Bode Lab
@HelgeBode_Lab
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Run by members of the Bode Lab. Doing all things related to natural products.
Marburg, Hesse
Joined March 2019
Happy to announce the first steps into NRPS/PKS engineering thanks to the work from Leonard and collaborations with the labs from Markus Kaiser and Michael Groll: Bioengineering of syrbactin megasynthetases for immunoproteasome inhib...
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Leonard has applied the XUT NRPS engineering technology to solve the biosynthesis of the potent antibiotic odilorhabdin in collaboration with the Rolf Müller lab at @Helmholtz_HIPS. See his paper in @angew_chem:
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@mpi_marburg @HannahJeckel @IMPRS_Mic @knutdrescher Congratulations Hannah and Nadya! Well deserved!!!
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CRISPR now also available for Xenorhabdus and Photorhabdus for easy access to natural products and manipulation of their biosynthesis: Please see the paper from Alexander in Microbial Cell factories:
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And here is another cool story about trans-AT PKS engineering in the same issue from the @piel_lab. Congratulations!!
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Finally! After a long journey our latest NRPS engineering story is out at thanks to the hard work of several members from the @HelgeBode_lab
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With our newest preprint on engineering NRPS we succeeded in optimizing our first-of-its-kind biocombinatorial technology. Read more here: Guidelines for Optimizing Type S Non-Ribosomal Peptide Synthetases
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The latest update for NRPS engineering, based on a evolutionary breakpoint within thiolation domains is out:
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RT @papenfortlab: Next round in "the many things that regulatory RNAs can do" - this time: controlling natural-product synthesis. Fantastic…
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An awesome addition to polyketide biosynthesis. TE disguises itself as KS catalyzing branched polyketide formation. Read about Molecular Basis for the Biosynthesis of an Unusual Chain-Fused Polyketide Gregatin A
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Luckily, despite severe jet lag, Helge’s given a clear, nice talk @SIMB_Microbio #NaturalProducts on NRPS engineering with a more efficient approach. Showing the advantages of artificial docking domains in splitting and reconstructing the megasynthetases
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Finally... more than a module! Great NRPS work from the Schmeing lab: Structures of a dimodular nonribosomal peptide synthetase reveal conformational flexibility
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Who makes antibiotics and how do NRPS work? See the Grininger/Bode group performance for kids here:
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🤔 could have submitted more
JOC invites you to take a look at this Note from first-time corresponding author Helge Bode & coworkers: (±)-Alternarlactones A and B, Two Antiparasitic Alternariol-like Dimers from the Fungus Alternaria alternata P1210
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RT @LabPiel: We have new, hypermodified peptides for you! Check out our aeronamide (from Microvirgula) & polygeonamide (from deep-rock meta…
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Natural products go RNA: The Natural Product Butylcycloheptyl Prodiginine Binds Pre-miR-21, Inhibits Dicer-Mediated Processing of Pre-miR-21, and Blocks Cellular Proliferation
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RT @LabPiel: Read Jörn‘s @nature #behindthepaper on how we developed the TransATor, a web tool for de novo structure predictions of trans-A…
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First time to achieve peptide ligation in water, offering a chemical perspective of chicken-and-egg problem for the origin of life
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Nice work by the Stanley-Wall lab: Pulcherrimin formation controls growth arrest of the Bacillus subtilis biofilm
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