Dr. Jacob Glanville
@CurlyJungleJake
Followers
29,745
Following
219
Media
169
Statuses
4,505
Founder & CEO of Centivax, computational immunoengineer
San Francisco, CA
Joined May 2017
Don't wanna be here?
Send us removal request.
Explore trending content on Musk Viewer
Venezuela
• 2760477 Tweets
Nicolás Maduro
• 1357389 Tweets
Edmundo
• 1272332 Tweets
María Corina
• 614839 Tweets
El CNE
• 537878 Tweets
#HouseOfTheDragon
• 324830 Tweets
Chávez
• 308016 Tweets
Gala
• 281948 Tweets
Ganó Maduro
• 211306 Tweets
Robo
• 191531 Tweets
#LaCasaDeLosFamososMx
• 135801 Tweets
Rhaenyra
• 128250 Tweets
Miraflores
• 110133 Tweets
Diosdado
• 98538 Tweets
Maldito
• 88263 Tweets
Golpe de Estado
• 87256 Tweets
Vermithor
• 80762 Tweets
Boric
• 80383 Tweets
#HOTD
• 70931 Tweets
#FueraMaduro
• 60448 Tweets
Latinoamérica
• 59930 Tweets
Daemon
• 57334 Tweets
Venezolanos
• 42950 Tweets
Aemond
• 40260 Tweets
Pinochet
• 38314 Tweets
Paola
• 37587 Tweets
Vhagar
• 33238 Tweets
Cállate
• 26525 Tweets
Jace
• 25517 Tweets
Capriles
• 20064 Tweets
サザエさん
• 17247 Tweets
一粒万倍日
• 16249 Tweets
Honduras
• 15317 Tweets
山田くん
• 14222 Tweets
山本圭子さん
• 14219 Tweets
KerjaHARMONIS KerjaSELARAS
• 14049 Tweets
花沢さん
• 12590 Tweets
ちびまる子ちゃん
• 12571 Tweets
Pinned Tweet
I gave an enjoyable podcast interview with
@Fishawack
- talking about everything from growing up in Guatemala, machete scars, team building philosophy, to the biotechnology revolution and universal vaccines.
Are we close to the discovery of broad-spectrum vaccine?
@CurlyJungleJake
delves into his idea to develop “universal” vaccine technology in Beyond the Molecule.
@centivax
#FishawackHealthEndorses
#WorldImmunizationWeek
#FH
1
1
2
3
6
33
Dear internet: the vaccines are about to come out. They need both shots to work. You will probably get injection site tenderness & swelling. A lot of people will feel lousy the day after taking it. This is normal for these vaccines. It’s way better than COVID-19. Take both shots.
275
3K
13K
vaccine mandates for businesses and restaurants / etc are similar to the 2004 Clean Indoor Air Act when we banned smoking indoors. Smoking is a personal choice but it puts others at risk in an airborne fashion. The difference is that you can’t “just smoke outside” with covid-19
308
3K
12K
SARS-CoV-2 sticks all over your infected cells (lung, heart, neurons). Your body attacks itself trying to fight it off. Long-haulers are left with a wide range of symptoms that resemble autoimmunity or organ damage. I don’t want this virus in my brain. I’m getting vaccinated.
73
655
3K
Anti-
#COVID19
#therapeutic
update. After 9 weeks we have generated extremely potent picomolar antibodies that block known
#neutralizing
#ACE2
#epitopes
, blocking the novel
#coronavirus
from infecting human cells. Read more at .
201
1K
2K
Timelines to cure & what that time is spent on, antibody therapeutics and how they work. RNZ
97
543
1K
Pleased to announce that 3 independent laboratories at
@utmbhealth
,
@Stanford
, and
@DeptofDefense
USAMRIID confirmed that multiple
@centivax
antibodies are potent neutralizers of the pandemic coronavirus:
147
504
1K
Well this is bad. Some weeks ago I voiced concerns that COVID-19 patients had very low T-cells. The disease had many features indicating immunosuppression (clearance failure, wide onset variation, demographics of disease, etc).
146
721
1K
97% reduction of coronavirus in lungs in 48 hours, reduction of lung tissue pathology, elimination of symptoms (I.e. they keep getting happy and chonky)
#happyhamsters
83
242
1K
For those asking: we have held off for a week so as not to compete with the protest movement coverage, but we do have a substantial progress announcement on our COVID19 therapeutic. In the meantime, we wish health and safety for everyone.
63
126
1K
We are happy to announce a partnership with Erwin Calgua and Guatemala’s University of San Carlos to enable rapid diagnostic testing of COVID19 convalescent plasma antibodies. USAC will test plasma to find donors with the best antibodies and then bank their plasma as a treatment.
39
278
933
Photo taken by Erin in our neighborhood - don’t know which coffee ship but kudos!
24
277
919
People shouldn’t worry so much about the WHO announcement on COVID19 immunity: 80% of people appear to produce antibodies and people produce T-cell immunity. Many of the “reinfection cases” were test error. Monkeys get immunity. We will discuss tomorrow live at 11AM PST
54
254
888
Anti-
#COVID19
#therapeutic
update. After 9 weeks of concerted effort, I’m pleased to report that we have generated multiple extremely potent picomolar antibody binders that block known
#neutralizing
#ACE2
#epitopes
,…
61
278
818
It is simple: the minute we have a medicine for patients, this crisis is over and we can go back to work again and hug our grandmothers again. An antibody is the fastest way to fix this.
58
242
796
A potent
#antibody
can cost around $100/dose to manufacture. Even given packaging, distribution and overhead, a lifesaving antibody drug could be sold at a profit for less than an iPhone ($399). Remdesivir costs pennies per dose to manufacture: patients shouldn’t pay $3,120.
32
201
775
Get ready for a positive announcement this week.
89
148
759
Ok folks, radio silence almost over. As soon as I get all quotes back from partner labs, the first press release goes out. Then media blitz and Q&A Apex podcast with Shahrad, Jack, Sindy, Gangemi, Sawsan, tentatively Wed 11AM PST. Then weekly press releases in May - buckle up.
87
110
719
4 of 5 labs now reporting in on neutralization by my antibodies: some variation on degree of signal depending on assay setup, but overall striking how reproducible everyone’s assays are. A refreshing change to see such consistency compared to the diagnostics quagmire.
45
117
703
6-way press release including US. Army Research Institute of Infectious Diseases
@USAMRIID
, Kim lab at
@Stanford
, UTMB/Galveston National Laboratory
@utmbnews
,
@CRiverLabs
,
@centivax
and
@distributedbio
dropping on Monday - coordinating with media outlets to maximize impact
81
178
676
UK mutant strain: 8-9 mutations over 1213 spike positions = 99.24%-99.34% identical. From flu and other viruses, we can estimate that this isn’t enough mutation to escape vaccine antibody responses. Likely more infectious, certainly concerning, but vaccines should still work.
30
216
676
Press release imminent. A couple weeks ago sent our anti-COVID19 antibodies out to 5 independent labs across three nations for neutralization potency and in-vivo protection. It’s more work and logistics but makes for much better science. Thanks
@atulbutte
for this strategy.
41
117
654
Quarantine toast! (I’m not sick). Tonight we are sharing our antibodies with diagnostics companies so that they can use them in kits to more quickly detect virus, as we move the therapeutic program forward.
34
99
587
@Tearoy24
COVID slams your immune system making it harder to clear the virus out of your system and makes you more easily infected by other things.
51
202
580
Dr. Fauci is asked about our work and supports the concept of monoclonal antibodies as very well established.
47
111
561
Just in case you hadn’t heard: huge respect to Prime Minister
@jacindaardern
and the people of New Zealand. Their determined early actions resulted in complete clearance of the virus from their islands. It’s a valuable case study, and I’m happy that I got this one wrong.
25
64
573
I’m grateful to have been added to the congressional
#COVID19
Rapid Response Taskforce by the Federation of American Scientists. First conversation with Congressman Bill Foster on manufacturing capacity
57
66
528
We’re back! Antibodies sent out to UTMB, U Kent, Sino, Stanford, USAC and more to USAMRIID yesterday. Prepping a weekly update with Apex on program status and our involvement in their donor plasma screening program.
40
80
526
#COVID19
current treatment update: right now, hospitalized patients should ask their attending nurses and physicians about A) remdesivir to slow the virus, B) dexamethasone to slow immune overreaction tissue damage, and C) convalescent plasma. Agree?
56
149
511
My aunt has been infected with COVID19, along with over 20 other residents at her assisted living facility in Pasadena. I just heard her oxygen is low and she is being transferred to intensive at a nearby Hospital. asking if they have remdesivir and/or plasma transfer protocols.
187
52
500
Last night my grandfather, Stanley Virin Gunn, passed away. He had a such a huge effect on my philosophy and my life, that by the time i was 4 years old, when people asked me what i wanted to be when i grew up, i had…
151
16
486
As a patriot, I know we can do better than this, and I fear for my fellow Americans. August is going to be brutal but we can still take steps to protect ourselves now. Antibodies and vaccines will likely be here by the end of the year - we need to be strong until then.
50
128
468
As I’ve mentioned previously, keep an eye on this. There are papers now in review concluding that Omicron is more mild (less likely to hospitalize the infected) but the glaring exception is in children under 5. They seem more prone to hospitalization from Omicron.
Increase in COVID-19 Pediatric Hospitalizations Across New York State with “approximately half of the admissions are <5 years of age and thus vaccine ineligible.”
89
549
932
53
292
464
Tell your representatives that
#Gilead
shouldn’t be charging $3120/patient for
#remdesivir
: taxpayers already subisidized $70 million & it costs less than a dollar/dose to manufacture. The world needs a lifesaving therapy that costs less than an iPhone.
27
198
458
The Pfizer / BioNTech vaccine. Even 14 days after the first shot, you can see a separation of the treatment (blue) vs placebo (red) groups, with 95% reduction in new infections in vaccinated group. This is a very effective vaccine
26
110
452
Since January antibody treatments/therapies have been incorrectly called a “stopgap until vaccines arrive.” Treatments are the long term solution - consider influenza, HIV, tuberculosis, staph infections, Ebola - all modern infectious disease is made manageable with therapies.
25
97
445
A major reason to vaccinate your child is to avoid long-hauler COVID-19, which has a roughly 13% chance of occurring and can range from annoying for a few months to having far more serious chronic symptoms (cognitive function, heart function, lung function, psychological effects)
27
153
441
@JonnyThePhoenix
@GretaThunberg
Wasn’t he trying to provoke her and she slapped him around good for it? I don’t understand how this is political. He was just trying to bully a teenager and got pownd
35
5
444
Nice job, NZ! New Zealand records ZERO new coronavirus cases for the first time via
@HaleyCAnderson
19
64
412
Nice article about our work on the homepage of yahoo:
20
98
401
97% reduction of virus in the lungs within 48 hours
#happyhamsters
.
@CurlyJungleJake
is an admirer of the human immune system — but he thinks we can do better. His company
@centivax
announced that they have created optimized antibodies that protect hamsters from lethal amounts of the virus that causes
#COVID19
.
6
51
145
20
89
407
US is still having clear covid weather but it looks like there’s a wave brewing in Europe. Also outbreaks in some parts of Asia. Only a matter of time for US: get your partying and events in while you can.
47
187
400
Whether election is making you want to shout for joy or out of frustration, please remember that we are in a major outbreak escalation and large crowds and shouting both spread the virus. Now might be a moment better served by stoic reflection. For everyone. For many reasons.
20
46
399
#POTUS
has received 8g of antibody therapy from Regeneron. This is a very high dose, but also their successful strategy with Ebola to dose very high. Here’s wishing to a speedy recovery and more widespread use of antibody therapies to come.
30
59
376
Folks, it’s simple: hospitals are overflowing with infected, over 90% of those patients unvaccinated. Hospitals are not overflowing with vaccine side effect cases, even though more of humanity has been vaccinated than infected. The vaccine is clearly way safer than the disease.
33
86
393
Recovered from COVID19? Consider donating your plasma to Red Cross. It’s being used as a potential treatment.
25
148
382
Lindsay prepping our shipment - anti-COVID19 antibodies heading out for testing to the military on schedule
22
68
377
About to do the next
#COVID19
project update, and was thinking that it would be cool to do occasional interactive updates via Instagram live / Facebook live. Would this be of interest? If so, what times are best? If…
73
37
367
My mother Susan Gunn asked that I perform a correction on her father’s eulogy: Stanley V. Gunn lead the engineering and development of the F1 NASA rocket engines and not just the J2 rocket engines. These rockets took humans to space and the moon.
27
26
371
“Vaccines aren’t 100% effective therefore mandates don’t make sense” has the same logical problem as a highschool boy saying “condoms aren’t 100% effective therefore we must rawdog.” Let’s respectfully engage legitimate vaccine-hesitant concerns, but time to cut out BS arguments.
28
59
375
There has been speculation that
@POTUS
condition was serious due to treatment by antibodies and remdesivir. Not reasonable to draw this conclusion: antivirals are most effective given early to thwart virus. This is where treatment of everyone would move if it was affordable.
22
72
354
Deeply appreciative to be named an associate professor of the University of San Carlos.
38
17
362
The Moderna vaccine. Even 14 days after the first shot, you can see a separation of the treatment (orange) vs placebo (purple) groups, with them reporting a similar 95% reduction in new infections in vaccinated group to the Pfizer vaccine . This is a very effective vaccine.
14
68
370
I just found out I have the same birthday as Anthony Fauci. Happy birthday, Anthony
56
4
363
Interviewed on CNBC this morning regarding our
#COVID19
antibody cure. We discuss why a vaccine will take too long to avert the medical and economic crisis in 2020. Vaccines don’t work well in the elderly and immunocompromised. Thus we need an antibody.
18
116
335
Hacking comment. Nobody is hacking pharmaceutical companies to find out their vaccine/antibody secret recipe: the companies are already mostly sharing this information. The hacks are more likely to empower stock market movement prediction from trial result data.
14
68
335
We are COVID-19 antibody therapy experts. We have something that can help the president and his family immediately, as well as an affordable and mass-producible injectable antibody therapy to end the medical crisis in 2021. Join me live at 3PM PST.
27
85
335
Prior to the press release this week. here’s a recap of how
@centivax
and
@distributedbio
made our therapeutic antibodies against
#COVID19
The Quest for the Single Antibody to End the COVID-19 Pandemic:
@ourworldmag
@avaatresh
@CurlyJungleJake
10
69
176
38
96
335
The new B.1.1.529 strain out of South Africa has 15 mutations in the RBD where majority of neutralizing antibodies bind. The current vaccines and even Delta-based vaccines probably won’t work against this new strain. Swift, vigorous containment is needed.
163
128
339
Not real impressed with all these mask-off policies: I would have waited until we have the new generation of vaccines out and paxlovid widely available. Politics and economics, not science, are in the driver’s seat for this one.
33
60
329
Now would be a good time to check and make sure the rapid antigen tests actually work on Omicron
17
65
326
My first Father’s Day as a father. Spent the morning showing Seraphine bubbles and lighter flame tricks and blueberries. Trying to convince her that daddy is a sorcerer.
17
6
318
If you believe in democracy and the ideals upon which this nation was founded, today you need to stand, reach out to your neighbors, and reaffirm that commitment. My childhood was in the midst of a civil war in Guatemala - I don’t want to ever see that again.
11
25
329
I appeal to world institutions to immediately support monthly follow-up studies on
#COVID19
patients. Particularly their lung function, immune function, and comorbidity after illness. I’m not seeing enough of this and it’s essential that we track it.
7
85
323
Am I the only one that finds the outbreak modeling incomplete? I’m seeing a lot of “peak in mid-April” US modeling. That assumes shelter-in-place to reduce active cases and slow transmission, but what about the resurgence when people go back to work? I’m expecting waves - no?
50
73
318
Popped back onto social media after a break, and find that a Netflix documentary I was in (Pandemic: How to Prevent an Outbreak) has been nominated for an Emmy. Congrats to the production team!
30
23
327
I’ve seen two companies putting out devices that perform a
#COVID19
RNA test in 7 minutes for around $35/test. This seems to open up the possibility of venues that could check everyone at the gate and create a “tested bubble” of negative-test people. Boarding schools?
31
73
310
Fun fact:
@POTUS
currently has two antibodies currently flowing through his lungs and veins. One is from a Singaporean patient from early in the outbreak, and the other is from a mouse genetically engineered by Regeneron to make human antibodies.
33
102
304
@renaldipkesuma
Eat well sleep well relax and try to find some happiness - all are good for the immune system. Otherwise try not to be overweight, try not to be old and try not to be male - these will all count against you.
29
74
302
Early study results from two companies are showing that antibody therapies appear effective in protecting patients, lowering virus, and shortening hospital stays. This proves that mAbs work on coronavirus in people.
15
86
298
Here’s a cartoon representation of how we engineered the antibodies against the novel Coronavirus. I’d like to call out particular attention to Shahrad Daraeikia and Jack Wang who have been leading this work since…
23
86
290
Three things to hope come out of last 72 hours: 1) speedy recovery for
@POTUS
and others in cluster, 2) increased awareness of importance of antibody therapy, 3) increased awareness of and precautions to combat the seriousness of the coronavirus threat in USA.
37
57
301
“We should look to the future and make sure that we are solving the forever war against all future versions of Corona.” See our article about broadly neutralizing antibodies in MIT Technology Review
16
76
287
@elonmusk
Most likely scenario is that you were very recently infected with SARS-CoV-2, so that not all swabs are testing positive yet. Hit me up if you want to talk about treatment options.
21
7
281
@mrdavidhuddle
@haynesdeborah
@BritishArmy
They need to announce it so that if a British soldier over there gets captured, the Russians dont declare world war 3 by saying that UK is providing forces
7
5
270
Also, no one in 2021 is going to want to hear this, but an extremely effective thing we could do is a lockdown 2 months after vaccine campaigns are in full swing. This would reduce active cases while also slowing transmission by herd immunity: a regional eradication strategy.
41
37
277
Coronavirus update: NIH might have a vaccine in three months based on SARS research. We are making a bnAb in 8 weeks. Small molecule drugs might already have the solution: two drugs against other pathogens appear to work against this new virus.
21
107
269
Just voted. Please get all your friends and family to vote as well. If anyone has any questions about how to vote effectively and safely in the pandemic, please don’t hesitate to ask. I’m here to help.
16
10
275
Study at USAMRIID showing one of our antibodies protecting hamsters from
#COVID19
symptoms:
19
61
272
Una entrevista con Sarah Ives sobre nuestros anticuerpos contra COVID19
18
67
269
Old is good! Old is well validated. An amusingly titled but positive article about what we are up to. I better go call Fauci...
23
50
249
CDC mask recommendations seem premature by 2 months. We should prepare for another July 2020 scale wave. I wish CDC had waited until July 2021, or made their guidance regional based on local vaccination rates.
32
44
267
We will find treatments for COVID-19. Scientists all over the world are collaborating and coordinating to solve this. We are better and faster now than we were during Smallpox, AIDS, then Ebola. Small molecules, monoclonals, vaccines. We will find the missing medicine.
#covid19
15
62
254
Interview with
@TuckerCarlson
on
@FoxNews
regarding what antibody therapeutics are and why they are a critical path to economic recovery
34
67
241
@okmark5
“Candidate cure.” We need to run some validation tests, grow it up in big expensive batches, and then run a phase I/II human trial. Then we can release it.
18
35
236
The
@pfizer
vaccine reported as stored at -94C. Dry ice is -79.5C. I would strongly encourage a review of storage temperature requirements, as RNA should be equivalently stable at -79.5C and this would drastically simplify distribution.
@WhiteHouse
@ScottGottliebMD
@Transition46
12
41
261
Which nations of the world have
#bioreactors
and facilities suitable for therapeutic production of in
#CHO
? Which have bioreactors suitable for therapeutic production in bacteria? I need a comprehensive list. I have an idea...
37
99
249
Meet the team that is racing to a
#COVID19
cure and peek over our shoulders to watch us in near real-time as we fight to the finish line. .
18
59
250
Happy to report that I’ve just bought the Posada de Santiago from my parents - a 30 year Atitlan institution remains in family for third generation. Juanita Maria Quieju Ajanel continues as manager as I remain focused on
#Centivax
.
20
3
256
An image of what the biosafety containment labs look like at one of our collaborators for these live virus studies - spacesuits! (Image is from their website).
15
35
252
Dr. Fauci estimates we need 40M doses of mAb for USA. @ $5000/dose = 200 billion dollars. Making the medicine for $500/dose saves America 180 billion dollars and gets within a range where total government subsidy is possible (20B).
24
57
243