Biology of Sex Differences
@BiologySexDiff
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BSD is the journal of the Organization for the Study of Sex Differences ( @OSSDTweets ) and a publication of the Society for Women's Health Research ( @SWHR ).
Joined June 2011
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Pinned Tweet
Highlights from the “Hot Topics from Biology of Sex Differences”
@BiologySexDiff
panel at
#OSSD2024
:
@SWHR
@OSSDtweets
1
3
5
New article: Contrasting with other studies in rhesus monkeys, this study suggests that the previously documented
#sexdifferences
are likely context dependent – questioning the existence of a strong
#biological
basis to sex differences in toy preferences:
6
46
129
This
@NYTHealth
article explores why placental health is critical to the health of a pregnancy and cites a
@BiologySexDiff
paper that found 58 genes that are expressed differently in female and male fetuses during the first trimester.
#sexdifferences
4
55
101
#Women
have historically been underrepresented in
#biomedicalresearch
. This
#WomensHealthResearch
Day presents an opportunity to raise awareness of the importance of
#sexdifferences
research & inclusive health research for women. How are you celebrating
#WomensHealthResearchDay
?
5
31
105
How do you determine whether to consider and analyze for sex & gender in your research? Check out these decision trees presented by
@cara_tannenbaum
at
#OSSD2021
.
@OSSDtweets
1
30
51
This new review examines the role of
#androgens
in modulating the HPA axis & contributing to
#SexDifferences
in stress responses. Research into androgen mechanisms may provide insight into sex disparities in stress-related
#MentalHealth
issues.
@zuloagalab
0
12
47
Letter in
@Nature
by
@OSSDtweets
leadership on the debate around
#sexdifferences
in the brain: "Sex is a biological variable — in the brain too"
#SABV
1
20
43
How could sex as a biological variable impact
#COVID19
outcomes?
@sabraklein1998
lays out ways in which
#SABV
could play a role, including how the virus enters cells and
#sexdifferences
in innate and adaptive immune responses.
#OSSD2021
@OSSDtweets
0
14
40
Check out the article by
@ShanskyLab
&
@AnneZMurphy
calling for "a cultural & structural change in how we conduct research and evaluate scientific progress" to improve consideration of
#SABV
:
#OSSD2021
@OSSDtweets
0
19
40
Women experience adverse drug reactions nearly 2x as often as men & new research in
@BiologySexDiff
shows
#sexdifferences
in drug pharmacokinetics strongly predict sex-specific adverse reactions for women.
@OSSDtweets
1
16
34
New article: Despite mounting recognition of the importance of sex consideration in the
#biomedical
fields, male- and female-specific metabolic signatures have not been identified. This review focuses on the
#metabolic
differences related to sex:
0
12
36
New article: Authors hypothesized that the sex chromosomes (XX and XY) interaction with testosterone plays a role in arterial stiffening, based on the understanding that sex
#hormones
&
#chromosomes
play a vital role in cardiovascular disease. Read more:
1
13
35
Studying
#sexdifferences
continues to help improve our understanding of basic biological principles & foster development of therapeutic and diagnostic tools that are sex-specific. As the year closes, take a look at some of the most accessed articles on the BSD site:
1
6
32
While
#sexdifferences
in
#COVID19
are increasingly recognized globally, how sex differences shape immune responses to COVID-19 remains understudied. Researchers examined sex differences in the immune response to COVID-19. Read the new article:
0
11
33
BSD is seeking primary
#research
or review articles addressing
#sexdifferences
in development influenced by environmental, social, genetic, hormonal, other biological factors, for the "Sex Differences in Development" collection. Submissions due Dec 1 2022:
0
19
32
New review in
@BiologySexDiff
examines the latest evidence for gender &
#sexdifferences
in
#COVID19
and discusses potential sex-specific mechanisms modulating the course of disease.
@sabraklein1998
@RosemaryJMorgan
@OSSDtweets
3
20
33
This highlights the clear imbalance in
#SABV
represented in research.
1
6
31
New article: Sex differences in the human brain are a reality. Reproducible sex-based group differences in regional brain volume discussed here. More work needed to understand causes and functional consequences
@AlexDeCasien
@bogglerapture
@elisa_guma
:
0
12
29
Twice as many women suffer from major depressive disorder than men, but the underlying mechanisms of
#depression
&
#sexdifferences
in these mechanisms are poorly understood. This paper reviews what is known & what research is needed to address these gaps.
0
21
29
New article: Authors investigate potential sex differences in glutamatergic transmission within the medial prefrontal cortex (mPFC) with the goal of determining if there are baseline
#sexdifferences
in transmission and
#diseases
:
0
3
28
In "Sex Differences in the Trajectories of Cardiovascular Risk in Midlife," Dr. Samar El Khoudary reminds us normal
#bloodpressure
for men is not always the same as normal BP for
#women
, raising the question of if we should have different BP measurements for women.
#OSSD2022
1
6
28
Founded in 2010 to focus on all aspects of
#sexdifferences
, BSD remains unlike any other scientific journal as it works to improve understandings of sex differences & foster development of sex-specific tools. For
#WomensHistoryMonth
, check out some of BSD's earliest articles:
1
11
28
"Studying
#SexDifferences
requires nuanced approaches and considerations to ensure successful transition of the
#SABV
mandate into fruitful discovery." Read more from
@LiisaGalea
@FSohrabji
@arianneyka
@PegMcC
:
1
12
27
It's our Twitter anniversary! Help
@BiologySexDiff
get to 1,000 followers in honor of this milestone! We hope you will encourage your friends to follow us for the latest research on
#sexdifferences
!
#MyTwitterAnniversary
@OSSDtweets
0
14
26
Earlier this month
@ShanskyLab
and
@AnneZMurphy
published a piece in
@sciam
outlining the need for journals to incorporate more guidelines on
#SABV
justification while reporting research.
0
10
27
"Liisa Galea says that funding specifically for women’s health would draw more researchers’ attention to the area. 'If you put a pot of gold at the end of a funding rainbow, researchers are going to go for it.'"
@OSSDtweets
@LiisaGalea
Read more in
@Nature
for
#WomensHealthMonth
0
4
25
Monday is the start of
@OSSDtweets
virtual meeting! Register for 4 days of lectures, symposia, and poster presentations on various aspects of
#SABV
research.
0
14
25
Dr. Karyn Frick, Dr. Kristen Zuloaga, Dr. Rachel Buckley, & Dr. Paulo Pires presented their research during the "Endocrine aging and novel hormone therapies: impacts on physiology and the brain" session
#OSSD2022
2
1
25
#Cardiovascular
disease differs in women & men, likely due in part to genetic & molecular
#sexdifferences
in cardiac remodeling. This
@BiologySexDiff
review summarizes what we know about sex differences in remodeling & role of sex hormones like estrogen.
0
13
23
A study examining the influence of sex on expression of essential mitochondrial proteins in mice concludes that both sex & age are important parameters that should be considered by researchers studying the mechanistic aspects of diseases.
#SexDifferences
0
9
24
A new study shows distinct
#sexdifferences
in the composition of the
#gut
#microbiota
in mice, which may be associated with the different sensitivities of male & female mice to metabolic disorders in response to a high-fat diet.
#microbiome
0
5
24
Jill Becker,
@women_neurosci
, from the Molecular and Behavioral Neuroscience Institute at University of Michigan, opened her “Sex differences in addiction” presentation by explaining
#sexdifferences
are not strictly a bimodal distribution.
#OSSD2022
1
6
24
New research finds that in healthy neuronal cells, androgens & estrogens appear protective against oxidative stress insults, but in unhealthy cells, sex hormones have negative effects on cell viability by exacerbating oxidative stress-induced cell loss.
0
6
22
"Women have a higher incidence of stress related disorders including
#depression
and generalized
#anxiety
disorder, and epigenetic mechanisms likely contribute to this
#SexDifference
," these 2013 authors write. Read more this
#StressAwarenessMonth
:
0
8
23
"Ignoring sex as a biological variable discards potentially valuable insights into the clinical evidence of gender bias in disorders of the brain,"
@PegMcC
writes in
@PsychToday
blog post exploring the debate around
#sexdifferences
in the brain.
#SABV
0
5
20
New article: Authors "aimed to determine if
#menopause
worsens cognitive impairment in vascular contributions to cognitive impairment and dementia." They hypothesized menopause causes metabolic dysfunction & increases cognitive impairment in a mouse model:
0
8
22
Women and men are suggested to have different vulnerabilities to
#neuropsychiatric
disorders. This 2022 review explores
#sexdifference
& gut microbiota interactions in neuropsychiatric disorders. Read on this
#MentalIllnessAwarenessWeek
#MIAW
, October 3-7:
0
13
22
"Neuroscientist Liisa Galea is not surprised by the findings of Mirin’s study on funding for women’s health. 'Unfortunately it is really undervalued, understudied,'" writes
@Nature
.
#WomensHealthMonth
@OSSDtweets
@LiisaGalea
0
7
22
Save The Date! Join Biology of Sex Differences Editor-in-Chief Jill B. Becker, PhD
@women_neurosci
and
@SWHR
for a free webinar on June 5 all about
#SABV
and elevating
#SexAndGender
in publishing academic research. Register today:
0
13
20
Read a profile on our new Editor-in-Chief, Dr. Jill Becker (
@women_neurosci
). Dr. Becker joins us with +30 years of experience in
#SABV
neuroscience research. She was a founding member of
@OSSDtweets
and was honored for her work last year by
@SWHR
!
0
3
21
A new
@BiologySexDiff
meta-analysis suggests that carrying a male fetus is accompanied with a higher cardiovascular and metabolic load for the mother, resulting in maternal
#pregnancy
complications and adverse health in later life.
#sexdifferences
1
13
20
"The
#research
in this journal is part of the knowledge we need to treat
#women
as well as we can—and to treat men better too," said Biology of Sex Differences editor-in-chief Dr. Jill Becker
@women_neurosci
. Read more on
@SWHR
's blog:
#sexdifferences
1
3
19
Drs. Alisa Clyne (
@Clyne_Lab
), Chyren Hunter of
@NIH_ORWH
, Aditi Bhargava of
@UCSFHospitals
, and Rebecca Shansky (
@ShanskyLab
) contributed to a piece on
#sexdisparities
lab rats. We are excited to see
#SABV
being included in more popular science articles!
2
7
18
Congratulations
@amy_inkster
— winner of the
@BiologySexDiff
Best Poster Prize at the
@OSSDtweets
annual meeting for her poster on sex-specific patterns of autosomal DNA methylation in the human placenta. Keep an eye out for an upcoming blog on her work!
0
5
17
At
#OSSD2021
,
@cara_tannenbaum
kicks off the first session sharing the story behind the publication of this important
@nature
perspective explaining the importance of considering sex and gender in research:
@OSSDtweets
0
8
18
New article: Authors here developed a scoring system to evaluate the inclusion of biological sex in manuscripts published in
#Diabetes
, a journal published by the American Diabetes Association. Read the findings:
1
5
19
Congrats to Dr. Jill Becker, who has spent her career working to understand how
#sexdifferences
impact brain health & treatment. Learn more about her groundbreaking work in this video!
@women_neurosci
@OSSDtweets
#SWHRat30
: Congratulations, Dr. Becker, SWHR's Health Education Visionary Award Winner!
#WomensHealth
#SexDifferences
2
13
53
0
3
18
New article: Authors argue including the
#estrouscycle
variable in
#research
is important to enhance the resolution and quality of the data, to advance the health of
#women
and other
#menstruators
, and to make research more
#genderinclusive
. Read on:
0
7
18
#Women
show greater pathological Tau biomarkers than men in the
#AlzheimersDisease
continuum. Researchers examined
#testosterone
levels in 2020 to see if sex
#hormones
play a role. Read more during
#AlzheimersAndBrainAwarenessMonth
this June:
#ENDALZ
0
8
17
Female participants have historically been excluded from studies based on the idea that ovulatory cycle introduces variability. Researchers at
@UCSanDiego
found results that negated this notion using data from a population at
@NEIU
.
#SABV
Read more:
0
4
17
Men tend to have lower rates of hand washing, social distancing, and mask wearing, says
@RosemaryJMorgan
at
#OSSD2021
. Men are also less worried about
#COVID19
than women.
#gendergap
@OSSDtweets
0
5
17
The
@OSSDtweets
2024 Travel Award categories are now open! The OSSD currently offers numerous awards to trainees, with the goal of supporting a diverse attendance at the annual meeting in May. Check out the awards and apply today:
0
11
18
When
@women_neurosci
began working, the brain was thought to be the same in men &
#women
. Over time, she's seen
#sexdifferences
research gain prominence, recognition, & funding. Read about Dr. Becker's journey for
#InternationalWomensDay
, on
@SWHR
's blog:
1
5
17
0
7
17
This work sought to improve antidepressant efficacy in
#postpartum
rats. Researchers did this through immune signaling, focusing on the
#hippocampus
and studying
#anakinra
and
#fluoxetine
in combination.
@rominagl4
#OSSD2022
1
2
16
Female lung adenocarcinoma patients (LUAD) (a subtype of
#lungcancer
) have a higher incidence but better long-term survival rate than males, with unknown reasons. A new study aims to identify prognosis-related genes for patients of different sexes:
0
4
16
In case you missed it: We have a new Editor in Chief, Dr. Jill Becker!
@women_neurosci
Dr. Becker is a pioneer in
#SABV
research, & is a founding member of the Organization for the Study of Sex Differences (
@OSSDtweets
). Read more on Dr. Becker:
0
2
17
Study shows older men w/ APOE4 allele may be more vulnerable to cognitive decline after surgery & anesthesia than older women w/ APOE4, building on prior research indicating APOE4 has sex-based health implications that may affect treatment.
#sexdifferences
1
10
15
The
#SABV
101 Workshop's "Sex differences in drug response" presentation by Karen Reue, University of California, explored
#sexdifferences
in
#statin
use. “I’ve spoken about the effects of one drug, but I hope these findings will be helpful for other drugs," Reue said.
#OSSD2022
1
3
16
What a great group!!
#OSSD2023
@OSSDtweets
Thank you again to Dr. Jill Becker
@women_neurosci
for hosting, and to all speakers for an exciting and informative discussion during this “Hot Topics from Biology of Sex Differences Session”!
@UTHealthHouston
@KundakovicLab
@SBS_UNTHSC
@WWU
@BiologySexDiff
#OSSD2023
0
1
4
1
3
15
Women w/
#Alzheimers
tend to have higher Tau levels than men, especially
#APOE4
carriers.
@BiologySexDiff
study suggests women's usually lower
#testosterone
may predispose them to Tau & contribute to AD's higher prevalence/more aggressive profile in women.
0
7
16
.
@OSSDtweets
recognized their
#OSSD2022
Award winners this evening. Awardees included:
2022
@NIH_ORWH
Policy Travel Award Winners:
Laura Pritschet, University of California, Santa Barbara
Jillian Scheer, Syracuse University
1
2
15
Despite the importance of sex &
#gender
considerations in
#healthresearch
, they are rarely integrated into
#researchdesign
and reporting. This assessment of the inclusion of sex and gender in published reporting guidelines showed low use rates:
0
10
15
In this article for
@NatureBiotech
,
@CarolineSeydel
highlights the importance of
#SABV
in clinical research, and how failure to analyze
#sexdifferences
may hinder drug development for
#Alzheimers
,
#PTSD
,
#Depression
, and other neurological conditions.
1
10
15
Inhibiting glutamatergic neurons in the
#hippocampus
increases negative cognitive bias in
#females
but reduces it in males. But there are no other
#sexdifferences
in neural activity.
@anamchuk
@TravisEHodges
@LiisaGalea
#OSSD2022
1
2
14
#DYK
Biology of Sex Differences is the official journal of
@OSSDtweets
? OSSD strives to facilitate interdisciplinary
#research
on
#sexandgender
differences at all levels of biological organization, among other goals. Follow OSSD today to learn more.
0
8
15
New article:
#Females
are more likely to present with
#anxiety
disorders such as PTSD compared to males. Authors examined
#sexdifferences
in contextual pattern separation, functional connectivity, & activation of new
#neurons
during fear memory:
0
8
15
New review by
@sabraklein1998
&
@RosemaryJMorgan
: "There is a critical need for research that addresses the biological (i.e., sex) as well as sociocultural (i.e., gender) causes of male-female disparities in
#immunotherapy
responses, toxicities & outcomes"
0
14
15
New research in animals describes a novel potential mechanism through which
#dopamine
may be modulating
#SexDifferences
in vulnerability to
#stress
- and
#depression
-related behaviors.
0
6
15
During the Equity, Diversity and Inclusion Workshop,
@OSSDtweets
’s EDI Committee discussed what
#DEI
means to the work of OSSD and its members. The audience discussed
#diversity
challenges & opportunities in scientific literacy, resource access, mentorship, and more.
#OSSD2022
1
2
13
New study finds
#sexdifferences
in effects of a hormonal treatment in obese mice, beginning to fill a gap in knowledge caused by previously studying only male subjects.
#SABV
0
7
14
Biology of Sex Differences is calling for submissions to our Collection on Sex Differences and Similarities in the Human Brain! Due Dec 2023.
Topics may include structural and functional sex-based divergences, behavior, neurological disorders, etc.
0
18
14
New review looks at key
#sexdifferences
in gut
#microbiome
interactions with four primary determinants of cardiovascular disease: impaired glucose regulation, dyslipidemia, hypertension, and obesity.
@alexrazavi
0
4
13
0
5
13
Celebrate
#InternationalDayofWomenandGirlsinScience
by learning more about how
@BiologySexDiff
's editor-in-chief Dr. Jill Becker
@women_neurosci
discovered her love of
#neuroscience
and made it to her current role, on the
@SWHR
blog:
#WomenInScience
1
2
14
Check out takeaways from Laura Pritschet's presentation "The Scientific Body of Knowledge – Whose Body Does It Serve? Factoring women’s health into human brain imaging" in the thread below.
@laura_pritschet
@NIH_ORWH
#OSSD2022
The
@NIH_ORWH
Science Policy Scholar Travel Award was established in 2019 with the goal of creating change in policy related to
#womenshealth
& supporting junior investigators attending
#OSSD2022
.
Laura Pritschet, UCSB, is attending with the Travel Award this year.
1
1
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0
2
13
Hey
#SfN19
attendees: Are you looking for a great open-access journal to publish your
#SexDifferences
research? Submit to
@BiologySexDiff
— the premier journal focused on sex differences in physiology, behavior, & disease.
#sfn2019
@Neurosci2019
@SfNtweets
1
4
13
A new review highlights in vitro work studying
#sexdifferences
& the role of sex steroids in shaping mammalian neural stem cell biology, showing the novel role of sex steroid hormone influence in early brain development & throughout adulthood.
0
8
13
Learning from the past can help futher our work in researching
#SABV
!
Here is an interesting tidbit of
#SABV
history that gets less discussed. From the turn of the 20th c to the 1960s, sex in animal was not reported. Then a rapid switch to male dominance. That male-only studies were near 0 prior to then suggests it was males the whole time.
2
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0
5
12
Have you saved your seat for this
#SexAndGender
webinar?
Join Biology of Sex Differences Editor-in-Chief Jill B. Becker, PhD
@women_neurosci
and
@SWHR
for a free webinar on June 5 all about
#SABV
in publishing academic research. Register today:
0
8
13
Research has shown that women w/ the APOE4 allele are at greater risk for developing
#Alzheimers
than APOE4+ men. Surprisingly, a new study shows the APOE4+ men demonstrated worse cognitive decline than the women after exposure to surgery & anesthesia.
1
12
13
This new report validates an animal model of increased binge intake and higher motivation to seek & consume sugar in
#women
. Further studies may inform sex-specific treatment strategies for disordered eating and other conditions like substance use disorder
0
6
13
New article: Literature is mixed on the effects of biological (birth-assigned sex (BAS), sex hormones) and socio-cultural (gender identity, gender roles, sexual orientation) factors. Authors assessed the influence of sex
#hormones
on cognitive performance:
1
6
12
New research in rats examines gene expression profiles of
#PTSD
-relevant tissues (blood, amygdala & hippocampus) to identify sex-specific and shared mechanisms associated with individual differences in response to recent
#trauma
exposure.
#sexdifferences
0
6
13
Males and females are clearly different on many aspects of
#muscular
health and physiology, and these
#SexDifferences
can greatly influence the development and progression of various muscle atrophies. Learn more in this review article.
1
8
13
New article: Researchers conducted a parallel study to evaluate
#sexdifferences
in postprandial appetite ratings and
#ghrelin
concentration. Findings may be important for nutritional strategy to prevent and treat
#obesity
and eating disorders:
0
8
13
Attention
#SexDifferences
researchers! Don't forget to check this out.
@OSSDtweets
Today is the first day that
#biomedical
researchers can apply for NIH's first sex- and gender-focused R01 grant!
@NIH
hopes to award up to 7 grants totaling $3 million over the next 2 years.
#sexdifferences
1
15
22
0
6
12
New study shows female rats have a significantly larger number of neurons that produce a hormone involved in protecting an organism from stress in a brain area implicated in anxiety and fear.
#sexdifferences
0
7
12
We are excited to welcome Dr. Jill Becker (
@women_neurosci
) as our new Editor-in-Chief! Read more below about Dr. Becker's background and some of her work in
#sexdifferences
research.
@OSSDtweets
@SWHR
#SABV
0
1
13
Learn more about future outlooks and opportunities for engagement with
@BiologySexDiff
at this talk with our Editor in Chief, Dr. Jill Becker . You do NOT have to be a member to register (follow instructions on page).
#SABV
@OSSDtweets
Register below:
1
7
12
Hormonal and genetic mechanisms are implicated in
#sexdifferences
in
#migraine
@Morgan_Fitz_
#OSSD2022
0
3
11
Registration is NOW OPEN for the Organization of the Study of Sex Differences 2019 annual meeting, taking place May 5-8 in Washington, DC. Check out the event lineup and register today!
@OSSDtweets
#sexdifferences
0
9
12
New article: Authors focus on the interaction between
#SexHormones
and the gut
#microbiota
– in particular, its role in gut barrier integrity, inflammatory status, and the gut–brain axis, with relevance in the development of metabolic diseases:
0
5
12
Thank you
@OSSDtweets
for a wonderful Annual Meeting this week! We loved hearing all about the work being done & opportunities to advance
#sexdifferences
research.
Sign up for article alerts from
@BiologySexDiff
to get the latest on sex differences:
0
2
12
New article: Authors found "genes associated with key biological pathways including cell proliferation, immune response and drug metabolism are differentially regulated between males and females in both healthy lung tissue and tumor."
0
6
12
New article: Authors examined
#SexDifferences
in synaptic plasticity & excitatory transmission in nucleus accumbens, which may explain "potential mechanisms driving behavioral differences in motivated behavior & psychiatric disease"
0
5
12
#SexDifferences
research is growing! Dr. Becker wants
@BiologySexDiff
to be the leader in
#SABV
publication. She is asking what topics folks would like to see covered in the journal.
@OSSDtweets
@women_neurosci
What topics would you like to see? Reply to this thread! ⬇️
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