Now in #PAIN: “Meningeal KATP channels contribute to behavioral responses in preclinical migraine models” by Hao-Ruei Mei et al.

Check out articles like “Functional connectivity associations with menstrual pain characteristics in adolescents: an investigation of the triple network model” by Payne et al. in #PAIN

2025 marks the 50th anniversary of #PAIN! We’d like to thank all of our readers, authors, reviewers, and editors for their support over the years. Together, we can make the next 50 years even more successful!

Payne et al. find that menstrual pain severity, interference, and cumulative menstrual pain exposure were associated with functional connectivity of 3 key brain networks in adolescent girls with menstrual pain. Learn more in #PAIN

Now in #PAIN: “Functional connectivity associations with menstrual pain characteristics in adolescents: an investigation of the triple network model” by Payne et al.

Check out articles like “Decoding pain: uncovering the factors that affect the performance of neuroimaging-based pain models” by @dong_hee_lee et al. in #PAIN

The February 2025 issue of #PAIN is out now! Catch up on the latest pain research at

@dong_hee_lee et al.’s survey and benchmark analysis of neuroimaging-based pain biomarkers highlight the significant impact of data level, spatial scale, and sample size on model performance. Learn more in #PAIN

Now in #PAIN: “Decoding pain: uncovering the factors that affect the performance of neuroimaging-based pain models” by @dong_hee_lee et al.

Check out articles like “Transient receptor potential melastatin 8 contributes to the interleukin-33-mediated cold allodynia in a mouse model of neuropathic pain” by Lixia Du et al. in #PAIN

This week’s #PAIN Featured Image is a schematic illustration of IL-33/ST2 signaling in DRG mediating neuropathic cold pain. To learn more, check out Lixia Du et al.’s new study

Lixia Du et al. find that interleukin-33/ST2 signaling mediates neuropathic cold pain through downstream cold-sensitive transient receptor potential melastatin 8 channels, thereby identifying a potential analgesic target for treatment. Learn more in #PAIN

Now in #PAIN: “Transient receptor potential melastatin 8 contributes to the interleukin-33-mediated cold allodynia in a mouse model of neuropathic pain” by Lixia Du et al.

Check out articles like “High-frequency electrical stimulation increases cortical excitability and mechanical sensitivity in a chronic large animal model” by @CNAP_AAU et al. in #PAIN

The February 2025 issue of #PAIN is out now! Catch up on the latest pain research at

@CNAP_AAU et al. find that high-frequency stimulation resulted in increased event-related potentials and mechanical hypersensitivity. Event-related potentials and mechanical hypersensitivity were correlated. Learn more in #PAIN

Now in #PAIN: “High-frequency electrical stimulation increases cortical excitability and mechanical sensitivity in a chronic large animal model” by @CNAP_AAU et al.

Check out articles like “Where do we start? Health care transition in adolescents and young adults with chronic primary pain” by Feinstein et al. in #PAIN

@IASPpain has designated 2025 the Global Year About Pain Management, Education, and Research in Low- and Middle-Income Settings. Read our collection of corresponding articles in #PAIN

Feinstein et al. review complexities of the health care transition process for adolescents and young adults with chronic pain, including key structural differences between pediatric and adult chronic pain management systems. Learn more in #PAIN