Mariella Filbin
@FilbinMariella
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pediatric neurooncologist and physician scientist, passionate about finding new treatments for pediatric brain cancer @dfbc_pedcare @danafarber @bostonchildrens
Joined March 2019
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We will always remember sweet Beans - she lit up every room and person she touched. In her honor, and for all other children with this horrendous tumor: We will never give up the fight to find new therapies!
#TeamBeans
#atrt
Join us in honoring baby Francesca's memory through a donation to the Dana-Farber Cancer Institute:
Andrew and Rachel, stay strong. We love you. And know that Francesca's memory will always be a blessing.
#TeamBeans
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🔥off the press, our new study with
@MatsNilssonLab
is online! Very proud of this work led by fearless and fabulous
@IlonLiu
, Li Jiang and Erik Samuelsson on the spatial organization of adult and pediatric H3K27M gliomas.
@DFBC_PedCare
@karolinskainst
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Enormously honored and grateful to
@NIH_CommonFund
,
@NINDSfunding
and
@NIHDirector
for supporting our research on pediatric brain tumors!
#NIHHighRisk
#DIPG
#GBM
#ChildhoodCancer
@DanaFarber
@DFBC_PedCare
@BostonChildrens
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Thrilled to announce our new single-cell RNAseq
@Cancer_Cell
paper investigating cellular hierarchies in
#ependymoma
. We identified impaired neurodevelopmental trajectories that led to prognostically-relevant signatures & new therapeutic targets:
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So excited to see our work out back to back with Zhiguo Zhang’s! This one was 8 years in the making - started as a postdoc
@broadinstitute
and finished as a fantastic collaboration on chemically targeting the BAF complex with friend and colleague
@JunQiLab
. Congrats to all! 🥲
BAF Complex Maintains
#Glioma
Stem Cells in Pediatric H3K27M Glioma by
@Eshini_Pandit
Joana Marques
@JunQILab
@FilbinMariella
and colleagues
@DanaFarber
#Epigenetics
#SWISNF
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Wohoo!!! Beautiful cover art from
@CD_AACR
on our BAF complex in H3K27M glioma work. Thank you so much!! 🤩🤩🤩
The December issue of
@CD_AACR
is now online! The newest cover to add to my office wall highlights work by
@JunQILab
@FilbinMariella
and colleagues & Zhiguo Zhang and colleagues showing H3K27M-mutant
#glioma
is dependent on SMARCA4 🧠
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Happy
#InternationalWomansDay
from the Filbin lab! Together we can change our field and the world! ❤️
#defeatbraintumors
#EmbraceEquity
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Incredibly honored to be awarded an Impact Award from the DOD together with terrific friend and colleague Dr. Stephen Mack (
@emacalate
). Together, we will develop new therapeutics for children with ependymoma. Another great collaboration between
@DanaFarber
+
@StJude
. 🔥🎉🚀
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We will not stop our fight against
#childhoodcancer
until every child can live the full life they deserve! 💪💪💪
#InternationalChildhoodCancerDay
#dipg
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Changing the field of
#pediatricBrainTumors
together!
#GoGold
#ChildhoodCancerAwarenessMonth
@DanaFarber
@BostonChildrens
@DFBC_PedCare
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Beyond thrilled to work with this stellar all-female leadership team. All with the same goal: To move the needle for our patients. Unthinkable a few years ago, and now - the sky is the limit.
#WomenInMedicine
#womeninscience
@DanaFarber
@BostonChildrens
@DFBC_PedCare
We’re celebrating
#WomenInMedicineMonth
by recognizing our incredible team of leaders. We are one of the only
#BrainTumor
ctrs in the country with an all
#WomanLeadership
team! Their specialties include Neurosurgery, Neuro-Oncology, Neurology, Neuropathology, & Radiation Oncology
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So excited to see the beautiful data and artwork of
@IlonLiu
and Olivia Hack from our lab on the cover of
@NeuroOnc
today! Congrats also to Nick Gonzalez Castro for writing this beautiful review with us!
@DanaFarber
@DFBC_PedCare
@BostonChildrens
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Sometimes you just have to take the lab to the beach and celebrate the past, present and future. Onwards and upwards! ❤️
#bestlabever
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Love this team!! Happy holidays from the Filbin lab! 🎄🎶
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#ChildhoodCancer
stands no chance on this
#dfci
research floor - the
@KStegmaier_DFCI
@hovestadt
and Filbin labs work together to find new cures.
@DFBC_PedCare
@DanaFarber
@BostonChildrens
#ChildhoodCancerAwarenessMonth
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The Filbin lab goes gold for
#ChildhoodCancerAwarenessMonth
! Our international team of the most dedicated scientists, striving to find a cure. Together, we will beat it!!
#DIPG
#gbm
#etmr
#atrt
#ependymoma
@DFBC_PedCare
@DanaFarber
@BostonChildrens
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Happy
#InternationalWomensDay2024
from the Filbin lab! Strong together to defeat pediatric brain cancer!
@DFBC_PedCare
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4
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Glioma synapses recruit mechanisms of adaptive plasticity | Nature
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Bursting with joy watching
@IlonLiu
receiving the
#Eano2023
youngster award!! Biggest congrats Ilon, it’s been amazing watching you unfold into the rockstar neurooncologist you are (and can’t wait for the next few decades!!)🎉🎊❤️
@DFBC_BrainTumor
@ChariteBerlin
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Introducing the Brain Cancer Revengers! A team of dedicated physician scientist with only one goal: to end pediatric brain cancer as we know it.
#BrainCancerAwarenessMonth
@LissaCBaird
@gojojohannes
@eugewang
@Dana
-Farber
@BostonChildrens
@Ependymoma
@PNOC_kids
and many more
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Wonderful lab retreat with the best lab crew ever! So happy we could enjoy this gorgeous summer day in Woods Hole together. I’m floored by all your amazing stories and determination to move the needle for our patients. The (pie in the) sky is the limit! 😍☀️🤩
#BrainCancer
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So thrilled about amazing
@DaeunJeong10
defending her thesis successfully yesterday! First graduate student out of my lab, and especially meaningful with my own mentor
@RosalindSegal
as head of the committee:
#proudmentor
#gratefulmentee
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Out in print now, wohoo!! 🎊🎉💃
Check out this week's SNO featured article from Neuro-Oncology: Characterizing the biology of primary brain tumors and their microenvironment via single-cell profiling methods
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Finally! Lab BBQ with the whole lab family. Biggest joy and honor to work with such extraordinary people from all around the world - united in our passion to cure
#ChildhoodCancer
#braintumors
❤️
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Had the most fabulous day
@Stanford
, thank you
@michelle_monje
and
@MancusiRebecca
for inviting me! What a terrific community and beautiful campus. 🤩
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Excited to see our review on single cell methods in brain tumors out - written with the fabulous
@IlonLiu
and Nick Gonzalez! 👇🏻👇🏻👇🏻
Characterizing the biology of primary brain tumors and their microenvironment via single-cell profiling methods.
#btsm
@FilbinMariella
@NeuroOnc
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Super excited about this work! Thank you also to fabulous collaborators
@MatsNilssonLab
@scilifelab
@stockholm_uni
,
@michelle_monje
@CancerNeurosci
,
@gojojohannes
@MedUni_Wien
, and to all of our patients and families who contributed! ❤️
@BostonChildrens
@DanaFarber
@DFBC_PedCare
🎉 PUBLISHED TODAY
@NatureGenet
📰 The landscape of tumor cell states and spatial organization in H3-K27M mutant diffuse midline glioma across age and location
🧑🏽🤝🧑🏻
@FilbinMariella
@IlonLiu
@Eshini_Pandit
and colleagues
👇🏽
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Very excited to share this great collaborative paper with you, led by the one and only
@DHaasKogan
and terrific Sharmista Pal
@BrighamRadOnc
@DFBC_PedCare
@DanaFarber
. New therapies for
#DIPG
#DMG
are on the horizon! 🔥🥳🎉
Online Now: A druggable addiction to de novo pyrimidine biosynthesis in diffuse midline glioma
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Great news for kick-starting 2020: I am honored to be chosen for the A-award by
@AlexsLemonade
. Together we can defeat pediatric high-grade gliomas!
#dipg
#ChildhoodCancer
#gbm
@DFBC_PedCare
@DanaFarber
@BostonChildrens
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Three of the world’s top research institutions join forces to drive progress against pediatric cancer - Dana-Farber Cancer Institute | Boston, MA
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Watch out DIPG - we are coming after you! 💪💪💪
Proud to be funding $750,000 in
#DIPG
research projects at
@DanaFarber
with
@chadtough
, SoSo Strong & our chapters & partner families. This piece highlights a recent grant for exploration of a promising new therapeutic target for DIPG. Your donations make this happen!
#DefeatDIPG
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An honor to be here with so many friends and families - all with the same goal: to end DIPG.💪🏻❤️
A great discussion with
@FilbinMariella
of
@DanaFarber
about her important work on developmental pathways and spatial architecture of
#DMG
/
#DIPG
at the
@chadtough
Defeat DIPG Research Workshop.
@broadinstitute
@BostonChildrens
@harvardmed
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Excited to share our editorial on a fascinating paper out of the Pollard lab - GBM cells can partially imitate myeloid cells as another way to evade immune attack. 🤯
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Excited to see our paper out today! Extremely grateful to Yang Shi and Jamie Anastas for this great collaboration.
@DFBC_PedCare
@broadinstitute
@DanaFarber
@BostonChildrens
Online Now: Re-programing Chromatin with a Bifunctional LSD1/HDAC Inhibitor Induces Therapeutic Differentiation in DIPG
@broadinstitute
@BostonChildrens
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The Filbin Lab women stand together with all women in science on
#womaninscience
Day. Together, we will change the world.
#February11
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In honor of DIPG Awareness Day, we are excited to share a graphic of our findings on the origins of DIPG.
#dipg
#dipgresearch
#childhoodbraintumors
#ChildhoodCancer
#btam
#btsm
#gogray
#DFCI
@DFBC_PedCare
@DefeatDIPG
@CureStartsNow
@sajnifund
@sontagfdn
@AlexsLemonade
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Today we buried one of my first and closest patients from heme-onc fellowship. Sydney, I will never forget you. You will stay my forever inspiration to work as hard and fiercely as I can towards finding new therapies. One day, we will win and laugh cancer in the face. Together.
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Thrilled to see our joint story on VRK1 dependency in neural-lineage cancers (including DIPG) out! This was a wonderful collaboration with Bill Hahn and Kim Stegmaier, led by our three fantastic postdocs - grateful to be at
@DanaFarber
where cross-disease projects are possible!
Excited to share our newest story with
@JCI_insight
. A joint collaboration between William Hahn,
@FilbinMariella
, and
@KStegmaier_DFCI
labs. VRK1 is a synthetic lethal target in neural-lineage cancers expressing low VRK2.
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So much fun talking about developmental origins and trajectories across all
#pediatriccancer
with fantastic colleagues!
#AACR23
. Fantastic session on developmental origins of childhood cancer at the pediatric cancer working group town hall.
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👇🏻👇🏻👇🏻 DIPG/H3K27M glioma on center stage!
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Fantastic talk by rockstar
@IlonLiu
- so very grateful and proud to work with you - you will move mountains! 🎉🎊
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Our latest story, getting ready for print! 🥲
#ICYMI
: BAF Complex Maintains
#Glioma
Stem Cells in Pediatric H3K27M Glioma, by
@Eshini_Pandit
, Joana Marques,
@JunQiLab
,
@FilbinMariella
et al.
@DanaFarber
#Epigenetics
#SWISNF
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Scary RNAvelocity in the Filbin lab! Happy Halloween to everyone! 🎃👻💀
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Thank you to each and every patient and family - you are our inspiration! ❤️
Wonderful article on parents who are funding
#pediatriccancer
research through art.
@FilbinMariella
, one of the grant recipients, is using single-cell sequencing to move the needle in the fight against pediatric
#braincancer
: via
@BostonGlobe
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Terrific talk by fabulous
@Bando_Lab
at
#AACR
on targeting aberrant transcription in pediatric brain tumors!
@DanaFarber
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We are all excited to see you there! 🎉🎊🚀
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Merry Christmas to all the children and families battling brain cancer, especially those who have to be in the hospital today. We are here for you and will never give up the fight on your behalf!!
#danafarber
#bostonchildrens
#dipg
#dfbc_pedcare
#etmr
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Coming home from an inspiring day full of fascinating science, clinical application and joint mission. Full heart, and beyond grateful to be part of this amazing community. 💚
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Such a big honor and pleasure to work with this terrific group of scientist and share the same vision: to finally move the needle on one of the toughest brain cancers. Thank you to all who make this possible!
@ICR_London
@bambinogesu
@GustaveRoussy
@gliomatosisCER
Collaborating with researchers from
@ICR_London
,
@bambinogesu
, and
@GustaveRoussy
, Mariella G. Filbin, MD, PhD, recently received funding to target cellular connectivity in gliomatosis cerebri, an especially aggressive
#braincancer
. Cc:
@FilbinMariella
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We are so excited to see your abstracts and change our field together!! 🧠💪🏻💃🔥
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What an honor to host
@GutmannLab
at our Dana-Farber/Harvard Cancer Center Grand Rounds today! A symphony on the neuronal-immune-glioma axis by one of the trailblazers in the field. Thank you David, you inspired us all!
@DanaFarber
@harvardmed
@DFBC_PedCare
@BostonChildrens
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Great science, great friends, great food = triple joy 🎉
#teamscience
@DFBC_PedCare
@StJude
@drpaulnorthcott
@hovestadt
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We’re putting together some research factsheets on
#pediatricbraintumors
in a graphical & easy-to-understand format. Excited to share our first one!
#DIPG
#dipgresearch
#childhoodbraintumors
#childhoodcancer
#dfci
@DFBC_PedCare
@sontagfdn
@AlexsLemonade
@CureStartsNow
@DefeatDIPG
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Very proud of fantastic Joana Marques to receive a fellowship grant from ChadTough Defeat DIPG!!! So grateful for
@chadtough
and
@DefeatDIPG
for all that they do to move the needle!! 💪🏻💪🏻💪🏻
#enddipg
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Come to our session on New Therapeutic Targets in Childhood Cancer - excellent science and progress is waiting for you!
#AACR22
#childhoodcancer
⚡️🔥
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Two outstanding papers published today on the origins of group3/4 medulloblastoma - amazing! 🔥 Biggest congrats to the brilliant teams and collaborators of
@drpaulnorthcott
and Michael Taylor!
#teamscience
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4
46
Fantastic to see first data coming out of
#projectCARE
, in which matched patient samples are compared at diagnosis and relapse, all by single cell RNAseq - fascinating! Pediatric
#projectHOPE
data following soon as well, stay tuned!
@NCICancerBio
@NBTStweets
Great molecular follow up talk in the session on how glioma cells co-opt neuronal programs by
@roelverhaak
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So great to see this fantastic and complementary paper back to back with ours
@NatureGenet
. Biggest congrats
@ClaudiaKleinman
, Nada Jabado and team!
💫 PUBLISHED TODAY
@NatureGenet
📰 K27M in canonical and noncanonical H3 variants occurs in distinct oligodendroglial cell lineages in brain midline gliomas
🧑🏽🤝🧑🏻
@ClaudiaKleinman
Nada Jabado, and team
👇🏿
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Terrific session on stalled development in Brain tumors by
@drpaulnorthcott
@Sloan_Lab
, Michael Taylor and Claudia Kleinman. Very cool to see how war the field has come, and how we can use this information to treat and prevent cancer in the future 🎊🎉👏🏻
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We are hiring!! Searching for a motivated wet-lab staff scientist and computational scientist to lead cutting edge
#SingleCellMultiomics
and
#SpatialTranscriptomics
in childhood brain tumors, as well as
#TumorCellShapeShifting
projects. Please RT and DM if interested. 🥳
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#COVID19
does not stop the Filbin Lab from fighting
#ChildhoodCancer
!
#gogold
#CCAM
cc:
@DFBC_PedCare
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So honored to be at this fantastic conference with so many friends and colleagues!
Up next at
#CRUKBrain22
, Neil Carragher, Richard Mair,
@FilbinMariella
& Nada Jabado will discuss targeted therapies and precision medicine, including how multi-omics analyses are key to informing disease mechanisms and advancing precision medicine in the clinic.
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@vennetilab
rocking the plenary stage with his fantastic work in H3K27M gliomas. Congratulations on your very much deserved Sontag award!!!
#sno2023
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Fantastic session with
@PorterAlyx
, Paula Aristizabal
@radychildrens
,
@TheLizArmy
!! Woman power with co-chair
@JennieWTaylor
🎉💪🏻
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Biggest congrats Marta and team!!!! 🎉🎊🍾🥳👏🏻
We are pleased to share our work revealing the efficacy of TIM-3 blockade as a therapeutic approach to diffuse intrinsic pontine gliomas (
#DIPG
) published today in
@Cancer_Cell
! A thread below by our talented first author
@IkerAusejo
(1/14). Link here!
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A big honor to work with this stellar team.
#teamscience
is unbeatable! Thank you
@CureSearch
for believing in us. 🎉🎊
Congrats to
@CureSearch
Acceleration Initiative Award recipients
@FilbinMariella
@jbernstock1
, who are working with partners
@UABNews
@BrighamWomens
@AvideaTech
to develop a combination immunotherapy to improve outcomes in pediatric high-grade gliomas:
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So proud of rock star
@SinaNeyazi
!! 🎊🎉🎊🎉
Sina from
@FilbinMariella
presenting exciting data on PDGFRA inhibition in DMG in collaboration with
@CarlKoschmann
and
@gojojohannes
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4
42
Fantastic talk by
@platten_michael
on his recent successes using cancer vaccines in IDH- and H3K27M mutant gliomas. 👏🏻
#Eano2023
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💕🧠
Our talented scientists at the 2024 Scientific Retreat reflected on the greatest benefit of being a part of the DSA Community.
@FilbinMariella
, a DSA 2019 grantee, highlights the family-like bond of this community and the transformative impact that can have on her research.
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So much fun, and always inspirational, to see old friends at
@PNOC_kids
meetings.
#braincancerawarenessmonth
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Excited to co-chair the 4th
#GliomatosisCerebri
conference at
@WeillCornell
with
@JonesLabICR
, Dr. Andres Morales and Dr. Jeffrey Greenfield. Excited to meet with our supporting families and foundations, and see how we can push the field forward together! 🧠
@DFBC_BrainTumor
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Also incredibly proud of
@Gavcruzeiro
who recently won the ‘Best CNS Cancer Neuroscience Abstract’ for his work in H3G34-mutant glioma. Biggest congrats Gustavo!! 🎉🎊🥳
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4
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Amazing talk by
@VarunVenkatara2
on new technology developments in
#cancerneuroscience
#eano2023
👏🏻🎉
@CancerNeurosci1
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Thrilled to be honored by The Sontag Foundation with their 2019 Distinguished Scientist Award and to become part of this impressive community of scientists who all share the same mission: To conquer brain cancer. Congratulations also to
@giladevrony
@Sloan_Lab
@VanRechemLab
!
#dipg
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…which ended with these fabulous friends, colleagues and trailblazers:
@humsav
, Nathalie Agar and Nicky Ullrich.
#WomenInMedicine
#momPIs
#defeatbraincancertogether
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Rockstar team!! 🎉🎊💃💪🏻
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So incredibly proud of
@IlonLiu
!! Amazing talk in a fantastic setting. Thank you
@EANOassociation
!!
@IlonLiu
presenting here work in
@FilbinMariella
's lab on DMG K27M, dissecting distinct cell compartments stratified for localization and age in single-cell and spatial resolution.
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An honor to speak at this wonderful conference!
@FilbinMariella
on single cell analysis of
#ependymoma
at
#EANO2021
#Educational_Day
. Transcriptomic signatures correlate with pt survival, potential for targeted therapy:
@dfbc_pedcare
@danafarber
@broadinstitute
@BostonChildrens
@gojojohannes
#btsm
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We couldn’t be prouder and happier for you!! And will miss you so very much.
@nyugrossman
- rockstar in the making! 🎉🎊🎉🎊
I’ll be starting my MD-PhD training at
@nyugrossman
this June!! Here’s to a career of learning, discovery, empathy, and creativity. I am beyond excited 😁😁🧠🩺❤️
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#EpendymomaAwarenessDay
We are coming to get you, Ependymoma! Team work at its best - our working group will solve the secrets of this tumor and many others. 💪🏻💪🏻💪🏻
@gojojohannes
@LoetschD
@eugewang
@emacalate
@Pajtler_Lab
@vennetilab
@LissaCBaird
@PNOC_kids
@DFBC_PedCare
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Excellent keynote talk on medulloblastoma by great colleague and friend
@drpaulnorthcott
. Amazing how far this field has come in the last decade!!
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What an incredible group of rockstar scientist! Congratulations to all, and particularly proud of
@costanza_lc
🎉🥳🎊. The future is bright!
Congratulations to the first class of Damon Runyon-
@StJudeResearch
Pediatric Cancer Fellows! These exceptional early-career scientists are working to accelerate progress and develop cures for some of the most difficult-to-treat cancers affecting children:
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Terrific talk by The Godfather of single cell genomics in gliomas, the one and only
@MarioSuva
! 😍
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Our own Dr. Wright kicking off a wonderful LGG session on new targeted treatments. The needle is moving! 🎉🎊
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Had the BEST day filled with fantastic science and friends. Thank you
@LabNowakowski
for hosting! So hopeful that together we can answer some of the toughest questions in our field. 🧠
#teamscience
Enjoying sharing a view
@UCSFstemcell
and some epigenetic and transcriptomic inspiration 🧬 with
@FilbinMariella
.
#cuttingedge
✂️science 🧫🔬🥼🧪for
#pediatrics
@UCSFPediatrics
👶🏿👧🏻🧒🏼👦🏽
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Biggest congrats again!! And we are all so excited to welcome you to my lab next week!! 🎉🎊🚀
I would like to thank everyone involved in this work which could not have been possible without the joint enormous efforts by everyone involved ! It was a great journey and I am looking forward to the next steps ! (24/24)
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To all the inspiring, incredibly strong women on whose shoulders we stand - mothers, sisters, teachers, mentors, colleagues, trainees, patients - THANK YOU! We will carry your light forward and change the world. ❤️
#InternationalWomensDay
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Great to see our Gbm paper chosen as a top 10 pick by NCI genomics! Go team science!
@MarioSuva
@BradEBernstein
@TiroshLab
@DFBC_PedCare
@DanaFarber
@BostonChildrens
@broadinstitute
#gbm
#ChildhoodCancer
Single-cell RNA-seq of 28 tumors and lineage tracing help derive a unified model of cellular states and genetic diversity in
#Glioblastoma
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So proud of amazing
@costanza_lc
! Fantastic scientist and athlete, and inspiring lab member - reminding us all of our shared values. 🎊🎉❤️
A year ago I could barely run 2 miles. Yesterday I completed the
#ChicagoMarathon
running for the
@AlexsLemonade
team to raise funds and awareness for pediatric cancer research. This amazing journey has taught me so much about perseverance, discipline, and to believe in yourself!
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Very much looking forward to
#sno2023
! Wonderful place to connect, re-connect and to enjoy that we are all on the same mission together.
#curebraincancer
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The Filbin lab is taking the day to reflect on our implicit biases and privileges, our habits and ability to ask questions and listen to all.
#ShutDownSTEM
#ShutDownAcademia
#BlackLivesMattters
0
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30
👇🏻🧠
Excited to share our new paper in
@CellCellPress
on spatial organization in glioblastoma . We combine spatial transcriptomics (Visium) and proteomics (CODEX) to reveal five-layer organization of cellular states and a role of hypoxia as tissue organizer. 1/
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Legendary Kai Wucherpfennig teaching us about new communication lines between GBM cells and T-/NK cells that can be used therapeutically. The future is bright!
#sno2021
@DanaFarber
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The Filbin Lab is all in to fight childhood cancer! Go Gold last day of September!
#gogold
#ChildhoodCancerAwarenessMonth
#CCAM
#dipg
#etmr
#gbm
#gc
#filbinlab
@DFBC_PedCare
@BostonChildrens
@DanaFarber
@broadinstitute
@harvardmed
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