GE Notes
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✍️ Notes from Generative Energy podcast | Not medical advice | Not affiliated with @DannyRoddy or @haidut
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Aspirin is so effective at prolonging life that it could increase pension liabilities by $100 billion, according to a statement by Risk Management Solutions Inc.
#4
Jun 14, 2019
19:49, Georgi Dinkov
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A drug called Cytoflavin (succinic acid, inosine, riboflavin, and niacinamide) is used in many different contexts in Russia because of how effective and versatile it is. Originally developed in the ‘60s as a non-toxic stroke-recovery drug, it was later found to have many
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Anything less than 5 grams of elemental sodium (~12 grams of sodium chloride or ~20g of baking soda) per day activated the renin-angiotensin-aldosterone system (RAAS) and the serotonin-cortisol system.
#5
Jun 29, 2019
40:12, Georgi Dinkov
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Insulin resistance is almost entirely driven by cortisol and adrenaline.
Progesterone (P4):DHEA in a 10:1 ratio (e.g. 50 mg P4, 5 mg DHEA) two to three times daily got a type 2 diabetic’s blood sugar back to normal (from the 200s to under 100). The change was so significant that
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Aspirin is helpful in diabetes.
At higher doses, aspirin is much better at inhibiting prostaglandins, aromatase, and 11β-hydroxysteroid dehydrogenase type 1 (11β-HSD1) which is involved in synthesizing cortisol from cortisone.
At higher doses, aspirin acts as an uncoupler and
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Aspirin is pro-metabolic.
Aspirin speeds up all the enzymes in glycolysis and activates the electron transport chain complexes. Aspirin can decrease nitric oxide and serotonin and has been shown to be more effective than fluoxetine (Prozac) at treating depression.
Antagonists
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About half a kilogram of sugar can be consumed before it turns into fat. Fructose most readily converts into glycogen and only then into fat.
#3
May 31, 2019
1:02:43, Georgi Dinkov
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High doses of caffeine increase oxidative metabolism comparably to 2,4-dinitrophenol (DNP), active thyroid hormone (T3), and high doses of aspirin.
#5
Jun 29, 2019
1:28:06, Georgi Dinkov
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Cancer is a metabolic disease driven by chronic, low-grade acidosis.
The cancer cell is alkaline on the inside and acidic on the outside, rather than entirely acidic, as previously thought. All that is needed for significant metabolic stress is excessive extracellular acidity
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Frequent urination is often a sign of high adrenaline, too much water in relation to salt, low blood osmolarity, and low blood volume. The way the body tries to combat this is by excreting extra water, increasing blood volume.
#6
Jul 12, 2019
2:04:54, Georgi Dinkov
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Adding just 100 IU vitamin E to 100,000 IU vitamin A was able to completely prevent any toxicity or anti-thyroid effects. In Russia, there is a drug sold for cardiovascular disease that contains 200,000 IU vitamin A palmitate combined with 100 IU alpha-tocopherol acetate (which
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Most people have candida without it being invasive—it only becomes invasive when you deprive it of carbohydrates.
Some people respond well to apple cider vinegar and 5-10 mg of methylene blue in combination with red light (photodynamic therapy). Potent anti-fungals
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Freely drinking fructose-rich Coca-Cola quadrupled calorie intake in rats without weight gain. Not only did the rats fail to gain weight, they became leaner. The human equivalent dose (HED) of Cokes consumed was about 8. For a diet so high in sugar to work, fat intake must be low
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Steroids that have more than one double bond are usually estrogenic, and steroids that have no double bonds are usually potently anti-estrogenic.
Testosterone has one double bond, like a monounsaturated fat. Estradiol has three.
DHT metabolizes into androst𝗮nediol, a fully
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Nicotinamide mononucleotide (NMN) and red light therapy (RLT, LLLT) were shown to restore female fertility by raising NAD+ and ATP.
All successful anti-aging protocols have one thing in common: they restore oxidative metabolism to the organism.
Aging is a set of symptoms of
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Saturated fat was shown to protect the liver from alcohol, restore the gut barrier, reduce endotoxin, and act as a B vitamin mimetic. Sufficient amounts of saturated fat prevented lipid peroxidation.
Long-chain saturated fats (LCSFA), such as palmitic and stearic acid, were
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Iron excess, along with oxidized unsaturated fat, is responsible for lipofuscin (age pigment). Lipofuscin accumulates with aging, blocking mitochondrial function in any organ. Iron chelation is gaining traction as cancer treatment. Deferoxamine (Desferal), a medication that binds
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Fasting can initially provide the benefit of reduced endotoxin load, but this is quickly outweighed by the spike in cortisol, adrenaline, lipolysis (which liberates stored PUFA)[1], serotonin[2], cyclooxygenase (COX) and lipoxygenase (LOX) enzymes, and a drop in body
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The young have become the old. Many in their early 20s are developing diseases that used to predominantly affect the elderly.
• Heart attacks are on the rise in young women[1].
• Health of young people has declined strongly in the last 30 years[2].
• Colorectal cancer rates
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Pregnenolone was shown to be very helpful in schizophrenics, partially due to its ability to raise allopregnanolone, “a molecule with neuroprotective effects that also increases neurogenesis, decreases apoptosis and inflammation, modulates the hypothalamic-pituitary-adrenal axis
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“𝘐𝘧 𝘵𝘩𝘦 𝘱𝘢𝘵𝘩 𝘣𝘦𝘧𝘰𝘳𝘦 𝘺𝘰𝘶 𝘪𝘴 𝘤𝘭𝘦𝘢𝘳, 𝘺𝘰𝘶’𝘳𝘦 𝘱𝘳𝘰𝘣𝘢𝘣𝘭𝘺 𝘰𝘯 𝘴𝘰𝘮𝘦𝘰𝘯𝘦 𝘦𝘭𝘴𝘦’𝘴.”
—Joseph Campbell
#6
5:22, Danny Roddy
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The naturally occurring vitamin B6 isomer pyridoxamine was approved for treating chronic kidney disease. Shortly after, in January 2009, it was made illegal to buy without a prescription.
#7
Jul 26, 2019
31:57, Georgi Dinkov
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𝘈𝘴𝘪𝘥𝘦 𝘧𝘳𝘰𝘮 𝘱𝘳𝘦𝘴𝘤𝘳𝘪𝘱𝘵𝘪𝘰𝘯 𝘢𝘯𝘵𝘪𝘣𝘪𝘰𝘵𝘪𝘤𝘴, 𝘸𝘩𝘢𝘵 𝘤𝘢𝘯 𝘣𝘦 𝘶𝘴𝘦𝘥 𝘵𝘰 𝘭𝘰𝘸𝘦𝘳 𝘣𝘢𝘤𝘵𝘦𝘳𝘪𝘢 𝘪𝘯 𝘵𝘩𝘦 𝘪𝘯𝘵𝘦𝘴𝘵𝘪𝘯𝘦?
-Activated charcoal
-Indigestible fiber (carrot salad, bamboo shoots, well-cooked white button mushrooms)
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Ray took a high dose of T3 (active thyroid hormone) and his blood oxygen dropped very low, to about 87-88. His friend, a doctor, suggested they go to the hospital. Within a few hours at the hospital, his blood oxygen climbed back up to 92-93. The doctor at the hospital was
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Allopregnanolone is considered the main inhibitory neurosteroid in the brain because it is the most potent known agonist of the GABA receptor. This inhibitory neurosteroid has been shown to have potent neuroprotective, antidepressant, anti-infective, and anti-dementia properties.
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Cholesterol and saturated fat (SFA) are anabolic; polyunsaturated (PUFA) and monounsaturated (MUFA) are catabolic, estrogenic, and anti-androgenic. The degree of unsaturation is highly correlated with the degree of estrogenicity.
The more unsaturated the fat, the more
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David Geary, a University of Missouri scientist, wrote an editorial claiming that there is no single gene, group of genes, nor GWAs (genome-wide associations) to suggest that specific genes determine health outcomes. Instead, high metabolism, i.e., high-functioning mitochondria,
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Sleep apnea is nothing but a chronic deficiency of CO2 and is especially prominent at night because this is when the metabolic rate slows. If methylene blue helps, that is a sign of a high lactate/CO2 ratio.
#1
May 3, 2019
2:07:26, Georgi Dinkov
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Negative effects from testosterone replacement therapy (TRT) may stem from using esters instead of tocopherol. While the specific mechanism is not clear, there is something about testosterone esters that make them more amenable to aromatization.
All of the DHT esters
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Raising the NAD/NADH ratio may be a viable treatment for every autoimmune condition.
Most autoimmunity may be due to dysbiosis and excess nitric oxide (NO).
Estrogen and serotonin are also involved.
Cleaning the gut and lowering NO, estrogen, and serotonin would be effective
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Methylene blue (MB) is a quinone shown to accept electrons at every stage of the electron flow from food to oxygen (glycolysis, the Krebs cycle, and the electron transport chain [ETC]).
The enzyme pyruvate dehydrogenase (PDH) is necessary for the transition from glycolysis to
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Despite being considered very healthy in their prime, competitive athletes often stress their bodies and slow metabolism to a crawl. In women, this is known as the “female athlete triad”—amenorrhea, low energy availability, and decreased bone mineral density. Exercise-induced
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The excess of serotonin and deficiency of serotonin transporter (SERT or 5-HTT) is likely behind Alzheimer’s, Parkinson’s, schizophrenia, and bipolar disorder.
The deactivation of serotonin depends on two things: sodium (because SERT is a sodium-dependent protein), and carbon
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“Is serotonin an upper or a downer?” (Andrews et al., 2015) makes three bold claims:
1- Serotonin is elevated in multiple depressive phenotypes.
2- The serotonergic system evolved to regulate energy, and by increasing extracellular serotonin, SSRIs disrupt energy homeostasis and
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Aging, cortisol, serotonin, and depression:
Psychiatry now admits that excessive cortisol causes depression. Most successful antidepressants have been shown to be partially antiserotonergic (antagonists of the 5-HT2C receptor, which is the primary driver of the synthesis and
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A 3:1 or 8:1 ratio of progesterone:DHEA with a small amount of pregnenolone (5-10mg) may be enough to restore libido in people with hypogonadism and could even act as an effective TRT (testosterone replacement therapy) substitute. This combination is very anti-catabolic.
#15
Jan
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Blocking endotoxin may cure type 1 (insulin-dependent) diabetes.
The beta cells (cells that make insulin) of the pancreas are not dead, but their synthesis of insulin is blocked by endotoxin. Elevated free fatty acids and/or excessive nitric oxide production are likely causes of
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Psychiatric diagnoses are scientifically meaningless.
In psychiatry, there are no objective biomarkers like in biomedicine; rather, it is based on the ever-growing, ever-compartmentalized DSM criteria. While biomarkers can still be misinterpreted and imperfect, they are
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Even a minute drop in active thyroid hormone (T3) in the blood leads to an elevation of prolactin. Before dopamine agonists were invented, hyperprolactinemia (abnormally high levels of prolactin in the blood) and gynecomastia (overdevelopment of breast tissue in men) were
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About 80% of the inflammatory reaction in the body is driven by arachidonic acid which is derived from dietary omega-6 (ω-6) polyunsaturated fatty acids (PUFA). These ω-6 fatty acids are precursors to the inflammatory prostaglandins, leukotrienes, and thromboxanes.
Due to their
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Serotonin can interfere with energy metabolism, oxygen delivery to the tissues, and the use of glucose. Serotonin plays a role in the onset of hibernation in animals. In humans, this low-energy, high-serotonin state reduces people to the lowest layer of Maslow’s hierarchy of
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ATP has an affinity for magnesium and ADP has an affinity for calcium, so if metabolism is not working well, the ADP/ATP ratio will rise and the cell will begin drawing calcium in and excluding magnesium. Restoring synthesis of ATP solves this. Supplementing magnesium may help,
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Some neurotransmitters, despite being nowhere near structurally similar to hormones, are capable of activating steroid receptors. Dopamine and dopamine agonists have been shown to activate progesterone receptors A and B. Conversely, serotonin is known to activate estrogen
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Endotoxin is the byproduct of bacterial metabolism in the GI tract and typically occurs in the colon but can also occur in the small intestine in those who have small intestinal bacterial overgrowth (SIBO), which is common in hypothyroid people. Endotoxin is perhaps the cardinal
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Niacinamide is protective in almost any condition.
Niacinamide inhibits fatty acid oxidation (FAO), and cancer has been shown to be a disease of excessive FAO. Doing anything to even mildly inhibit FAO has been shown to be hugely therapeutic.
Activating the sirtuins promotes
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Increased fatty acid oxidation (FAO) does not inherently lead to weight or fat loss; it proportionally decreases glucose oxidation (via the Randle effect) and can damage the liver and lead to insulin resistance.
While fat is being oxidized, the body increases the activity of
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Niacinamide and tetracycline antibiotics may reverse vascular calcification due to inhibition of the poly [ADP-ribose] polymerase (PARP) enzyme.
PARP consumes NAD+, hurting the NAD+/NADH ratio, and seems to be directly involved in taking calcium from bones and depositing it in
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[𝘖𝘯 𝘱𝘺𝘳𝘶𝘷𝘢𝘵𝘦 𝘰𝘹𝘪𝘥𝘢𝘵𝘪𝘰𝘯, 𝘵𝘩𝘦 𝘴𝘵𝘦𝘱 𝘭𝘪𝘯𝘬𝘪𝘯𝘨 𝘨𝘭𝘺𝘤𝘰𝘭𝘺𝘴𝘪𝘴 𝘵𝘰 𝘵𝘩𝘦 𝘒𝘳𝘦𝘣𝘴 𝘤𝘺𝘤𝘭𝘦]
In order for pyruvate to get into the mitochondria, it needs to be converted into acetyl coenzyme A (acetyl-CoA) by an enzyme called pyruvate
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Anything that increases metabolism and supports the thyroid will lower elevated cholesterol by increasing its conversion into downstream sex hormones.
For something more immediate, 30-50 mg of pregnenolone daily was enough to drop Georgi’s cholesterol by 30-50 points to the
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Cancer is a reversion to an ancient pre-oxidative metabolism. Cellular energy (ATP) is necessary to guide and restrain growth. Cellular differentiation is mediated by thyroid hormone and the youth-associated hormones (pregnenolone, progesterone, and DHEA), which are all dependent
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If CO2 labs are 25 mmol/L or below, good dental health is unlikely. 28 mmol/L and above is optimal.
#15
Jan 4, 2020
1:52:50, Georgi Dinkov
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Vitamin D status is inversely correlated with non-alcoholic fatty liver disease (NAFLD).
#5
Jun 29, 2019
2:23:00, Georgi Dinkov
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People suffering from post-finasteride syndrome (PFS) filed a lawsuit to pull Merck’s drug Propecia (finasteride) from the market due to serious side effects such as depression, insomnia, anxiety, panic attacks, cognitive dysfunction, erectile dysfunction, and suicidal ideation.
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Endotoxin causes pericarditis. In some countries, pericarditis is treated with antibiotics, not because it treats the present bacteria but because it lowers the endotoxin load. Ketotifen and cyproheptadine are recommended because they are TLR-4 (endotoxin receptor) antagonists.
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Prolactin is a good surrogate biomarker for tissue estrogen. Estrone sulfate (E1S), while a less common test, can give a clearer picture of total body estrogen reserves.
#1
May 3, 2019
2:07:26, Georgi Dinkov
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The three stages of glucose oxidation are: glycolysis, the Krebs cycle, and the electron transport chain (ETC).
Glucose and fat compete in oxidation through the Randle cycle. When glucose undergoes glycolysis in the cytosol, the output is pyruvate, which then has to enter the
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Succinic acid is a great way to help a very stressed cell get out of excessive glycolysis.
If a cancer cell is forced, even temporarily, out of excessive glycolysis, it will undergo apoptosis because the intracellular alkalinity of the cell will fall and, as soon as energy
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The bioenergetic view of health is that energy and structure are interdependent at every level; anything that interferes with one will interfere with the other. The movement of electrons from food to the ultimate electron acceptor, oxygen, must occur without bottlenecks to avoid
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Rifaximin (an antibiotic commonly given to people with SIBO because it cannot be absorbed in the gut) is given to people with liver disease because it destroys the ammonia-producing bacteria in the gut. Neomycin and ampicillin may also work to kill ammonia-producing bacteria, but
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The keto diet can directly cause diabetes and obesity.
When someone starts the keto diet and loses a lot of weight, it is usually water weight—not fat—because the keto diet acts as a diuretic.
After water weight is lost on a keto diet, there is excessive lipolysis and
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Low CO2 means high nitric oxide, always. High nitric oxide means oxidative phosphorylation is impacted, further lowering CO2.
“At the molecular level, CO2 is necessary for respiration through its displacement of O2 on hemoglobin [17]. At the tissue level, CO2 relaxes the smooth
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Vitamin K2 MK-4 (menatetrenone, or menaquinone-4) is the primary endogenous K2 isomer. Most industrially produced vitamin K2 in the MK-4 form is extracted from tobacco. Most dietary K comes from K1 (phylloquinone), found in leafy greens. K1 has a hemostatic effect but lacks the
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Bruxism tends to go hand-in-hand with nightmares, PTSD, cortisol, and high serotonin, all of which are common in the hypothyroid state.
#3
May 31, 2019
2:45:34, Georgi Dinkov
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“You can’t understand the other things I’m working on unless you know where serotonin fits in. For example, estrogen and progesterone, estrogen does a lot of its work by way of serotonin. And to understand unsaturated fatty acids versus saturated, you have to understand estrogen
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Omega-3 (ω-3) polyunsaturated fats eicosapentaenoic acid (EPA) and docosahexaenoic acid (DHA) are both precursors to lipid peroxidation products like acrolein. Lipid peroxidation is not possible with saturated fats.
#1
May 3, 2019
46:43, Danny Roddy, Georgi Dinkov
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Despite being touted as “good” cholesterol, elevated HDL (high-density lipoprotein) can be a surrogate biomarker for endotoxin.
In alcoholics, HDL is often elevated because it is needed to transport endotoxin back to the liver. This is why context matters when interpreting blood
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Taking exogenous thyroid hormone (triiodothyronine, T3, or thyroxine, T4) when cholesterol is low is dangerous because thyroid hormone will lower cholesterol further by converting it into the downstream sex hormones. Cholesterol rises in the absence of adequate thyroid hormone.
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It is well known that people who have insulin resistance and high fasting blood glucose always have hyperlipidemia (elevated free fatty acids in the blood). There is never a case of the former without the latter.
#3
May 31, 2019
59:58, Georgi Dinkov
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Acetazolamide helps the body retain carbon dioxide (CO2) because it is a carbonic anhydrase inhibitor. It is given to mountain climbers who experience mountain sickness or to people struggling with epilepsy and edema (fluid retention).
Good substitutes for acetazolamide are
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Nitric oxide has an inverse relationship with carbon dioxide as the emergency vasodilator.
The nitric oxide hypothesis of aging (1998) by S M McCann outlines some problems with nitric oxide.
Nitric oxide:
• activates COX enzymes which produce prostaglandins
• activates
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Testing iron status is valuable, but most only get serum iron tested, which is an almost meaningless biomarker without the context a full iron panel provides. Normal serum iron can be observed in a patient who is iron-deficient or iron-toxic.
In addition to serum iron, it is
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Dieting is deleterious.
A low-carb diet enhances cortisol regeneration and synthesis while decreasing its inactivation independently of weight loss.
11 β-Hydroxysteroid dehydrogenase type 1 (11β-HSD1) turns cortisone into cortisol, 11β-HSD2 takes active cortisol and oxidizes it
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Dopamine and all dopamine agonists are inhibitors of the enzyme tryptophan hydroxylase (an enzyme involved in the synthesis of serotonin). Parkinson’s disease is a premature aging of the brain, and serotonin and cortisol can accelerate this.
#5
Jun 29, 2019
34:55, Georgi Dinkov
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“The chemical machinery of biological oxidation is a rather bulky one. It involves solid state and structure. When the cell divides it has to rearrange its whole interior, which demands mobility. To achieve this the cell has to dispense with its bulky oxidative machinery,
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“Carbon dioxide is maximally oxidized carbon, [whereas] glucose and fatty acids—and a couple other energy substrates—are maximally reduced, so as they go from maximally reduced to completely oxidized, they give off those reductive electrons to NAD+ and FAD, and that’s what makes
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When mammals are fed carbohydrate and they make lipids de novo, they make mostly saturated, some monounsaturated and almost no polyunsaturated.
𝘋𝘦 𝘯𝘰𝘷𝘰 𝘭𝘪𝘱𝘰𝘨𝘦𝘯𝘦𝘴𝘪𝘴 (𝘋𝘕𝘓) 𝘰𝘳 𝘥𝘦 𝘯𝘰𝘷𝘰 𝘧𝘢𝘵𝘵𝘺 𝘢𝘤𝘪𝘥 (𝘍𝘈) 𝘴𝘺𝘯𝘵𝘩𝘦𝘴𝘪𝘴 𝘪𝘴 𝘵𝘩𝘦
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The Departments of Agriculture and Health and Human Services removed its restriction on dietary cholesterol in its 2015–2020 Dietary Guidelines for Americans, saying it plays no role in the development of cardiovascular disease. The same study used to reverse their stance also
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Any gram-negative bacteria capable of producing endotoxin (lipopolysaccharide, LPS) is potentially dangerous. This includes gut bacteria and many store-bought probiotics. Two seminal studies came out demonstrating LPS was able to translocate from the colon into various organs and
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A clear biomarker of aging and disease is decreased blood CO2, which means increased fatty acid oxidation compared to glucose.
#2
May 17, 2019
1:05:33, Kyle Mamounis
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The antimicrobial component of vitamin D is called cathelicidin antimicrobial peptide (CAMP).
CAMP (not to be confused with cAMP, cyclic adenosine monophosphate) is made by immune cells and cells that provide a barrier against infection, such as skin and gut cells.
Vitamin D
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It is a well-known clinical fact that most of the hyperglycemia seen in type 2 diabetes comes from gluconeogenesis in the liver. In insulin resistance, not only is dietary glucose cleared more slowly, but the main problem is the excessive glucose produced in the liver. In
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Hyperammonemia can be a sign of poor liver health, low thyroid function and excessive muscle breakdown.[1][2]
People under a lot of stress are known to oxidize protein[3], which can lead to too much ammonia in the blood. When there are too many amino acids in the bloodstream,
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“Mitochondria produce cellular energy in the human body, and energy availability is the lowest common denominator needed for the functioning of all biological systems. My model shows mitochondrial function might help explain the link between general intelligence, health and
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Retraction Watch is a website where scientific papers, mostly biomedical, are posted upon being retracted (and “there’s retractions all the time”). Reasons range from fundamental mistakes that invalidate results to outright fraud.
#2
May 17, 2019
41:36, Kyle Mamounis
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If someone suspects they are hypothyroid but their labs are “normal”, the next biomarkers to look for are elevated cholesterol, low vitamin D, and low CO2.
#15
Jan 4, 2020
17:43, Georgi Dinkov
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Eating foods that produce endotoxin (lipopolysaccharide, LPS) will replicate the stress response without the brain being involved at all. 90% of serotonin is produced in the GI tract, and one of the primary signals for its production in the enterochromaffin cells (neuroendocrine
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“Insulin-resistant states of obesity and Type II diabetes show a multitude of metabolic abnormalities that could cause vascular dysfunction. Non-esterified fatty acid levels increase long before hyperglycaemia becomes present.” (Steinberg and Baron, 2002)
#16
Feb 8, 2020
41:00,
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“The reduction of glycemia seen in low carb dieting is not a sign of increased insulin sensitivity, but simply a removal of the challenge. An analogy is the removal of dairy from the lactose intolerants diet; the reduction seen in their symptoms does not reflect an improvement in
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“The biochemical processes that mobilize stored and dietary fat for use as energy substrate are initiated due to a depletion of blood glucose. The key hormonal switches involved, adrenal glucocorticoids [5] and catecholamines [6], are secreted as a hypoglycemic response. These
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“As information about the many physiological and biochemical events associated with diabetes has accumulated, the basic doctrine that "sugar causes diabetes" has extended itself to whatever the topic of discussion is: "Glucose causes" the death of beta-cells, glucose causes blood
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“Plant seeds and cold-water fish have very different metabolisms and physiological needs than mammals. The suppressive actions of PUFA may explain why one of the symptoms of so-called essential fatty acid deficiency is a 25-30% increase in the basal metabolic rate [57]. Thyroid
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[1]
[2]
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[4]
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