Jessica Wilcox, MD
@JessicaWilcoxMD
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Assistant Attending Neuro-Oncologist @sloan_kettering | Focus on CNS metastases | Views are my own
New York, NY
Joined November 2020
We have found that patients with neurologic manifestations of #COVID19 have inflammatory cytokines in their CSF, at levels approaching that of CAR T cell neurotoxicity. What’s more, this can be detected weeks after the acute infection. Role for steroids?
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RT @BrainMets_MSK: Recurrent #Brainmets after SRS are a formidable challenge. In @JNeurooncol, insights from the largest surgical salvage e…
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RT @GreenJournal: Clinical Reasoning: A 59-Year-Old Woman Presenting With Diplopia, Dysarthria, Right-Sided Weakness, and #Encephalopathy h…
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RT @DrYasminKhakoo: Women in Neurology @sloan_kettering @WCMCNeurology Thank you to all who galvanized us! @JessicaWilcoxMD @KlebanoffLouis…
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RT @sloan_kettering: May is #BrainTumorAwarenessMonth. Dr. Ingo Mellinghoff, Chair of MSK's Dept. of #Neurology, has devoted his career to…
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@WCMCNeurology @virginia_gao @WeillCornell @nyphospital Well deserved! Congratulations @virginia_gao !!
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RT @LaurenSchaffMD: Excited to announce this labor of love is published. Our look at the current state and future of CNS #lymphoma trials.…
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RT @sloan_kettering: Could more sugar available for immune cells mean better immune responses against cancer? MSK researchers Taha Merghoub…
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@YochaiReemMD Good question! I suspect the CSF cytokine elevation is more closely linked to systemic CRS severity than to cancer, based on our matched CoV- controls. Selecting for milder patients and smaller cytokine panels (we used a 92-marker assay) might also explain reporting differences.
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@winstoncb Unclear. Drawing from our experience managing CAR T cell neurotoxicity, tocilizumab (an IL-6 receptor blocker) improves systemic cytokine release but does NOT improve neurotoxicity; in fact it worsens neurologic outcomes. Most biologics also don't cross the blood brain barrier.
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@ahandvanish It would be highly valuable to learn if this finding also applies to #LongCOVID! There certainly seems to be some symptom overlap.
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@ahandvanish All had at least a mild dysexecutive syndrome or "brain fog." A subset experienced additional specific neurologic symptoms: severe prolonged delirium following intubation, limbic encephalitis, headaches, seizures, etc.
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RT @sloan_kettering: It's International #WomenInSTEM Day! RT and join us as we celebrate and give a virtual high-five 🖐 to our incredible f…
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RT @stemcellpodcast: Discussed in this week's episode: A team led by Dr. Viviane Tabar (@TabarViviane) at @sloan_kettering has generated la…
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