Shih-Chieh (Jeff) Ti
@JeffTiLab
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Assistant Professor @ University of Hong Kong, School of Biomedical Sciences
Hong Kong
Joined January 2018
The latest research article from Ti Lab. We employed cryo-EM structural analysis, single-particle fluorescence microscopy, and recombinant tubulin to reveal how tubulin acetyltransferases modify the K40 residue inside the microtubule lumen. (1/N)
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RT @DivIDE_2025: We are delighted to announce that the 3rd DivIDE Conference will take place from 22–25 September 2025 with a fantastic l…
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RT @Alushin_Lab: Excited that the peer-reviewed version of our fascin structure paper is now out in @NatureSMB. Thanks very much to the ref…
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With help from @RuiZhangWUSTL we have successfully adopted Rui's protocol to achieve high-resolution cryo-EM 3D reconstruction of undecorated microtubules polymerized from recombinant tubulin. Please see the following user-friendly version of the workflow.
I want to take the opportunity to mention that I've written a slightly more user-friendly tutorial for the original microtubule seam-search protocol, together with other useful MT processing tricks.
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RT @cell_club: Force-transducing molecular ensembles at growing microtubule tips control mitotic spindle size
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This work is a great collaboration with Dr. Yuanliang Zhai , @ChaoguZheng, and @XiangDavidLi1 at the University of Hong Kong. (4/4)
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RT @HLGroup2: Our lab’s recent work uncovers why T2D patients are more susceptible to severe viral infections Check it out here: https://t.…
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The last day of my first PhD student, @FGuoling , in the Ti Lab. Wish you all the best at MRC.
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RT @Alushin_Lab: Pleased to present our latest work, where we show that the cell-cell adhesion protein afadin coopts mechanically-regulated…
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RT @KapoorLab_RU: We are pleased to share our latest preprint on bioRxiv! Led by graduate student @VostalLauren, we use chemical proteomics…
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RT @Alushin_Lab: Excited to present a new story, where we use purified proteins to reconstitute repair of mechanical damage in contractile…
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RT @BiochemistryACS: "Here, we describe our efforts to illuminate RNA biology through the application of chemical tools, focusing on post-t…
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