Check out our new paper on the synthesis of spirooxindoles (and a few other azacycles) using an acetylene surrogate. We can also derivative the resulting alkene in a few interesting ways. It was amazing to work with Xavier and Bianca on this project!

@Longlarf I would refer to this as a parallel kinetic resolution. Each enantiomer in this case goes to a unique product.

@MannDelany I love when compounds are foams 🙃

RT @CorinWagen: Inspired by @owl_poster, I wrote a post about why robotics alone won't solve the synthesis bottleneck in organic chemistry.…

Who knew the old sodium hydride + methyl iodide could be improved upon! This is a particularly nice alkylation strategy for more sensitive substrates. I love to see methods to improve upon classically "simple" transformations.

RT @MarkLautens: Great news today at @chemuoft @UofT @UofTArtSci as two colleagues are recognized by the @AmerChemSociety @andrei_yudin a…

Oxygen walking seems pretty sweet to access these C-3 oxygenated pyridines. It's also pretty cool to see the formation of a Dewar-type lactam from the C-2 byproduct. Another banger from the Qin group.

RT @Cam1stry: Delighted to be able to share a short review that @LaurelSchafer and I wrote regarding direct C-H bond functionalization of S…

Stunning work out of the Rawal group. I have no doubt that this is going to see quite a bit of adoption in the total synthesis community.

RT @thiemechemistry: ❇️ In this Synfact of the month Mark Lautens (@MarkLautens) highlighted the ‘Terminal C–H Borylation Enabled by Visibl…

@awhspeed I’m personally a huge fan of any of Heathcock’s biomimetic daphniphyllum alkaloids syntheses. Most of the steps aren’t too crazy leading up to the cascade and really highlight Heathcock’s foresight.

This is absolutely brilliant way to access meta-phenols. Looking forward to see what comes out next from the Lumb Group!

RT @hanzyduzit: @zohanchao is on a roll with his paper #2 in as many weeks. Now up on @JOC_OL

@shawshankrxn Was there any luck using any of Christina White’s C-H hydroxylation catalysts?

@aplooby28 I'm not sure how good the Wolff rearrangement d.r. would be, but it could a reasonably cheap way to access this compound.

RT @hanzyduzit: A quick little manuscript here where we developed a one-pot method to synthesize a key amino acid motif found in amanitin –…

RT @J_A_C_S: Boronic Acid-Catalyzed Regio- & Stereoselective N-Glycosylations of Purines & Other Azole Heterocycles: Access to Nucleoside A…

@tnoel82 @ScienceMagazine Beautiful work! Congratulations!

RT @RovisGroup: Forming tertiary carbanions from primary amines?? No problem! Check out our latest in ACIE for a reductive radical polar cr…

RT @TheLautensGroup: If you are interested in C(sp3)-H activation with Nickel, check out our latest review in #Synlett. A special issue ded…

RT @J_A_C_S: From the Glovebox to the Benchtop: Air-Stable High Performance Molybdenum Alkylidyne Catalysts for Alkyne Metathesis | Journal…