We’re more than excited to announce our new paper out in @NatureNeuro! A novel mechanism of short-term #plasticity? We found that synaptic vesicles dock transiently after an action potential. Fantastic work @ultrafastgrant and everyone else involved!

RT @Chelsy_Eddings: Fresh preprint of some of my PhD work released today: if you like human synapses, STED and time-resolved EM check it ou…

and axons in human brain!? yep, it's pearled!!

RT @RichKramerLab: Announcing the first annual Visual Neuroscience summer course, Woods Hole, MA, Aug 1-16, 2025. Come for an eye-opening,…

RT @OneNeuroJHU: Study finds axons are not the cylindrical tubes pictured in books but more like pearls on a string. Article Link: https://…

RT @MBLScience: This new study, led by Shigeki Watanabe & partially conducted in the MBL’s Neurobio course, challenges a fundamental tenet…

RT @EricTopol: Did we conceive the structure of neurons incorrectly all these years? @NatureNeuro not smooth, cyli…

@SebastianSeung yes, axon beading is definitely observed when neurons are sick, but the scale is quite different. these are nanoscopic structures. Like in classic in vitro exp, axonal membranes tend to adapt this morphology - wonder if more energy is required to make perfect cylindrical cables

@Awedness @NatureNeuro thanks! and yes, some of these varicosities are likely (or assumed to be) synaptic but may well be non-synaptic!

@JasonSynaptic @TheValleeFdn Thanks!!

and of course, funding from @TheValleeFdn was crucial in piloting the project, especially given that our NIH grant was ND 4 times.