Combining omega-3s, vitamin D, and regular exercise may reduce biological aging far beyond the impacts of these interventions in isolation, a new study indicates. Specifically, supplementing with omega-3s alone reduced biological age on several next-generation epigenetic clocks during the 3-year study. It also slowed the pace of biological aging. Omega-3s combined with vitamin D or exercise had an even greater benefit on phenotypic age when compared to any singe intervention. The biggest benefit for phenotypic age—a nearly 4-month reduction—was observed when omega-3s, vitamin D, and exercise were combined. This aligns with what we know about the individual effects of these interventions. Having a low omega-3 index is more strongly associated with all-cause mortality than smoking. Vitamin D plays a critical role in modulating several mechanisms associated with the "hallmarks of aging." Being sedentary is one of the strongest predictors of an early death—and exercise is one of the most powerful ways to delay it. These results suggest that while omega-3s have powerful anti-aging effects, they also enhance the benefits of supplementing with vitamin D and engaging in regular exercise. There is a synergy among healthy lifestyle habits. Study PMID: 39900648