Caroline Arber
@ArberCaroline
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Immuno-hemato-oncologist, T cell engineer, mountain lover, violinist
Joined September 2022
RT @BarthPD: Happy to see our study on the design of dynamic peptide-GPCR complexes for guiding chemotaxis published!
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RT @andrewpekosz: A snapshot of 2022-23 influenza testing at the Johns Hopkins Hospitals compared to the previous 5 influenza seasons... #i…
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RT @BarthPD: Happy to see our study on the design of quaternary receptor structures with selective signaling functions published. https://t…
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RT @ETH_BSSE: Come and work with us at the Departement of Biosystems Science and #Engineering in #Basel: we are looking for an Assistant Pr…
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RT @jitcancer: New #JITC article: Both APRIL and antibody-fragment-based CAR T cells for myeloma induce BCMA downmodulation by trogocytosis…
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RT @benita_wolf1: #ImmuneSynapse imaging of CAR T cells in living (#lightsheet) and fixed cells for deeper understanding of #CARTcell anti-…
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Super excited to see our work published @jitcancer ()!! Congratulations to Nicolas, @benita_wolf1 and thanks to our great collaborators @GiancarloCroce8 @GfellerD Vincent Zoete in this #CARTcell paper for #myeloma (5/5).
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Our study sheds light on common mechanisms underlying CAR T cell failure in #myeloma when targeting BCMA and helps to devise new strategies for the development of more efficient treatments (4/5).
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Big thanks to @benita_wolf1!! We developed novel live cell #lightsheet imaging using label free dies to study single T cell tumor cell interactions and #immunesynapse (3/5).
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Both dual antigen-targeted natural ligand CARs (APRIL CARs) as well as clinically used single-chain variable fragment or heavy-chain only based CARs led to rapid downmodulation of BCMA on #myeloma. Downmodulation was due partly to trogocytosis and mostly to internalization (2/5).
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Our paper on mechanisms of resistance of both APRIL- and antibody-fragment-based CAR T cells targeting BCMA on #myeloma just published! By @ArberCaroline, Nicolas Camviel, @benita_wolf1 @unil @CHUVLausanne @Ludwig_Cancer Read the paper @jitcancer () (1/5)
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Congratulations Jan Rath for an outstanding PhD defense !! I can't wait to wrap up your next manuscript on engineered T cells !
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@Johanna_A_Joyce @ScienceTM @Davide_Croci_ @NewsfromScience @ScienceMagazine @RuudMRI @IVIF_Lausanne @Ludwig_Cancer @unil @RuiSantalla @evomet_itn Wonderful work! Congratulations!!
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