Inside Precision Medicine
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Exclusive news, features, and analysis on the research, tools, regulations, and applications driving precision medicine. From the publisher of @GENBio
New Rochelle, NY
Joined April 2014
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A New Generation of
#CRISPR
Technology
At the age of 30,
@janiceschen
has not only completed a PhD with Nobel prize winner Jennifer Doudna, but she has also helped co-found her own successful
#biotech
company
@mammothbiosci
. Read more about her journey:
1
45
159
Eric Topol, MD, in a keynote interview described his vision of how AI can help redefine cancer screening and diagnosis. Learn more:
0
16
51
A drug for
#idiopathicpulmonaryfibrosis
designed by
#AI
specialist
@InSilicoMeds
has passed its safety goals in a phase I trial. Learn more:
1
9
36
The FDA has approved the first blood test that can help identify hundreds of potentially cancer-associated hereditary variants. Learn more:
0
11
35
Natural Suppressor Mutations May Help Protect Us from Genetic Disorders. Learn more:
1
10
34
Researchers have identified a previously unknown signaling pathway in cells that protects their DNA while it is being copied—a discovery that suggests this pathway could be targeted for treating cancer. Read more:
0
9
34
The Human Immunome Project Plans to Unlock the Immune System’s Secrets
The Human Immunome Project has revealed plans to decode and model the immune system by generating the largest immunological dataset to date. Learn more:
1
14
32
High quality
#microscopy
has captured mammalian translation of
#SARSCoV2
viral RNA in unprecedented detail. The virus uses a ‘pseudoknot’ structure to create tension in the ribosome and promote frameshifting to translate viral RNA. Learn more:
1
20
31
#Alzheimers
DNA Methylation Study Uncovers 84 New Genes Associated with the Disease
This meta-analysis, believed to be the largest of its type, reviewed six earlier DNA methylation studies of AD. Learn more:
0
9
30
Blood Proteins Predict 10-Year Risk of 67 Diseases
Prediction models developed from blood proteins may be superior to clinical information for assessing the 10-year risk of 67 diseases, according to a study using data from the UK Biobank. Read more:
1
12
27
Lipid-Lowering Drug Repurposed for
#Parkinsons
#AI
analysis of research papers has enabled the identification of a potential new role for the lipid-lowering drug probucol in Parkinson’s disease. Learn more:
0
9
25
Changes in Gut Microbiome Linked to Parkinson’s Disease Symptoms
People with Parkinson’s disease often develop gastric symptoms that can sometimes start years before they develop any movement problems. Learn more about this new study:
0
9
29
Parkinson’s Test Predicts Disease Years before Symptoms
An eight-biomarker protein blood test can predict the onset of Parkinson's disease up to seven years in advance of motor symptoms. Learn more:
0
7
28
.
@MayoClinic
researchers are developing ways to employ
#artificialintelligence
to increase the detection of potentially cancerous polyps during colonoscopy. Read more:
0
5
26
Scientists have linked a protein complex, GEMIN5, that controls RNA metabolism in neurons to a rare disease for the first time. Learn more:
0
6
28
U.S. researchers have developed an
#antiviral
candidate drug targeting iron-sulfur clusters needed for
#SARSCoV2
RNA replicase to function properly and for the virus to reproduce successfully. Read more:
#COVID19
0
8
26
Researchers developed a novel technique called CReATiNG (Cloning, Reprogramming and Assembling Tiled Natural Genomic DNA), offering a more straightforward and more cost-effective approach to constructing synthetic chromosomes. Learn more:
0
5
27
It is estimated that rare diseases affect more than 30 million people in the US alone, and between 300 million and 400 million people. Here, we profile three such parents whose commitments to their cause are impacting the
#raredisease
community. Read more:
2
9
24
CRISPR-Based Epigenome Editing Platform Identifies Genes That Improve T-Cell Therapies for
#Cancer
Treatment
Scientists engineered a
#CRISPR
based
#epigenomeediting
platform and discovered a master regulator of the genome that reprograms T cells:
0
11
26
A stem cell-based treatment for progressive multiple sclerosis (MS) achieved good results in a Phase I trial led by researchers at the University of Cambridge and the University of Milan Bicocca. Learn more:
1
10
25
Scientists Restore Brain's Waste Disposal System to Combat Aging
Reversing aging-related decline in the brain’s waste-clearing process, offers a potential new treatment for neurodegenerative diseases. Learn more:
1
12
26
#GeneEditing
Shows Potential for
#CysticFibrosis
A single injection that deploys gene editing technology can correct a common mutation that causes cystic fibrosis and improve lung and gastrointestinal symptoms, research in mice has revealed. Learn more:
0
7
23
A new class of antibiotics has been discovered that is effective against multidrug-resistant bacteria, offering new opportunities to tackle these dangerous microbes. Read more:
1
9
24
Digital Biomarker Company Imagene AI Secures $21.5M Investment
Imagene’s uses digital pathology images and proprietary algorithms to identify and classify patterns not discernible by human examination. Learn more:
1
8
22
Blood Biomarker Flags Alzheimer’s Neurodegeneration
A new blood-based biomarker, brain-derived tau, can identify neurodegeneration specific to Alzheimer’s disease without requiring brain scans or samples of cerebrospinal fluid. Learn more:
0
11
23
High quality
#microscopy
has captured mammalian translation of
#SARSCoV2
viral RNA in unprecedented detail. The virus uses a ‘pseudoknot’ structure to create tension in the ribosome and promote frameshifting to translate viral RNA. Learn more:
0
9
24
Researchers have developed a new CRISPR-based technology that increases the recognition of cancer cells to the immune system. Learn more:
0
10
24
Alzheimer’s Vaccine Shows Good Safety, Immunogenicity at Phase II
An experimental, therapeutic vaccine developed by Araclon Biotech showed good safety and immunogenicity results at Phase II. Learn more:
0
6
23
Quicker and Cheaper Single Cell RNA Sequencing Method Developed
Austrian scientists have developed a method to individually barcode different cells before they are loaded onto a microfluidic chip. Learn more:
#sequencing
#rnasequencing
0
8
23
Antioxidant Could Help Combat Drug Resistance in Breast Cancer
The antioxidant N-acetylcysteine could help overcome resistance to alpelisib in PI3Kalpha mutated
#breastcancer
patients. Learn more:
1
13
21
Experts suggest that when a virus enters an immunosuppressed system, such as a cancer patient’s immune system, it lingers in the absence of adequate defenses and accumulates many mutations. Read more:
#COVID19
#coronavirus
0
12
24
Fatty Acid Found in Palm Oil Can Promote
#Cancer
Metastasis
In a mouse model of human mouth and skin cancer, researchers found that dietary consumption of palmitic acid, but not oleic acid or linoleic acid, seemed to promote metastatic tumor growth:
5
19
23
Scientists uncover new biomarker predicting the clinical response to
#CARTcelltherapy
for
#lymphoma
treatment. Learn more:
0
6
22
Mark your calendars for Friday, October 23rd and register today for our upcoming webinar--Optical Mapping in Rare Genetic Disease Diagnosis. Sponsored by .
@bionanogenomics
Registration is free:
#geneticdisease
#genetics
#opticalmapping
0
10
23
A second patient with HIV has been cured with a stem cell transplant at Berlin’s Charité, which, in 2008, famously treated the “Berlin Patient,' who became the first person in the world to be cured of HIV. Learn more:
1
12
23
0
8
24
Single-cell RNA Sequencing Reveals Kidney Cancer Cellular Origins. Learn how:
#sequencing
#singlecellsequencing
0
11
23
Small Handheld Device Can Detect Bacterial Infections in Minutes
A USB stick-sized device can quickly and accurately detect bacterial urinary tract infections and has the potential to analyze blood or saliva and to detect viruses as well. Read more:
0
5
22
Brazilian Researchers Develop Compound That Combats Multidrug-Resistant Bacteria in One Hour
A team of researchers has discovered a peptide that has shown promising action against six antibiotic-resistant bacterial pathogens. Learn more:
0
11
22
RNA Sequencing Can Increase Diagnostic Rate for Rare Diseases
#RNAsequencing
can help diagnose
#rarediseases
caused by changes in
#geneexpression
that are not detectable using standard
#genomicsequencing
methods. Learn more:
0
5
20
Bayer and NextRNA Therapeutics will jointly develop two first-in-class small molecule programs targeting long non-coding RNA. The deal is worth $500M+. Read more:
1
7
22
Doubling of Y Chromosome Doubles Autism Risk
Risk of autism appears to be linked to the Y chromosome, a Geisinger study found, which may explain the greater prevalence of Autism spectrum disorder (ASD) in males.
1
4
22
Junk DNA Sequence a Likely Driver of Telomerase Gene Activity
Researchers found that deleting VNTR2-1 from
#cancer
cells—both in a human cell line and in mice—caused telomeres to shorten, cells to age, and tumors to stop growing. Learn more:
0
7
22
Researchers based in Madrid have identified a microRNA biomarker that can accurately diagnose patients with the cardiac inflammatory condition
#myocarditis
, something that has been hard to diagnose accurately in the past. Learn more:
0
9
22
Lab-on-a-Chip Genetic Test Can Identify a Virus within Three Minutes
A lab-on-a-chip genetic diagnostic test can provide lab-quality results to identify a virus within three minutes. Learn more:
1
10
21
Biomarkers Found That May Predict Risk of Common Pregnancy Complications
Microbiome-related biomarkers that could predict three common and dangerous pregnancy complications have been identified . Read more:
0
9
22
AI Tool Can Predict Hospitalized Patients at Risk of Deterioration
An AI-driven early warning tool can help predict which hospitalized patients are about to deteriorate and allow them to get fast treatment. Learn more:
0
6
20
Researchers discovered eliminating the gene SRC-3 in breast and prostate
#cancer
animal models led to a lifelong anti-cancer response. Also, transferring immune cells without SRC-3 to animals with breast cancer tumors killed the tumor. Learn more:
0
9
21
A new study confirms previous suspicions that
#Parkinsonsdisease
may have an inflammatory or autoimmune component, as those with the condition have a notably different gene expression profile in their T cells compared with healthy controls. Learn more:
0
12
20
ICL and Oxford Nanopore Technologies have developed a DNA barcoding method that allows nanopore sequencing to identify dozens of biomarkers in one test. The method shows promise to identify specific biomarkers of diseases such as cancer. Learn more:
0
5
19
Researchers at
@UCSF
have discovered how
#cancer
cells evade targeted therapy using an escape mechanism called phenotype switching, potentially explaining the failure of precision therapies for
#glioblastoma
to date. Read more:
0
3
21
Mitochondrial DNA Triggers Inflammation in
#SickleCellAnemia
Patients
The red blood cells of people with this chronic condition seem to accumulate mitochondria, which are absent from healthy blood cells. Learn more:
1
15
20
New Study Illuminates Bacteria’s Role in
#PancreaticCancer
Live bacteria from cystic pancreatic lesions, which are precursors to pancreatic cancer, have been found to have an over-representation of Gammaproteobacteria and Bacilli. Learn more:
0
7
20
.
@IncellDx
Receives CE Mark for First
#LongCOVID
Diagnostic
The test, which demonstrated greater than 90% accuracy across
#COVID
strains is set to launch in the European Union this month. Learn more:
0
8
18
The FDA has approved the first blood test that can help identify hundreds of potentially cancer-associated hereditary variants. Learn more:
0
9
21
Targeting a New Receptor on T Cells to Improve Immunotherapy
A new anticancer immunotherapy targets the activin receptor 1C on T cells to boost immune system attack against cancer cells. Read more:
0
7
21
Scientists find a new way to track peripheral artery disease (PAD). Learn more:
1
8
19
.
@RevealGenomics
’ ctDNA- and
#machinelearning
based liquid biopsy predicts response to certain therapies and survival in
#breastcancer
study. Read more:
0
10
19
THIS FRIDAY, join us for our upcoming free webinar--Optical Mapping in Rare Genetic Disease Diagnosis.
Sponsored by .
@bionanogenomics
. Register today:
#geneticdisease
#genetics
#opticalmapping
#webinar
#raredisease
1
8
20
Scientists at
@UTokyo_News_en
have designed an artificial hairpin-like DNA molecule which is able to target and kill
#cancer
cells by binding to microRNA (miRNA) molecules that are overproduced in certain cancers. Learn more:
0
9
20
Five RNA Therapeutics Startups to Watch in 2022
Five RNA therapeutics startups to watch that have opened their doors since 2020 and are developing the next generation of RNA medicines. Learn more:
1
8
19
Designer Peptide Halts
#Neurodegeneration
Researchers have designed a peptide that can block the toxic effects of a protein linked with neurodegenerative disease, which could potentially be delivered via nasal spray. Learn more:
0
8
18
The digital edition of the December issue is now available.
We find ourselves in this issue focusing on the burgeoning field of
#proteogenomics
and the advancement of single-cell technologies being used to delve into the proteome more deeply. Read now:
0
7
20
Researchers at
@ColumbiaMed
have engineered probiotic bacteria to act as personalized cancer vaccines that can activate the immune system to target and destroy cancer cells. The new approach harnesses the natural tumor-targeting properties of bacteria.
1
5
20
Researchers at the Johns Hopkins University School of Medicine and the Johns Hopkins Kimmel Cancer Center have identified a protein called METRNL that depletes energy from T cells, severely limiting their ability to fight cancer. Read more:
1
10
19
New Technique Improves T Cell-Based Immunotherapies for Solid Tumors
A new technique that removes a sugar on the outside of solid tumor cancer cells enhances the ability of T cells to recognize and kill tumor cells. Learn more:
0
8
19
Changes in Gut Microbiome Linked to Parkinson’s Disease Symptoms
People with Parkinson’s disease often develop gastric symptoms that can sometimes start years before they develop any movement problems. Learn more about this new study:
1
9
20
AI-Designed Protein Used to “Wake Up” Silenced Genes
By combining
#CRISPR
technology with a protein designed using
#artificialintelligence
, individual dormant genes were awaked by disabling the chemical “off switches” that silence them. Learn more:
0
9
16
Scientists have discovered a new
#genetic
disease, which causes some children’s brains to develop abnormally, resulting in delayed intellectual development and often early onset cataracts. Affected children also developed microcephaly. Learn more:
0
3
20
Innovative research from
@uottawa
suggests that edaravone, a drug currently used to treat ALS, could be repurposed to fight glioblastoma. The study demonstrates that edaravone targets brain tumor stem cells, responsible for tumor growth and recurrence.
1
6
20
Researchers at
@umichmedicine
report the development of new biomarkers that help in the early screening of patients for the development of
#myocarditis
following ICI
#cancer
therapy. Learn more:
0
2
18
A research team at the Albert Einstein College of Medicine has made a significant discovery that could enhance the effectiveness of stem-cell transplants, a critical treatment for patients with cancer, blood disorders, or autoimmune diseases. Learn more:
1
10
20
In Another Hemophilia Advance,
@pfizer
Reports Positive Results for
#GeneTherapy
. Learn more:
0
7
18
A biomarker has been found that distinguishes whether ductal carcinoma in situ, a sometimes benign
#breastcancer
, will become invasive. Learn more:
0
7
19
Gene Therapy Targeting Myddosome May Prevent Retinal Degeneration
Large intracellular signaling complexes called Myddosomes are implicated in the progression of age-related macular degeneration (AMD). Learn more:
0
10
20
Scientists at
@UTokyo_News_en
have designed an artificial hairpin-like DNA molecule which is able to target and kill
#cancer
cells by binding to microRNA (miRNA) molecules that are overproduced in certain cancers. Learn more:
0
8
19
Since the start of the pandemic, mRNA vaccine development to combat
#COVID19
has happened extremely quickly, but can these scientific advances can have a positive impact on the development of cancer vaccines? Read more:
0
10
19
#DeepLearning
Model Can Predict Adverse Drug-Drug Interactions
A deep learning model based on gene expression data can accurately predict whether a drug will adversely interact with other drugs. Learn more:
0
11
15
Multi-Omics Study Reveals Four Types of Alzheimer’s
A cross-omics approach has identified four distinct molecular profiles of Alzheimer’s Disease, one of which is particularly serious. Learn more:
0
4
20
Vitamin D May Improve Cancer Immunity by Altering the Gut Microbiome
Researchers have discovered that vitamin D can increase the amount of a certain type of gut bacteria, providing better immunity to cancer. Learn more:
1
7
19
Join us November 15 for our free webinar sponsored by
@bionanogenomics
This webinar is intended to provide the perspectives of
@kanagalshamanna
and
@garciamanero
on the utility of Optical
#GenomeMapping
in Myelodysplastic Syndromes. Register today:
0
4
19
Could a Tiny Molecule Be the New Target for Alzheimer's Disease?
Scientists have discovered that a tiny molecule called microRNA-132 could pose as a potential therapeutic target for
#Alzheimersdisease
. Learn more:
0
7
17
Machine Learning Algorithm Predicts Cancer Drug Efficacy. Learn more:
0
13
19
AI-Powered Liquid Biopsy Delivers Ultrasensitive Cancer Detection
An AI-powered test shows unprecedented sensitivity in predicting cancer recurrence from blood samples. Learn more:
0
12
19
Enhertu (AstraZeneca and Daiichi Sankyo's trastuzumab deruxtecan) has been FDA approved for all HER2 positive solid tumors. Learn more:
0
6
19
AstraZeneca is the latest big pharma to partner with a company using artificial intelligence (AI) to help design drugs in collaboration with U.S.-based Absci to design a cancer-fighting antibody drug. Learn more:
0
5
18
New liquid biopsy technique by VHIO monitors metastatic prostate cancer in real-time, enhancing personalized treatment and response prediction. Learn more:
0
8
17
Gene Therapy for Inherited Retinal Dystrophy Shows Promise
A gene therapy for Bothnia dystrophy, an inherited eye disease that is common in Sweden, shows good tolerability and efficacy at Phase I/II. Read more:
6
8
18
Quicker and Cheaper Single Cell RNA Sequencing Method Developed
Austrian scientists have developed a method to individually barcode different cells before they are loaded onto a microfluidic chip. Learn more:
#sequencing
#rnasequencing
0
8
19
Promising Early Results from Lexeo’s Gene Therapy for Friedreich Ataxia Cardiomyopathy
Lexeo Therapeutics's LX2006 showed positive results in Friedreich ataxia (FA) cardiomyopathy trials. Learn more:
0
11
19
A recent study has linked spike protein in the bloodstream with rare cases of
#myocarditis
following vaccination with an
#mRNA
#COVID19
vaccine. Learn more:
0
6
17
New research from
@WUSTLmed
shows that a focused ultrasound technique called
#sonobiopsy
releases
#neurodegenerative
disease biomarkers, a technology that could be leveraged for the earlier detection of
#Alzheimersdisease
. Learn more:
0
4
17
.
@precisionlifeAI
released research that identifies 73 genes that are highly associated with the severe and fatigue-dominant forms of
#longCOVID
. Learn more:
0
9
19
.
@PacBio
is collaborating with
@RadyGenomics
on a study using long-read whole
#genomesequencing
to identify rare disease cases, aiming to provide genetic answers for undiagnosed patients. Learn more:
0
6
19
ALS and Frontotemporal Dementia Linked to Mutation Causing Inflammation
A mutated gene is linked to Amyotrophic lateral sclerosis and frontotemporal dementia through the overproduction of Interleukin-17A. Learn more:
0
7
17
A new method by which cells turn genes on and off has been described by
@UTSWNews
researchers in Cell. Their findings could lead to new ways of controlling gene regulation and possibly new treatments for various diseases. Learn more:
0
3
17
Microbial genomic information from ancient oral and fecal samples is remarkably similar to samples from modern humans. But this research also reveals disturbing changes in the gut microbiome in modern industrialized countries. Learn more:
0
6
18
Researchers ID Four Distinct Subtypes of Autism
A brain study has found that people with
#autism
can be classified into four distinct subtypes based on their brain activity and behavior. Learn more:
0
4
13
Brain Atlas of Alzheimer’s Disease Could Help Design Better Treatments
An in-depth, single-cell map of gene expression in the brain of Alzheimer's disease patients shines new light on the disease pathology. Read more:
2
7
17