Bukau Lab
@BukauLab
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Our research group @ZmbhH is interested in protein biogenesis and quality control. This account is run by the members of the @BukauLab.
Heidelberg
Joined October 2020
Our first 2021 paper reveals the prevalence and mechanism of a co-translational protein assembly mechanism in human cells: co-co assembly. Congratulations to the co-co team @KaiFenzl, @matildebertolin and @guenter_kramer! @Sciart by @munafomarzia 1/6
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RT @MelnykAndrij: What shall Germany deliver next? A good question posed by @faznet, thanks šš» Well, the answer is obvious: Ukraine desperā¦
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Our team will combine advanced ribosome profiling, cryo-EM and single-molecule experiments, to study how multiple ribosomes, mRNAs, nascent chains, chaperones and other factors form dynamic super-assemblies that act as coordinated protein complex assembly lines.
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Hier eine schƶne Allegorie wie das von @LabJoazeiro und @PfefferCryoLab beschriebene MutS2 Protein fehlerhafte Proteinbiosynthese anhand kollidierter Ribosome erkennt und verschiedene QualitƤtskontrollmechanismen initiiert bevor das fehlerhafte Protein der Zelle schaden kann.
Auffahrunfall auf der āRibosomen-Autobahnā: Wissenschaftler identifizieren bakterielles Protein, das āstehengebliebeneā Ribosomen erkennt und rettet @ZmbhH
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RT @PfefferCryoLab: How do cells fire up the #RQC engine? Check out our structural and mechanistic blueprint for bacterial #ribosome collisā¦
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B. subtilis MutS2/RqcU deals with stalled ribosomes by binding collided disomes, recruits the RNA degradosome and initiates #RQC by #ribosome splitting. Happy we could contribute to this work led by @LabJoazeiro in collaboration with @PfefferCryoLab
A team of researchers led by ZMBH's PIs C. Joazeiro @LabJoazeiro and S. Pfeffer @PfefferCryoLab discovered how the bacterial MutS2 protein prevents damage by stalled ribosomes! Further details in Nature
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@DellaDavid_Lab @BabrahamSignal1 @BabrahamInst This is wonderful, Della. Have a great start in your new lab
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RT @ZmbhH: A new study by the @bukaulab in @CellReports sheds light on role of Nt acetylation in eukaryotes
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@bioSavinov Hi Andrew, that's a good question! Indeed, our method may enrich for more stable interactions which survive the purification procedure. Some additional work in the lab suggests we are not missing many disomes by DiSP, but it is definitely worth further investigation :)
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@AChemSynBio Thanks Abhishek, glad you enjoyed our work! That's a good question, some heteromeric subunits are indeed hits of our screening, but they await deeper investigation!!
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Congratulations to our colleagues @ZmbhH for the great work!!
How do you synthesize proteins with only half a ribosome? We are excited to share our work on the structural basis of Alanine tailing in bacterial ribosome-associated quality control (RQC). Great collaboration with @LabJoazeiro @ZmbhH.
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RT @lab_rosenzweig: PNAS selected our joint work with @BukauLab on the mechanism of fiber disaggregation to be highlighted on their journalā¦
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