I'm thrilled to share my lab's first manuscript identifying that paraspeckle protein NONO regulates active chromatin through allosteric activation of NSD1 on BioRxiv: As a baby PI who started in a literally empty building, we weren't able to do biochem until a year after. Very proud that my PhD student @cheni_hsu pulled this through within 2.5 years! In this study, we uncovered a novel allosteric mechanism of NSD1 central to active chromatin formation and early development. Surprisingly, we identified NONO allosterically stimulates NSD1 through the aromatic pocket of PWWP2 domain in NSD1. NONO deficient stem cells partially phenocopies the defect of neural differentiation in NSD1-null cells. Our work has several key implications in the interplay between paraspeckles and active chromatin, the development of possible allosteric inhibitors for NSD1, and understanding neurodevelopmenal disorders in NSD1- and NONO-mutant patients.

@RobertMSterling DC is a lawyer’s town. Not sure what you are trying to get into.

RT @mbeisen: The indiscriminate and ill-conceived slashing of indirects by the @NIH yesterday must be amended if want to restore America’s…

@KJArmache @valendraica Wow. I can’t imagine how much efforts behind the scene👍👍👍

@Ella_Maru Yes! That’s exactly we are looking into now 🙃🙃🙃

@raisahmad Thank you 🥰 how are you doing there??

@KJArmache Thanks so much KJ!! Looking forward to seeing you in a conference soon

@nitin_shirole89 Thanks so much Nitin I miss you guys a lot 😭

@SunSherine Thanks Sherine!! Lots of sweat and tears.......

@escobar_thelma @theNCI @NIH @NogalesLab @lichtenmj So great to see you after a long overdue!!! ❤️

RT @MolecularCell: Structural insights into the cooperative nucleosome recognition and chromatin opening by FOXA1 and GATA4

RT @MolecularCell: Online Now: A CPF-like phosphatase module links transcription termination to chromatin silencing

@JamieSmythLab @CircRes @FralinBiomed @virginia_tech @nih_nhlbi @American_Heart 😍🎉

RT @aemonten: Yes.

RT @LabPadhu: Elements of successful NIH grant applications | PNAS Wow! a brilliant article from the grant writer…

RT @DrChrisHourigan: Today I started a new job as Director of the Virginia Tech FBRI Cancer Research Center in Washington, DC. https://t.co…

RT @FralinBiomed: 🚨 Breaking News 🚨 Christopher Hourigan, a globally recognized physician-scientist, is joining @virginia_tech as a profes…

@JamieSmythLab @rae_padget @poelzing_lab @SwangerLab Congrats Jamie!! 😍

RT @mitchguttman: PRC2 is reported to bind RNA. Yet, genetic experiments have raised serious questions about their functional relevance. Ou…