Aaron Novikoff
@AaronNovikoff
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The rich man's wealth is his strong city
TU München
Joined August 2011
Amgen's new GLP-1R agonist/GIPR antagonist, AMG 133, is making waves in the anti-obesity field. Curious? Our latest short piece highlights the first clinical success of AMG 133, its background, and the GIPR-centric questions that arise from its success.
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Damn.
A driver drove a vehicle into a group of people in Munich, injuring several, German police said. Authorities didn’t immediately give a specific number of injuries or provide details about the incident.
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Number 2 especially relevant since research is the reason universities exist; and collegiate sports can only exist if there is a university 🤷🏻♂️ Also.. probably want to optimize your university toward the paying bachelor and master’s students, and not toward being a sports club.
Top 10 ways American Science can survive the 15% indirect cap: 1.Breed special transgenic mice that can run for days in tiny hamster wheel turbines to keep lights on 2.Get athletic program staff to donate 1% of their salaries to research thus raising 100 billion dollars a year.
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RT @Cell_Metabolism: Ergothioneine improves healthspan of aged animals by enhancing cGPDH activity through CSE-dependent persulfidation htt…
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This one hits home. Translational science at its finest.
Simulations and experiments suggest that an egg is best cooked by repeatedly alternating between boiling and tepid water
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RT @ScienceMagazine: Bioengineered sensors have helped reveal the activity of neuropeptides in the brain, researchers reported in 2023 in S…
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RT @LoewyLawFirm: Sharing this A+ analysis on the Luka trade by the always insightful @chris_kratovil Makes a ton of sense to me from the…
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RT @DanielJDrucker: Can one selectively modulate the RAMP-3 GLP-1R interaction to augment GLP-1R signalling? https:…
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@TheBiotechBear Cool thoughts, I like this idea too. However the BWs at start of treatment discontinuation are different (Rimonabant -10% vs Sema -18% BW loss). When Sema rebound hits -10%, the rate of body weight regain following that point seems less than the CB1 inverse agonist.
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RT @jens_lund: @ethanjweiss Regarding the biological function of these pseudodipeptides: the main problem is not that it is studies in mice…
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RT @ethanjweiss: This one is pretty cool. It’s mice and all but could explain the anorectic mechanism of ketones A β-hydroxybutyrate shu…
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RT @AgnesCallard: If we were designed to think solo, monologue would be easier than dialogue. Dialogue involves INCREDIBLY complex acts of…
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RT @DanielJDrucker: Subcutaneous Amycretin moves the needle with up to 22% weight loss over 36 wks in P2 #obesity @novonordisk
https://t.co…
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RT @EricTopol: We knew about the potential origin of Parkinson's disease from the gut (known as Braak’s hypothesis). But the kidney?! https…
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RT @zenbrainest: Wow! This is incredible: Resolving native GABAA receptor structures from the human brain
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RT @DanielJDrucker: Can one selectively target the anorectic but not the aversive GLP-1R circuits for weight loss? Depends on how one does…
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RT @BarteltLab: Today, we report that chronic intermittent fasting impairs beta-cell maturation & function in adolescent mice. Using scRNAs…
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