The Lehtiö Lab
@LabLehtio
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Structural and Chemical Biology team at the Faculty of Biochemistry and Molecular Medicine, University of Oulu. Lab account but tweets from Lari #unioulu #fbmm
Oulu, Suomi
Joined February 2020
RT @UniOulu: Tutkijamme ovat onnistuneet kehittämään yhdisteen, joka estää koronaviruksen lisääntymisen ihmissoluissa. Yhdiste on tuoreiden…
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Our paper on oligomerization of DTX3L E3 ubiquitin ligase and how this allows DTX3L-PARP9 compex to recognize ADP-ribosylated proteins is now online in Protein Science. Structure was solved with sulphur SAD @DiamondLightSou #PARP #BiocenterOulu #UniOulu
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Our paper on #PARP HPF1 interaction inhibitors and assay is now online. Mainly some validation with full-length enzyme and activity added to the preprint version.
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Small contribution from us to a collaborative study on the design of new small molecule inhibitors. Naturally using #PARP as an example. #fbmm #biocenteroulu
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RT @UICOulu: @UniOulu @LabLehtio tekemälle #parp lääkeaihiokeksinnölle on myönnetty #patentti Euroopassa. Kyseessä on pienimolekyylinen kem…
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A doctoral researcher position available in our team focusing on mono-ART's and their complexes. #PARP #fbmm #structuralbiology
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A different kind of preprint. This is about the MSc crystallography course we organize in Oulu. Actually at the moment the R-factors start to be below 20% for some students :) #fbmm #biocenteroulu @UniOulu
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A preprint is available about the HTS assay to find inhibitors for #PARP HPF1 interaction developed and carefully optimized by @SaurabhSinghDh8 . We even found some early hit molecules. #drugdiscovery #FBMM #BiocenterOulu @SuomenAkatemia
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How DTX3L-PARP9 complex can bind dual ADP-ribosylated peptides? Nice collaboration paper with @LeidenADPr and Paschal team. #BiocenterOulu #PARP #FBMM
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Saurabh is representing our team! The course is likely extremely nice based on the programme and the picture.
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We have 3 doctoral researcher positions available in projects studying human mono-ADP-ribosyltransferases. These are funded by the #BiocenterOulu spearhead project and by the Research Council of Finland. @SuomenAkatemia
@UniOulu #PARP #FBMM
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A preprint now available for the macrodomain inhibitor which inhibits coronavirus replication. Great collaboration between teams from @UniOulu, @UnivOfKansas and @McDanielCollege #PARP #Drugdiscovery #SARSCoV2
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The paper on the FRET-assay and discovery of DTX3L E3 ligase inhibitors is now published. Congrats and big thanks especially to Carlos! #BiocenterOulu #UniOulu #drugdiscovery #LifelongHealth
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RT @UniOulu: Lloyd Ruddockille tutkimuksen kaupallistaminen näyttäytyi pitkään Tähtien sodasta tutun pimeän puolen kaltaisena pahana voiman…
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