Cardiac Trials
@CardiacTrials
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Simplified landmark cardiology trials app 📱 by @JSharimMD. Mission: to spread evidence-based medicine worldwide 🌎
Joined March 2022
Just a Sunday perusing the Cardiac Trials app📱😎 (sound on 🎶)
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AIM-HIGH negated this hypothesis, and was later confirmed by HPS2-THRIVE (2014), establishing low HDL as a risk marker for increased CV risk, but without demonstrable benefit in raising HDL 📚
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Improving mortality in coronary artery disease with PCI? This landmark trial was one of the first to suggest that in the absence of acute coronary syndrome, PCI improves symptoms alone — WITHOUT mortality benefit. COURAGE Trial, NEJM 2007 ♥️
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Niacin for hyperlipidemia? We know it to raise HDL — but do we see a positive effect, clinically? Beyond being poorly tolerated, this trial showed NO clinical benefit to niacin. Clinical trials — equally important in showing us what does NOT work. HPS2-THRIVE Trial, NEJM 2014 ♥️
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Riociguat for pulmonary arterial hypertension? This pulmonary vasodilator (via potentiation of the nitric oxide pathway) has shown benefit for both PAH and CTEPH (groups I and IV pulmonary hypertension). PATENT Trial, NEJM 2013 ♥️
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DOACs for rheumatic atrial fibrillation? This trial showed INCREASED mortality and stroke/thromboembolism when compared to warfarin, our standard of care. A trial in support of current guidelines for vitamin K antagonism in this population. INVICTUS Trial, NEJM 2022 ♥️
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RT @CardiacTrials: 6 weeks of IV antibiotic for endocarditis? This trial converted endocarditis patients to oral antibiotic, tearing at the…
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CAC staging to guide interventions - a proposed algorithm, JACC Advances 2024 ♥️
Reminder: an elevated coronary artery calcium score on CT is not a risk factor for coronary artery disease. …it IS coronary artery disease.
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The conclusions of this trial were corroborated by the TOMAHAWK Trial, published two years later (also included in the Cardiac Trials app 📱👇)
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RT @JSharimMD: Reminder: an elevated coronary artery calcium score on CT is not a risk factor for coronary artery disease. …it IS coronar…
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Mitral m-mode, with integrative physiology and echo 📚 Sunday cardiology #fundamentals in ✌️ diagrams
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Why do we give statins to patients with coronary artery disease? Where does this data originate? This landmark historic trial — dubbed the king 👑 of statin trials — was the first to definitively show the profound life-prolonging effects of statins. 4S Trial, Lancet 1994 ♥️
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Acetazolamide for decompensated heart failure? Carbonic anhydrase inhibitors like acetazolamide block renal reabsorption of sodium bicarb, leading to ⬆️ natriuresis. This landmark trial showed faster achievement of euvolemia with acetazolamide added. ADVOR Trial, NEJM 2022 ♥️
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6/ Routine beta blockade for acute MI with preserved EF? Standing in stark contrast to historic pre-PCI era beta blocker trials, this landmark trial showed NO outcomes difference — calling into question other “accepted” practices in the modern era. REDUCE-AMI Trial, NEJM 2024 ♥️
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RT @CardiacTrials: Preventing remodeling after myocardial infarction? One of the first randomized trials to show RAAS inhibition to preserv…
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