LUMICKS
@LUMICKS_nl
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Empowering scientists with tools that reveal crucial insights not available before, at the molecular and cellular level | Dynamic single-molecule & Cell avidity
Amsterdam (NL), Boston (USA)
Joined May 2014
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🔔More webinars coming up! Don't miss the talks by Dr. Ariel Kaplan (
@TechnionLive
) and Dr. Ingrid Tessmer (
@Uni_WUE
) who will discuss their exciting research on DNA-protein interactions. Register now!
➡️
#DNApackaging
#chromatin
#DNArepair
#DNAlesions
2
39
293
🔔 Don't forget to join this Wednesday's webinar by Dr. Raya Sorkin (
@TelAvivUni
).
@SorkinRaya
will discuss her exciting research on protein-membrane interactions and
#membranefusion
. Register now!
➡️
#WebinarWednesday
#OpticalTweezers
#MembraneBiophysics
0
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110
Did you ever want to see a dynamic
#SingleMolecule
experiment from start to finish? Now’s your chance! In this
#webinar
series, we demonstrate how to use the C-Trap to perform different experiments in just 1 hour! Join us for the demo and Q&A:
2
22
90
Next week, we open the doors to our brand new HQ in
#Amsterdam
Amsterdam and kick-start the Dynamic
#SingleMolecule
Symposium Series! Secure your spot now for the upcoming
#seminars
with after-drinks.
Find more information and the
#registration
form at .
0
9
61
Organized by
@BiophysicalSoc
, let’s celebrate the annual
#BiophysicsWeek
together! Join
#LUMICKS
’
#virtualevents
to learn more about cutting-edge scientific developments and possibilities to advance your
#research
!
➡️
0
13
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Who needs scissors to cut a ribbon when you have a laser? Yes, you read it right. We officially opened our new HQ in Amsterdam with a spectacular ceremony led by the Minister of Education, Culture, and Science. Since seeing is believing, watch the video! |
1
8
42
It FINALLY happened! After much preparation, LUMICKS hosted its first ever C-Trap User Meeting at our HQ in Amsterdam. We were delighted to have over 25 users join us this year for a unique and unforgettable experience!
1
8
40
Exciting New Publication on
#Nature
! A major advancement in DNA repair research by Prof. Lorri Passmore and Prof. David Rueda unveiled key mechanism in Fanconi Anemia pathway! Profound insights in genomic stability and potential cancer therapies!
0
10
40
Dear network, we are co-organizing a
#BPS
subgroup meeting on the research of
#biomolecular
processes using single-molecule tools that combine force w/ imaging. To make it happen, please help us by signing this petition or
#RT
#biophysics
#SingleMolecule
0
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Join this
#live
#webinar
by Prof. G. Montoya
@g1_guillermo
, an expert on
#ProteinStructure
and function from CPR, Copenhagen. He will show exciting results of DNA-binding protein experiments acquired by
#DynamicSingleMolecule
techniques!
Sign up here⬇️
1
15
34
LUMICKS has raised $93 million to help us achieve our bigger, bolder vision to improve human health by unlocking the power of Dynamic Single-Molecule and Cell Avidity analysis!
Read all about it here ⬇️
#News
#SeriesD
#LifeScience
#Biotechnology
1
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36
Don't miss the first UK Single-Molecule Meeting! On May 14-15, scientific pioneers from across the UK will present their latest research at the
@MRC_LMS
- your chance to learn, connect and share your own results. Register now and secure your poster board:
0
9
28
We’ve gathered the newest Dynamic Single-Molecule innovations to arrange thought-provoking and interactive talks in a dedicated
#webinar
series, now with expert guest speakers. Click here for free registration or more information!
#SupercoiledDNA
#OpticalTweezers
#DNA
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Dynamic single-molecule technology is changing the way
#biological
#research
is performed, helping scientists to finally uncover real-time interactions of
#molecules
! Wanna learn how? We show you in our talk at the upcoming
#ExpBio
/
#EB2021
. Join here➡️
0
5
25
An exciting new paper in
@NAR_Open
from the lab of Bennett van Houten describes a novel method that enables the direct measurement and analysis of how
#DNAbindingproteins
interact with
#DNA
in nuclear extracts using the
#CTrap
. Read the blog post!⬇️
1
6
24
We are excited that the C-Trap® was utilized in important research published in
@Nature
by the
@BoultonLab
,
@RuedaLab
, and Dr. Powell's team (
@sloan_kettering
). The research focuses on understanding the function of a key protein involved in double-stranded break (DSB) repair.⬇️
0
2
23
Do you want to learn how the lab of
@StephanGrill
(
@mpicbg
,
@PoLDresden
) used LUMICKS’ C-Trap to directly visualize the interaction between
#DNA
and the pioneer transcription factor
#Klf4
? Read our news article about this recent
@NaturePhysics
paper!⬇️
0
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Are you Interested in finding out new ways to identify the best
#CART
cells for
#immunotherapy
? Don’t miss our next webinar on Wednesday, 8 July!
Register now!
➡️
1
4
21
🔬Study protein droplet dynamics in real time to understand
#phaseseparation
.
This study by
@BanerjeeLab_UB
uses C-Trap to test droplet fusion as a function of molecular crowder concentrations. Here, you see the fusion properties of trapped droplets upon concentrations of PEG.⬇️
0
8
22
Can we obtain both structural and functional information of
#biomolecules
in real time and at the molecular level? Join LUMICKS' talk at
#MM2020Virtual
this Wednesday at 6 PM (GMT-5) to learn all about cutting-edge dynamic single-molecule technologies!
➡️
0
8
21
The
#SMBLesHouches
2020 meeting is definitely what you call a 'conference with a view'! We are excited to have spent this week among the top leaders in the field of
#singlemolecule
#biophysics
. Luckily, we also had time to enjoy the beautiful French Alps!
0
3
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Play the world's smallest pinball game on the
#CTrap
! It's made with Python scripts to control the 4.5 μm beads. Check out more scripts to automate your experiments and perform data analysis here ⬇️
0
4
21
A breakthrough in DNA repair research!
@SimonBoulton
and
@StephenWest
at
@TheCrick
has used
#C
-Trap technology to explore the BCDX2 complex. This could lead to new therapeutic strategies for diseases linked to RAD51 paralog complex mutations. Check here:
1
9
21
Did u know that dynamic single-molecule (DSM) methods can help you generate breakthrough results for your
#molecularbiology
and
#biochemistry
research? Watch Prof. Steve K talk about the value of DSM & don’t miss our talk at
#EB2021
to learn more!
#ExpBio
1
6
20
What a milestone! We're proud to announce the C-Trap installation and training for our
#100th
customer sale at the MRC-LMB! We're delighted to celebrate this and to help
#scientists
continue their work in pushing the boundaries of what we know today.
Find the
#PressRelease
⬇️
0
5
19
A recent publication on Nature showed new DNA repair mechanism uncovered by the
@Francis
Crick Institute with C-Trap, proving RAD51 paralogs as crucial as the BRCA2 pathway in cancer prevention. Learn more about it:
0
4
19
For the very first time, researchers from
@FMorenoHerrero
lab were able to visualize the dynamics of ParB binding to DNA and its 1D sliding! Their results further our understanding of how individual proteins contribute to
#DNA
condensation in vivo. Learn more in our blog post!⬇️
0
4
19
Another interesting publication using the C-Trap®. Congrats to all the authors!👏
@chillzaa
,
@LukasPekarek1
,
@nevacaliskan
and others from
@AtomicVirology
,
@FirthLab
,
@CamPathology
and
@Helmholtz_HIRI
report insights into the programmed ribosomal frameshifting promoting mechanism of protein 2A from a cardiovirus.
0
7
21
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5
19
We're happy to share our news about the most recent C-Trap® and m-Trap® installations in the UK, including one of our most advanced systems in the Prof. Aragon and
@RuedaLab
(
@MRC_LMS
@ImperialMed
).
Curious to learn more? Find the details below:
⬇️
0
4
18
Say what...?!
🥔: Practical Optical Tweezers Analysis TOol
Read this cool preprint on a new open-source python-based tool for batch analysis of C-Trap data.
0
3
16
Do you want to see the dynamic interplay between
#histone
-like proteins and DNA? A
@SciReports
recent study from
@DameLab
and
@gwuite
shows exactly this while analyzing the influence of ionic conditions &
#DNAconformation
on these interactions. Check out our news item.⬇️
0
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Are you also counting down the days until
#BPS2022
? Step into a new dimension with the launch of our new C-Trap product line!
Join our Exhibitor Talk with
@arnegennerich
live
@BiophysicalSoc
(22 Feb, 11:30 am PST) or register now to watch online (23 Feb, 10 am or 4 pm CET)⬇️
0
4
18
Only a few days left until
#BPS2022
! Did you know we are stepping into a new dimension with the launch of a new C-Trap product line? Join our Exhibitor Talk with
@arnegennerich
live
@BiophysicalSoc
(22 Feb 11:30 AM PST) or register now to watch online (23 Feb 10 AM or 4 PM CET)⬇️
0
7
16
Combining research with skiing? Sign us up!⛷️
The Les Houches meeting aims to explore the dynamics and mechanics of fundamental biological processes at the
#singlemolecule
level. Abstract submission is open and will be reviewed by the co-chairs
@RuedaLab
& Nynke Dekker.⬇️
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Our next webinar is hosted by application scientist Dr. Bärbel Lorenz, who'll discuss the applications of
#OpticalTweezers
on lipid membranes and membrane-protein interactions, including experimental setups and recent studies. Join us live on 25 & 30 June:
0
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Here you see a single
#microtubule
being manipulated using
#OpticalTweezers
while simultaneously imaged label-free using IRM (left) or visualized via TIRF microscopy with fluorescent labeling (right).
Discover all possibilities of our newly launched C-Trap Edge!⬇️
1
8
16
We are thrilled to announce the recent C-Trap installation at
@ENSdeLyon
, France, where it will be utilized by 8 teams across 3 departments. We wish all groups the best of luck with their new projects and are very excited about their results!⬇️
0
3
17
Special week for the LUMICKS family, we are celebrating our 5th birthday! Many thanks to everyone who made LUMICKS possible. It has been an amazing journey so far.
Since the move to our current HQ, we started the yearly team photo tradition. Which differences do you spot?
2
3
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Last week, over 30 enthusiastic single-molecule researchers joined our
@LUMICKS_nl
C-Trap User Day in Dresden to network and exchange ideas.
A big thank you to
@Michael_Schlierf
for hosting us at the
@BCUBE_TUDresden
#DynamicSingleMolecule
#OpticalTweezers
#Microscopy
#DNA
1
3
16
Join Prof. David Rueda for a deep dive into DNA repair!
Registration now open 👉
Don’t miss out!
0
4
16
The wait is over! We’ve launched an entire catalog of reagents, kits, and services for your dynamic single-molecule experiments. Say goodbye to tedious setup times and maximize the reproducibility of your data.
Check out the full range here ➡️
0
6
16
Did you miss our webinar with
@FMorenoHerrero
(
@CNB_CSIC
) presenting his recent findings on the bacterial
#DNAcondensation
system using
#DynamicSingleMolecule
methods? Great news: The talk is now available on-demand. Watch it anywhere at any time!⬇️
0
2
16
Why rely only on one technology if you can combine multiple? Here, you see correlative IRM/TIRF imaging enabling the study of motor proteins (cyan) walking along
#microtubules
, all at the single-molecule level. Learn more about the possibilities on the application page.⬇️
0
5
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Time for part 5! "Optical Tweezers [...] has permitted us to study and define problems that haven’t been able to be addressed by ensemble methods for 20-30 years." - Prof. Stephen Kowalczykowski. ➡️
1
6
16
In the paper published in Biomolecules (2019), Kaur et al. studied how entropic forces contribute to the formation & dynamics of
#membranelessorganelles
. In the video, Dr. Priya Banerjee explains the journey to this publication!
Want to learn more? Meet us this week at
#bps19
0
3
15
The 1st C-Trap™ system combining
#OpticalTweezers
with 3-color
#TIRF
and
#labelfree
#IRM
is set up in the lab of Prof. Arne Gennerich (
@EinsteinMed
)! Read the news item to learn how they will use it to study molecular (dys)functions of
#microtubule
-associated motor
#proteins
.
1
1
15
❤️ Love is in the lab this Valentine's Day!❤️
Our scientists played Cupid with
#proteincondensates
, merging them on a C-Trap to create a heart shape!
Learn C-Trap experiments in protein condensates:
0
0
15
📜Attention scripters!📜We're launching another single-molecule scripting competition and you have all the way until Thursday, 30 September to enter. All scripts submitted after Monday 22 February are valid entries. The top 3 scripts will be taking home prizes so enter today⬇️
1
6
14
Imagine if you could pull the
#cellmembrane
while measuring
#force
and observing
#fluorescence
. You would be able to directly investigate the
#cellularresponse
to
#mechanicalstimuli
!
Find out how: ➡️
0
1
15
In our upcoming webinar, we'll introduce Harbor - the new user platform for sharing dynamic single-molecule automation and analysis scripts. We'll introduce the readily downloadable scripts, the interface, getting citations and how to upload and download scripts. Register here!⬇️
0
7
14
A novel
@NatComm
study by
@nevacaliskan
lab (
@Helmholtz_HZI
@Helmholtz_HIRI
) reveals how the endogenous ZAP-S protein prevents refolding of SARS-CoV-2 RNA and thus can act as a direct replication inhibitor of this pathogen. For quick insights, read our blog.⬇️
0
5
15
Meet us at
@ebsa_in
this week to learn about our most recent
#advancements
to enable the analysis of the complex dynamic details related to the behavior and interaction of
#biomolecules
at the single-molecule level!
#ebsa
#biophysics
#OpticalTweezers
1
0
14
Do the mechanisms behind CRISPR-Cas proteins interest you? In a recent paper from
@RuedaLab
,
@marilu_losito
et al. used their C-Trap to uncover new insights about the dynamics of Cas12a binding, target search, and cleavage of λ-DNA!
Check out our news item ⬇️
0
5
15
A day to remember for
#LUMICKS
! 👑 Her Royal Highness Anne, The Princess Royal is behind one of our instruments at
@MRC_LMS
. When will we see the 1st royal publication? 😉
#RoyalSupport
#CTrap
#DNA
@RoyalFamily
Delighted to have HRH The Princess Royal open our cutting-edge research facility! Housing nearly 400 scientists & staff, we're advancing discovery research with our
#TeamScience
ethos.
@the_MRC
@imperialcollege
@royalfamily
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Have you tried bending a microtubule just like a flexible rod? With C-Trap, you can!
Read more:
0
2
15
Do you have a background in biophysics, biochemistry, molecular biology, or systems/computational biology? Are you considering a PhD position?
@univgroningen
is forming an interdisciplinary team across 5 labs including
@HeinemannLab
and
@BiophysK
!
Learn more about the roles ⬇️
0
6
15
We have installed another C-Trap, this time in the lab of
@DrJorine
at
@Radboud_Uni
! We're happy to be a part of her team’s exciting research striving to reveal the fundamental properties of
#chromatin
organization and its impact on
#geneexpression
regulation!
Find the
#Blog
⬇️
0
2
14
Check out this publication
@MolecularCell
by
@BoultonLab
and
@RuedaLab
showing how
#Rad51
-filaments are formed during
#DNA
homologous recombination.
Congrats to all authors!
0
3
14
Last week we had the chance to welcome
@NLAmbassadorUSA
and
@KennTurner
to our
#Boston
office. Our scientists demonstrated our instruments, and our guests even caught some molecules themselves. We want to thank them both for coming over!
0
6
13
.
@RockefellerUniv
now houses 1 more C-Trap! The new system will support the research of Prof. O’Donnell and his collaborator
@InLiuOfBulkExps
, to unveil the mechanisms of enzymes, such as multi-protein DNA
#ReplicatingMachines
of bacteria and eukaryotes.
Read the
#PressRelease
⬇️
1
0
14
🔔 It’s again time for
#WebinarWednesday
! This week, Dr. Kasia Tych (
@BiophysK
) from
@univgroningen
will discuss her exciting research on the folding mechanism of the chaperone heat shock protein Hsp90 using
#opticaltweezers
.
Make sure to secure your spot by registering now! ⬇️
1
5
13
🔬♀️ In honor of today’s International Day of Women and Girls in Science, we want to put some of our awesome colleagues in the spotlight. Cheers to all women in STEM making a difference every day!
#WomenInSTEM
#WomenInScience
0
4
13
From all of us at LUMICKS, wishing you happy holidays. Stay safe, and we will see you next year! 🌟
#HappyHolidays
#HappyNewYear
1
4
14
Are you as excited for
#BPS2022
as we are? Join us to step into a new dimension with the launch of our new C-Trap product line!
Watch our Exhibitor Talk with
@arnegennerich
live
@BiophysicalSoc
(22 Feb, 11:30 am PST) or register now to watch online (23 Feb, 10 am or 4 pm CET)⬇️
2
5
14
🚀We’re proud that LUMICKS has placed 6th in the Dutch
#LinkedInTopStartups
2020 list! The list ranks the most resilient and fast-growing start-ups of the year. Many thanks,
@LinkedIn
@LinkedInBenelux
for the recognition!
Are you curious about this ranking? Check out our post!⬇️
0
3
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🧡 Tomorrow the Dutch are celebrating
#KingsDay
! In honor of this celebration, we dressed up in orange during our weekly kick-off meeting. For those working in our HQ, the office team has prepared some awesome treats to enjoy. Are you planning to celebrate King's Day?
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4
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After more than 5 amazing years at the VU University Amsterdam, we are thrilled to announce that our team in the Netherlands has moved to a new location! We are looking forward to welcoming you to our
#newoffice
soon!
Read more about it here:
0
2
13
Did you know that the C-Trap™
#OpticalTweezers
–
#FluorescenceMicroscopy
can actually film
#proteins
interacting with
#DNA
? The data shows the position of bound XRCC4 and XLF proteins on DNA unveiling the binding kinetics and diffusion. Learn more via .
0
2
13
For the final talk of the DSM Symposium Series, we welcomed our co-founders Prof. Peterman and Prof. Wuite (
@VUamsterdam
). They nicely complemented each other by describing the true value of combining
#opticaltweezers
and
#imaging
. Stay tuned, we will release
#coolcontent
soon!
0
2
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The wait is over…Our kits and reagents are already in the hands of our dynamic single-molecule community and it’s no surprise how they feel about it! With these products, they’re able to generate DSM data much more quickly.
Check out the range here ➡️
1
5
13
As we gather to untangle Christmas lights🎄, let's not forget the helicases, tirelessly unwinding DNA strands🧬. Read the exciting publication of our valued customers
@KaceyMersch
and
@nicfaz9
from
@Lohman_Lab
featuring our C-Trap! We can't wait to see your new data next year!
Are you looking for a good read this holiday season? Check out this new publication from
@Lohman_Lab
!
@nicfaz9
and I describe the role of RecBCD's nuclease domain in DNA unwinding using both bulk and single-molecule methods!
@LUMICKS_nl
@LUMICKS_US
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1
13
Check this beautiful review from
@InLiuOfBulkExps
to see how advanced single-molecule techniques are unlocking the secrets of DNA-binding proteins!
Learn about the powerful combination of fluorescence microscopy and optical tweezers, providing unprecedented insights into
Our review on using single-molecule correlative force and fluorescence microscopy to study protein-DNA interactions is out! Honored to share our perspective on this fast-growing field. Thanks to
@AnnualReviews
for the open access volume 👍🏼
@BadAtCloning
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101
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1
13
Exciting science for the
#DSM
field! This
@NAR_Open
pub by Dr.
@IddoHeller
(
@VUamsterdam
) shows a new
#superresolution
inverse imaging approach tracking unlabeled proteins through fluorophores that transiently label bare DNA but not protein-bound DNA. ➡️
0
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Wait for it...!
We wrote LUMICKS using the C-Trap®, cool right? The systems’ ease-of-use and high trap accuracy makes it possible to move a trapped bead with great precision.
We’d like to
#challenge
all C-Trap® users to write their lab names! Who’s up for it?
1
3
13
🧬 Did you ever hear of
#DNA
breathing? It’s a phenomenon describing the local conformational transitions occurring within a dsDNA. Using the C-Trap®, you can observe these fluctuations in the recorded force signal by holding the dsDNA molecule at a constant distance over time.⬇️
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We couldn't agree more! 😂
1
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Did you know that you can use the C-Trap system to study
#ProteinDroplet
dynamics in real-time and understand
#PhaseSeparation
? Explore our application page showing how scientists answer their research questions using the C-Trap! ➡️
0
5
13
🔬 Study
#DNAreplication
mechanisms and the activity of its
#motorproteins
at the nanoscale.
The C-Trap® can quantify DNA polymerase activity during replication. Here, you can see that the DNA-associated polymerase executes short activity bursts (3 to 10 nucleotides). ⬇️
0
6
13
We are happy to see that the C-Trap enabled the
@nevacaliskan
research team to shed light on the mechanisms involved in RNA virus replication, as shown in two recent
@NatureComms
publications! Download our new application note to learn more!⬇️
1
6
13
The
@LugerLab
investigates the impact of
#chromatin
architecture on genome-related processes such as
#DNArepair
. Listen to Prof. Luger and her views on
#DynamicSingleMolecule
analysis and how it complements structural biology and bulk approaches.
#ExpBio2022
#ASBMB
#ExpBio
0
8
13
Are you attending
#BPS2022
? Meet us at booth 409 and join our launch presentation of the new C-Trap product line with
@arnegennerich
live
@BiophysicalSoc
(22 Feb 11:30 AM PST).
Not attending? Register now to watch online (23 Feb 10 AM or 4 PM CET) via .
0
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“Combined with the power of having a simultaneous mechanical and fluorescent readout, we will be able to uncover previously unexplored details of the conformational cycles of our model proteins.” - Dr. Katarzyna Tych (Rief Lab). Read more about the C-Trap® installation below!
1
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Did you see last week's launch of the new C-Trap products?
👉 Dymo & Edge
This video shows how the Edge combines the power of the C-Trap with new ways of imaging, using
#TIRF
, label-free
#IRM
, and
#widefield
, unlocking a wide variety of game-changing surface experiments.⬇️
0
3
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In the past months, we've hosted >10
#webinars
on cutting-edge research performed using DSM tools to study
#DNA
editing, phase separation, protein unfolding,
#viralpackaging
, and many more. Did you miss some? No worries! You can watch them on-demand via .
0
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We're proud to say that more than a third of our employees are women. In an industry that is extremely male-dominated, we try to set an example as a company by pushing diversity as a top priority.🥇
#IWD2020
#EachForEqual
#InternationalWomensDay2020
#WomenInSTEM
#WomenInScience
0
1
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Some super exciting news! Early next year, our
#Amsterdam
HQ will be moving to IQuarters - Marie. IQuarters is a newly-built
#LifeScience
District in Amsterdam, where the buildings go by the names of female Nobel Prize winners. Yes indeed, ours is named after Marie Curie. PROUD!
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#BPS2021
might be virtual this year but this doesn’t mean you can’t experience live C-Trap demonstrations! We’ll be presenting live labinars, showing hands-on experiments on
#ProteinFolding
#DNAbindingProteins
and
#ProteinDroplets
. Secure your spot below⬇️
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7
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Decades-long mystery of how DNA damage is identified!
A collaboration between MRC-LMB and MRC-LMS with the recent
#Nature
publication by Prof. Lori Passmore and Prof. David Rueda!
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We’re hiring! As a result of a continuously growing dynamic single-molecule and immuno-oncology communities at LUMICKS, we’ve added 14 vacancies across a wide range of positions in the US, the Netherlands, and China. Click to check out the full list of vacancies here! ⬇️
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The DSM Symposium Series was the first of its kind – bringing forward 8 leading experts in a variety of areas that relate to dynamic single-molecule research. 1/2
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Congratulations! The C-Trap® looks good on you,
@BiophysK
.😉
I know that this is not so important in the context of what is going on in the world right now, but it's a big event for me. My lab's shiny new dual-trap optical tweezers instrument from
@LUMICKS_nl
is now installed!
@univgroningen
@ResearchGbb
@AcademicChatter
#sciencetwitter
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#Sinterklaas
visited
@LUMICKS_nl
last Friday! We celebrated this traditional Dutch festival with delicious
#chocolate
,
#pepernoten
, a lot of
#presents
, and a lot of fun!
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