RT @RG_EggLab: Hormone-free infertility treatment....well, here we are finally...it's a clinical reality!! 20 years ago, our old IVM allian…

RT @maclaudiaa: Past, present and future of IVM: 👉what role in clinical practice? 👉which obstacles to overcome? 👉new perspectives from res…

RT @TuongMHo: The first live birth after vitrification of ocytes from CAPA-IVM. It was from a single blastocyst transfer.

RT @RG_EggLab: What an achievement from @TuongMHo and the @research_hope , completely hormone-free ART with good pregnancy outcomes. Only p…

RT @RG_EggLab: fantastic work @TuongMHo @research_hope . OTO-IVM (ex vivo IVM; immature oocytes from ovarian tissue) is a no-brainer for fe…

RT @RG_EggLab: This is what mastery of IVM looks like #ESHREjc and with zero patient stimulation!

@RG_EggLab @SofiaMakieva @OmarRawi89 @VuongThiNgocLan @krammecc Sorry… Yes, if it is maternal age what you meant, then is similar than for COS-ART 😅

@SofiaMakieva @OmarRawi89 @VuongThiNgocLan @krammecc In PCOS women, biphasic ivm seems to be more effective (MII and GQE rates) when COCs derive from >6mm compared to <6mm follicles. However, for COCs from <6mm foll, the use of biphasic ivm is more beneficial compared to standard IVM (Sánchez et al 2019, Akin et al 2021) #ESHREjc

@SofiaMakieva @OmarRawi89 @VuongThiNgocLan @krammecc Good question … An inverse relationship between the oocyte developmental status at collection and the length of pre-IVM culture has been hypothesized (Gilchrist et al. 2024) @RG_EggLab. Oocyte developmental status depends on gonadotropin (dose) priming, follicle size. #ESHREjc

RT @RG_EggLab: Delighted to share our new review from HRU on development and application of pre-IVM. It details the…

RT @TuongMHo: Our new article - Update on IVM. It is a potential alternative in modern ART.

RT @TuongMHo: Do we need FSH priming in CAPA-IVM? RCT gonna finish soon. My Duc Hospital @research_hope

RT @VuongThiNgocLan: @juanjo_fraire Good to read about the new IVM system. We have good results with this. More tha…

RT @SofiaMakieva: Wrapping up February #ESHREjc with summaries in 🧵👇🏼 It was a pleasure talking about IVM and envisaging its future! ✨🧫…

@SofiaMakieva @RG_EggLab @juanjo_fraire @ESHRE @krammecc @VuongThiNgocLan @Eugin_Group @maclaudiaa @GLiperis @MdevosMD @BortolettoMD So far, an interesting study from Akin 2020, showed that the use of AREG in the IVM phase after CAPA, have beneficial effects on the maturation response by modulation of gene expression in the cumulus cells, this indicates CC could be ready to respond to IVF. #ESHREJc

@SofiaMakieva @RG_EggLab @juanjo_fraire @ESHRE @krammecc @VuongThiNgocLan @Eugin_Group @maclaudiaa @GLiperis @MdevosMD @BortolettoMD IVF following a conventional IVM system (in oocytes from 2-10mm follicles) using patient serum have been used earlier and proven to work, by Walls (2012). This needs to be studied in oocytes from smaller (<6mm) follicles using biphasic IVM yet. #ESHREjc

@SofiaMakieva @RG_EggLab @juanjo_fraire @ESHRE @krammecc @VuongThiNgocLan @Eugin_Group @maclaudiaa @GLiperis @MdevosMD @BortolettoMD In theory, you could do IVF both after conventional IVM and after biphasic IVM. Once oocytes reached the MII stage they could be fertilised either by IVF or ICSI. #ESHREjc

@SofiaMakieva @GLiperis @BortolettoMD @RG_EggLab @MdevosMD @krammecc @VuongThiNgocLan @maclaudiaa @juanjo_fraire @SRomero_Biol Yes, sure. Many, as Rob mentioned. And have been used in many biphasic systems… CNP is the “natural” meiotic inhibitor though 😅 #ESHREjc

@GLiperis @RG_EggLab @SofiaMakieva @juanjo_fraire @ESHRE @krammecc @VuongThiNgocLan @Eugin_Group @maclaudiaa @MdevosMD @BortolettoMD Not as far as I know either... Something that needs to be tried yet in the human scenario… Indeed, the concept of CAPA-IVM developed in mouse, was on oocytes from small antral follicles from Non-stimulated 19-20 day-old animals using IVF and went perfectly good. #ESHREjc

@SofiaMakieva @RG_EggLab @GLiperis @BortolettoMD @MdevosMD @krammecc @VuongThiNgocLan @maclaudiaa @juanjo_fraire Completely agree with you Sofia. And that is the aim! These processes take time though… but it is coming! #ESHREjc