Craig A. Goodman
@CraigAGoodman1
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Senior Scientist that investigates the molecular mechanisms that regulate skeletal muscle mass and function in health and in various disease states
Melbourne, Victoria
Joined April 2019
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Why exercise builds muscles: Titin mechanosensing controls skeletal muscle growth under load
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Tracing the lactate shuttle to the mitochondrial reticulum
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A century of exercise physiology: key concepts in muscle energetics
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How the amino acid leucine activates the key cell-growth regulator mTOR
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For muscle devotees, here is an old book on the history of muscle physiology, spanning from the 6th Cent. BC to the mid 1700s. It's a dry, but interesting, read on the history and philosophy of medicine with an emphasis on muscle and movement. Not sure if still available.
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Skeletal muscle: A review of molecular structure and function, in health and disease
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Skeletal muscle undergoes fiber type metabolic switch without myosin heavy chain switch in response to defective fatty acid oxidation
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Increased mitochondrial surface area and cristae density in the skeletal muscle of strength athletes
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Eccentric muscle contractions: from single muscle fibre to whole muscle mechanics
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Mechanisms of Estrogen Influence on Skeletal Muscle: Mass, Regeneration, and Mitochondrial Function
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Molecular mechanisms of muscle contraction: A historical perspective
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Human skeletal muscle-specific atrophy with aging: a comprehensive review
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Molecular profiling of high-level athlete skeletal muscle after acute endurance or resistance exercise - a systems biology approach
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Autophagy gene expression in skeletal muscle of older individuals is associated with physical performance, muscle volume and mitochondrial function in the study of muscle, mobility and aging (SOMMA)
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Exercise mediates ubiquitin signalling in human skeletal muscle
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Need for Speed: Human fast-twitch mitochondria favor power over efficiency
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Infiltration of intramuscular adipose tissue impairs skeletal muscle contraction
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Resistance training diminishes mitochondrial adaptations to subsequent endurance training in healthy untrained men
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Sphingolipids accumulate in aged muscle, and their reduction counteracts sarcopenia
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This new pre-print from Clara Franzini-Armstrong is an amazing resource (download the suppl. files for images):
Muscle: 50 Years of Electron Microscopy
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Muscle wasting: emerging pathways and potential drug targets
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Mechanical compression creates a quiescent muscle stem cell niche
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A novel deep proteomic approach in human skeletal muscle unveils distinct molecular signatures affected by aging and resistance training
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Fat infiltration in skeletal muscle: Influential triggers and regulatory mechanism
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Physiology of intracellular calcium buffering
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Early Satellite Cell Communication Creates a Permissive Environment for Long-Term Muscle Growth
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Metabolomic analysis of skeletal muscle before and after strenuous exercise to fatigue
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Leptin mediates the regulation of muscle mass and strength by adipose tissue
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a new paper from
@JaesungYou
and
@HornbergerLab
: mTORC1 mediates fiber type-specific regulation of protein synthesis and muscle size during denervation
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Crosstalk between mechanotransduction and metabolism
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Mitochondrial dynamics maintain muscle stem cell regenerative competence throughout adult life by regulating metabolism and mitophagy
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Muscle physiology and its relations to the whole body in health and disease
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The anabolic response to protein ingestion during recovery from exercise has no upper limit in magnitude and duration in vivo in humans
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Remodeling of the human skeletal muscle proteome found after long-term endurance training but not after strength training
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Impact of Aging and Lifelong Exercise Training on Mitochondrial Function and Network Connectivity in Human Skeletal Muscle
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Proteomic and Transcriptomic Changes in Hibernating Grizzly Bears Reveal Metabolic and Signaling Pathways that Protect against Muscle Atrophy
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Glucose restriction enhances oxidative fiber formation: A multi-omic signal network involving AMPK and CaMK2
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Mitochondria-localized AMPK responds to local energetics and contributes to exercise and energetic stress-induced mitophagy
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Cellular and Molecular Pathways Controlling Muscle Size in Response to Exercise
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Downregulation of mitochondrial metabolism is a driver for fast skeletal muscle loss during mouse aging
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The Role of Autophagy in Skeletal Muscle Diseases
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Unraveling the causes of sarcopenia: Roles of neuromuscular junction impairment and mitochondrial dysfunction
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Peripheral limitations for performance: Muscle capillarization
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Automatic and unbiased segmentation and quantification of myofibers in skeletal muscle
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Single muscle fibre contractile function with ageing
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Very interesting - rapamycin not only inhibits mTOR but may also directly inhibit Stat3
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Defining roles of specific reactive oxygen species (ROS) in cell biology and physiology
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MCU genetically altered mice suggest how mitochondrial Ca2+ regulates metabolism
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Skeletal Muscle Transcriptomic Comparison between Long-Term Trained and Untrained Men and Women
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Hey
#myotwitter
- come to beautiful Melbourne this November & bring your research for 3 fantastic back-to-back muscle- and exercise-related events.
Follow the thread below for details.....
1/4
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Enhanced skeletal muscle insulin sensitivity after acute resistance-type exercise is upregulated by rapamycin-sensitive mTOR complex 1 inhibition
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Mechanisms and regulation of protein synthesis in mitochondria
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Simulated altitude is medicine: intermittent exposure to hypobaric hypoxia and cold accelerates injured skeletal muscle recovery
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Sex differences in skeletal muscle fiber types: A meta-analysis
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Regulation of adult stem cell quiescence and its functions in the maintenance of tissue integrity
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Mitochondrial involvement in sarcopenia
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Skeletal Muscle Extracellular Matrix – What Do We Know About Its Composition, Regulation, and Physiological Roles? A Narrative Review
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Muscle mitochondrial catalase expression prevents neuromuscular junction disruption, atrophy, and weakness in a mouse model of accelerated sarcopenia
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Our new
@AJPCellPhys
paper on the understudied polyamine pathway in skeletal muscle, expanding the potential mTORC1-regulated network that supports overload-induced protein synthesis and growth, with interesting regulation in denervation-induced atrophy.
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Mitochondria-SR interaction and mitochondrial fusion/fission in the regulation of skeletal muscle metabolism
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a potential link between lactate, muscle hypertrophy and muscle regeneration:
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Identifying the Structural Adaptations that Drive the Mechanical Load-Induced Growth of Skeletal Muscle: A Scoping Review
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Resistance exercise training and the motor unit
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Maintenance of muscle mass in adult male mice is independent of testosterone
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The TOR Pathway at the Neuromuscular Junction: More Than a Metabolic Player?
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AMPKα2 is a skeletal muscle stem cell intrinsic regulator of myonuclear accretion
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Effects of lactate administration on hypertrophy and mTOR signaling activation in mouse skeletal muscle
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mTOR at the nexus of nutrition, growth, ageing and disease
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AMPK as a mediator of tissue preservation: time for a shift in dogma?
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Mixing it up: the biological significance of hybrid skeletal muscle fibers.
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New Nature Review: Diet and exercise in the prevention and treatment of type 2 diabetes mellitus
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The Mechanisms of Muscle Mass and Strength Increase during Strength Training
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Interesting new Nature Review.
The effects of endurance exercise on the heart: panacea or poison?
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Age-related changes in human skeletal muscle transcriptome and proteome are more affected by chronic inflammation and physical inactivity than primary aging
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Muscle injury induces a transient senescence-like state that is required for myofiber growth during muscle regeneration
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Reactive oxygen species promote endurance exercise-induced adaptations in skeletal muscles
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Perturbed BMP signaling and denervation promote muscle wasting in cancer cachexia
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Age-related structural changes show that loss of fibers is not a significant contributor to muscle atrophy in old mice
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Powerpenia Should be Considered a Biomarker of Healthy Aging
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Human myotube formation is determined by MyoD-Myomixer/Myomaker axis
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Impaired proteostatic mechanisms other than decreased protein synthesis limit old skeletal muscle recovery after disuse atrophy
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Single skeletal muscle fiber mechanical properties: a muscle quality biomarker of human aging
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p53 regulates skeletal muscle mitophagy and mitochondrial quality control following denervation-induced muscle disuse
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The mTOR-Autophagy Axis and the Control of Metabolism
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See our new MCP paper that is the first to combine quantitative proteomics and ubiquitinomics with overexpression of an E3 ligase that leads to muscle atrophy (Asb2b). There are some fascinating changes to protein ubiquitination (see titin in graph below)
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Skeletal Muscle Adaptations Following 80 Weeks of Resistance Exercise in Older Adults
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Interesting new mTOR/muscle paper:
Mechanical Stretch Induces mTOR Recruitment and Activation at the Phosphatidic Acid-Enriched Macropinosome in Muscle Cell:
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The legacy of A. V. Hill's Nobel Prize winning work on muscle energetics
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Skeletal muscle hypertrophy rewires glucose metabolism: An experimental investigation and systematic review
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Ribosome profiling analysis of human skeletal muscle identifies reduced translation of mitochondrial proteins with age
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Time to Train: The Involvement of the Molecular Clock in Exercise Adaptation of Skeletal Muscle
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Piezo1 regulates the regenerative capacity of skeletal muscles via orchestration of stem cell morphological states
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The genetics of human performance
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Role of autophagy in aging: The good, the bad, and the ugly
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The effects of myosteatosis on skeletal muscle function in older adults
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Metformin and leucine increase satellite cells and collagen remodeling during disuse and recovery in aged muscle
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Differential impact of sex on regulation of skeletal muscle mitochondrial function and protein homeostasis by hypoxia-inducible factor-1α in normoxia
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