Glycation-induced stress has been associated with various human pathologies such as cancer and diabetes. This article from Santo et al. the protective role of iron, copper, and manganese coordination compounds in Saccharomyces cerevisiae was investigated.

The PI3Kα kinase domain has important functional intermolecular interactions. New #OA research from Gong et al shows that ATP-competitive inhibtors of PI3K enzymes regulate this PI3Ka membrane interaction.

Are you currently researching new developments in glyobiology? Head over to The Biochemical Journal to submit your work to our new special collection on Glycobiology, guest edited by Natasha Zachara.

Here, we identified RNF138 as an E3 ubiquitin ligase for C/EBPalpha which inetracts with C/EBPa and promotes its ubiquitin-dependent proteasome degradtion leading to myeloid arrest in AML.

@amandahnecker et al. explore the upregulation of IKKε by inflammatory cytokines, demonstrating the dependence of cytokine-induced IKKε on NF-κB. #GeneExpression #RespiratorySystem #NFKappaB

Explore our themed collection, Cell Signaling in the 21st Century. This collection captures new developments in cell signaling through research, review articles and perspective pieces.

In this #OA review article, Haltenhof et al. explore the functions and molecular mechanisms that underlie temperature-dependent alternative splicing, as well as potential therapeutic targets. #RNA #GeneExpression #Temperature

This #OA review, by Wang et al., critiques the literature on the trafficking of APP, the intracellular sites of APP processing and Aβ production and the impact of familial Alzheimer’s disease mutations on these processes. #Neuroscience #Trafficking

Check out this #OA research article, where Mazzone et al. present a crystal structure of the T. gondii DXR enzyme, complexed with an inhibitor and NADPH, and investigate analogues that can also act as DXR inhibitors. #Enzymes #StructuralBio

Elucidation of key barriers and mechanisms of H₂O₂ and H₂O permeation in open and closed states of dual functioning PIP channels. #Aquaporins #Peroxiporins

The cytosolic glutathione-degrading enzyme, ChaC1, is highly up-regulated in several cancers, with the up-regulation correlating to poor prognosis. This article from Suyal et al used a robust yeast screen to identify potential ChaC1 inhibitors.

The cytosolic glutathione-degrading enzyme, ChaC1, is highly up-regulated in several cancers, with the up-regulation correlating to poor prognosis. This article from Suyal et al used a robust yeast screen to identify potential ChaC1 inhibitors.

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Adaptor proteins play central roles in the assembly of molecular complexes and co-ordinated activation of specific pathways. This review from Teyssier et al discusses the dynamic and dual roles of the archetypical modular adaptor proteins NCK1 and NCK2.

All Biochemical Journal papers undergo a rigorous peer review process; however, the Editorial Board is committed to ensuring that, if revisions are recommended, extra experiments not necessary to the paper will not be asked for.

Check out this #OA review article, where Parkhill and @EachanJohnson explore potential routes to discover new antibacterial drugs, highlighting various classes of antibiotics, such as glycopeptides. #AMR #Microbiology #DrugDiscovery

We understand that fast dissemination of your work is essential. This is why our Production team work tirelessly to get accepted papers out into the community, with a median acceptance to publication time of 17 days across our journals.

This perspective from Oldham and Mabbitt explores our growing understanding of the plant Arg/N-degron pathway, highlighting the latest research on E3 ligases. #OA

In this #OA research article from Bloemen et al, the regulation of GAPDH activity by hydrogen peroxide is investigated.

With over 1.1M article views in 2023, Biochemical Journal has been at the forefront of exploring the mechanisms of life for over 100 years. Find out more about the journal on our website, and consider submitting your high-impact research