RT @AegeanConf: SAVE THE DATE May 15-20, 2025 - 20th International Conference on #InnateImmunity in #Sissi #Crete #Greece at the Kalimera K…

Dudakov and colleagues report the age-associated emergence of unique TEC states linked with tissue degeneration. Read it here:

Irvine and colleagues suggest that targeting IL-12 and IL-15 to CD45 is an effective antitumor treatment and limits adverse effects associated with cytokine therapies. Read it here:

Zhou and colleagues suggest that the p97–Npl4 complex promotes the differentiation and recruitment of tumor infiltrating Tregs and this can be blocked with thonzonium bromide. Read it here:

Sun and colleagues suggest that nucleophosmin 1 expression in ILC3s regulates IL-22 production and mitochondrial function and is required for gut homeostasis and colitis prevention. Read it here:

Pinho and colleagues identified a serum glycome signature on circulating antibodies IgGs detectable up to 6 years before Crohn’s disease diagnosis. Read it here:

Marie and colleagues identify a population of tumorigenic Th17 cells in the intestine. Read it here:

Vinuesa and colleagues identify patients with a pathogenic variant in TNIP1 that resulted in B cell mediated autoimmunity by enhancing IFN1 signaling and reducing mitophagy. Read it here:

Muppidi and colleagues find that loss of the G-protein Gα13 suppressed diffuse large B cell lymphoma formation in the mesenteric lymph nodes by limiting the effects of dietary nutrients. Read it here:

Uldrich and colleagues describe the crystal structure of the Vγ9Vδ2 TCR interacting with BTN2A1. Read it here:

Regev and colleagues describe the role of BACH2 in promoting immunomodulatory Th17 cells. Read it here:

Seshadri and colleagues find that resistance to infection with Mycobacterium tuberculosis is associated with CD4+ T cells with of TH17 and regulatory T cell-like functional programs. Read it here:

Kreslavsky and colleagues describe a role for thymic innate-like T cells in tolerance by direct antigen presentation to autoreactive CD8+ T cells. Read it here:

Colonna and colleagues provide a resource of ILC1 heterogeneity in human tissues. Read it here:

Vivier and colleagues integrated scRNA-seq and CITE-seq data to provide a resource of human NK cell heterogeneity in healthy tissues and in the tumor setting. Read it here:

Malmberg and colleagues provide a single-cell transcriptional reference map of healthy human NK cells and use this profile of tumor infiltrating NK cells. Read it here:

Dong and colleagues describe the reciprocal regulation of TFH cells and DCs in colonic lymphoid follicles and how this promotes colitis. Read it here:

Great group photo of all the attendees at the Aegean Conference on Mesenchymal Cells in Health and Disease.

Congratulations to all of the trainee winners @AegeanConf #fibroblasts #mesenchyma_cells #stromal_immunology

Casali and colleagues describe a mouse model with a human lymphoid and myeloid immune system, that expresses BCR and TCR repertories as diverse as humans and mounts antibody responses to infection and vaccination. Read it here: