No evidence from RCTs is currently available to evaluate the benefits and harms of fluid restriction for the treatment of symptomatic PDA in preterm infants. We identified no ongoing studies.

@cochranecollab @CochraneLibrary @Cochrane_Child @VTOxfordNetwork @EBNEO @MBruschettini @CochraneSweden

The 2024 update of this review included 4 studies (464 infants); all studies evaluated acupuncture versus no treatment. Limited evidence on acupuncture for HIE in neonates. Link: #NeonatalCare #HIEResearch

Surfactant therapy guided by tests for lung maturity in preterm infants. Listen to this new podcast by Mike Clarke, with two study authors (@GretaSibrecht @BorysFranciszek) and lead investigator for one of the ongoing studies (Anna Lavizzari).

RT @cochranecollab: Cochrane reviews are informing @WHO guidelines for preterm infant care! 👶✨ Evidence from @CochraneSweden & @CochraneNeo…

Cochrane update NCPAP may be more effective than no CPAP in preventing extubation failure in preterm infants if applied immediately after extubation We consider there is no need for further research on this intervention, which has become standard practice

RT @AAPneonatal: This year’s #SONPM2024 Thomas E Cone Lecture at NCE is being given by Dr. Kanekal Gautham @Dr_KSGautham from @Nemours and…

Podcast: Medicines to reduce pain and discomfort during spinal tap in newborns @cochranecollab @ORomantsik @MBruschettini @Cochrane_Child @CochraneLibrary @VTOxfordNetwork

Donor human milk reduces the risk of NEC in very preterm infants: RR 0.53, 95% CI 0.37 to 0.76; RD −0.03, 95% CI −0.05 to −0.01; 11 trials, 2261 infants Probably little or no effect on late‐onset invasive infection or mortality before hospital discharge

Methodological considerations by @CochraneNeonate members when conducting systematic reviews: Should "objective outcomes" (e.g. bronchopulmonary dysplasia) be downgraded for lack of blinding in randomized trials? @cochranecollab @EBNEO @cochranemthds

This review compared different strategies for caffeine cessation in preterm infants: - different PMAs - before or after 5 days without symptoms - at a predetermined PMA vs at symptoms resolution Findings of larger & just completed RCTs to be included soon

RT @CochraneLibrary: Sound in #neonatal intensive care units often exceeds the recommended max acceptable level👶 👂 What are the benefits &…

This review included 3 types of intervention: 1) intervention at the unit level, 2) at the section or room level, or 3) at the individual level. The included study compared the use of silicone earplugs versus no earplugs in very low birth weight infants.

Transcutaneous bilirubin screening: - may reduce readmission for hyperbilirubinemia and increase need for phototherapy before discharge - probably has little or no effect on exchange transfusion and acute bilirubin encephalopathy (1 RCT; 1858 newborns)

Exposure to the smell and taste of milk with tube feeds may have little to no effect on time to reach full sucking feeds and full enteral feeds. No clear difference between exposure and no exposure to the smell or taste of milk on safety outcomes.

Despite the increasing use of dexmedetomidine, there is insufficient evidence supporting its routine use for analgesia and sedation in newborn infants on mechanical ventilation. Furthermore, there are no data available on its long‐term effects. Link ⤵️

To evaluate the effects of nasal high‐frequency ventilation compared to invasive ventilation via an ET tube or other non‐invasive ventilation methods in preterm and term infants with or at risk of respiratory distress. This review included 33 RCTs ⤵️

RT @CochraneLibrary: @MBruschettini @drbretty It is important to still publish reviews which include only one study (or no studies) to show…

Late systemic administration of dexam. is considered an effective intervention to reduce the risk of BPD in infants with a high risk profile for BPD. Endotracheal instillation of budesonide with surfactant as a carrier is a promising intervention.