@joaquinnieves55 Yes, ths is poxvirus infection. PCR = cowpox

@MeredithKHerman Bilateral buttocks for chordoma

@vlodavsky66556 Lots of good suggestions here. But yes I think this is a naevus with balloon cell change.

Thanks all - middle aged female. All cells Melan-A positive.

@BarnacheaShelby cylindroma. Brooke-Spiegler syndrome?

It is ASPS (TFE3 fusion detected). Tumour had diffuse Melan-A, but no SOX10 or S100.

Thanks for all your comments, was thinking MIFS, but awaiting IHC to exclude melanoma and vascular tumour.

So - this is an SFT - STAT6 here. Uncommon in superficial soft tissue/subcutis.

Should have read suprafascial🙄- that was a point of interest in this case!

@muathalyahya5 re: 2 - CD4 + , some reduction in CD7. Rest of T cell markers retained. CD30 -

@DanGrahamMD EHE?

@DanGrahamMD @SumantaDas_7 ALK was focally positive - which I understand is possible in AFH

@SumantaDas_7 Got it in 1! Desmin positive, EWSR1::CREB1 fusion. c/w angiomatoid FH

@Immanuel_Paul30 Good thoughts! CD34 negative.