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The study titled "Mapping Extrachromosomal DNA Amplifications During Cancer Progression" by Anna Golebiewska and Kevin C. Johnson explores the role of extrachromosomal DNA (ecDNA) amplifications in cancer progression by analyzing data from 8,060 cancer samples, including newly diagnosed, untreated metastatic, and heavily pretreated tumors. The research reveals that ecDNAs are more frequently found in untreated metastatic and pretreated tumors compared to newly diagnosed cancers, indicating their potential involvement in treatment response and providing a competitive advantage during cancer progression and metastasis.

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Base editing screens define the genetic landscape of cancer drug resistance mechanisms

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Obesity-dependent selection of driver mutations in cancer

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The ZmCPK39–ZmDi19–ZmPR10 Immune Module Regulates Quantitative Resistance to Multiple Foliar Diseases in Maize

The paper titled "A Temporal Cortex Cell Atlas Highlights Gene Expression Dynamics During Human Brain Maturation" focuses on creating a detailed atlas of 75 cell subtypes in the human temporal lobe, utilizing single-nucleus RNA sequencing and spatial transcriptomics. This study reveals significant differences in gene expression dynamics between pediatric and adult brains, especially among excitatory neuron subtypes, offering insights into brain development and its implications for neurological conditions. The research highlights genes and pathways involved in brain maturation, such as those associated with cognition and synaptic plasticity, and provides valuable data for understanding the molecular mechanisms underlying neurological diseases. Additionally, the inclusion of data from African donors enhances the diversity of the Human Cell Atlas, contributing to global efforts to build a comprehensive brain cell map.

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