subjects with cancer! Important clinical evidence that dietary interventions CAN impact the tumor.
@CD_AACR
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We're starting recruitment for a new post-doc interested in diet, cancer, and metabolism. Cell, mouse, and human studies ongoing. Share with any obesity/metabolism students looking to broaden into cancer or cancer biologists interested in diet/metabolism.
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The more I travel, the more I realize that happiness in academia is about having colleagues and lab members you can enjoy your life with.
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We officially launched our effort to genotype/phenotype 500 people with metabolic disease (preDM, DM2, HLD, NAFLD). 4 consents today! Features WGS, blood lipids and hormones, and tissue banking. cant wait to fill up the freezers!
@EngIPM
@WeillCornell
@nygenome
@BostonHeartDX
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Tirzepatide inhibits tumor growth in mice with diet-induced obesity | bioRxiv
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Lucky to be together with these hot shots
@TheMarkFdn
meeting.
@Samuel_Bakhoum
@CantleyLab
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We were short-listed for the
@CancerGrand
#cachexia
with
@EileenWhitePhD
,
@JanowitzTobias
,
@DrR_DUNNE
@realTonyHui
@BiffiGiulia
@StephenORahilly
@theayreslab
@OMaddocks
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Excited to start recruitment for our paxalisib (PI3K inhibitor) +
#keto
trial for patients with
#Glioblastoma
. Please spread the word
@EvanNoch
@KaziaTx
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I'm pleased to have contributed to this review on
#cachexia
, Cachexia: A systemic consequence of progressive, unresolved disease
@CellCellPress
@JanowitzTobias
@EileenWhitePhD
@miriamferrer95
#CANCAN
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Can we please move on from the idea of metformin as cancer treatment?
RCT data: metformin does NOT benefit pts on
#activesurveillance
for
#prostatecancer
. In obese pts, pathological progression >2-fold more w/ metformin. Study rationale: observational data showing “benefits”. Association does not mean causation. This is why we need RCTs!
#ASCO24
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Check out our match this year in endocrinology! two physician-scientist rock stars
@WeillCornell
@nyphospital
@sloan_kettering
@HSpecialSurgery
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24-hour TSH levels in a healthy subject. This is why we (endocrinologists) ignore your TSH of 8
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We are hiring! This exciting opportunity is part of our efforts to address the increasing incidence and mortality of endometrial cancer, particularly in the context of the obesity epidemic. Apply if you love metabolism, signaling, cancer biology, and NYC!
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Resistance Exercise Counteracts the Impact of Androgen Deprivation Therapy on Muscle Characteristics in Cancer Patients
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Did I just hear a collective slap to the forehead from every endocrinologist in the country?
"Scientists at the University of Oxford said they had identified the first drug shown to reduce coronavirus-related deaths: a steroid called dexamethasone"
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Light modulates glucose metabolism. 11 mice per group to get this difference:
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The bottom line is that academia can’t pay physician-scientists enough. My equivalently trained friends in industry get paid double.
Physician Scientists have dropped from 4.5% to 1.5% today. Main causes: fundings, clinical demands, disparities in salaries between research track physician scientists and full-time clinicians, inequitable support for women and minorities
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welp. I was finally called off the bench. re-deployment training starts next week.
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Adipose tissue loss is identified up to 6 months, and skeletal muscle wasting is identified up to 18 months before the clinical diagnosis of pancreatic cancer and is not present in the matched control population
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Ketogenic diet alters the epigenetic and immune landscape of prostate cancer to overcome resistance to immune checkpoint blockade therapy | Cancer Research | American Association for Cancer Research
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Tumor-produced and aging-associated oncometabolite methylmalonic acid promotes cancer-associated fibroblast activation to drive metastatic progression | Nature Communications
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We are hiring a PhD scientist to serve as Manager for The Metabolic Phenotyping Core at
@WeillCornell
in NYC. Needs experience in mouse metabolic cages, EchoMRI, Seahorse, FLIR infrared thermography, GTT/ITT/PTT, and/or bomb calorimetry. Email metabolic-center
@med
.cornell.edu
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How much water should you be drinking? Variation in human water turnover associated with environmental and lifestyle factors | Science
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We were blown away by the finalists for
@WeillMetabolism
Emerging Scientists in Metabolism award. Congrats to winner John Haley from
@guertin_lab
, runner up
@dbezwada
from
@RJDLab
, and other finalists
@__btjackson
from
@lydfinley
Lab and
@YuyangLiu9
from
@KivancBirsoy
lab
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GDF15 neutralization restores muscle function and physical performance in a mouse model of cancer cachexia: Cell Reports
@pfizer
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Congrats to my post-doc
@Ezequie73167169
for being awarded this prestigious fellowship. Thank you to
@AACR
@AstraZeneca
for their support! And Ezequiel for his hard work
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👀Brown adipose tissue is not associated with cachexia or increased mortality in a retrospective study of patients with cancer.
#PaulCohen
@RockefellerUniv
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Alpelisib, a PI3K inhibitor, increased total daily insulin by 5-fold in a woman with type 1 diabetes.
#Keto
helped to cut that in half. A new little case series in collaboration with
@jamflo2k
,
@AaronNeinstein
,
@maryam_lustberg
,
@NeilVasan
, Jeff Volek.
@WCM_MeyerCancer
#Cancer
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Congrats to
@Othman_Al_Sawaf
@MariamJHanjani
@CharlesSwanton
for this impactful study! Body composition and lung cancer-associated cachexia in TRACERx
@CancerGrand
@CancerCachexia
@SCWDnews
#cachexia
@NatureMedicine
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“we found a higher density of PIK3CA gain-of-function mutations in the esophagus of individuals with high body mass index compared with those with normal weight.”
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Are you a finishing a post-doc and considering your next step? Come to NYC and help us investigate the systemic effects of cancer
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@dskrausemdphd
The pay is way too low for staff scientists. Why would they choose that path over biotech/pharma?
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I’m happy to finally have this news released. Thank you
@TheMarkFdn
and
@AACR
for supporting our work to understand the role of insulin in endometrial cancer and the therapeutic response to PI3K inhibition.
In a new blog post,
@Becky_ABC
highlights the work of several of our partners dedicated to uncovering new insights about the complicated whole-body response to cancer. CC:
@JanowitzTobias
,
@theLundLab
,
@MarcusDGon
,
@cshl
,
@nyulangone
,
@WeillCornell
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Happy to announce
@FaethTX
’s $47 million in Series A financing. Great days are ahead as we move our clinical trials forward from the
@seed2growth
-led funding round.
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Thank you, Weill Cornell, for all your support. Let’s continue to find exploitable connections between diet and cancer!
Is there a link between
#cancer
and high-fructose corn syrup?
A new study by Drs. Lewis Cantley and Marcus D. Goncalves of
@MeyerCancer
&
@nyphospital
may have found the connection in a new pre-clinical research study.
Link:
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“The Intestine is a Major Contributor to Circulating TCA Cycle Intermediates in Mice” | bioRxiv
@MarkHermanMD
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Trying our best to avoid 5% weight loss
@ottolenghi
with
@JanowitzTobias
@EileenWhitePhD
@BiffiGiulia
@PerrimonLab
@Yvonne_Diaz_
@acmoorephd
. Team
#CANCAN
invades London
@CancerGrand
@theNCI
#cachexia
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PHGDH interacts with PFK to modulate the hexosamine pathway output like sialic acid, which contributes to cancer metastasis. Very cool downstream mechanism
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Thank you to my wonderful wife
@thetoothiron
for somehow convincing my favorite chef
@marcforgione
to bring us food
@nyphospital
@weillcornell
!!! This place has never smelled so good. Can’t wait until the restaurants are open again.
#customer4life
@khe_yo
@TasteofTribeca
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MDG travel season kicked off in style. This year’s locations include Miami, London, Chicago, San Diego, Novato, Tokyo, Boston, Orlando, Banff, Munich, Bilbao, and Aspen. Perks of
#AcademicLife
#skymiles
#global
$€£¥
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Sorry to be the bearer of bad news but the best diet to be lean and muscular is not the best diet to avoid CVD, which is also not the best diet to treat your cancer.
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Keto vs CR “diet-induced mismatches between tumour fatty acid desaturation activity and the availability of specific fatty acid species determine whether low glycaemic diets impair tumour growth”
Another gem by
@mvh_lab
🔥
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#MdgLab
in full force
@CantleyLab
retreat. Had a blast catching up with alumni and hanging with the team
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Who is reviewing this garbage!?
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Thoughts on my first week of covid care: 1) very obvious gender bias in the young and middle age adults (all men). Older patients equally split. 2) It’s not clear that Plaquenil does anything. 3) dramatic acute phase response: ferritin 5000, CRP >100, etc. 1/3
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getting on board with chatGPT fun. I asked for a poem about fructose:
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So inspired by the work of the
@CancerGrand
teams and can’t wait to make our mark.
#notimetowaste
#yeswecancan
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Metabolite kinase as a protein kinase. Is it possible?
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@DGlaucomflecken
They charge on the front and back end. We pay grant money to publish and then our indirects go to pay for institutional subscriptions. It’s a genius business model. Academics will forever be taken advantage of because of our self-righteous commitment to science and the patient.
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Ketone Body Infusion Abrogates Growth Hormone–Induced Lipolysis and Insulin Resistance
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LY3437943, a novel triple GIP, GLP-1, and glucagon receptor agonist in people with type 2 diabetes: a phase 1b, multicentre, double-blind, placebo-controlled, randomised, multiple-ascending dose trial - The Lancet
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Thanks
@MolMetab
&
@helmholtz_diabc
for including me in
#Flashtalks
today. Covering diverse biology in nearly all tissues: brain, liver, adipose, kidney, immune.
#HelmholtzDiabetes2022
@harry_brennan
@martaapp
@IsmaelGlezGcia
#DariaOpaleva
@DanielLabMunich
@GLamers3
@MatiasSimons
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Randomized phase II trial of two different nutritional approaches for patients receiving treatment for their advanced pancreatic cancer. | Journal of Clinical Oncology
1
14
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Excellent summary from the godfather of incretin biology
@DanielJDrucker
Looking forward to a bright future of powerful agents. “We are really just starting after 35 years.”
#JDS2024
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