Paul Kiesow
@KiesowPaul
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Septuagenarian with extraordinary result DOB June, 1952 Forestalling α-synucleinopathies ESSENTIAL for LE
Pennsylvania, USA
Joined June 2022
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De rigueur bathroom mirror photo
Sept. 14, 2024 aged 72
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Life extension becomes a fruitless enterprises unless the brain's practically inexorable deterioration, shrinkage and neuronal losses are addressed early on. The brain is one's identity and master regulator—nothing takes precedence. Few acknowledge or articulate this exigency.
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"Brain volume loss in the adult life span: 1%/year from 20 to 50 years and 2%/year after age 50. . . . CT scans with radiographically normal findings"
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Have done due diligence investigating rapamycin, listening, observing visible results. Rapamycin is a dead end with many unwanted effects—classic example of animal studies not transferring to humans. It affects differentiation & autophagy, which may account for animal successes.
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(1 of 2) I turn 72 in June. The really hard stuff comes now. Lots of bad things (aging-wise/disease conditions) are imminent or happen on the way to 80—many septuagenarians won't make it there alive, quite apart from the mundane task of maintaining a youthful appearance & affect.
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The thymus gland is programmed to go offline at about age 65 with ramifications for immunity. Losses in one's immune response make infectious disease and even cancer more likely:
Intrathymic Somatotropic Circuitry—consequences upon thymus involution
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The decline in enhancer regulation of the catecholaminergic brain engine, the main activator of the cortex, is the prime factor of brain aging. Regulation’s decay in the rapidly aging dopaminergic system is responsible for the decline in learning ability.
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Septuagenarian to octogenarian, sans senescence: indeed an unforgiving gauntlet, yet eminently doable. One I'm running right now. 😉
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Metformin summarily reduced any fixation w/ eating and has brought about intermittent daily fasting without my even being aware of it. It resets one's metabolism in my opinion and can be implemented after age 40. A1c of 5.0, O2 98%, complete GI balance, no workout/dietary program
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• HMB (β-hydroxy-β-methylbutyrate) 3.5 grams
• Leucine 4.5 g —
• Arginine 4 g — hGH secretagogue, activates mTOR
• Hyaluronic acid 2.2 g
• Creatine monohydrate 5 g — converts adenosine diphosphate back to ATP
• Taurine 4 g
• Collagen peptides 9 g
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L-arginine activates mTOR/stimulates protein synthesis.
L-leucine/BCAAs inhibit muscle catabolism
Creatine monohydrate ATP recycling in muscle & brain. HMB counters muscle wasting of disuse/disease.
Collagen peptides, source 'predigested' key proteins.
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July 2004 — 52 y.o. No disrespect to the many high-profile life extension players, but let's be honest: practically no such result even comes close. In this photo, I had been involved in my anti-aging protocols for more than 15 years—no exercise regimen, no special diet.
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Selegiline has been hiding in plain sight and may be principally responsible for my youthful preservation and vigor. Other important things, such as EPA fish oil, metformin & NAD, affect metabolic health. The brain and its structures direct traffic and must do so smart & strong.
@LivingForever8
Reposting this picture needs to happen as a specific head-to-head comparison with David Sinclair since he is 52 and I'm shown at that exact same age. As for attribution, I had been taking selegiline for seven years; brain preservation per se is not in his wheelhouse—nor in BJ's.
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Upped EPA/DHA to 8+ grams/day for one week now. Naturally, a bit early to tell, but I feel great! TY to Julia B. and Miss Mitochondria for investigations and thoughtful input.😁
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Selegiline 1.25 mg/day, six days per week. A quite low dosing schedule that protects nigrostriatal dopaminergic neurons, as well as against a range of α-synucleinopathies.
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@KiesowPaul
This has "summoning the Kali of Time to renegotiate the contract" vibes ;-) (You look great.)
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Today's smoothie: 4 grams L-arginine; 3 g L-leucine (BCAA/branched-chain amino acid); 5 g creatine monohydrate; 3 g HMB; and 10 g collagen peptides powder. Add something sweet and tart for palatability.
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Seventeen years selegiline—one of my four aces. Selegiline/deprenyl protects against 'normal' loss of nigrostriatal dopaminergic neurons after age 40, as well as against a range of α-synucleinopathies. Brain compromise = LE queen taken
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Forty- and 50-somethings monetizing LE regimens—perhaps before being aged out by changes in appearance. Apart from hype, "gurus emeritus" or methylation test results, people deserve more: visibly compelling anti-aging results at 60 and beyond may be better arbiters of efficacy.
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Retaining one's thymus deserves more attention. Its 'normal' involution (atrophy/disappearance) after about age 60 is like the loss of key chess pieces in the game of life, yet this need not be so. Preservation and rejuvenation have been demonstrated.
The thymus gland is programmed to go offline at about age 65 with ramifications for immunity. Losses in one's immune response make infectious disease and even cancer more likely:
Intrathymic Somatotropic Circuitry—consequences upon thymus involution
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Father & Son at post-reception get-together August 6, 2023 under the gazebo overlooking SF bay. Free-range egg, Will finishing his nectarine—from their mini-farm. Great times!
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1.) metformin 1g — 21 years
2.) selegiline 1.25mg — 19 years
3.) nicotinamide mononucleotide 1.3g
4.) dehydroepiandrosterone 75mg
5.) EPA/DHA 1.5g — 15 years
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LE/anti-aging pursuits extend to my mid-30s. They have worked. With zero internal medicine issues (yes, zero), I'm uniquely positioned to preempt pending insults with a reservoir of defensive measures. The human body is actually frail and ephemeral. Constructing a stasis is huge.
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I quit resveratrol six months ago. It passes muster as a sort of placebo, and in smaller doses it's likely *another decent/benign polyphenol. However, gram+ dosages carry potential unintended consequences/risks. Honestly, could sense no benefits.
@davidasinclair
Recently eliminated resveratrol, which may possess 'sidelined' side effects. Fisetin is cozy, like a warm cup of chamomile tea. DHT, prominent cause of follicular atrophy/hair loss; 5-alpha-reductase inhibition counters it. Cheers
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Adding vitamin K2-MK7 plus vits K1 & 2
My sister-in-law, 83, shattered her arm two years ago. Doctors took a wait-and-see re surgeries. Went on vit K2-MK7. PTs and orthopedists were surprised, given age and severity. K, more than about bones.
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People should pay more attention to cell loss—skeletal muscle, organ, lean body mass diminishment—an unequivocal trend in age progression. As for sarcopenia, strength training and even steroids merely increase muscle fibers/thickness; they don't replenish muscle cells. Yet . . .
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Bushy enough. Adding KGF (keratinocyte growth factor) hasn't hurt. Most of what you see here is either from finasterine, or good livin' and genes ~ although my bro is totally bald.
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Question to all antiaging and LE folk: What are your top-three essential nutraceutical and nutritional supplements to support health, preserve youthful vitality and mental clarity?🙂 (I'll tell you mine if you tell me yours.)
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The kicker: Triglycerides 115 last blood draw. After markedly upping fish oil intake—BOOM, half that at 60 mg/dL
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@YasonWave
@deantaplin
@BakaKarasu
@BeamsOfEnergy
Metformin 1g — 21 years for AA only
Selegiline 1.25mg — 19 years (few have even heard of it)
Nicotinamide mononucleotide/NMN 2.8g (NAD+ slam dunk)
Dehydroepiandrosterone/DHEA 75mg — 33 years
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DAY 4 serialization
The answer is that by 70 most people’s appearance has changed so markedly they’re no longer ‘players’ in the youth preservation game. So, how is age progression assessed: DNA methylation patterns, blood work, inflammation? The gold standard is physiognomy.
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DAY 1 Tweet serialization
I'm noticing that I have apparently stopped aging. Between age 70 and 80 much happens and it happens fast. Film stars, media personalities, influencers, notable and powerful people—even gerontologists—begin to “age out” as they approach 80. . . .
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BTW,
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L-leucine, isoleucine, taurine, creatine, hydroxymethylbutyrate (HMB), arginine and collagen peptides have been studied specifically for skeletal muscle maintenance. I take them all daily.
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Epidermal growth factor (EGF) is a potent, specific mitogenic polypeptide that stimulates cell growth and differentiation. It increases collagen production and the formation/restructuring of elastin fibers in the extracellular matrix for skin rejuvenation. ADDING, not subtracting
@cavepaleo
Found Skin Actives Scientific after long searching for the pure peptides EGF and KGF. They sell formulated products, as well as pure forms. 50-mcg vials KGF [or EGF] about US$16, mixes into any base. Works on many hair types—full alopecia is challenging.
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A typical octogenarian may have lost 24 percent of brain mass and be medically seen as normal—and will die at age 86 of natural causes. If that individual possessed a healthy, fully intact brain. . . .
Perhaps this aging brain is aging itself.
@LivingForever8
Sounds like a sophism, but the brain likely controls nearly everything regarding mammalian aging.
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On the steepest ramp of aging acceleration: Decade Eight. The AA degree-of-difficulty is practically at its height RIGHT NOW. Do I have a general plan? No, I have a specific, targeted, proactive 'high-amplitude' plan—to the extent not every detail is suitable for general posting.
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Per the TRIIM study, the thymus need not 'involute'/fade away as it does for most.
@deantaplin
@BakaKarasu
@BeamsOfEnergy
The TRIIM studIes highlight the importance of thymus health & preservation in maintaining the integrity of one's immune system.
I will tell you with a straight face my immune system is at least as robust as it's ever been. No infections, no fear.
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My son Will Kiesow just received his M.D. He turns 28 in July. Celebrating with Dad!
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Piece by Steve Hill for
@LifespanIO
. Addresses NMN's past, present, future. Mentions high cost; NMN is about as much as many items in people's stacks. Cardiologists are seeing 'deathbed' cardiomyopathy patients perk up, and Hill alludes to such efficacies.
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DAY 3 serialization
. . . young people wary of cosmetic issues, seeking preserved youth and aging indemnity; mid-lifers boasting age regression and workout muscles—some sporting shaved heads, cordial botox stares. How many 70+ folks does one encounter looking two decades younger?
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Breaky, 4 p.m. Broccoli rabe, limas, garden peas, surti papdi lilva beans, country ham, EVOO. Serves one. 😉
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Metformin affects NF-kB transcription of genes. Underscored here are pleiotropic effects of metformin in eliminating the susceptibility to common aging-related diseases via its effects to the modulation of NF-kB signaling. Metformin, my
#3
go-to 21 years
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Someone mentioned K: for four full decades, I've used Morton Lite Salt—an equal balance of potassium and sodium chloride—as my all-use salt. Its balance of potassium is key. This Morton product has been lurking under the radar since its introduction in 1973.
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At Palo Alto Hills Golf & Country Club for my son and daughter-in-law’s wedding reception.
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Trees don't regress to saplings, yet extreme longevity can be seen in the otherwise unassuming form of a large thriving oak. If aging were to stop in a human, it might be revealed as nearly complete homeostasis housed in the adult human form—not as an adolescent or teenager.
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Liking my January 2024 panel — 53 parameters
CBC, Chemistry, Coagulation, GI, Liver enzymes, Kidney function, Nutrition markers, Cardiac/lipi, Glucose/HbA1c, BP, Weight: ALL ideal values, including several immunity/'inflammaging' components (sorry, no CRP or others this round)🙂
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Dr. Joseph Knoll said that a minuscule/'subclinical' amount of selegiline is effective in maintaining acquired specialized goal-directed cognitive behaviors—rather than just a stimulant like many other drugs: maintenance of brain performance against aging.
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I don't always smile, but I'm still happy . . . VERY happy about my hold on aging. (So humble.)
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I have gathered a good bit of knowledge from observations, studies and personal experience regarding a great many supplements and strategies employed by antiagers across the spectrum. I will take questions and happily pass judgment😃on efficacies.
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By the time Parkinson's is diagnosed via a shaking hand or a dragging foot, it may have been active under the radar for decades—and destroying roughly half of the dopamine-producing neurons in the substantia nigra. (No mention of preventive selegiline)
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From my May visit
Blood Pressure: 122 mmHg / 74 mmHg
Weight: 168.65 lbs
Total cholesterol/HDL: 3.1
HbA1c: 5.0
Triglycerides: 60 mg/dL
eGFR CKD-EPI: > 90 mL/min/1.73 m2
Na: 138 mmol/L
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Key in this study is hGH, presumably behind tissue replacement. D₃ and zinc are known immune supporters. Metformin also addresses glycemic issues sometimes seen with hGH. As for DHEA, I have taken it 30+ years; ditto for L-arginine, which can release hGH to an extent.
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NMN stands out in another way: to boost NAD+ it need not be taken sublingually, and the presence or not of food in the stomach has minimal effect on its efficacy/bioavailability. Since November 2021, 650 mg twice daily, no skipped days. Lunulae appear 3-22
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For those itchin' to see my face sans whiskers, one of the few times I did not have 'em. In the hot & humid tropics—shaved to stay cool and see what had been lurking underneath. My 54th birthday, June 2006
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Nunzio brought forth an epiphany that's also eminent common sense: almost no aging exists unaccompanied by cell number losses—skin thinning, sarcopenia, a substantial reduction in brain neurons, and those of organ/lean body mass.
It hugely guides my antiaging agenda/protocols.
@IsmanAnar
@DanilaImmortal
this is nothing new! today we ignore the only true and common knowledge that causes aging of all tissues, (cellular subtraction) aging manifests itself with the lack of cells that make up the tissues and if this is not remedied it is impossible to repair.
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At 71, lunulae suddenly appearing on great toenails. Timeline: Started 1g/day NMN November 2021; nails start growing out whiter sans ridges March 2022; December 2022 smoother more translucent; April 2023 lunulae appear. Only ever recall seeing them on my fingernails.
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"Nigral dopamine neurons are progressively lost during normal aging." I circumvented this "normal aging" atrophy/death of substantia nigral neurons by using the MAO-B inhibitor deprenyl (selegiline) from 1996 - 2014. Just resumed it.
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Interesting that a half-dozen following accounts disappeared immediately after I came out as an advocate of activating mTOR ~ as opposed to inhibiting it. I respect others' takes. However, one won't find a rapamycin supporter here. I strive to openly share and discuss, always.
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First meal today, 5:30 p.m. Broccoli rabe, asparagus, lima beans, surti papdi lilva. I don't eat it because it's healthful, but because it's insanely delicious 😋
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Haircut today. Still the '70s 'Shag' . . . just a bit shorter
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Most think of glucosamine mainly as a joint and connective tissue component.
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Quite a bushy head of hair, especially after applying pure KGF to temples, vertex and hairline. Pure growth factors, I was able to find and obtain. It's always about ADDING, not subtracting.😉
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Do you remember when you joined Twitter? I do!
#MyTwitterAnniversary
(Twitter kindly wrote me an anniversary Tweet!)
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Gut microbiota are often implicated in whole-system health. At no time in my life has my GI resiliency and balance exceeded what it is now. At times I wonder if it has positively affected everything else. What have you learned about the microbiome's potential pervasive influence?
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(4 of 4) For 17 years, from age 45 to 62, I took 1.25 mg deprenyl/selegiline daily and I resumed this recently. Since my SN remains healthy, my current affect and movements are, as well. I look forward to deprenyl’s continuing brain protection as I progress forward from 71 to 80.
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Omega-3 EPA fish oil — A beautiful, powerful 'no-brainer' part of one's stack. Consequential in an expanding number of known areas. Rhonda and Dr. McGlory elucidate one. (Also HALVED my triglycerides in three months: 115 to 62.)
Devastating us in old age, a short stint in the hospital can cause just enough atrophy that we may not be able to perform the basic activities of daily living - progressing us catastrophically towards early mortality.
In my recent interview with Dr. Chris McGlory, Chris
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This correctly speaks to the etiologies of Parkinson's, critical to forestalling even its precursors. Studies showing preclinical PD indicators [perhaps by AI] are fine. By then, patients are well down that road. Noticing is good—prevention, priceless. 17 years selegiline. 😎
Learn more about alpha synuclein oligomers and clinical implications for Parkinson disease here! 👩🔬
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Mixing things up a bit. . . . Recognize the hand model? That's also my wedding band. Only my partner and I craft them from the most precious and rare metal on earth: 999 solid rhodium.
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'Hot Tub Time Machine'
Holmes created a bullet list of my 1998 stack:
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(2 of 2) Works against toxic oligomerization/aggregation of α-synuclein and a blockbuster range of synucleinopathies, such as [including broader etiologies of] PD, AD, Lewy body dementia, multiple system atrophy (MSA).
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The youthful affect (behavior/kinesthetics) part comes from a healthy, intact nigrostriatal/dopaminergic pathway. You will recall why I believe this is so. ;-)
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My favorite cut of beef overall: USDA Choice New York strip steak.
Baked potato, daikon salad, glass of aronia berry juice
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"Aging beyond young adulthood is associated with accumulating deficits in cognition and motor control. Among the neuronal populations most affected by aging, dopaminergic neurons of the substantia nigra are essential for volitional motor control and several cognitive functions."
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Finally, someone comes out to state the obvious. Thanks for noticing and saying so. Morale builder.
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Rap has a list of adverse effects as long as one's arm. 1 g/d metformin has NONE, prolongs health span, reduces cancer incidence, optimizes glucose utilization, attenuates Electron Tranport Chain. I don't do the gym, period.
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Dr. Steve Horvath, Rhonda Patrick, Andrew Huberman on anti-inflammatory effects of fish oil supplementation, and effects on life expectancy of populations consuming high-fish diet
0:43 — ‘Aging’ Horvath & Patrick
1:45 — ‘Healthspan’ Patrick
4:36 — ‘Limiting Inflammation’ Huberman
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(1 of 2) More than substantia nigra domaminergic neuron protection: selegiline impedes mitochondrial apoptosis, induces anti-apoptotic Bcl-2 protein family, fosters pro-survival brain- and glial cell line-derived neurotrophic factors.
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Methylation & Metformin ~ this just in . . .
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Twenty-five percent of my 1952 birth cohort deceased; regretfully, the majority remaining face age-related disease conditions/chronic health issues; few look/comport youthfully. Increasingly difficult to present findings/successes sans unfruitful debate, crude insults.
@KiesowPaul
The weakness of X is the same weakness as all social media sites, that great messages can be drowned out by excessive adversarial replies. Be they genuine, or trolls, the effect is the same.
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@Holmes1618
Just started taurine today. Good safety profile, findings showing significant promise, largely missing in collagen peptides, not present in most plant foods. PureBulk 300ct 800mg caps, standard delivery two days.📦
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@LaraPo8
@LivingForever8
The app says I am 42 in this pic taken when I was 70. There ya go. 😄
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Began antiaging pursuits as a 35 year old—so far it has worked. This proclivity conspicuously belongs to the young/middle-aged. In those older, disease conditions and facial appearance can sap enthusiasm and sense of youthful invincibility. Depends of the person, the regimen.
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Had been taking selegiline to reduce/arrest [normal and generally considered acceptable] substantia nigra dopaminergic neuron loss (13% per decade after 40); selegiline is now shown also to intervene in the synucleinopathies of AD, Lewy body dementia, multiple system atrophy, PD
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MAO-B inhibitor selegiline reduces *18F-THK5351 uptake in the brain
With age, MAO-B increases 9% per decade. MAO-B *imaging is a biomarker for astrocytosis in various neurodegenerative conditions associated with cell death or activation of immune responses
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Two decades of metf♥rmin: one gram per day, every day. Underestimation of this remarkable drug could work to one's disadvantage.
Metformin: A diabetes drug with FASCINATING anti-aging and anti-cancer properties. Data shows it can improve response to cancer treatments. Our new study suggests that it can enhance tumor response to Y-90 radiotherapy in HCC. Manuscript here:
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The paradigm of human aging is profoundly unique—not a conceit, just a fact. Murine, worm, yeast studies while sometimes elucidative, can easily be superfluous or inapplicable to human lifespan.
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Have heard surprisingly little about EGF — 1986 Nobel Prize in Physiology or Medicine.
Much more than cosmetic, skin is our largest organ and a top aging marker. I use EGF and KGF.
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Experienced 3:48 totality in often-cloudy Erie, Pennsylvania. My 3rd total solar eclipse, yet the first when clouds didn't 'eclipse' the eclipse! Well worth the wait: 99% is but a dim day, then unequivocal magic—suddenly dark as night with the black-hole sun floating in gossamer.
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Adult net cell numbers ALWAYS wane. The body has fewer, and metabolic processes compensate for accumulating losses. Often, compensatory mechanisms foment a negative cascade. An antiaging linchpin remains the issue of cell losses—we're not here to let that happen. 😉
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Here's a circulating petition. For me, I do agree that aging is a disease condition, certainly a prodrome to a multitude of diseases. When Nir Barzilal sought FDA go-ahead for his TAME trial, a hurdle was getting them to begrudgingly countenance this notion of aging.
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This p53 study just in.
. . . and SIRT6 won't stay below the radar much longer'
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You can also just protect/rejuvenate it.
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(2 of 2) . . . facilitates activity of nigrostriatal dopaminergic neurons with utmost selectivity and protects them from their age-related decay.
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Synucleinopathies successfully obviated:
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