Dr. Gustavo Aguirre-Chang
@Aguirre1Gustavo
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Treatment of LongCOVID,Post-Vax,ME/CFS,FM Creator of Test for: Viral Persistence,Microclots
San Isidro. Lima. Perú.
Joined April 2020
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UNDIAGNOSED VIRAL PERSISTENCE
IN 32.5% OF PATIENTS UNDERGOING BARIATRIC SURGERY
All had Negative PCR before Surgery
They were unaware they had a Persistent Infection due to SARS-CoV-2
One part had more than 1 year since infection
Are
#UndiagnosedLongCOVID
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ASYMPTOMATIC OR LATENT PERSISTENT INFECTION IN CHILDREN.
SARS COV-2 WAS DETECTED IN BIOPSIES OF TONSILS OR ADENOIDS
IN 25% OF ASYMPTOMATIC CHILDREN
None had experienced signs or symptoms
Authors point out:
lymphoid tissue may be a Reservoir of SARS-CoV-2
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VIRAL PERSISTENCE
IT IS THE MAIN CAUSE OF MYOCARDITIS IN
#LONGCOVID
In 85.7%(12/14) of Endomyocardial Biopsies
persistence of up to 18 months of SARS CoV2 was detected
It was identified in Cardiomyocytes,Endothelium,Macrophages
Also Anticardiac Antibodies
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AUTOPSY IN A CHILDREN WITH MULTISYSTEM INFLAMMATORY SYNDROME (MIS-C)
SHOWS VIRAL PERSISTENCE IN MULTIPLE ORGANS
Authors point out
persistence of SARS-COV-2 is a feature in all autopsies of MIS-C patients reported to date, suggesting a role in pathogenesis
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Autopsy study in patients with COVID shows that:
SARS-CoV-2 infects, replicates and persists in Macrophages within the coronary vasculature
Since CARDIAC MACROPHAGES have a half-life of 8.8years
they would act as VIRAL RESERVOIRS in Atherosclerotic plaques
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We reaffirm
that the main cause of LongCOVID
is the Viral Persistence
It should not be considered Post-Infectious,Sequelae
There is an active infection
that mainly affects the blood vessels
and there are often co-infections
Something similar happens in CFS
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New study published by THE LANCET:
ANTIVIRAL EFFECT OF ¡IVERMECTIN. IN HIGH DOSES IN COVID-19:
Conclusion: A concentration-dependent antiviral activity of ¡Ivermectin. was identified. High doses were well tolerated.
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IN HOSPITAL IN LONDON, UK, THEY DEMONSTRATE THAT THE LONG COVID (OR CHRONIC COVID) IS DUE TO VIRAL PERSISTENCE
And by means of sequencing of the complete genome (WGS) they identify mutations that cause Drug-Resistance
Report 4 cases with
#LongCOVID
treated
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100% of the PCR tests were False Negatives
If the infection persists
the virus will no longer be found in secretions from the nose & throat
It is located inside the cells
Viruses cause Intracellular Infections
PCR cell/tissue samples required in
#LongCOVID
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PAXLOVID IN
#LONGCOVID
We have observed that the antivirals
Nirmatrelvir and Ritonavir = Paxlovid
produce a significant improvement in the patient with
#ChronicCOVID
The problem is that only 5 days of treatment is allowed
with which in many the entire Viral Load is not eradicated
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There is a Subgroup of patients with
ME/CFS
Long COVID
Fibromyalgia
Arthritis
Autoimmune diseases
Others
Who present with MITOCHONDRIAL DYSFUNCTION
In them the LACTATE (Lactic Acid) rises at rest
And decreases the extraction of oxygen from the venous blood
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The patients operated on in whom it was performed
the finding of
undiagnosed persistent infection
had on average 274 days from the onset of SARS CoV-2 infection
and surgery
61.5% were vaccinated (>2 doses Pfizer)
No differences were identified between vaccinated and unvaccinated
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SARS-CoV-2 Spike Protein facilitates the development of Cancer
“Our findings have implications for the natural history of prolonged or repeated SARS-CoV-2 infection as well as design of anti-COVID vaccines that are administered repeatedly as booster shots"
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It has been 1 year 1 month since the 1st Cases Report of the use of IVM in COVID. The document remains valid:
Dose according to Severity
Evaluation of the response to treatment and according to this, the viral load and the tendency to persist are estimated
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It had already been identified that the Biofilm or Dental Plaque harbors SARS CoV-2
To this is added the Tonsils and Adenoids in children
Therefore, it is confirmed that the oral cavity is a potential reservoir for the virus
There are Asymptomatic Carriers
THE
#BIOFILM
OR DENTAL PLAQUE HARBOURS SARS-CoV-2
The presence of viruses in the Dental Biofilm indicates that the oral cavity is a potential reservoir for the virus.
Patients with
#LongCOVID
and
#CFS
must eliminate dental infectious foci of microorganisms
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CO-INFECTION WITH STAPHYLOCOCCUS AUREUS
INCREASES SARS COV-2 REPLICATION BETWEEN 10 TO 15 TIMES
This proviral activity is due to the fact that the IsdA protein of S. aureus modifies the Janus Kinase-STAT signaling of the patient to the benefit of SARS CoV2
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DETECTION OF SARS COV-2 IN THE RETINA FROM COVID AUTOPSIES
...Specifically, this is the first report to definitively localize SARS-CoV-2 to the Retinal inner and outer nuclear cells, retinal ganglion cells, and ocular surface by In Situ Hybridization (ISH)
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DETECTION OF SARS COV2 INSIDE THE THROMBUS USING PCR
Study observed that the size of thrombus correlates with a higher Viral Load inside the clots
Findings support our proposal to perform PCR using
#microclots
or centrifuged blood as a sample in
#LongCOVID
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USE OF IVERMECTIN IS ASSOCIATED WITH A LOWER FREQUENCY OF PERSISTENT SYMPTOMS OF COVID (Long haulers).
The % of people with persistent or post-acute symptoms is only 2 to 4% of all treated cases.
This is due to the reduction or elimination of viral load that is achieved with IVM
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CHRONIC FATIGUE SYNDROME (CFS) AND FIBROMYALGIA ARE VASCULAR DISEASE.
To support that Fatigue and Chronic Pain are due to Hypoperfusion and Hypoxia of the tissues, a blood test of: MEASUREMENT OF VENOUS BLOOD GASES should be requested.
Which is not complex
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A LOW LEVEL OF OXYGEN IN THE MUSCLES
(HYPOXIA)
IS THE MOST FREQUENT CAUSE OF
CHRONIC FATIGUE
POST-EXERTIONAL MALAISE:PEM
NON-RESTORATIVE SLEEP
MUSCULOSKELETAL STIFFNESS AND PAIN WHEN WAKING UP
This occurs in
ME/CFS
Fibromyalgia
LongCOVID
Post-Vac Syn
Other
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HISTAMINE
ACCELERATES
SARS-COV-2 SPIKE PROTEIN
ENTRY INTO ENDOTHELIAL CELLS
Without Histamine, entry into cells takes between 6 to 12 hours
With Histamine, it takes only 30 minutes.
This effect can be treated
with Histamine H2 Receptor blockers:
FAMOTIDINE
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PATIENTS WITH PERSISTENT SYMPTOMS
WITH MULTIPLE PCR NEGATIVE TO SARS COV2
UP TO 300 DAYS
THEY DIED WITH DIFFUSE ALVEOLAR DAMAGE (DAD)= ARDS
AND IN THE AUTOPSIES IT WAS CONFIRMED
THEY DID HAVE COVID
Bronchoalveolar Lavage (BAL) PCR also gave False Negatives
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#LongCOVID
82% RECOVERY WHEN USING 3 DRUGS AGAINST THE VIRAL LOAD
And this in immunocompromised patients
All were Symptomatic
Anti-spike Monoclonal antibodies:Mabs were included
+Nirmatrelvir/Ritonavir: Paxlovid
Study supports our 3-3-3 TREATMENT PROTOCOL
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In NATURE
THE MECHANISMS OF ACTION OF IVERMECTIN AGAINST SARS-COV-2
The probability that an ineffective treatment generated results as positive for the 55 studies to date is estimated to be 1 in 23 trillion (p =0.000000000000043)
IVM is worthy of attention
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AMANTADINE FOR LONG COVID
This Antiviral
(and later indicated for Parkinson's
and Multiple Sclerosis)
In 2weeks it
significantly reduced PostCOVID Fatigue
We recommend adding it to the Protocol
which should include 3-7 drugs with effects against Viral Load
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HISTAMINE
PROMOTES VIRAL PERSISTENCE
BY INHIBITING THE PRODUCTION OF CYTOKINES
SECRETED BY T HELPER TYPE1 (Th1) LYMPHOCYTES:
IFNγ, IL2,12
Patients with Allergies must be identified
We have simplified this with
the HSA-MCAS Question.
@DanDraitser
The 2nd most common cause of Long COVID symptoms is Histaminosis/MCAS
To find out if you have this
you must answer the HSA-MCAS questionnaire
If you have a low score on this test
and in the HHM Test
there would be no Viral Persistence
Look for other causes
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In Acute COVID, on the 1st day we indicate IVM 0.4- 1.2 mg/kg depending on severity
If after 27-30 hours, the improvement in symptoms is <25%, the Viral Load is estimated to be HIGH and added
Nitazoxanide
Nifuroxazide
Bromhexine
Doxycycline or Azithromycin
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It has been identified that infection by SARS CoV2
even in its mild/asymptomatic forms
is a powerful trigger for the reactivation of latent viruses
that lay dormant
the most frequent are the herpesviruses EBV and HHV-6
and the human endogenous retrovirus K
0
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Publicado hoy en la Revista Médica NATURE
LOS MECANISMOS DE ACCIÓN DE LA IVERMECTINA CONTRA EL SARS-COV-2
La probabilidad que sea ineficaz es 1 en 23 trillones (p= 0,0000000000000043)
La consistencia de los resultados positivos es notable. No es casualidad
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COVID-19: EFFECTIVENESS OF PRE-EXPOSURE PROPHYLAXIS WITH IVERMECTIN IN EXPOSED PERSONS
High efficacy of IVM Prophylaxis is found.
With a dose of 0.2 mg. per kilo of weight every 7 days: 100% efficiency.
Every 14 days: 98 to 100%
Every 30 days: 90 to 95%
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SARS COV2 INFECTION
TRANSMITTED BY A LUNG TRANSPLANT DONOR
Nasopharyngeal PCR tests were Negative before transplantation
Donor transmission was confirmed by PCR+ of lung Bronchoalveolar lavage (BAL) samples
This is now mandated
so this risk will be reduced
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ANTIVIRALS FOR LONG COVID
ENSITRELVIR ERADICATES PERSISTENT SARS-COV-2 INFECTION IN A LYMPHOMA PATIENT
… Her symptoms resolved quickly, with a reduction of the SARS viral load
Ensitrelvir is produced by the Japanese company Shionogi under the name XOCOVA
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THE STUDY IMAGES DEMONSTRATE THE PRESENCE IN THE TISSUES (IN SITU) OF PERSISTENT VIRAL INFECTION BY SARS COV-2 (see photos).
OF THIS THERE IS NO DOUBT.
The virus replicates, and is present in a disseminated form and intracellularly.
THEY ARE NOT PARTICLES.
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#LongCOVID
,
#CFS
:
Amyloid deposits identified in the brain
in 10 of 10 Adults 37 to 58 years old
with up to 5 months from the start of COVID symptoms.
Associated with hypoxia
Our theory is that they are associated with
#bioclots
with high fibrin content
#ME
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Histamine causes greater endothelial damage in COVID
by increasing the number of complement C3/C3b binding sites
on the surface of endothelial cells
This
is one more support for our Antihistamine Protocols
before starting Antivirals
THERAPEUTIC TEST WITH SOFOSBUVIR
(OR BEMNIFOSBUVIR)
AS A DIAGNOSIS CRITERIA
FOR VIRAL PERSISTENCE
IN LONG COVID OR PACS,
POST-V SYNDROME and in ME/CFS
If it is a patient with Hypersensitivities or Allergies
First, must receive treatment with Antihistamines
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This study supports what we have stated since April 2020:
-Viral Persistence is the main cause of Severe COVID and Long COVID
-There is an overestimation of the role of the inflammatory response
-It is a error to indicate only 5 days of antiviral treatment
The Hyperinflammatory Phase without presence of Virus
it's a mistake
and thinking that there is no longer a Virus
it is indicated a treatment insufficient
with Paxlovid and mAbs,
causing Reactivation and Drug-Resistance.
Viral spread
activates Inflammation
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NATTOKINASE DEGRADES THE SPIKE PROTEIN OF SARS COV2
in this way inhibits the entry of the virus into host cells
So in addition to using it as a Fibrinolytic, Anticoagulant,Antiplatelet
is added this effect against Viral Load of
#Nattokinase
#LongCovid
#CFS
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The Microclots
that fulfill the function of Biofilms in the blood= Bioclots
They are not only found in the LongCOVID and Lyme
They are also present in:
ME/CFS
Fibromyalgia
Rheumat. Arthritis
Sjögren Syndrome
Lupus
Myositis
Other Autoimmune Diseases
See in:
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CHRONIC COVID
If the patient is identified as Viral Persistence xSARS CoV2
the correct Diagnosis is
#ChronicCOVID
#LongCOVID
#PACS
are Syndromes
And Syndromes should be used only temporarily
at the beginning
and then we move on to the Etiological Diagnosis
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STUDY REVEALS VIRAL PERSISTENCE FOR MORE THAN 2 YEARS IN LONG COVID
It was identified in 65% of 48 patients
who had up to 39 months since Acute COVID
Total blood viral load
was determined as the sum of all individual transcripts detectable above background
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TABLE OF THE THERAPEUTIC PLAN FOR COVID
Only minor updates were made to the version that was released in January
We ratify the use of Colchicine (instead of Corticosteroids) in the Moderates. And in the Severe the inclusion of Fibrinolytics
PDFavailable in
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New Meta-analysis of 24 randomized clinial trials of IVM in 3328 patients
Showed a 56% improvement in survival, faster time to clinical recovery and signs of a dose-dependent effect of viral clearance for patients given ivermectin versus control treatment.
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After 4years
many are still surprised that Viral Persistence is the main cause of LongCOVID
How long will it take to identify that this is also the triggering cause of:
Microclots
Amyloid deposits
Atheroma
Histaminosis,MCAS
POTS
...
It supports our statement that
LONG COVID IS AN INFECTIOUS DISEASE
THAT MAINLY AFFECT THE BLOOD VESSELS
It is a Persistent Intracellular Infection
In addition to endothelial cells
Infects macrophages and other blood cells
And it is accompanied by Biofilms
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Dr. GUSTAVO AGUIRRE-CHANG Substack: AFTER 3 YEARS OF THE COVID PANDEMIC WE REAFFIRM THAT THE MAIN CAUSE OF LONG COVID OR PACS IS VIRAL PERSISTENCE
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More than 70% of Athletes
reported having Persistent Symptoms PACS
months after they had COVID.
This high %
it would be because the symptoms become more evident
in people who performed greater physical activity and effort since before suffering from COVID
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As the Title of this study points out:
SARS-COV-2 INFECTION TRIGGERS PRO-ATHEROGENIC INFLAMMATORY RESPONSES IN THE CORONARY VESSELS
That is to say
Atherosclerosis has an infectious origin
Most frequently these are Viruses that infect the vascular walls
and a Refuge is generated
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NATTO inhibits viral infections including SARS CoV2
In our Schemes for COVID, CFS and Chronic Lyme we include Nattokinase, Lumbrokinase, Serrapeptase, Bromelain and Lysine to break down persistent bioclots.
See details and dosage in
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THE
#BIOFILM
OR DENTAL PLAQUE HARBOURS SARS-CoV-2
The presence of viruses in the Dental Biofilm indicates that the oral cavity is a potential reservoir for the virus.
Patients with
#LongCOVID
and
#CFS
must eliminate dental infectious foci of microorganisms
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VIRAL RESERVOIRS DISSEMINATED = LIFETIME PERSISTENCE
In a similar way to HIV
In a subgroup of LONG COVID patients
there has been a seeding of viral reservoirs that affects the walls of blood vessels and organ tissues
More details about these Reservoirs in:
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UNDIAGNOSED VIRAL PERSISTENCE
IN THE HEART TISSUE
It was detected in myocardial autopsy tissues
in 4 of 9=44%
patients undergoing cardiac surgery
considered recovered
since they did not report symptoms
All had 2 False Negative pharyngeal secretion PCRtests
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LOW COST ANTIVIRALS FOR LONG COVID
Our Protocols include:
TENOFOVIR/EMTRICITABINE (PrEP)
AZVUDINE (FNC)
ENSITRELVIR
VALACYCLOVIR/ACYCLOVIR
IVM
GENERIC
But they do not have Markup to receive support from institutions
More than 3 years and no further studies
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@tammbrant
When there is infection at the level of the intestines
we consider it a High Viral Load
it is scattered throughout the digestive system
by its extension
adding the small scattered viral loads give a High Total Body ViralLoad
Therefore, treatment will be required for several weeks
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None of the 14 cases had severe respiratory failure or evidence of cardiac injury during Acute COVID
In all of them Myocarditis only manifested itself after the acute phase of COVID
In
#LongCOVID
#PACS
This was diagnosed 2 to 18 months later
and confirmed by Endomyocardial Biopsy
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This is the Scheme for Acute COVID.
If after 24 hours there is no good response to the IVM at a dose of 0.4 to 1.2 mg, we add NITAZOXANIDE and NIFUROXAZIDE
If the Saturation drops below 92 we add SPIRONOLACTONE.
All this as part of the First Line of Action
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EN AUTOPSIAS DE PACIENTES QUE FALLECIERON DE COVID
SE IDENTIFICA AL SARS-CoV2 EN MULTIPLES ÓRGANOS
Se detectó en
Peritoneo 80%
Páncreas 73%
Riñones 68%
Hígado 65%
Cerebro 47%
El virus no desaparece a los 10 días
Al contrario
Se Disemina
a múltiples órganos
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STUDY SHOWS THAT ACTIVE INFECTION
BY THE SARS COV-2
TRIGGERS THE PRODUCTION OF AUTOANTIBODIES
So Autoimmunity in COVID
is Not a Triggering CAUSE
It is an Effect or Consequence of an Infection
And this is what happens in Autoimmune Diseases and Neoplasias
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PHOTOGRAPHS OF THE PRESENCE OF THE SARS COV-2 VIRUS IN THE BRAIN (see red Arrows) OBTAINED BY ELECTRONIC MICROSCOPY.
The first evidence of the direct spread (in endothelial cells) and presence of SARS-CoV-2 in human brain tissue was published in April 2020
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It supports our statement that
LONG COVID IS AN INFECTIOUS DISEASE
THAT MAINLY AFFECT THE BLOOD VESSELS
It is a Persistent Intracellular Infection
In addition to endothelial cells
Infects macrophages and other blood cells
And it is accompanied by Biofilms
LONG COVID IS AN INFECTIOUS DISEASE (CHRONIC COVID)
THAT MAINLY AFFECT THE BLOOD VESSELS
We are going more than 3years with Protocols against Viral Persistence
Studies should focus on this
The challenges are
Multi-Drug Resistance MDR
Co-infections
Biofilms
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In South America the Delta Variant has not advanced despite the fact that the first cases appeared about 2 months ago. In Peru of those cases none developed the serious disease
The Gamma and Lambda C37 variants still prevail. And the Delta has not been shown to be more aggressive
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Report of 2 cases of
#LongCOVID
with up to more than 200 days of Viral Persistence successfully treated with Monoclonal Antibodies against SARS CoV2.
Study supports our Schemes for LongCOVID with drugs against Viral Load as First Line of Therapeutic Action
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ASPIRIN + IVERMECTIN IN PROPHYLAXIS, TREATMENT AND PERSISTENT SYMPTOMS
New study supports our schemes:
Aspirin significantly reduces mortality (-60%).
Post-Exposure Prophylaxis is given to CONTACTS:
Details in the following link:
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We have been very clear since April 2020 that Viral Persistence is the main cause of
#LongCOVID
In our 1st Report we mentioned the tendency to Viral Persistence in part of the cases
The Rebound that is observed Paxlovid
we observed it in April2020 with IVM
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STUDY DEMONSTRATES THAT PERSISTENT SYMPTOMS OF COVID ARE CAUSED BY INFECTION BY SARS COV-2 NOT DETECTABLE BY PCR USING SWABS.
Using Cytobrushes to obtain olfactory epithelial cells samples persistence of infection was evidenced for up to more than 6 months
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AZVUDINE vs PAXLOVID
Study shows Azvudide is equal or better
It has been approved in China since July2022
Its cheap
The problem for citizens of the US & Europe is that their governments only buy Antivirals with a High Markup for the Pharmaceutical Industry
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Just as in Acute COVID there is 40% ASYMPTOMATIC
similarly in the
#LongCOVID
there would also be 40% Asymptomatic
So
for every 3 cases of LongCOVID (Symptomatic Infection)
there would be 2 carriers of Asymptomatic or Latent Infection= Undiagnosed LongCOVID
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A symptom of Hypoperfusion,Hypercoagulability and Microclots (HHM) are the
MUSCLE SPASM,
TWICHING or
FASCICULATIONS
That in children, adolescents and adults of low weight,
can be diagnosed as
INVOLUNTARY MOVEMENTS of neurological origin
but the problem is in the blood circulation
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It is confirmed that the cause of
#LongCOVID
is Viral Persistence
Apply at home, free of charge, the HHM Test questionnaire
With the result the Treatment will be established.
There is a correlation between the level of the Viral Load and that of Microclots
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This study included Biopsies of endothelial tissue and thrombotic clots
Fig.4 shows SARS CoV2 (light circles)
inside clots adhered to infected endothelial cells
It confirms what we graphed almost 3years ago
and we call them BIOCLOTS
@renardtif
@KunstJonas
Here is the link to the document
THE SARS COV-2 VIRUS AND OTHER MICROORGANISMS
USE CLOTS AS A REFUGE TO PROTECT AND PERSIST
Because they fulfill a protective function similar to how Biofilms
they are called BioClots
Its presence causes Hypoperfusion
#MECFS
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Why must it take so many years
for scientists from the WHO, FDA, CDC, NHS and other institutions
to be convinced of Viral Persistence in COVID?
With a clinical evaluation
and therapeutic tests
we have known this since April 2020
Here is one more study
📷
Breaking!: Research published today in Science Translational Medicine and supported by PolyBio Research Foundation shows that the
#SARS
-CoV-2 virus can chronically persist in the gut of patients with long COVID for over 2 years:
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In
#LongCOVID
For Viral Persistence,
for having Drug-Resistance
we indicate 3 or more medications or supplements with effects against Viral Load
In addition
any infectious focus at the oral level must be eliminated by the Dentist
and mouthwash is indicated
The cases of Long COVID have been produced by not having given an effective and complete treatment against the Viral Load
Low doses or for a few days, by not eliminating the Viral Load, cause Drug-Resistance
If the virus is not eliminated, it will persist inside the body,mutating
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#LongCOVID
#CFS
PROTOCOL WITH FIBRINOLYTICS IS MORE EFFECTIVE AND SAFE
TO BREAK DOWN MICROCLOTS
THAN THE TRIPLE ANTICOAGULATION
Due to its Proteolytic effect
Serrapeptase, Nattokinase and Lumbrokinase
they would also have effects against the Spike Protein
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ANTIVIRALS FOR LONG COVID
Reservoirs are expanding and DrugResistance is becoming more common
It is necessary to take antivirals for several months
Those who start with Paxlovid
they should then continue with
Sofosbuvir
Truvada
IVM
Azvudine
AMT
VAL
others
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COMMERCIAL BIAS IN ANTIVIRAL STUDIES FOR LONG COVID
Pharmaceutical Laboratories are for-profit organizations
whose objective is to earn more and more
There are several low-cost, off-patent Antivirals available that are useful in LongCOVID
but there is no support for these studies
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THE PRESENCE OF SYMPTOMS IN MULTIPLE ORGANS
IN LONG COVID AND ME/CFS
IT INDICATES A DISSEMINATED AFFECTATION
OF THE BLOOD VESSELS
with a lower contribution of Oxygen/Nutrients
being the Muscles and the Brain in which the consequences will be seen the most
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STUDY BASED ON BIOPSIES SHOWS IN SITU PRESENCE OF SARS COV-2
IN ENDOTHELIAL CELLS AND CLOTS
Findings support our Protocols established since 2020
The main thing is to reduce the VIRAL LOAD
Anticoagulant & Antiplatelet Therapy does not go against the CAUSE
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It was identified that viral replication was greater in FOAM CELLS
which are Macrophages that have internalized Low-Density Lipoproteins
Its presence and accumulation is accompanied by injury to the vascular walls
that progressively leads to the formation of atheromatous plaques
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Case2 corresponds to a patient with
#LongCOVID
who spent 411days with viral persistence confirmed by PCR Through WGS:Whole Genome Sequencing it is shown that the virus mutates within the patient's body and Drug-Resistance develops
TheWGS guided Antiviral and Monoclonal Ab therapy
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About 30% of the general population
is a nasal carrier of Staphylococcus aureus
and most don't know.
May be a cause of chronic fatigue and/or pain
In the linked document we explain how to remove it
using an antiseptic solution to apply with a cotton swab:
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THE EXISTENCE OF PERSISTENT INFECTION BY SARS COV-2 UP TO 230 DAYS AFTER THE ONSET OF SYMPTOMS IS CONFIRMED BY AUTOPSIES.
Recent publication by researchers from the National Institutes of Health (NIH) of USA
demonstrates disseminated viral persistence:
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EFFECTIVE TREATMENT FOR
#LONGCOVID
:
Since April 2020 we treat patients with COVID.
We are very clear that Viral Persistence exists.
Treatment remains to be completed for:
MULTIDRUGS-RESISTANT VIRAL LOAD,
AND COVERED IN
#BIOCLOTS
AND
#BIOAMILOID
(6th Step)
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AZVUDINE (FNC) FOR LONG COVID
Comes in 1mg pills
Dose in COVID: for those who weigh between 60 to 95 kilos it is 5 mg per day (5 pills/d)
Each bottle is priced in China at 270 yuan ($38)
Each bottle contains 35 1mg pills
For 21 days, 3 bottles are required
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ACYCLOVIR IN PATIENTS WITH LONG COVID
WITH MEMORY LOSS AND OTHER NEUROLOGICAL SYMPTOMS
Conclusion:Acyclovir may be a safe and effective treatment for COVID neurologic symptoms
We recommend it if you suspect
Viral Encephalopathy and/or
Coinfection with HSV1
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About Clots/Microclots in COVID it has been known since April 2020
It was demonstrated with the first autopsies
A lot of studies
they keep going around something that is already known
This is convenient for those who live on grants
And the studies with Antivirals are postponed
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It has been identified that infection by SARS CoV2
even in its mild/asymptomatic forms
is a powerful trigger for the reactivation of latent viruses
that lay dormant
the most frequent are the herpesviruses EBV and HHV-6
and the human endogenous retrovirus K
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In this study carried out with children and young people under 18 years of age who had had COVID confirmed by PCR
In 22.4% of the Asymptomatic
who were assumed to have already recovered from COVID,
Elevated D-Dimer found: Microclots
They are Undiagnosed LC
STUDY SHOWS RAISED D-DIMER
IN 64.3% OF PEOPLE UNDER 18 YEARS OLD
WITH
#LONGCOVID
This % was identified in those who had 3 or + persistent symptoms for at least 12 weeks
The authors conclude that these findings support the existence of Chronic Endotheliitis
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In 2of the cases
47year-o. women
Myocarditis symptoms appeared only after vaccination
this means
who were carriers of a latent infection
Authors point out:
This suggests a triggering (resolving) role of the vaccine
when administered after an infection
that can remain asymptomatic
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The BASIC SCHEME with IVT + Aspirin + Famotidine, has been developed for COVID by Variants.
In those with symptoms (fever, headache,etc), we recommend starting with 2 to 3 doses a day
The goal is to reduce the viral load before the infection progresses and affects multiple organs
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LONG COVID WITH VIRAL PERSISTENCE FOR LIFE
There is a Subgroup of patients with Long COVID/Chronic COVID in which the SARS COV2 infection persists indefinitely
The goal is to minimize the Viral Load
for the virus to go into a state of Latency or Inactivity
Interview that the Long COVID Apheresis Community carried out on me
I mention:
Treatment against Viral Load
Therapeutic Test for Viral Persistence
The free Test with which in a few minutes you can perform the Clinical Diagnosis of Microclots/Bioclots
And +
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LongCOVID:
ADVERSE EFFECTS OF
SUICIDAL AND HOMICIDAL THOUGHTS AND BEHAVIORS
DUE TO THE USE OF THE SSRIS
FLUVOXAMINE AND FLUOXETINE
These effects occur more frequently in young adults and adolescents
With Antivirals all the symptoms of LongCOVID are reduced
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If it is already known that the most frequent cause of
#LongCOVID
is a Persistent Infection by SARS CoV-2, it is not correct to use the terms Sequelae, PACS or Post-COVID
When an infection persists for more than 3 or 6 months, the disease is called CHRONIC
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In patients with
#LongCOVID
or
#PACS
,
in the Gut Microbiome,
there is a decrease in the following genres:
1.Blautia
2.Bifidobacteria
3.Roseburia
4.Faecalibacteria (F. prausnitzii).
The 2nd and 4th are Butyrate (short chain fatty acid) producers
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An antiviral
from which we have that:
Low-cost generics can be purchased
It has 2 decades of experience in its use
It is available in most countries
It is Emtricitabine/Tenofovir disoproxil=Truvada
More than half of the patients are responding to treatment
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VIRAL PERSISTENCE FOR 665-686 DAYS
This is the longest duration of SARS CoV-2 persistence identified
The 24 Long COVID patients were between 455 to 686 days from initial infection
and in almost all of them, SARS-CoV-2 was identified in the skeletal muscle
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DOSE OF
#SERRAPEPTASE
#NATTOKINASE
#LUMBROKINASE
BROMELAIN
LYSINE
GINGER
TAXIFOLIN
GARLIC
#FAMOTIDINE
The doses presented are for the 6days of the Therapeutic Test for the Diagnosis of Persistent Clots /Hypoperfusion
If is going to continue
be Re-evaluated
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FIRST EVIDENCE PUBLISHED OF PERSISTENT CLOTS IN PATIENTS WITH CHRONIC OR LONG COVID
Findings support the steps in the “MANAGEMENT OF THE PATIENT WITH PERSISTENT SYMPTOMS OF COVID” and our Schemes that include Fibrinolytics, Anticoagulants and Antiplatelets
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REMISSION OF SEVERE FORMS OF LONG COVID
AFTER SPECIFIC TREATMENT AGAINST VIRAL PERSISTENCE
=POSITIVE THERAPEUTIC TEST
Specific Monoclonal Antibody was used against SARS CoV-2
Rapid and complete recovery and sustained remission
We have seen it since May2020
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@EricTopol
@ahandvanish
@LisaAMcCorkell
@juliamv
@NatureRevMicro
Excellent review¡
ANTIVIRAL TREATMENT OF LONG COVID
2 out of 3 patients respond within a few days with
Tenofovir/Emtricitabine (Truvada or generic)
If there is Tachycardia/Myocarditis we include Mebivolol
For Drug-Resistance other antivirals must be added
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Antivirals for LongCOVID
By:
.Safety/fewer adverse effects
.Tolerance/possibility of taking it for several months
.Availability, ease of obtaining it/Cost
The first option to try is:
Tenofovir DF/Emtricitabine (Truvada)
Then they follow:
Sofosbuvir, IVM, Amantadine, Valacyclovir
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In the case of
#MECFS
#FIBROMYALGIA
RHEUMATOID ARTHRITIS
#SJOGREN
progress must be made towards the Etiological Diagnosis
being this mainly
PERSISTENT INTRACELLULAR INFECTIONS
so just like in
#LongCOVID
the main thing is to reduce the Viral/Microbial Load
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