Doris Loh
@DorissLoh
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Independent Researcher, writer, classical pianist.
Joined December 2014
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The
#Mitochondria
Chronicles of Melatonin and ATP is probably the first A–Z manual on phase separation processes that affect the health and function of mitochondria (Section 9). Melatonin enhances production, synergizing with ATP to regulate phase separation in mitochondria.
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A win-win-WIN for melatonin, doctors & cancer patients? Yes, yes, YES! My ground-breaking paper co-authored with esteemed Dr. Reiter explains why, how MEL supports, enhances anticancer therapies by regulating prions via phase separation,
@MDPIOpenAccess
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This picture is worth 14000 words! Find out how melatonin works with light and water in an ancient synergy to help regulate phase separation in our bodies to protect mitochondrial function. Bonus: Precise mathematical formulas for melatonin dose conversion
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Pathological prion isoforms enhance cancer drug resistance, helping tumors become even more aggressive. Melatonin is a "broad-based metabolic buffer" that can stop this feedback cycle: stress=>prions=>cancer=>stress & resensitize cancer cells to therapy.
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Ascorbic acid (AA) and melatonin (MEL) are my Dynamic Duo heroes because they maintain the perfect NAD+/NADH ratio.
Need NAD+?
AA recycles NADH back to NAD+.
Got too much NAD+?
MEL regenerates NADH from NAD+.
Simple, dynamic, and cheap. Now you know why you feel awesome.
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@dbkell
@Parsifaler
@AmaratungaGehan
@whofailedme
@DCGreenZone1
@resiapretorius
Melatonin is effective against SARS-CoV-2 precisely because it can regulate heme iron redox, as discussed in 06/2020 on spike protein:
and prions
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World-leading melatonin experts Tan and Reiter in recent peer-reviewed report provided detailed mechanisms of action and clinical evidence supporting the use of melatonin in severe
#COVID
-19 infections to reduce mortality due to low cost and high safety.
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At present, there is no consensus on how SARS-CoV-2 causes
#LongCovid
/PASC. There is no definitive solution for the ~200 symptoms associated with PASC. Why is melatonin the perfect solution for acute infection and development of PASC? This is your answer
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@Parsifaler
Not only iron. Viruses interfere with host genome translation (via phase separation, N protein for example). That is why you need melatonin to safeguard these processes and keep the virus on good behavior.
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This melatonin molecule is proving to be indispensable, anytime, anywhere.
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Imagine the first question you will have to answer when you to to your cardiologist in the future is whether you have been infected by SARS-CoV-2. Why? New HUGE peer-reviewed study found people with C19 exhibited increased risks for cardiovascular diseases after 12 months 1/3.
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Melatonin is an undervalued ancient molecule that can change your life. Why? It holds the key to fundamental biological processes that regulate the formation and dissolution of biomolecular condensates to shape health and disease. via
@MDPIOpenAccess
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New peer-reviewed report by Dr. Russel J. Reiter and colleagues examined more than 140 scientific studies published since the start of the pandemic on melatonin efficacy in treating COVID-19. [1/3]
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What makes melatonin so special? Do you know that it interacts with water molecules to lower viscosity in cells, making them healthier? Light can do that also. This ancient synergy between light, water, and melatonin is now recorded at Encyclopedia.
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#cancer
What if you can turn cancer cells into a 'Part-time' phenomenon, or even retire them altogether? A brilliant concept presented by Reiter and colleagues in their new peer-reviewed paper tells exactly how that can be achieved.
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Melatonin for COVID-19? A team from Texas Tech U asked and answered 3 important questions in a recent peer-reviewed report:
1. Has Melatonin Proven to be Beneficial for Other Viral Diseases? answer: YES
2.Would Melatonin Prove to be Beneficial for COVID-19? answer: YES [1/2]
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What is the relationship between methylene blue (MB) and melatonin?
MB oxidizes melatonin (in vitro) to produce a powerful antioxidant metabolite of MEL known as AFMK.
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Peer-reviewed clinical trial results on hospitalized patients with severe COVID-19 found oral melatonin to markedly improve clinical status, reduce mortality, need for invasive mechanical ventilation, and hospital length of stay compared to control group.
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9 mg melatonin x 14 days significantly altered cytokine gene expression, resulting in lowered cytokine production during COVID-19 infection. See dramatic difference in levels between controls and melatonin supplemented patients in peer-reviewed report.
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How do you increase NAD+? Take ascorbic acid (AA).
If you are on a low-carb diet, how do you make sure you have enough NADH to regenerate AA?
Take melatonin (MEL).
Life/health can be so simple.
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Melatonin promotes hair regeneration via upregulating the Wnt/β-catenin signaling pathway. This pathway is dependent upon optimal phase separation of component biomolecules. As such, by regulating phase melatonin can also suppress this pathway in cancer.
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Can you prevent or even reverse cataracts? Yes. 1) ensure phase-separating crystallins in the lens remain amorphous and don’t mature into toxic aggregates. 2) be able to solubilize misfolded crystallin aggregates by using MEL-ATP. How?
Read this preprint
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Melatonin is a suicidal antioxidant because it is not regenerated. An organism under stress needs to conserve energy to neutralize free radicals. Regenerating antioxidants require resources. 1 molecule of melatonin can scavenge 2 hydroxyl radicals but that's just the start. 1/2
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How much pain will this article generate?
First peer-reviewed article showing intracellular reverse transcription of mRNA vaccine BNT162b2 into DNA of human liver cells within 6 h of exposure via increased LINE-1 expression and distribution.
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Melatonin suppresses N protein phase-separated 'viral factories', is now supported by peer-reviewed evidence where melatonin/analogs dose-dependently reduced viral load/entry in mouse brains, inhibiting small cerebral vessels damage and brain inflammation.
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Cardiac arrests cannot be prevented. However, a new peer-reviewed study found using melatonin at 100 mg/kg via IP injection for 14 days in rats can prevent injury to vital organs, especially the brain. That converts to 8908 mg for a 70 kg man for 487 days.
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The most frequent comment on melatonin supplementation is "I feel awful taking the tiniest amount". When that happens, it is often a sign your mitochondria needs help from melatonin - A LOT of help, in fact. Take a look at this anecdotal comment. High-dose MEL & AA. Dynamic Duo!
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This is a photograph of ascorbic acid (AA) crystals using crossed polarizing filters. AA can depolarize light and other EMF wavelengths. This is why nature uses it to protect cells from potentially harmful EMFs and why mitochondria express high levels of AA transporters in humans
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Melatonin fed to cows reduces methane emission in respiration by 50%, increasing milk protein/lipid content but without affecting food intake. Livestock is responsible for ~18% of global greenhouse gas production.
Can melatonin help with
#globalwarming
?
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New peer-reviewed report showed high levels of entire spike proteins circulating in plasma of patients with
#LongCovid
even at 12 months post acute infection. More importantly, the presence of entire spike cannot be correlated with vaccination status. 1/x
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2023 Revised Guidelines for the use of melatonin during and after viral infections can now be downloaded.
If you missed the livestream yesterday when I explained why the dosage needs to be high during viral infections, there is a replay tomorrow.
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Is melatonin an antioxidant or a pro-oxidant? It depends on who's asking the question. If you're a cancer cell, then melatonin is a pro-oxidant for you. If you're a healthy normal cell, then melatonin is an antioxidant for you. Melatonin is just too smart for most people to get.
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Melatonin is a "suicide antioxidant" because it doesn't require regeneration after oxidization. Intead, MEL continues to form various metabolites that are potent antioxidants such as AFMK. This metabolite has been shown to also enhance long-term memory in both young & aging mice.
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The dynamic duo, MEL and AA, are finally being studied for their synergistic effects in the treatment of sepsis.
The results reported in the peer-reviewed study are more than impressive in reducing heart and kidney injury and improving organ functions.
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SARS-CoV-2 can upregulate NLRP3 inflammasomes in the brain to induce neurodegenerative disorders including Parkinson's disease Melatonin targets NLRP3 inflammasomes. Now you know why MEL is effective against brain fog and memory loss after C-19 infections.
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Whether SARS-CoV-2 is a product of a lab experiment or not does not negate the fact that ultimately, it is nature's wake up call for humanity to face the reality of the price of modernization. The presence of EMF and light at night suppresses melatonin production. 1/x
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I would like to take this opportunity to thank all my supporters at Twitter. ❤️❤️❤️
My peer-reviewed paper made it to the top of the "Highly Accessed Articles" at the International Journal of Molecular Sciences today.
This is such an honor!
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Understand phase separation and you will unravel the mysteries of melatonin's 'magical properties'. Melatonin is effective against viral infections because the immune system is dependent upon phase separation: the fundamental thermodynamic driver behind all biological processes.
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3. Should Melatonin Be Used as an Early Intervention in COVID-19? answer: YES
Due to melatonin's high safety profile, the authors recommended melatonin given at night to adults diagnosed with SARS-CoV-2 at 2.5 to 10 mg immediately upon diagnosis. [2/2]
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If you are wondering if SARS-CoV-2 & "related molecules" can reawaken dormant cancers or turn cancers into aggressive, drug resistant phenotypes, the answer is “probably yes”. To understand how and why, and if there are viable solutions, read my new blog:
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Why did FB take down my peer-reviewed paper, claiming it contains false information on COVID-19 and can cause physical harm? 🤔
Should I be happy that the paper actually contains information that FB wants to suppress? What are they concerned about? 🤔🤔🤔
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Just published peer-review study found infection by SARS-CoV-2 regardless of disease severity to induce compromised lung physiology equivalent to 15 years of aging. What is decreased in aging? Melatonin. Can MEL prevent C19 aging?
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Blue light (440 nm) elevates mitochondrial ATP production in yeast. Electronically excited cytochrome c transfers absorbed excitation energy for ATP synthesis. This is why mitochondria in retina absorb blue light, and without melatonin, blue light causes excess ROS and apoptosis.
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The hottest paper this summer will be published soon. Stay tuned!
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My recent nomination and initiation as a Full Member to Sigma Xi, The Scientific Research Honor Society for scientists and engineers, is both an exceptional honor and a humbling experience that inspires and motivates continued work at the highest caliber to better serve humanity.
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You recovered from a SARS-CoV-2 infection. Is that the end? It depends on whether the virus is still hiding inside your body to cause
#LongCOVID
symptoms.
Where can the virus hide? Take a look at the diagram.
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Science is uncovering, slowly but surely, all the excellent reasons why melatonin is produced not only in animals, but also plants.
If plants use melatonin to defend against viruses, do you think it odd that animals and humans would not do the same?
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Can someone please takeover FB please. Their operations are borderline insane, now venturing into the Twilight Zone.
This is a post I just tried to share for the first time from my FB timeline. Look at the warning for a one sentence informational, neutral, harmless introduction.
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SARS-CoV-2 infection can lead to LINE1 derepression resulting in global hypomethylation and genomic instability. . A new peer-reviewed paper identified LINE1 derepression to cause premature aging syndromes. Melatonin can inhibit LINE1 derepression. Amazing!
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Can you outsmart viruses?
Timeline:
- Dec 2020: Global deployment of vax targeting spike
- Jan 2021: B.1.1.7 - mutations outside of spike more effective at suppressing innate immune responses.
- Mar 2021: Delta
- Nov 2021: Omicron has 20 mutations in N/Orf9b similar to B.1.1.7.
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Is this MedPage headline exaggerating results from two COVID RCTs testing IV Vit C for hospitalized COVID-19 patients published recently at JAMA?
Not really.
Is the dosage too low?
Not really.
Is Vit C ineffective in C19?
Not really.
Then what is wrong with the study?
1/x
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2/2 Most antioxidants become prooxidants after reducing free radicals unless they are regenerated or recycled which require energetic resources. Melatonin is different. After interacting with free radicals, it takes on a different forms that continue to scavenge free radicals.
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The SARS-CoV2 virus is now believed to be able to cause more damage to human health than any other respiratory virus because it suppresses DNA damage repair resulting in cell senescence in addition to the seemingly-unending and growing list of symptoms associated with
#LongCovid
.
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Why hasn't the C19 pandemic ended?
Current paradigm shuns omega-6 PUFAs. New, shocking peer-reviewed article reported that the linoleic fatty acid binds to conserved spike protein binding pocket in RBD to lock it up, preventing binding to ACE2 receptors.
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Do you know why melatonin supplementation during the daytime can improve your vision? Read my FB post today.
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COVID-19 thrombotic microangiopathy mechanisms explained in detail.
#coronavirus
,
#CD147
,
#melatonin
,
#hemolysis
,
#endotheliitis
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Ascorbic acid is found in every mitochondria, cell, tissue and organ of the body. An individual's need for AA changes with variables such as REDOX, EMF exposure and sensitivity, genetic and epigenetic differences. A look at these diagrams will give you an idea of basic needs.
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If you can add, you can understand melatonin.
Simply add the results from the 2014 study to the 2023 study. What do you get?
Melatonin regulates phase separation of the LINE1 ORF1p protein and suppresses LINE1 retrotransposition. Wow.
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When a journal crafts a video to promote your manuscript, you know you are on to something a bit out of the ordinary.
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A lot of vaccines target spike RBD. This becomes an interesting proposition in the context of developing cardiovascular risks because the RBD harbors an RGD motif that binds integrins responsible for sarcomere assembly.
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For the first time, science presents a comprehensive picture of how melatonin may work inside the human brain to delay and ameliorate the aging of mitochondria, including the regulation of phase separation . I am proud to be a collaborator of this paper.
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#Spike
alert! New peer-reviewed pre-clinical study reports 50 mg/kg high dose melatonin delays severe clinical outcomes, reduces type 1,3 interferon, and improves survival in transgenic mice expressing hACE2 infected by SARSCoV2 [1/2]
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PUFA oxidation causes lipid peroxidation that can initiate a cascade of events to generate destructive reactive oxygen species. However, Nature has provided the perfect solution. Melatonin is one of the most effective inhibitors of lipid peroxidation.
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#Mitochondria
Chronicles is not your mundane melatonin-mitochondria paper. It is a provocative exposés on melatonin. Why?
Shocker
#1
Melatonin was synthesized in archaea ~4 Gya when there was almost no oxygen in the air.
Stay tuned for shocker
#2
tomorrow.
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I ❤️science. It gives answers and debunks myths. A long-standing myth against ascorbic acid (AA) is that it is the direct cause for the formation of kidney stones or calcium oxalates. AA is an easy target because it can form oxalates if it is not regenerated after oxidation 1/x
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An exciting anecdotal report on the difference between a 100% increase in MEL dose during infection. What's going on here? Simple. The magic of phase separation. Remember, MEL regulates viral phase separation to inhibit "viral factories" responsible for infectivity/replication.
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This is why melatonin and ascorbic acid are the Dynamic Duo. Regardless of diet and supplements you take, without AA and MEL, you are wasting your time and money.
@__as______
@ekverstania
@debralondon
@DrMcFillin_PsyD
MEL recycles NAD+ back to NADH. And THAT is the reason why many on keto diets love MEL. Whereas if you are on a high carb diet, taking ascorbic acid will ensure your NADH is oxidized to NAD+, because the body uses NADH to regenerate AA. Diets & vitamins without REDOX is useless.
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Shocking preprint from Japan reported COMPLETE ESCAPE from vaccine-induced immunity by
#Delta
variant via evolutionary pathway mutations in NTD & RBD, implying boosters under consideration with wild-type spike vaccines may not be effective against Delta.
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Why is my new peer-reviewed paper co-authored with Dr. R. J. Reiter a must-read? 1. A novel understanding on the synergy between light, water & melatonin showing why they are critical for the maintenance of everyone’s fundamental health is presented and explored in depth [1/2]
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#nanoparticle
Melatonin alleviates silica np-induced lung injury in live mice & human epithelial cell lines by inhibiting expression of TNF-α, IL-6, IL-1β & reduction of inflammatory macrophage & neutrophils in a dose-dependent manner (20 or 40 mg/kg in vivo; 50-400 µM in vitro).
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Biomolecular condensates are the holy grail in drug discovery because they allow access to undruggable pathways and targets. Dysfunction in regulation of condensates drive neurodegeneration, cancer, and viral infection. Melatonin is a regulator of biomolecular condensates, 1/2
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Immensely honored and proud to co-author "Melatonin: Regulation of Biomolecular Condensates in Neurodegenerative Disorders" with leading melatonin authority Russel J. Reiter. This seminal report may be the dawn of a new era in melatonin research.
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We are not only exposed to 60/50 Hz frequencies 24/7, but are also bombarded by much shorter, powerful frequencies that can completely penetrate membranes. Can these frequencies cause mitochondrial dysfunctions? I don't want to bet, but I'll take my MEL just to be safe thank you.
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Why do salivary glands and their mitochondria produce melatonin? If it is for antioxidant purposes, why would other endogenous antioxidants not be enough?
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Why would melatonin increase insulin in one study using diabetic rats but decrease insulin in another study using the same type of animal model?
Both studies showed melatonin to improve glucose homeostasis and rescue/regenerate damaged pancreas beta-cells. How is this possible?
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Solid scientific evidence that LINE1 ORF1p in plasma and serum can be used as a highly specific cancer biomarker.
What can elevate LINE1 ORF1p?
SARS-CoV-2 infection.
How?
Read Section 7 in
Can melatonin help?
Yes.
How?
Read ⬆️paper.
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Melatonin (MEL) and ascorbic acid (AA) are the Dynamic Duo because MEL regulates phase separation, the fundamental thermodynamic driver behind biological processes, and AA is a birefringent molecule that depolarizes EMF that can affect biological processes
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Both methods evade host immune defenses and are extensively documented in peer-reviewed literature including this report which also offers a simple solution to stop viral replication via either phase separation or activation of LINE1. Got MEL? 5/5
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The timely application of appropriate melatonin doses can prevent and attenuate the following mechanisms that enhance viral persistence in PASC, associate with than 200 long-term symptoms weeks/months after acute infection by SARS-CoV-2 is 'cleared'.
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This is huge! De novo purine synthesis is dependent upon phase separation. That means, if the phase separation process becomes dysregulated, your ATP, GTP, ADP, DNA, RNA, NAD, and other coenzymes will also be affected.
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I am speechless. A new peer-reviewed multicenter cohort study reported mean melatonin intake at 2.61 mg did not reduce mortality in hospitalized
#COVID19
patients.
Why?
Compare
#Lohprotocol
9/21 dosages for Day 3 & 4 indicated for severe symptoms.
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Why is melatonin important for your health?
Because it can regulate biomolecular condensates.
Why is SARS-CoV-2 important for your health?
Because it can regulate biomolecular condensates.
Why is melatonin important during the pandemic?.
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Melatonin protects mitochondria and ATP production via OXPHOS during SARS-CoV-2 infection is a topic you can now research in an online encyclopedia for scholars and researchers. This is true progress!
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#bloodclots
In vitro/in vivo evidence in human and animal models all showed RNA to be promoters of blood coagulation. This could be the most direct and simple answer as to why mRNA COVID-19 vaccines may cause abnormal blood clots in certain individuals.
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A comprehensive critique on mRNA vaccines that target SARS-CoV-2 spike protein.
The question is: how to attenuate potential damages.
All highlighted S protein targets: ACE-2, CD147, TLR-4/2, and ERα are all regulated by melatonin.
Melatonin, anyone? ;)
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Studies revealed that melatonin used alone or in combination with other medications lowered the death rate and shortened the duration of hospitalization of severely infected SARS-CoV-2 patients; MEL can also be used as co-treatment with vaccines to improve efficacy. [2/3]
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Finally, a much-needed short and sweet peer-reviewed "CliffsNotes" on melatonin regulation of liquid-liquid phase separation in health and disease.
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I would like to correct some outrageous claims against ascorbic acid and melatonin being passed around on Twitter.
100 mg MEL via intravenous delivery DID NOT INDUCE SEDATION or cause adverse reaction in human subjects tested. [1/2]
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Phase separation in viral infections is gaining attention by the day. What is more important is to recognize there is an easy, cheap, safe solution. At the proper dose, melatonin regulates phase separation in viral infections.
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@Parsifaler
Einstein played the violin; Feynman loved bongo drums; Ben Franklin played guitar, harp, & viola da gamba; while many contemporary composers have PhDs and Masters in mathematics (Brian May, Dan Snaith, Art Garfunkel). Creativity & discipline are requisite in both art and science.
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#COVID19
Just published results from small Iranian clinical trial on melatonin efficacy for mild to moderate symptoms in COVID19 patients aged 20-65 showed reduced CRP levels, and 82% improvement in recovery rate over controls in 14 days w/6mg melatonin.
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A recent-peer-reviewed paper explains just how 'smart' melatonin can be when it comes to being a pro-oxidant to kill cancer cells. Many thanks to authors for including my work on melatonin regulation of prion protein that increases ROS to kill cancer cells.
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We should test infected individuals who supplement with high-dose melatonin (1000+ mg) during SARS-CoV-2 infections. Melatonin at high doses (100 mcg/mL water) fed to flies increased maximum life span by 33% compared to controls.
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Why did a clinical trial on ascorbic acid for COVID19 produce insignificant results when it is obvious that this molecule is depleted during critical illness?
The trial used HDIVC at 12 g vit C/50 ml every 12 h x 7 days. 1 g per hour avg. is acceptable.
So what is missing?
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New peer-reviewed study finds mutations in nucleocapsid (N protein) are responsible for Delta’s increased infectivity, producing >50-fold virus. Vaccines target spike protein. Do you think the virus mutated N proteins as dynamic survival adaptations? [1/3]
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