Luke O'Connor
@Luke0connor
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Statistical genetics - Genetic architecture and disease biology - Assistant Professor @HarvardDBMI
Cambridge, MA
Joined April 2016
RT @seplyarskiy: Excited to share our preprint: Cohort-level analysis of human de novo mutations points to drivers of clonal expansion in s…
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RT @jkpritch: Super excited to release this new preprint: Jeff and Hakhamanesh drill into key questions about GWAS and rare variant studie…
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RT @HujoelM: Excited to share our recent work: expansions and contractions of DNA repeats have produced many genetic polymorphisms. We stu…
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RT @SashaGusevPosts: I wrote about the National Institutes of Health and the various serious and unserious proposals for NIH reform that ha…
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#ASHG24 come see @lu_wenhan speak today about rare variant architecture! Heritability and effect-size distribution of rare and de novo protein-coding variation 8:15 in room 501
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Also come see Hui Li’s poster, 4089F, which I’ll present in her absence👇
Excited to share our preprint, describing a method for heritability partitioning with GWAS sumstats that significantly improves upon S-LDSC Led by the fantastic Hui Li, and co-supervised by @XihongLin
#ASHG24 poster 4089F
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Come to Amber Shen’s #ASHG24 poster today: 4053T, “Efficient genealogical compression for biobank-scale datasets” Describes the “linear ARG”, a representation of the genotype matrix that is highly compressed, and convenient for applications Great collab with @nmancuso_
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Excited to share our preprint, describing a method for heritability partitioning with GWAS sumstats that significantly improves upon S-LDSC Led by the fantastic Hui Li, and co-supervised by @XihongLin
#ASHG24 poster 4089F
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RT @peter_j_park: This Monday (10/28) at 5pm (Eastern Daylight Time): Info session about our bioinformatics/genomics PhD program! I will d…
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RT @jkpritch: Two new chapters from my free online book in human genetics out this weekend! These complete Part 3 of the book, on human po…
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RT @Graham_Coop: My lab read this paper for journal club, and had some thoughts on the strong claims made about the…
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@epigenci Is your concern that their method produces false positives when s=0, or that it is biased due to drift when s!=0?
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@pjie2 @doctorveera This is possible, and I’d be interested to see it in simulations. Would this effect also necessarily reduce the fraction of nonnative H2?
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@pjie2 @doctorveera I haven’t read yet, but this was a good choice imo. If a variant has GxG effects, it will often have a main effect, unless interactions happen to cancel each other out perfectly - possible for one locus, but why would it happen for all of them?
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RT @NadigAjay: Just how impactful are large-scale perturbational data in single cell genomics? In the last two weeks, there have been *thr…
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