Alex Yermanos
@AlexYermanos
Followers
740
Following
67
Statuses
67
Assistant Prof at @UMCUtrecht - Dutch/Swiss immunology collabs🇨🇭🇳🇱🏳️🌈
Zürich, Switzerland
Joined May 2013
Sharing our computational immuno ecosystem - started for internal use but might help others too! CRAN package >100 functions (both custom&external tools eg cellphoneDB,projecTILs,alphafold) Database to download&integrate scSeq/VDJ directly into R + ~20 tutorials w/ code,data,text
ePlatypus: an ecosystem for computational analysis of immunogenomics data #biorxiv_immuno
4
33
122
Happy to share our review summarising the extremely recent explosion of protein language models (PLMs) that are being applied to adaptive immune receptors. Thanks to everyone involved and sorry if we missed some models - they are being released so quickly!
2
16
79
Happy to sharing a nice collab now out in @CellReports lead by @FGrabnitz & @LabOxenius investigating how asymmetric cell division influences T cell development!
Thrilled to share our newest publication by @FGrabnitz and colleagues in @CellReports showing that asymmetric cell division safeguards memory CD8 T cell development upon strong TCR stimulation. 🥳🔬 Congrats Fabienne!
0
1
14
Sharing our new pub in @iScience_CP relating Bcell repertoires & mAb specificity! Previously we saw ~35% of expanded IgG plasma cells were immunogen-specific. Here we show a similar % using a therapeutic protein (w/ self-homology) in young but not old mice
0
3
14
We are already sending out interview invites in the next few days for the two computational immunology #PhD positions at @CTI_UMCUtrecht in case you haven't submitted an application yet but wanted to 🧬🍾
We are hiring two computational immunology PhD students at @UMCU_Intl in the Netherlands working on adaptive immunity in my group and in the group of @FemkevanWijk1. Please spread the word and DM me for more info!🧬
0
2
4
I wanted to highlight some of our 2022 work published in PNAS and the European Journal of Immunology in light of a new publication that should be released in a few days 🍾 - thanks again to all collaborators! - particularly @LabOxenius @ReddyLab_ETHZ
0
0
16
RT @GCIR_Unige: How do #Bcells contribute to chronic inflammatory #CNS diseases? Read it in #ActaNeuropathologica by @AlexYermanos & @GCIR…
0
5
0
We are hiring two computational immunology PhD students at @UMCU_Intl in the Netherlands working on adaptive immunity in my group and in the group of @FemkevanWijk1. Please spread the word and DM me for more info!🧬
0
11
23
Also sharing this link for a longer summary/figure describing the manuscript
1
1
5
Huge thanks to everyone that made this happen especially @KreineVic+@andreasagra & the entire @ReddyLab_ETHZ & @LabOxenius. Please feel free to share your functions & pipelines or processed published data to help data reuse and code sharing ♥️
0
1
13
Happy to support monotreme awareness with our single-cell immune repertoire simulation tool Echidna now @BioinfoAdv. Integrated SC repertoires & transcriptomes. One fun case was simulating clonality & B cell evolution on spatial images for pipeline development for future projects
Echidna: Integrated simulations of single-cell immune receptor repertoires and transcriptomes Jiami Han et al #bioadv
1
6
17
One of my scientific mentors and role models said I need to update my pinned tweet with some more recent research. I agreed and updated w/ a grindr screenshot 🤠
2
0
18
Sharing our recent hodgepodge paper in Nature Genes & Immunity if anyone wants references & public scSeq datasets. Includes transcriptomes + repertoires from Tfh/Tfr/CD8 T cells (following infection/CNS neuropathology) + B/T cells from EAE (rMOG/MOG35-55)🍾
0
5
27
Riding the good news wave - honored to share I've been awarded an SNSF #Ambizione Grant to study the interplay between vaccination and original antigenic sin. Please DM if you know anyone interested in an experimental or computational immunology PhD in a fun Dutch Swiss collab!
2
0
21
Grateful to share I’ll join @CTI_UMCUtrecht NL as a TT Assistant Prof. So much love to all who have helped me follow my curiosity both professionally🧬and personally🏳️🌈 Excited to keep exploring how computational, synthetic and systems immunology can be translated to the clinic
9
1
55
Happy to share our recent manuscript from @ReddyLab_ETHZ has been published in Cell! Great work by @JosephMTaft & @cedricrweber et al. Moving towards predicting immune escape of future viral variants🤓
Now online! Deep Mutational Learning Predicts ACE2 Binding and Antibody Escape to Combinatorial Mutations in the SARS-CoV-2 Receptor Binding Domain
0
4
19
Sharing super special collab work 🙏profiling B cells in the CNS w/ infection and autoimmunity. Murine ASCs were expanded & class-switched following ic viral infection and proliferated/expanded after local induction of neo-self antigen 🧠 Similar phenotypes in CSF of MS patients
Persistent virus-specific and clonally expanded antibody secreting cells respond to induced self antigen in the CNS #biorxiv_immuno
0
2
22
"Unsupervised clustering resulted in 12 clusters, 7 of which resembled a whale and potentially represent terminally drowned T cells" 🥸 @d_shlesinger
0
1
17