Edwin Neumann
@EdwinNNeumann
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PhD student @MITdeptofBE in the lab of Jonathan Weissman @Jswlab @WhiteheadInst || BS '19 @UWMadison || he/him || Epigenome editing enthusiast
Cambridge, MA
Joined July 2020
Sharing my first 1st author paper, now published in Science! For my PhD I engineered CHARM, a compact, enzyme-free epigenetic editor which can be delivered via AAV vector to reach the brain. This work was done in @JswLab with @TessaBertozzi and @ElaineWu0
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RT @baym: We live in an age of (NIH-funded) biomedical miracles Within your lifetime, prion disease was considered potentially impossible…
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@EAHellerPhD I'm sorry I must have missed out on this- could you link the study? Very curious!
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@ZinselmeyerB @BiotechAnalysst @JswLab @TessaBertozzi @ElaineWu0 I do miss being at @UWMadison and paying half the rent!
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RT @EdwinNNeumann: Sharing my first 1st author paper, now published in Science! For my PhD I engineered CHARM, a compact, enzyme-free epige…
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@keaijumaomao @mn_whittaker @kiranmusunuru If it can be diagnosed early enough we can intervene. That's the goal.
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@Ella_Maru @JswLab @TessaBertozzi @ElaineWu0 Good question– that will be answered soon. DNA methylation without cell division should be stable without active recruitment of DNA demethylases, so I am optimistic that we will observe silencing with a fully optimized drug candidate for as long as we can measure it.
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@smead2 @JswLab @TessaBertozzi @ElaineWu0 Couldn't have done it without support from a spectacular PI and team :)
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We believe this will forge a path to a much-needed prion disease treatment, and we think CHARM could potentially be applied to other neurodegenerative diseases. Please also check out this excellent perspective piece by @mn_whittaker and @kiranmusunuru!
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RT @WhiteheadInst: .@JswLab and @broadinstitute collaborators have developed a gene-silencing tool that shows promise as a therapy against…
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RT @GayathriArunaM: Excited to share my first paper from grad school out today in @MolecularCell! We systematically define biogenesis pathw…
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RT @cureffi: On @medrxivpreprint today, we describe the plasma & CSF biomarker changes leading up to symptom onset in 4 cohort study partic…
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@thestrecker @durocher1 @zhangf @MGHMolBio Congratulations Strecker! Unfortunately I am unable to admire your new website thanks to the @WhiteheadInst firewall 🤔
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RT @davidrliu: Three of the more costly and frequently used reagents in molecular biology are rolling circle amplification (RCA) mix, chemi…
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RT @JswLab: We are looking for a motivated recent grad (or soon-to-be grad) to join us as a lab technician! A great opportunity to gain res…
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RT @JuliaJoung: Thrilled to share my primary PhD work: a Transcription Factor Atlas for understanding gene regulation and cell engineering…
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Exciting work from my undergrad lab. Coral was an amazing mentor!
Our discovery of changing cell identity by controlling histone modifications in the gene body (not enhancers) at essential housekeeping genes (not lineage specifying factors) is at 🧵
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