Structural Basis for Substrate Binding, Catalysis and Inhibition of Breast Cancer Target Mitochondrial Creatine Kinase by Covalent Inhibitor via Cryo-EM

Total syntheses of cyclohelminthol I–IV reveal a new cysteine-selective covalent reactive group

Highly Optimized CNS Penetrant Inhibitors of EGFR Exon20 Insertion Mutations

Discovery of STX-721, a Covalent, Potent, and Highly Mutant-Selective EGFR/HER2 Exon20 Insertion Inhibitor for the Treatment of Non-Small Cell Lung Cancer

Species Dependent Metabolism of a Covalent nsP2 Protease Inhibitor with in Vivo Anti-alphaviral Activity

Covalent Plant Natural Product that Potentiates Antitumor Immunity

CovCysPredictor: Predicting Selective Covalently Modifiable Cysteines Using Protein Structure and Interpretable Machine Learning

Identification of Novel Organo-Se BTSA-Based Derivatives as Potent, Reversible, and Selective PPARγ Covalent Modulators for Antidiabetic Drug DiscoveryClick to copy article link

Selective Protein (Post-)modifications through Dynamic Covalent Chemistry: Self-activated SNAr Reactions

Targeted Covalent Modification Strategies for Drugging the Undruggable Targets

N-Acyl-N-alkyl/aryl Sulfonamide Chemistry Assisted by Proximity for Modification and Covalent Inhibition of Endogenous Proteins in Living Systems

Selective Protein (Post-)modifications through Dynamic Covalent Chemistry: Self-activated SNAr Reactions

Hydralazine inhibits cysteamine dioxygenase to treat preeclampsia and senesce glioblastoma [@MegaMatthewsLab]

Chemoselective Stabilized Triphenylphosphonium Probes for Capturing Reactive Carbonyl Species and Regenerating Covalent Inhibitors with Acrylamide Warheads in Cellulo

Probing the Protein Kinases' Cysteinome by Covalent Fragments

Discovery of a Potent Triazole-Based Reversible Targeted Covalent Inhibitor of Cruzipain

Identification of Novel Organo-Se BTSA-Based Derivatives as Potent, Reversible, and Selective PPARγ Covalent Modulators for Antidiabetic Drug Discovery

Covalent Proximity Inducers