Jens Luebeck
@Jens_Luebeck
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Cancer genomics · extrachromosomal DNA #ecDNA · computational methods & bioinformatics · Assistant Project Scientist at @UCSanDiego @ucsd_cse 💻🧬
Joined December 2015
So when does ecDNA arise, exactly? Our study on #ecDNA and the transformation of pre-cancerous Barrett’s esophagus into cancer is out today. This collaboration brought together @Team_eDyNAmiC, @RFitzgerald_lab and the @FredHutch Seattle Barrett’s Study.🧵
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RT @biorxiv_cancer: Reconstructing the three-dimensional architecture of extrachromosomal DNA with ec3D #biorxiv_ca…
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RT @SihanSean: 🥳Review paper online: Modern biology of extrachromosomal DNA: A decade-long voyage of discovery👏You'll find modern ecDNA bio…
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Inducible ecDNA that give robust, strong amplifications that are persistent over time! This can create amazing new model systems to study ecDNA. Congratulations to Andrea and team for pioneering this work.
1/ 🚨New paper on ecDNAs from our lab! We reveal a strategy to engineer extrachromosomal DNA (ecDNA) amplifications in cells & mice. Let's dive in! 🧵👇
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RT @CancerGrand: New in @Nature from team eDyNAmiC 📢 @aventura71's lab provides a precise method to engineer ecDNA, demonstrating its abi…
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RT @FaltasLab: Please retweet! We are looking for outstanding postdocs interested in studying cancer evolution! 🌟 See our recent work https…
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RT @Sanjusinha7: Understanding ecDNA (tiny circular DNA) is among important open problems in cancer research. However, it can only be detec…
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RT @Guiping_W: A tweetorial for our work: we revealed an actionable therapeutic vulnerability of ecDNA by targeting hyperreliance on the re…
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RT @CharlesSwanton: ecDNA are rogue genetic material that amplify genes, contribute to treatment resistance and drive genomic heterogeneity…
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Tremendous work by all the authors and contributors - and a big win for the "team science" approach, through the @CancerGrand team eDyNAmiC! 💪
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RT @kinglhung: Cancer cells often harbor oncogenes outside chromosomes on extrachromosomal DNA (ecDNA), which is unevenly inherited by divi…
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RT @drimrannoorani: Very pleased to share our new online pre-print! We explore the spatial-temporal evolution of extrachromosomal DNA (ecDN…
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Also unlocked a personal achievement as this is my first time being listed among the senior authors 😃
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@FaltasLab @Nature @WeillCornell @WCMEnglanderIPM @nyphospital @WCM_MeyerCancer @WCMGUcancer @WCMUrology @nygenome @ASCOPost @UrologyTimes @urotoday Amazing work, Bishoy and team! What an absolute tour de force. 💪
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RT @FaltasLab: 🚀Big News! Excited to share our work “The Interplay of Mutagenesis and ecDNA Shapes Urothelial Cancer Evolution” published i…
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RT @PeterLyLab: 🚨 Excited to share our latest paper in @CellCellPress identifying how under-replicated chromosomes in micronuclei become sh…
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