Jeremy Day
@DayLabUAB
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UAB Neurobiologist and Director of the UAB Comprehensive Neuroscience Center. Full justification and Oxford comma advocate.
UAB
Joined August 2014
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It's called a CV because those are the keys that you will spend countless hours using to copy and paste the same information into other forms with slightly different orders and formats for the rest of your academic life.
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This is why you don’t tell your lab what day your birthday is.
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I hope the Oxford University Press journal that removed all of the Oxford commas in our manuscript at proof stage at least appreciates the irony.
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I'm excited to take on this new role as Director of the UAB Comprehensive Neuroscience Center!
@UAB_CNC
supports the incredibly strong (and growing) neuroscience community at UAB in many ways, and I am thrilled to lead this organization towards a bright future.
Congratulations to the new
@uab_cnc
director Dr. Jeremy Day
@DayLabUAB
, and many thanks to Dr. Adrienne Lahti for her service during challenging times!
Looking forward for great new advances for the Neuroscience community at UAB!
@UABNews
@UABHeersink
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My first PhD student defended (successfully) today! Was a pleasure to have
@Kathorine
in my lab for 5 years, and I can’t wait to see the awesome things she accomplishes in her postdoc with Bruce Hope at NIDA.
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Honored to be a recipient of the 2022 Neurobiology of Brain Disorders Award from the McKnight Foundation for a collaborative project with Ian Maze
@themazelab
!
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Really excited to share the published version of this recent work from
@Kathorine
,
@Jtuscher
,
@ZipperlyM
,
@coreygduke
,
@R_Phillips_3
, and others, out today.
This was a huge amount of work from an awesome team - long explainer thread below.
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My lab knows I dislike celebrating my birthday, so they make a big deal of it every year - apparently even in a pandemic. Happy to be able to share science and life with these awesome people
@Jtuscher
@coreygduke
@ZipperlyM
@NancyGallus
@R_Phillips_3
@AllieNilsen
and others!
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With the lab shutting down activities, we were able to donate over 200 N95 masks and several packages of surgical masks to the
@UABSOM
COVID19 command center. Thanks to
@coreygduke
for organizing these efforts.
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Our paper using single nucleus transcriptional profiling to define heterogeneity in the rat ventral tegmental area (VTA) has now been published! A short thread on this work, which was led by stellar scientists
@R_Phillips_3
and
@Jtuscher
in the lab...
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Hard to believe its already been 20 years since I began my PhD at UNC Chapel Hill, but it was an honor to come back for a visit to receive the Distinguished Alumni award from the Department of Psychology and Neuroscience!
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Thrilled that lab superstar
@Jtuscher
has been awarded a K99 Pathway to Independence award from NIMH! This award will support Jen’s research into estrogenic regulation of memory using cutting edge single cell sequencing tools and CRISPR manipulation approaches. Congrats Jen!
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I am looking for a full-time research technician to join my lab to assist in several NIH-funded projects. Experience in molecular genetics and/or behavioral assays would be a plus, but not required. Waiting on official application link, but please contact me if interested!
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New preprint from the lab! Here Nancy Carullo (
@NancyGallus
) describes a Cre-dependent CRISPRa system that we hope will enable cell-specific gene regulation in neurons.
A Cre-dependent CRISPR/dCas9 activation system for gene expression regulation in neurons
#bioRxiv
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Me: Paste and match formatting
Microsoft Word: How about just a little of the old formatting?
Me:
Microsoft Word: Completely new formatting?
Me:
Microsoft Word: Do you like blue underlined text?
Me: Nevermind, I'll do it myself
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I'm very grateful to have had the chance to participate in this ceremony with the Dr. Heersink! His support for UAB Medicine has been incredible, and it was an honor to be involved as part of this endowment.
Dr. Jeremy Day, Associate Professor of Neurobiology at UAB Heersink SOM, celebrating his appointment as the Michael Friedlander, PhD, Heersink Endowed Professorship! From left to right, Drs. Marnix E. Heersink himself, Craig Powell, Jeremy Day, & Interim Dean Dr. Anupam Agarwal.
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Really excited about the UAB Neurobiology seminar series lineup this year - even in a global pandemic (and associated Zoom fatigue) we managed to get an amazing group of people to agree to come talk to us virtually.
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Our first lab preprint - showing that enhancer RNAs are necessary and sufficient for activity-dependent neuronal gene transcription.
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Very happy and proud that lab superstar postdoc Jen Tuscher (
@Jtuscher
) has been awarded a 2020 Young Investigator Grant from
@BBRFoundation
for her work exploring transcriptional dynamics in drug addiction. Congrats Jen!
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I am hoping to add two postdocs to our team in the next year - if you are interested in using CRISPR, single-cell sequencing, molecular biology, and systems/behavioral approaches to understand the neurobiology of drug abuse and/or genomic enhancer function, please apply!
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We've updated our preprint describing a Cre-dependent CRISPR activation system to include characterization of a corresponding CRISPR interference approach. These tools enable bidirectional, Cre-inducible gene regulation with the same CRISPR sgRNA.
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New preprint out from the lab -
@coreygduke
and others generated a modified CRISPR interference system for gene knockdown in neurons. We had hopes to take this quite a bit further, but COVID19 got in the way. Plasmid will be submitted to Addgene soon!
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Bioinformatics: Provide code for your analysis, it will allow others to easily reproduce your figures and extend your work!
Also Bioinformatics: This code will only work in R version 2.5.1 running legacy versions of 38 different packages. Good luck finding them all!
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Excited to join UAB leadership along with city and state officials today for the groundbreaking of this world-class research facility. This building will create space for many new neuroscience labs, including the entire Department of Psychology.
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With several new grants starting recently, I am looking to recruit postdocs and/or data scientists in my lab in the Department of Neurobiology at UAB. Please contact me if interested! 1/4
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Incredibly proud of
@ZipperlyM
following an awesome presentation in her PhD defense today. Morgan's project spanned a really large technical range, and included a lot of cutting edge approaches. I'm glad the committee saw things the way I did - congrats Dr. Zipperly!
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Self-reminder: Don't answer your office phone, it is almost never worthwhile.
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UAB Neurobiology is recruiting tenure-track faculty (open rank) again this year - come join our growing department!
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Annual lab holiday party selfie stick photo. I’m happy to work with a team of people that are not only fantastic scientists but also just great to be around. Looking forward to 2020!
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Our CRISPRi tool publication is out - look for it on Addgene (plasmid
#155365
) shortly. This adds to our existing CRISPRa toolbox to enable bidirectional, modular gene regulation in neurons, often with the same CRISPR sgRNAs. Congrats Corey and team!
Always a fun day when the final version of an article goes public. Check out our updated CRISPRi tool ready for neuronal gene suppression! Works exceptionally well in our hands. Very excited to get this out to the community and see what you all do with it!
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Nothing like a great grant score to start the week - the idea for this project goes back almost a decade, but also relies on really cool techniques being worked out by some incredibly talented lab members. Excited to see where it takes us.
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Want to use data from our published snRNA-seq datasets in your presentation, paper, or grant application? You can now download .png or .pdf versions of the feature and violin plots directly from our browser! Thanks to
@UAB_BDS
for making this happen!
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Very excited to share this new preprint led by the super talented
@klbrida
. We started by asking what marks drug-activated ensembles and stumbled onto a surprising answer that identified a key regulator of neuronal excitability and reward. A brief 🧵...
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New preprint from
@ZipperlyM
,
@FarazSultan9
, and others in the lab. Here we show that Gadd45b is a dopamine-regulated immediate early gene that is critical for drug-related place memory. Feedback welcomed!
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I’m an assistant professor and the other day I tried to lock my office door with the key fob for my car.
I’m a PhD student. Yesterday I tried to open the library with my house keys.
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Incredibly proud of lab postdoctoral fellow
@Jtuscher
, who was awarded the 2021 UAB Most Esteemed Postdoc award. Jen is an exceptionally gifted scientist, and I cannot imagine a better choice for this award. Congrats Jen!
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Incredibly proud of lab PhD student Nancy Carullo (
@NancyGallus
) on her successful PhD defense today. Nancy was one of the first members of the lab and has been instrumental in our success from day one. Congrats Dr. Carullo!
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Great science month for the lab -
@ZipperlyM
and
@coreygduke
were awarded spots on institutional T32s,
@Kathorine
and
@NancyGallus
were selected for big talks at SfN and EMCCS/FENS, and a new R01 exploring genomic enhancers was funded. Looking for postdocs!
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Excited to be heading to
#ACNP2021
in Puerto Rico tomorrow to share our work on drug-induced transcriptional and epigenetic programs in brain reward circuits. Lucky to be speaking with a fantastic panel including
@ChristophWCowan
,
@Cate_cholamine
, and
@martinowk
!
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My department (UAB Dept. of Neurobiology) is looking to add tenure-track faculty. We offer great colleagues, a strong neuroscience community, modern lab space, and highly competitive start-up packages. Search is open rank. Apply in link below.
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Excited to share the published version of our work characterizing the location and function of RNAs transcribed from genomic enhancers in neurons.
Congrats to lead author
@NancyGallus
and co-authors
@R_Phillips_3
and
@rcatsimon
, among many others!
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Our paper on the role of Gadd45b in cocaine memory and dopamine-dependent gene regulation is out today in
@NPP_Journal
- congrats to
@ZipperlyM
,
@FarazSultan9
, and many others.
In
@NPP_Journal
from
@ZipperlyM
and the
@DayLabUAB
team - new paper showing regulation of dopamine-dependent transcription and cocaine action by Gadd45b
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My Macbook Pro keyboard has started to type "ee" for every "e" that I type.
In other news, lab papers and grants will now feature exclusive use of the literary/archaic "thee".
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Incredibly proud of undergraduate students in my lab right now - 2 headed to IRTA postbac program at NIH, one to graduate school at Rutgers, one to a WAVE fellowship at Caltech, and 2 staying in the lab over the summer on UAB presidential fellowships.
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Our review paper on applications of CRISPR/Cas9 in the mammalian CNS is out! Congrats to
@Kathorine
, who gets all of the credit here.
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A former lab REU trainee in Puerto Rico told me this morning that he has had difficulty submitting summer fellowship apps (e.g., Amgen, NSF REU) due to power outages on the island.
Institutions, if your fellowship submission deadline is this week, please keep this in mind.
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Congrats to my (twitterless) department colleague Scott Cruikshank on this beautiful paper defining rules for sensory information flow in the thalamic reticular nucleus!
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I'm looking for 1-2 postdocs to join our research team to work on gene regulatory mechanisms in drug abuse models or the role of genomic enhancers in neuronal function. If you are interested and will be at SfN this year, let me know - happy to chat.
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Underrated part of running a lab for a little while is former trainees that have graduated and moved on to next steps coming through town and stopping by the lab to grab lunch or coffee and hang out. Getting to hear about successes at the next level is so rewarding!
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If you will be in DC for
#SfN23
next week, be sure to check out the six (!) awesome posters from the lab. A little bit of everything, from markers of drug-activated neurons to neuronal chromatin/transcription factor dynamics to new cell types to ion channel pharmacology!
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Excited to receive a grant supplement from NIDA and ORWH to extend some of our ongoing studies to examine sex differences in transcriptional and epigenetic mechanisms in drug abuse. Shout out to lab postdoc
@Jtuscher
for her major contributions to these efforts.
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New preprint from the lab (2nd in two days!) -
@coreygduke
found that blue waveform light induces immediate early genes and phototoxicity in vitro, but that this effect is prevented by use of photoinert media with photostable supplements.
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The UAB Heersink SOM has just relaunched its highly successful strategic neurosciences recruiting initiative! We are looking to recruit up to 20 faculty (at any rank) across UAB neuroscience departments. See posting linked here for details!
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What is true in science is also true in politics:
1. Extraordinary claims require extraordinary evidence.
2. What can be asserted without evidence can also be dismissed without evidence.
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New work from
@R_Phillips_3
and
@Jtuscher
in the lab using snRNA-seq to define the organizational principles of VTA cell subtype heterogeneity.
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Review on multigenerational epigenetic mechanisms in the nervous system by lab postdoc
@Jtuscher
just published in Neurobiology of Disease. Not an easy topic to review, but I think we ended up with a very balanced perspective on this emerging field.
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Hard to believe that
@R_Phillips_3
's time as a PhD student in the lab is already coming to an end! Robert has had a fantastic run in the lab and was a key driver on almost all of our recent papers. We even used some of his ATAC-seq data for the dissertation announcement below!
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Really nice study exploring the molecular heterogeneity of the mouse nucleus accumbens using scRNA-seq and multiplexed in situ hybridization.
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Annual lab holiday party selfie stick photo. Glad to have the opportunity to have worked with all of these awesome people over the last year!
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Had a great time at the Neurobiology of Addiction Gordon Conference this week - many thanks to
@MarinaP63
and
@SergeAhmed
for the invitation to share our work! I met so many fantastic people and learned a lot. GRCs are the best, especially when you can hike through this scenery!
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Congrats to lab MSTP student
@coreygduke
on passing his PhD dissertation defense this morning! Corey has made numerous key contributions in my lab over his time here, and I'm looking forward to seeing all of the things he will accomplish in the coming years.
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Incredibly proud of two former lab MD/PhD students that both matched into their top residency choices today -
@ZipperlyM
at University of Colorado Denver, and
@coreygduke
at Boston Children's/Harvard! Congrats Morgan and Corey!
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Excited for my first stint as director of the UAB Neurobiology seminar series - here's our 2018-2019 lineup.
Credit to
@mlphillips17
and
@PozzoMillerLab
for the awesome hippocampus image in this flyer.
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Manuscript accepted and complimentary upgrade for tomorrow’s ATL-ASE flight for Winter Brain conference. Great morning so far.
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New lab swag has arrived! Perfect for my coffee overconsumption problem.
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New lab preprint with work from
@SvitlanaBach
is now out! Here we explored distinct functions of transcript variants that arise from the Bdnf gene, which codes for brain-derived neurotrophic factor. A short thread...
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UAB Neurobiology has re-launched our faculty search (open-rank, tenure-track). Come join us!
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Interested in the striatum, opioid receptors, and new markers of understudied cell types? Check out this new preprint, which was led by the incredible
@emma_andraka
. A brief 🧵...
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“Injustice anywhere is a threat to justice everywhere” - this phrase was true when written in 1963 in a jail cell in my city, and it’s still true in Minneapolis in 2020. We must do better.
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The UAB Department of Neurobiology is seeking applications for tenure-track faculty positions - apply within to join an excellent and rapidly growing group of colleagues.
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Major cluster hire in UAB neurosciences - up to 12 new faculty will be added across multiple departments.
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Update! This work has now been published in eNeuro - congrats to
@coreygduke
,
@Kathorine
,
@Jtuscher
, and
@R_Phillips_3
.
New preprint from the lab (2nd in two days!) -
@coreygduke
found that blue waveform light induces immediate early genes and phototoxicity in vitro, but that this effect is prevented by use of photoinert media with photostable supplements.
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I’m very excited to announce the completion of this special issue of Molecular and Cellular Neuroscience (co-edited with
@WestLabDuke
), focused on Genetics and Epigenetics of Substance Use and Substance Use Disorders!
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Just flew directly over Manhattan on way into the city for a seminar at Mt. Sinai tomorrow. Always amazing for me to see. But on this date, especially so.
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2017 lab holiday party was a success! Proud to be able to work with this awesome group.
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The UAB Department of Psychiatry is looking to hire clinical researchers in area of mental illness, including mood disorders and addictions. Our neuroscience community is growing rapidly, come join us! Link below.
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Our CRISPRi plasmid is now on Addgene! Interested to see how this works for others in the community.
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Thanks to
@Addgene
for everything they do to archive and distribute plasmids for scientific research! Just received this Blue Flame Award for plasmids generated and validated by
@KatherineSavell
,
@SvitlanaBach
,
@ZipperlyM
,
@jasmin_revanna
, and others in the lab.
#HappyDepositor
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Excited for my first UAB Neuroscience Center retreat as Director of
@UAB_CNC
! Our speaker lineup represents 9 departments in 5 distinct schools - this is a testament to the incredible breadth and diversity of neuroscience at UAB. Special thanks to
@LisaMonteggia
for joining us!
The 2022 UAB Comprehensive Neuroscience Center retreat is only 10 days away! In addition to a keynote presentation from
@LisaMonteggia
, our retreat will feature presentations from new UAB faculty (including
@ewhizabeth
,
@bdemiranda
, and
@not_kristie
) and trainees.
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Lab outing at Top Golf to celebrate a number of recent achievements - too many to name in a single tweet (at my subscription level, anyways). Short version: faculty position for
@Jtuscher
, F32 for
@dr_emjorgensen
,
@R_Phillips_3
defends dissertation and heads to postdoc at Penn...
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Gotta say, there is a fantastic group of early career neuroscientists at UAB right now, each of which are all-stars. I could not be happier to see this.
@constanza343
@hardawayja
@bnlasse
@summerbthyme
@not_kristie
@sophiebeas
@mus_elegans
@bdemiranda
What is this even
#R01
I'm crying in my office right now
@bnlasse
@mattheyseslab
couldn't have done this without your support and encouragement. To my lab, who made this happen. And to my husband, my rock and compass. We will be hiring soon!!! 🤞🤓🤓🎉🎉
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My lab is looking for postdocs - if you are interested, check out the opportunity below!
Interested in a neuroscience-related postdoctoral position in a research lab
@UABHeersink
? The Brain-PRIME program offers elevated stipends, career development funds, and advanced career mentoring for selected candidates. Visit to learn more!
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Headed to
#SfN22
next week and interested in combining single cell sequencing, CRISPR tools, ephys, and behavior to study brain reward circuits? My lab is hiring at all levels (including postdoc, data scientist, and technician). Email me to arrange a chat!
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Really excited to present some recent work from
@Jtuscher
and
@R_Phillips_3
in Phoenix next week
#ACNP2022
in this session on application of single cell sequencing technologies to understand brain function!
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Congrats to my awesome colleague Summer Thyme on being awarded a Klingenstein-Simons Fellowship in Neuroscience!
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Departing the Neurobiology of Addiction GRC and while there were a number of excellent talks, the most impressive part to me was the uniformly excellent quality of the trainee posters. The future of the field is in good hands!
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My lab doesn’t study stress, but all the images of Banff in my timeline have me wishing we did.
#stress2018
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Kudos to lab postdoctoral fellow
@nithrobinson
for receiving an Emerging Scholar Award (with considerable research support) from the Civitan International Research Center!
@Civitan
@civitan_rcc
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My lab is looking to fill an open lab manager position. Application links below!
Researcher III:
Researcher IV:
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Super proud of
@dr_emjorgensen
for taking the chance on my lab and getting this F32 proposal funded on the first pass! Also excited to explore this area - this is the lab's first project looking at potassium channels in the ventral striatum.
SHE’S A FUNDED GIRLY!! 🥹🥲🥳
Truly still floored that this got funded on my first submission. Stay tuned for some fun and exciting projects!!
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@cmotpow
Thanks Craig! It was an honor to be selected for this, and also so cool for it to be named after our very first
@UNeurobiology
department chair
@mikejfriedlan
!
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Had a lot of fun writing this Hot Topics piece with
@martinowk
on single cell profiling in brain reward circuits for
@npp_journal
! So many new developments in this space - I am excited to see how the field uses these technologies moving forward.
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