Bhupesh K Prusty
@BhupeshPrusty
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A passionate molecular virologist who believe in patient oriented scientific research. Using viruses to understand human existence. Science is for society.
Riga, Latvia
Joined November 2009
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For the first time we have convincing experimental evidence to show mechanism of herpesvirus-mediated mitochondrial alterations that makes sense for ME/CFS and possibly LongCovid. This is huge. It will take time to dissect out every aspect of it but we are thrilled and excited.
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We will announce a biomarker for
#MECFS
and
#LongCovid
very soon. A very interesting piece of the puzzle to unfold in coming weeks. Knowingly I did not use the word 'Novel Biomarker' as a lot is known about it and that is actually a very good news. Fingers crossed!
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ME/CFS paper Alert: Our study on tissue specific, localized herpesvirus infection in ME/CFS is now accepted for publication. Many thanks to the reviewers and the funders.
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Today for the first time we had a long discussion on ME/CFS research in our lab meeting where everyone except for me was a non-ME researcher. was a interesting discussion & was clear that exciting & modern science is on its way to solve this disease. Am hopeful than ever before.
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For all those who rejects the idea of herpesviruses playing a key role in ME/CFS and LongCovid, be prepared for the future. We are slow but we are coming.
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1. To bridge the knowledge gap between LongCovid and ME/CFS, we have acquired 2 grants worth almost 1 million Euro. Two new projects employing world class, state-of-the-art single cell RNA & protein biology will soon kick start in our group. Thanks to all of you for your support.
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Increased circulating fibronectin, depletion of natural IgM and heightened EBV, HSV-1 reactivation in ME/CFS and long COVID
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Good news for COVID-19 Long Haulers and CFS patients: after a long wait and extensive preparations, today we started our first set of experiments to see if COVID-19 has a direct effect on mitochondria and if HHV-6 is a potential mediator in this process. Fingers crossed.
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Today we welcomed Sam into our group who is going to do his master’s thesis on single cell ME/CFS transcriptomics data analysis. Sam himself suffers from ME/CFS & wants to understand the disease through his work. We hope that he succeeds in his work and continue his PhD with us.
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Finally, the most awaited week is here. Stop 1 will be Berlin with 15 minutes of talk covering ME/CFS, long COVID, herpes, autoimmunity, a unique serum protein that usually helps in complement pathway but is not doing its job as it should be, how it ties with Lyme, TLR4, ROS etc.
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As a researcher, it took me several years to fully understand the complexities of ME/CFS. So, my request to everyone: When you hear about ME/CFS from a patient or a doctor or just from internet, take a pause, spend a few moments to understand this modern day medical mystery.
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1. I am going to start a test on a novel diagnostic platform for ME, CFS and ME/CFS and long Covid over the next 2 months time. If it works as expected, we can have a robust quantitative diagnostic test in as less as 50-100 eur per sample and within 24h time.
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We are a small group started working in 2022 on a topic, which is a tough nut to crack. And now we are going out as a team to Charite, Berlin tomorrow with loads of awesome data. If by any chance you are attending the meeting, then come by to meet us in person.
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Immune activation, allergy are key secondary clinical features of ME/CFS. We are concluding a study in this regard throwing light on a key cytokine levels in a subset of ME/CFS patients providing insight into role of Eosinophils, ECP, specific cytokines in mast cell activation.
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The Prusty lab is up to grab. Decided to move my lab wherever ME/CFS and Long Covid research is appreciated. I hope that the academia works the other way around and instead of me keep searching for a new location, the new location finds me. Fingers crossed!
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#MECFS
#LongCovid
You don’t have to wait long. We will present our work in Berlin & Hinxton meeting. As always, we believe in functional & meaningful, data driven biomedical research that can make sense for understanding complex molecular processes. Let’s dive deeper this time.
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2022 was full of stress and struggle both at personal and professional front. But it was also one of the most successful years on every front. Now I am looking forward to 2023. Hoping to have some major scientific breakthroughs this year and to provide new insights into ME/CFS.
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Today we officially started our project on LongCovid-ME/CFS. We are looking forward to include at least 10 healthy controls, 10 LongCovid patients & 10 Mild to moderate ME/CFS patients within the next 2 years of the project. I would like to thank UniWürzburg for the full support.
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10. Our ambitious project of developing a diagnostic test for ME/CFS is moving ahead with full throttle. We have now tested more than 100 cases and controls. The results are so overwhelming that we are now going ahead to apply for a BMBF consortium grant.
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Imagine a viral infection doing this to your mitochondria...This will be the topic of our next grant application to solve the mystery behind ME/CFS.
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On a happy note, we are on a perfect path for identifying potential transferable factors in ME/CFS blood that can cause mito dysfunction. Today was a great day for us in the lab. We might have our first factor in hand and as an icing on cake we have two potential diagnostic tests
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My wish for the new year is to see science succeeding in 2023 helping people to recover from both ME/CFS & LongCovid and to return to their normal life. Every life saved will be a tremendous achievement. Those who can help will never get a better chance to achieve this goal.
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The real effect of this pandemic on our society will only be visible in 5-10 years from now when several of us will be left suffering from chronic illnesses arising out of Covid-19 infection. LongCovid is one of them. A joint effort is necessary to understand and prevent them.
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A massive paper writing effort is done and the draft is now sent to all the co-authors. Hoping to submit it soon. If you know my work, then you know how to expect a unique flavor in our results, which was never tried before. Fingers crossed.
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Excellent day, full of exciting science on ME and long COVID. I am glad that my work was highly appreciated. Looking forward to public engagement from tomorrow evening and my open talk for all of you on Friday.
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ME/CFS is more interesting than any other human disease. The moment I start thinking that I know a lot about this disease, I face a wall where I realize that I am wrong. Every day it teaches me something new.
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For the Long-COVID community, a very interesting pattern is emerging from our COVIDOM cohort analysis suggesting not every Long-COVID is ME. Hopefully results will be clearer once we cross 350 sample mark. The question remains – Which is first Chicken or EGG? Crossing my fingers.
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Our results suggests presence of reactivated HHV-6 within spinal nerves along the spinal cord, possibly explaining ANS dysfunction associated with ME/CFS.
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Yesterday we joined three continents over Zoom and had one of the best 200 min scientific discussions about the ongoing works and ideas about ME/CFS and LongCovid research. Thank you Bob Naviaux, Rob Phair,
#ChrisArmstrong
and Vinod for this.
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It will be exciting to find a common thread explaining why Borrelia-induced Lyme disease shares common features with ME/CFS and now with long COVID patients.
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Developing a treatment is a billion dollar business, which is out of reach for small scale labs like us. We are focusing on understanding the disease development process. We are confident that our work will help others to take over the business part.
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We also thank patient communities without whose help we could not have dared to start and finish this study. At this stage, even if we don’t claim role of herpesviruses in ME/CFS, we are confident that we can do more mechanistic studies in the future in this direction.
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After 22 years of long scientific journey, for the first time got a paper accepted in the elite group of journals as a corresponding author. Excited to read the final acceptance email from the journal Nature. Looking forward to see the print version very soon.
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@scotjess3
No bigger trial required. We are already trying it on a larger patient cohort with beautiful results. Moreover we know how things work and it fits to many known clinical issues. But we definitely will need functional studies in future.
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Going to collect a small cohort of Post-Vac patients and compare them to Long-Covid and ME/CFS patients. It will be exciting to do this curiosity project.
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This information is not intended to provide you with a treatment tomorrow. This is aimed to keep you in loop about our work.
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Thank you Ron Davis and Stanford CFS Center for inviting to give a talk and share my work at the Working Group meeting next week. Excited to share our working model on ME/CFS with so many great minds.
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2. It will also be possible to make it partially automated. I sincerely hope that it works as it has been working in a few pilot experiments so far. I am keen to have it as a Christmas gift for me and for all of you. Wish me good luck.
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1. This is a heat map showing amounts of 3 proteins (in 3 rows) in serum of ME/CFS patients and healthy controls (columns). For a layman those on right side (red) are from healthy controls and those on left side are from patients.
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As a team, we are determined to understand the molecular mechanisms behind ME development. We have already added four new young colleagues to focus on ME. I will introduce you to them and their projects in the coming weeks as we continue our collective effort in this research.
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It is painful & puzzling to see so many medical doctors leaving their full time job because of ME/CFS. Should not we be worried for this? I don't know how many more will be away in next couple of years. If medical doctors have to accept this fate, you can imagine about patients.
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Unforgettable 2 days of brainstorming with some of the best minds and meeting some of the idols in the field of science. There is no better place to learn.
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A new ME/CFS Foundation has been initiated in Germany. I sincerely hope that this fulfills the expectations and hopes of German patient community. All the very best for the success of the Foundation.
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Join me for a webinar to understand our views on Long Covid, overlapping biomarkers and differential biomarkers with ME/CFS, and concepts of Virology that questions accepted scientific paradigm on 20th September at 14:30 ET. Don’t forget to register at
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Today we also restarted our quest to scan almost the entire human body for localizing potential sites for viral infection, which might be a source of trigger for ME/CFS. In coming months we will test biopsies from most of the human body parts including the entire brain.
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It's 7pm and after 12 h of a working day, I am still waiting to finish my experiments and see the results. I am anxious to see what I find after all. 40 cases and 40 controls are on test today for a potential marker. Crossing my fingers and waiting for another 30 minutes.
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I am going to spend some time in August visiting Ireland. Will be happy to meet and discuss our work with ME/CFS or Long-Covid patients. If any patient organization is interested, please write me an email.
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Tissue specific signature of HHV-6 infection in ME/CFS
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The first grant that came our way last week is funded by ME Research UK. I am so excited to get this support from Scotland. Scotland always remains in my heart. Beautiful place and lovely people. Was planning to go back in 2020 but couldn’t happen. Hope for next year.
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It’s a new year that brings new challenges, new hope, and a new beginning. It’s time to say goodbye to Germany (for the time being) and take up a new challenge at Riga Stradins University. More to follow after 1st April 2024....
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2. I will reveal more details about our forthcoming projects in coming days. I am sure we will learn tons of new things from these new projects. Rest assured, we will bring in some of the most intelligent ideas into this field and hope to solve some of the scientific questions.
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I am glad to share the full version of our Perspective article on Virus-induced autoimmunity, which revisits the idea of Cryptic peptides and their potential role in several human diseases including ME/CFS and Long-COVID.
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Sitting here in the kinderklinik waiting area. 5 young Long-Covid patients in the surrounding waiting for ECG. Got a call that my long scheduled appointment in the clinic has been canceled because of lack of staff. Asking myself- are we done with the pandemic? On what basis?
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Picture of the day: Astrocytes stained from a CFS brain.
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8. This year we published our first paper on ME/CFS. We started a collaborative project with Prof. Naviaux. We are almost close to finishing work for two more projects on various aspects of ME/CFS, which will be completely novel, will force us to change our thinking about ME/CFS.
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This one is to end a hectic but productive week and to let you think over the weekend.
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I hope to bring in some of the best ideas and research to one common platform where they can stimulate science on ME/CFS. Please join me in creating a special issue on Biomarkers in Chronic Fatigue Syndrome (ME/CFS)
#mdpibiomolecules
via
@Biomol_MDPI
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1. Working group of Bhupesh Prusty at Univ. of Würzburg, Germany is looking forward to hiring a talented PhD student to work on various aspects of ME/CFS and mitochondrial dysfunction in ME/CFS. Please spread the words in case anyone is interested in applying for this position.
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Thanks to the generous donations from all of you through GofundMECFS campaign in 2020, one of my bachelor students is working tirelessly throughout the pandemic to finish this study looking into ME/CFS brain. This study will soon be submitted for publication. Fingers crossed.
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A brain tissue section from human cerebellum showing a few Purkinje neurons (green) and the nucleus of these neurons carrying HHV-6 viral proteins (Yellow). Purkinje neurons are the master motor neurons within our brain.
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Grateful for the excellent news of approval of our pilot grant application by
@dg_mecfs
. Thank you for your support. In this 1 year pilot project, we aim to identify cell-specific protein targets of serum antibodies in ME/CFS patients using various types of primary human cells.
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2. Next time when someone tells you that this disease is in brain, show them this and ask for an answer. Science has the power to differentiate patients from healthy people. Let the research find its way forward.
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I visited Frankfurt downtown today to buy some Groceries. It was a shocking experience for me to see the crowd on the street, no mask, no social distancing. It’s a Corona disaster ready to unfold any time. Have we not learnt anything so far from more than a year of Pandemic?
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I believe in the philosophy of walking together. Announcing some upcoming results is not intended to create hype. It is just another strategy for stimulating brainstorming ideas and to motivate you to join me in thinking more about science behind these complex disorders.
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A tissue section showing HHV-6 miR-aU14 (red) within axons surrounded by Myelin sheath.
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A very famous scientist from Karolinska Institute once laughed at me when I told that patients seems to know more about our work than us. She mocked me saying 'Do you think Patients read your papers'. I am so glad today to see the active knowledge of ME/CFS patient community.
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Today is International Women’s day. I am taking this opportunity to thank Prof. Carmen Scheibenbogen & Prof. Uta Behrends from Germany for their efforts to tackle ME/CFS in Germany. Glad to work together with you on this difficult scientific research topic.
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Thanks to all of you who believed in our work and our approaches. Your support speaks for itself and from the success of team GOFundMECFS. I would like to assure you that we will achieve more than what we planned and will not leave a single stone unturned to achieve our goal.
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Its so satisfying to see our paper getting recommended by Faculty Opinions and that too getting rated as 'exceptional'.
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Our lab website is online now. We hope to update you about our ongoing research through our website.
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11. We will test this not only in ME/CFS but also in other diseases having overlapping symptoms with ME/CFS. We are now searching resources to make the analysis on automated platforms. We have many hurdles ahead but results are promising and we will keep fighting to go ahead.
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This is one single genome of HHV-6 virus (roughly 160 kbp linear DNA) and this is how it is organized to pack itself into a viral particle. Amazing science!
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In the words of Guru Ravindranath Tagore - “Jodi tor dak shune keu na ashe tobe ekla cholo re”. It means “If no one responds to your call, then go your own way alone”. This song reminds me to continue the journey, despite abandonment or lack of support from others.
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The sooner we educate our society about this disease, the better is the chance of having a solution for this. Share and educate people around us. A disease that affects millions of people worldwide | DW Do... via
@YouTube
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CONGRATULATIONS to all of you who fought for your rights at the EU parliament. A big step forward in the field of ME/CFS research. I would say 'Better late than never'.
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Before we jump into the idea of SARS-CoV-2 causing ME/CFS, we should think about all those latent viruses that literally lives with us. It is very much possible that infections like SARS-CoV-2 reactivates other latent pathogens which actually is the cause of CFS like conditions
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Good Morning Australia and Sweden. We are coming to work with you in near future. Let's get the ball rolling.
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Time to rethink the concept of infectious triggers behind a disease. This paper is a good learning tool for all those who think viral particles, viral proteins, and viral DNA and RNA in the blood are a must for a virus-induced disease.
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Myalgic Encephalomyelitis, Viruses, and the Innate Immune System
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Read our most recent work just published in Nature. Selective inhibition of miRNA processing by a herpesvirus-encoded miRNA
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Many thanks to ME Research UK
@MEResearchUKSci
and Gordon Parish Charitable Trust for funding this microscope in 2022. This is very helpful in our daily research life.
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Here is a very informative article to read. Immune system in female body is developed in a unique way and is more dependent on certain factors that can play a role in these type of diseases.
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1. How different is the liver function in severe ME/CFS patients in comparison to mild/moderate patients? 2. Is there any specific clinical abnormalities to lower respiratory tract that is observed in severe patients specifically?
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Saying Goodbye for now. Will be back in Twitter in December.
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Can we invite famous personalities to get involved in this great cause of fighting against ME/CFS? There are many big sports and film personalities as well as big financial entities donate for social causes. They might help us in moving faster towards our goal.
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My journey started 4 decades ago in a very small rural area of India with a bunch of kids and some simple and honest teachers. It seems like a journey of a life time. Nostalgic moments!
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The complexities of immunity, mitochondria, metabolism and cell death makes it as fascinating as anything else. For sure it is going to be a bumpy ride.
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We are looking forward to test blood cells twice from each individual over a period of 3 months, which will cost us roughly Eur 30,000 per person. We are excited to kick start this much awaited project. The project aims to understand role of herpesviruses in LongCovid and ME/CFS.
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The need of the hour is to open a central organization for ME/CFS research and treatment in Germany where clinicians and researchers can work under one roof. One of the best examples from the past is DKFZ where once everyone joined hand to fight against cervical cancer.
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Once upon a time when a virus attacked a cell..
Cell: You shall not pass!
Virus: I am not here to pass. I am here to stay with you and become your friend forever. But if you ever break my friendship and try to kick me out, I will make your life a living hell. Let’s make a deal.
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1. For those who use ROC analysis to judge a biomarker: The ROC from our paper shows a comparison of FN1 & IgM-FN1 against controls from a random general population. If we do the same against matching healthy controls with every health record in hand, then it is 99.7% accurate.
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2 nice papers got accepted today but I am not feeling that happy and excited when there are so many sad things happening around the world.
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He was my first post-doctoral mentor. Together with him, I learned to enjoy science rather than just doing it as a career. He taught me to be excited with unexpected results rather than searching for expected results. I am going to miss him. R.I.P.
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It is mind boggling to imagine a disease that affects females more than males. There has to be some evolutionary explanations to it.
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12. Many of you asked me why I decided not to take any more funding from patient community for my research. The answer is very simple. I am aware of the financial situations of many of the ME/CFS patients. I do not want to burden them any further.
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Team Armstrong, Team Bergquist and Team Prusty are joining hands to work together.
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Remember to join tomorrow for a one-of-a-kind event. Hats off to the 5 who made this possible.
#UniteToFight2024
Here we are! 🤩
Only 23 hours left until
#UniteToFight2024
There are still some seats available in the audience.👈
Make sure you don’t miss these amazing people and many more👇👇👇
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